STRINGSTRING
RACK1 RACK1 MAPKAPK2 MAPKAPK2 ARHGEF16 ARHGEF16 TRAF1 TRAF1 ARHGEF39 ARHGEF39 FASLG FASLG TRADD TRADD USP4 USP4 LOC378902 LOC378902 MCF2 MCF2 ARHGEF12 ARHGEF12 AKAP13 AKAP13 RAC1 RAC1 FADD FADD SPATA2 SPATA2 CASP8 CASP8 NET1 NET1 ARHGDIA ARHGDIA NCSTN NCSTN ECT2 ECT2 TBK1 TBK1 CYLD CYLD ARHGEF26 ARHGEF26 OBSL1 OBSL1 SOS2 SOS2 ARHGEF33 ARHGEF33 OTUD7B OTUD7B IKBKE IKBKE RASGRF2 RASGRF2 ARHGEF10 ARHGEF10 ARHGEF5 ARHGEF5 ARHGEF17 ARHGEF17 ADAM17 ADAM17 UBE2D1 UBE2D1 RHOA RHOA RIPK1 RIPK1 NFKB1 NFKB1 PRKCI PRKCI FAS FAS MYD88 MYD88 MCF2L MCF2L FGD3 FGD3 VAV2 VAV2 SMPD3 SMPD3 ABR ABR NGEF NGEF TRIO TRIO TIAM1 TIAM1 NGFR NGFR RIPK2 RIPK2 TNFAIP3 TNFAIP3 ITSN1 ITSN1 RPS27A RPS27A ARHGEF10L ARHGEF10L UBE2D3 UBE2D3 SOS1 SOS1 IKBKB IKBKB TAX1BP1 TAX1BP1 ULK1 ULK1 LOC101747587 LOC101747587 SMPD2 SMPD2 ARHGEF38 ARHGEF38 UBE2D2 UBE2D2 SQSTM1 SQSTM1 TIAM2 TIAM2 ARHGEF11 ARHGEF11 VAV3 VAV3 KALRN KALRN PLEKHG5 PLEKHG5 STUB1 STUB1 LOC107051192 LOC107051192 TNFSF10 TNFSF10 CASP10 CASP10 ARHGEF9 ARHGEF9 APH1A APH1A MAPK8 MAPK8 ARHGEF7 ARHGEF7 PREX1 PREX1 FGD4 FGD4 TRAF6 TRAF6 CASP3 CASP3 PSEN1 PSEN1 TRAF2 TRAF2 TNFRSF10B TNFRSF10B BIRC8 BIRC8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RACK1Receptor of activated protein C kinase 1; Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity). Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. (317 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (395 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16. (701 aa)
TRAF1TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
ARHGEF39Uncharacterized protein. (338 aa)
FASLGTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (295 aa)
TRADDTNFRSF1A associated via death domain. (461 aa)
USP4Ubiquitin carboxyl-terminal hydrolase. (963 aa)
LOC378902Uncharacterized protein. (416 aa)
MCF2MCF.2 cell line derived transforming sequence. (1122 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
AKAP13Uncharacterized protein. (1341 aa)
RAC1GTPase cRac1A. (192 aa)
FADDFas associated via death domain. (195 aa)
SPATA2Uncharacterized protein. (523 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
NET1Uncharacterized protein. (540 aa)
ARHGDIAUncharacterized protein. (204 aa)
NCSTNNcstrn_small domain-containing protein. (717 aa)
ECT2Epithelial cell transforming 2. (914 aa)
TBK1Protein kinase domain-containing protein. (729 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (941 aa)
ARHGEF26Rho guanine nucleotide exchange factor 26. (784 aa)
OBSL1Obscurin like 1. (2245 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1330 aa)
ARHGEF33Rho guanine nucleotide exchange factor 33. (794 aa)
OTUD7BOTU deubiquitinase 7B. (843 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (837 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1232 aa)
ARHGEF10Rho guanine nucleotide exchange factor 10. (1352 aa)
ARHGEF5Uncharacterized protein. (1733 aa)
ARHGEF17Rho guanine nucleotide exchange factor 17. (1433 aa)
ADAM17Tumor necrosis factor alpha converting enzyme. (829 aa)
UBE2D1UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
RHOAGTP-binding protein. (193 aa)
RIPK1Uncharacterized protein. (682 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit; P105 is the precursor of the p50 subunit of the nuclear factor NF-kappa-B, which binds to the kappa-B consensus sequence 5'- GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. The precursor protein itself does not bind to DNA. (983 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (599 aa)
FASUncharacterized protein. (339 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (299 aa)
MCF2LUncharacterized protein. (1259 aa)
FGD3FYVE, RhoGEF and PH domain containing 3. (940 aa)
VAV2Uncharacterized protein. (844 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (662 aa)
ABRABR activator of RhoGEF and GTPase. (873 aa)
NGEFUncharacterized protein. (533 aa)
TRIOTrio Rho guanine nucleotide exchange factor. (3076 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1594 aa)
NGFRTumor necrosis factor receptor superfamily member 16; Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (By similarity). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (By similarity). Necessary for the circadian oscillatio [...] (416 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (574 aa)
TNFAIP3TNF alpha induced protein 3. (806 aa)
ITSN1Intersectin 1. (1696 aa)
RPS27AUbiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa)
ARHGEF10LRho guanine nucleotide exchange factor 10 like. (1224 aa)
UBE2D3UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1319 aa)
IKBKBProtein kinase domain-containing protein. (753 aa)
TAX1BP1Uncharacterized protein. (816 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1081 aa)
LOC101747587Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...] (305 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (410 aa)
ARHGEF38Rho guanine nucleotide exchange factor 38. (772 aa)
UBE2D2Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (238 aa)
SQSTM1Sequestosome 1. (453 aa)
TIAM2Uncharacterized protein. (1705 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1785 aa)
VAV3GDP/GTP exchange factor VAV3. (846 aa)
KALRNKalirin RhoGEF kinase. (2980 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1416 aa)
STUB1STIP1 homology and U box-containing protein 1; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Mediates polyubiquitination of DNA polymerase beta (POLB), thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. May ubiquitinate EPHA2 and regulate the receptor stability and activity through proteasomal degradation. (314 aa)
LOC107051192RanBP2-type domain-containing protein. (1255 aa)
TNFSF10TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (292 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (455 aa)
ARHGEF9Cdc42 guanine nucleotide exchange factor 9. (1300 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (311 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1680 aa)
FGD4FYVE, RhoGEF and PH domain containing 4. (890 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (283 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (544 aa)
TNFRSF10BUncharacterized protein. (429 aa)
BIRC8Inhibitor of apoptosis protein 3. (493 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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