(12 nodes) IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation network (Gallus gallus)

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Your Input:
	TLR4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
	TAB1	PPM-type phosphatase domain-containing protein. (502 aa)
	TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (697 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (679 aa)
	TICAM1	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (735 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7. (643 aa)
	RPS27A	Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa)
	CD14	Uncharacterized protein. (465 aa)
	LOC101747587	Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...] (305 aa)
	LY96	Lymphocyte antigen 96. (155 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
	IRAK2	Protein kinase domain-containing protein. (725 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD14	IRAK2	ENSGALP00000052840	ENSGALP00000072173	Uncharacterized protein.	Protein kinase domain-containing protein.	0.601
CD14	LOC101747587	ENSGALP00000052840	ENSGALP00000053353	Uncharacterized protein.	Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...]	0.515
CD14	LY96	ENSGALP00000052840	ENSGALP00000066705	Uncharacterized protein.	Lymphocyte antigen 96.	0.893
CD14	MAP3K7	ENSGALP00000052840	ENSGALP00000043939	Uncharacterized protein.	Mitogen-activated protein kinase kinase kinase 7.	0.546
CD14	RPS27A	ENSGALP00000052840	ENSGALP00000050085	Uncharacterized protein.	Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...]	0.515
CD14	TAB1	ENSGALP00000052840	ENSGALP00000019817	Uncharacterized protein.	PPM-type phosphatase domain-containing protein.	0.546
CD14	TAB2	ENSGALP00000052840	ENSGALP00000020155	Uncharacterized protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.566
CD14	TAB3	ENSGALP00000052840	ENSGALP00000026205	Uncharacterized protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 3.	0.566
CD14	TICAM1	ENSGALP00000052840	ENSGALP00000041887	Uncharacterized protein.	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines.	0.688
CD14	TLR4	ENSGALP00000052840	ENSGALP00000011319	Uncharacterized protein.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.981
CD14	TRAF6	ENSGALP00000052840	ENSGALP00000068399	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.655
IRAK2	CD14	ENSGALP00000072173	ENSGALP00000052840	Protein kinase domain-containing protein.	Uncharacterized protein.	0.601
IRAK2	LOC101747587	ENSGALP00000072173	ENSGALP00000053353	Protein kinase domain-containing protein.	Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...]	0.540
IRAK2	LY96	ENSGALP00000072173	ENSGALP00000066705	Protein kinase domain-containing protein.	Lymphocyte antigen 96.	0.659
IRAK2	MAP3K7	ENSGALP00000072173	ENSGALP00000043939	Protein kinase domain-containing protein.	Mitogen-activated protein kinase kinase kinase 7.	0.718
IRAK2	RPS27A	ENSGALP00000072173	ENSGALP00000050085	Protein kinase domain-containing protein.	Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...]	0.531
IRAK2	TAB1	ENSGALP00000072173	ENSGALP00000019817	Protein kinase domain-containing protein.	PPM-type phosphatase domain-containing protein.	0.787
IRAK2	TAB2	ENSGALP00000072173	ENSGALP00000020155	Protein kinase domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.967
IRAK2	TAB3	ENSGALP00000072173	ENSGALP00000026205	Protein kinase domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 3.	0.896
IRAK2	TICAM1	ENSGALP00000072173	ENSGALP00000041887	Protein kinase domain-containing protein.	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines.	0.719