STRINGSTRING
MDH2 MDH2 PDPR PDPR PDP2 PDP2 SUCLG2 SUCLG2 DLAT DLAT PDK4 PDK4 GSTZ1 GSTZ1 ACO2 ACO2 FH FH PDK1 PDK1 PDK3 PDK3 SUCLA2 SUCLA2 SUCLG1 SUCLG1 FAHD1 FAHD1 VDAC1 VDAC1 NNT NNT PDHB PDHB RXRA RXRA DLD DLD IDH2 IDH2 HAGH HAGH LDHB LDHB PDHA2 PDHA2 D2HGDH D2HGDH ADHFE1 ADHFE1 DLST DLST PDHX PDHX PDK2 PDK2 GLO1 GLO1 PDP1 PDP1 ME3 ME3 SDHC SDHC L2HGDH L2HGDH OGDH OGDH ME1 ME1 PPARD PPARD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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MDH2Malate dehydrogenase. (337 aa)
PDPRPyruvate dehydrogenase phosphatase regulatory subunit. (940 aa)
PDP2Pyruvate dehyrogenase phosphatase catalytic subunit 2. (534 aa)
SUCLG2Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (432 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (632 aa)
PDK4Protein-serine/threonine kinase. (414 aa)
GSTZ1Uncharacterized protein; Belongs to the GST superfamily. (266 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (785 aa)
FHUncharacterized protein. (507 aa)
PDK1Protein-serine/threonine kinase; Belongs to the PDK/BCKDK protein kinase family. (408 aa)
PDK3Protein-serine/threonine kinase. (406 aa)
SUCLA2Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (463 aa)
SUCLG1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (331 aa)
FAHD1FAA_hydrolase domain-containing protein. (223 aa)
VDAC1Uncharacterized protein. (307 aa)
NNTNicotinamide nucleotide transhydrogenase. (1086 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
RXRARetinoid X receptor alpha. (467 aa)
DLDDihydrolipoyl dehydrogenase. (508 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
HAGHHydroxyacylglutathione hydrolase, mitochondrial; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. (310 aa)
LDHBL-lactate dehydrogenase B chain; Belongs to the LDH/MDH superfamily. LDH family. (333 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (404 aa)
D2HGDHD-2-hydroxyglutarate dehydrogenase. (541 aa)
ADHFE1Fe-ADH domain-containing protein. (465 aa)
DLSTLipoyl-binding domain-containing protein. (474 aa)
PDHXDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (502 aa)
PDK2Protein-serine/threonine kinase. (412 aa)
GLO1Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (180 aa)
PDP1PPM-type phosphatase domain-containing protein. (580 aa)
ME3Malic enzyme; Belongs to the malic enzymes family. (783 aa)
SDHCSuccinate dehydrogenase complex subunit C. (140 aa)
L2HGDHL-2-hydroxyglutarate dehydrogenase. (459 aa)
OGDHTransket_pyr domain-containing protein. (1506 aa)
ME1Malic enzyme. (655 aa)
PPARDUncharacterized protein. (545 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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