STRINGSTRING
SNRPE SNRPE SRSF3 SRSF3 NCBP1 NCBP1 LSM10 LSM10 CPSF4 CPSF4 SNRPD3 SNRPD3 NCBP2 NCBP2 ALYREF ALYREF CLP1 CLP1 CSTF1 CSTF1 RNPS1 RNPS1 SRSF5 SRSF5 CPSF2 CPSF2 SRSF11 SRSF11 CSTF3 CSTF3 POLDIP3 POLDIP3 FIP1L1 FIP1L1 CDC40 CDC40 SLBP SLBP CPSF3 CPSF3 PCF11 PCF11 DHX38 DHX38 EIF4A3 EIF4A3 UPF3B UPF3B SARNP SARNP LSM11 LSM11 SNRPN SNRPN SRSF5A SRSF5A PAPOLB PAPOLB CASC3 CASC3 CPSF7 CPSF7 RBM8A RBM8A THOC2 THOC2 SRSF2 SRSF2 SRSF7L SRSF7L THOC3 THOC3 FYTTD1 FYTTD1 THOC1 THOC1 THOC7 THOC7 SNRPF SNRPF SNRPGP15 SNRPGP15 U2AF2 U2AF2 CSTF2 CSTF2 NUDT21 NUDT21 PABPN1 PABPN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SNRPESmall nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (92 aa)
SRSF3RRM domain-containing protein. (164 aa)
NCBP1Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U sn [...] (793 aa)
LSM10LSM10, U7 small nuclear RNA associated. (123 aa)
CPSF4Uncharacterized protein. (243 aa)
SNRPD3Small nuclear ribonucleoprotein Sm D3. (126 aa)
NCBP2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (159 aa)
ALYREFRRM domain-containing protein. (255 aa)
CLP1Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phospho [...] (425 aa)
CSTF1Cleavage stimulation factor subunit 1. (537 aa)
RNPS1RNA binding protein with serine rich domain 1. (284 aa)
SRSF5Uncharacterized protein. (264 aa)
CPSF2Cleavage and polyadenylation specificity factor subunit 2. (782 aa)
SRSF11RRM domain-containing protein. (541 aa)
CSTF3Suf domain-containing protein. (718 aa)
POLDIP3RRM domain-containing protein. (418 aa)
FIP1L1Fip1 domain-containing protein. (545 aa)
CDC40WD_REPEATS_REGION domain-containing protein. (580 aa)
SLBPHistone stem-loop binding protein. (274 aa)
CPSF3Cleavage and polyadenylation specific factor 3. (691 aa)
PCF11PCF11 cleavage and polyadenylation factor subunit. (1690 aa)
DHX38Uncharacterized protein. (1230 aa)
EIF4A3Eukaryotic initiation factor 4A-III; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the [...] (412 aa)
UPF3BSmg4_UPF3 domain-containing protein. (478 aa)
SARNPSAP domain-containing protein. (210 aa)
LSM11LSM11, U7 small nuclear RNA associated. (361 aa)
SNRPNSmall nuclear ribonucleoprotein-associated protein B; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (By similarity). Is also a component of the minor U12 spliceosome (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity). (240 aa)
SRSF5AUncharacterized protein. (278 aa)
PAPOLBPoly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (737 aa)
CASC3CASC3 exon junction complex subunit. (657 aa)
CPSF7Cleavage and polyadenylation specific factor 7. (533 aa)
RBM8ARNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (163 aa)
THOC2THO complex 2. (1505 aa)
SRSF2Serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. (221 aa)
SRSF7LUncharacterized protein. (250 aa)
THOC3WD_REPEATS_REGION domain-containing protein. (381 aa)
FYTTD1UAP56-interacting factor; Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore (By similarity). (307 aa)
THOC1Death domain-containing protein. (671 aa)
THOC7Uncharacterized protein. (323 aa)
SNRPFSm domain-containing protein. (86 aa)
SNRPGP15Small nuclear ribonucleoprotein G. (76 aa)
U2AF2U2 small nuclear RNA auxiliary factor 2. (699 aa)
CSTF2RRM domain-containing protein. (573 aa)
NUDT21Nudix hydrolase domain-containing protein. (473 aa)
PABPN1RRM domain-containing protein. (474 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.