STRINGSTRING
PSMF1 PSMF1 FBXL17 FBXL17 PSMD7 PSMD7 PSMB7 PSMB7 PSMB3 PSMB3 PSMD5 PSMD5 VCP VCP PSMA4 PSMA4 SKP2 SKP2 PSMD9 PSMD9 CUL3 CUL3 PSMD2 PSMD2 SKP1 SKP1 PSMA6 PSMA6 PSMD14 PSMD14 PSMB1 PSMB1 EP300 EP300 RBX1 RBX1 PSMA3 PSMA3 BACH1 BACH1 PSMB4 PSMB4 UFD1L UFD1L PSMC3 PSMC3 PSMD11 PSMD11 PSMD12 PSMD12 PSMB2 PSMB2 PSMD4 PSMD4 PSMA5 PSMA5 CUL1 CUL1 MAFK MAFK SESN1 SESN1 PRDX1 PRDX1 PSMD3 PSMD3 RPS27A RPS27A PSMA2 PSMA2 TRIM58 TRIM58 SESN2 SESN2 LOC101747587 LOC101747587 MUL1 MUL1 SQSTM1 SQSTM1 PSMD13 PSMD13 CREBBP CREBBP NPLOC4 NPLOC4 PSMC2 PSMC2 PSMB6 PSMB6 PSME3 PSME3 PSMC6 PSMC6 MAP1LC3B MAP1LC3B GSK3B GSK3B AKT1 AKT1 PSMD6 PSMD6 UBXN7 UBXN7 PSMC5 PSMC5 SRXN1 SRXN1 SESN3 SESN3 NFE2L2 NFE2L2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMF1Uncharacterized protein. (271 aa)
FBXL17F-box and leucine rich repeat protein 17. (442 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
PSMB7Proteasome subunit beta. (277 aa)
PSMB3Proteasome subunit beta. (205 aa)
PSMD5Uncharacterized protein. (457 aa)
VCPValosin containing protein. (806 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
SKP2F-box domain-containing protein. (520 aa)
PSMD9PDZ domain-containing protein. (207 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). (163 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
PSMD14MPN domain-containing protein. (310 aa)
PSMB1Proteasome subunit beta. (237 aa)
EP300E1A binding protein p300. (2450 aa)
RBX1RING-type domain-containing protein. (108 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
BACH1BTB domain and CNC homolog 1. (675 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (258 aa)
UFD1LUbiquitin fusion-degradation 1-like protein. (307 aa)
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (422 aa)
PSMD11PCI domain-containing protein. (422 aa)
PSMD12PCI domain-containing protein. (456 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMD4VWFA domain-containing protein. (376 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
MAFKTranscription factor MafK; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. (156 aa)
SESN1Sestrin 1. (564 aa)
PRDX1Peroxiredoxin-1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron diffe [...] (199 aa)
PSMD3PCI domain-containing protein. (602 aa)
RPS27AUbiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
TRIM58Uncharacterized protein. (559 aa)
SESN2Uncharacterized protein. (474 aa)
LOC101747587Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...] (305 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (252 aa)
SQSTM1Sequestosome 1. (453 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. (376 aa)
CREBBPCREB binding protein. (2522 aa)
NPLOC4NPL4 homolog, ubiquitin recognition factor. (609 aa)
PSMC2AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa)
PSMB6Proteasome subunit beta. (204 aa)
PSME3Proteasome activator complex subunit 3; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity). (421 aa)
PSMC6AAA domain-containing protein; Belongs to the AAA ATPase family. (431 aa)
MAP1LC3BUncharacterized protein. (125 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (400 aa)
UBXN7UBX domain protein 7. (623 aa)
PSMC5AAA domain-containing protein; Belongs to the AAA ATPase family. (427 aa)
SRXN1Sulfiredoxin. (155 aa)
SESN3Sestrin 3. (492 aa)
NFE2L2BZIP domain-containing protein. (593 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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