32 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	SKP1	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). (163 aa)
	CASP8	Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
	IRAK4	Protein kinase domain-containing protein. (373 aa)
	RBX1	RING-type domain-containing protein. (108 aa)
	PELI2	Pellino E3 ubiquitin protein ligase family member 2. (420 aa)
	TAB1	PPM-type phosphatase domain-containing protein. (502 aa)
	TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (697 aa)
	USP14	Ubiquitin carboxyl-terminal hydrolase. (466 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (679 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit; P105 is the precursor of the p50 subunit of the nuclear factor NF-kappa-B, which binds to the kappa-B consensus sequence 5'- GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. The precursor protein itself does not bind to DNA. (983 aa)
	PELI3	Uncharacterized protein. (418 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (299 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7. (643 aa)
	TNIP2	CCHC NOA-type domain-containing protein. (521 aa)
	FBXW11	Uncharacterized protein. (531 aa)
	IL1R1	Uncharacterized protein. (554 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (776 aa)
	RPS27A	Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	NLRC5	NACHT domain-containing protein. (1862 aa)
	IKBKB	Protein kinase domain-containing protein. (753 aa)
	LOC101747587	Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...] (305 aa)
	SQSTM1	Sequestosome 1. (453 aa)
	IL1R2	Interleukin 1 receptor type 2. (412 aa)
	MAP2K6	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (378 aa)
	MAP3K3	Mitogen-activated protein kinase kinase kinase 3. (710 aa)
	NFKBIB	NFKB inhibitor beta. (320 aa)
	MAP3K8	Mitogen-activated protein kinase kinase kinase 8. (487 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (544 aa)
	IRAK2	Protein kinase domain-containing protein. (725 aa)
	IL1RAP	Interleukin 1 receptor accessory protein. (795 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP8	IL1B	ENSGALP00000013591	ENSGALP00000050171	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-1; Belongs to the IL-1 family.	0.850
CASP8	MYD88	ENSGALP00000013591	ENSGALP00000042597	Uncharacterized protein; Belongs to the peptidase C14A family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.551
CASP8	SQSTM1	ENSGALP00000013591	ENSGALP00000053754	Uncharacterized protein; Belongs to the peptidase C14A family.	Sequestosome 1.	0.552
CASP8	TRAF2	ENSGALP00000013591	ENSGALP00000070161	Uncharacterized protein; Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.900
CASP8	TRAF6	ENSGALP00000013591	ENSGALP00000068399	Uncharacterized protein; Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.825
CUL1	FBXW11	ENSGALP00000046909	ENSGALP00000045042	Cullin 1; Belongs to the cullin family.	Uncharacterized protein.	0.994
CUL1	LOC101747587	ENSGALP00000046909	ENSGALP00000053353	Cullin 1; Belongs to the cullin family.	Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...]	0.770
CUL1	MAP3K8	ENSGALP00000046909	ENSGALP00000068369	Cullin 1; Belongs to the cullin family.	Mitogen-activated protein kinase kinase kinase 8.	0.499
CUL1	NFKB1	ENSGALP00000046909	ENSGALP00000036814	Cullin 1; Belongs to the cullin family.	Nuclear factor NF-kappa-B p105 subunit; P105 is the precursor of the p50 subunit of the nuclear factor NF-kappa-B, which binds to the kappa-B consensus sequence 5'- GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. The precursor protein itself does not bind to DNA.	0.644
CUL1	NFKBIB	ENSGALP00000046909	ENSGALP00000065843	Cullin 1; Belongs to the cullin family.	NFKB inhibitor beta.	0.552
CUL1	RBX1	ENSGALP00000046909	ENSGALP00000019539	Cullin 1; Belongs to the cullin family.	RING-type domain-containing protein.	0.999
CUL1	RPS27A	ENSGALP00000046909	ENSGALP00000050085	Cullin 1; Belongs to the cullin family.	Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...]	0.839
CUL1	SKP1	ENSGALP00000046909	ENSGALP00000010447	Cullin 1; Belongs to the cullin family.	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity).	0.999
CUL1	TNIP2	ENSGALP00000046909	ENSGALP00000044555	Cullin 1; Belongs to the cullin family.	CCHC NOA-type domain-containing protein.	0.511
FBXW11	CUL1	ENSGALP00000045042	ENSGALP00000046909	Uncharacterized protein.	Cullin 1; Belongs to the cullin family.	0.994
FBXW11	LOC101747587	ENSGALP00000045042	ENSGALP00000053353	Uncharacterized protein.	Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...]	0.639
FBXW11	MAP3K8	ENSGALP00000045042	ENSGALP00000068369	Uncharacterized protein.	Mitogen-activated protein kinase kinase kinase 8.	0.510
FBXW11	NFKB1	ENSGALP00000045042	ENSGALP00000036814	Uncharacterized protein.	Nuclear factor NF-kappa-B p105 subunit; P105 is the precursor of the p50 subunit of the nuclear factor NF-kappa-B, which binds to the kappa-B consensus sequence 5'- GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. The precursor protein itself does not bind to DNA.	0.665
FBXW11	NFKBIB	ENSGALP00000045042	ENSGALP00000065843	Uncharacterized protein.	NFKB inhibitor beta.	0.655
FBXW11	RBX1	ENSGALP00000045042	ENSGALP00000019539	Uncharacterized protein.	RING-type domain-containing protein.	0.977