STRINGSTRING
PSMF1 PSMF1 PSMD7 PSMD7 PSMB7 PSMB7 PSMB3 PSMB3 PSMD5 PSMD5 PSMA4 PSMA4 PSMD9 PSMD9 PSMD2 PSMD2 SKP1 SKP1 PSMA6 PSMA6 PSMD14 PSMD14 PSMB1 PSMB1 RBX1 RBX1 PSMA3 PSMA3 PSMB4 PSMB4 PSMC3 PSMC3 PSMD11 PSMD11 PSMD12 PSMD12 PSMB2 PSMB2 PSMD4 PSMD4 PSMA5 PSMA5 CUL1 CUL1 PSMD3 PSMD3 RPS27A RPS27A PSMA2 PSMA2 LOC101747587 LOC101747587 PSMD13 PSMD13 PSMC2 PSMC2 PSMB6 PSMB6 PSME3 PSME3 PSMC6 PSMC6 GSK3B GSK3B PSMD6 PSMD6 PSMC5 PSMC5 NFE2L2 NFE2L2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMF1Uncharacterized protein. (271 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
PSMB7Proteasome subunit beta. (277 aa)
PSMB3Proteasome subunit beta. (205 aa)
PSMD5Uncharacterized protein. (457 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
PSMD9PDZ domain-containing protein. (207 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). (163 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
PSMD14MPN domain-containing protein. (310 aa)
PSMB1Proteasome subunit beta. (237 aa)
RBX1RING-type domain-containing protein. (108 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (258 aa)
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (422 aa)
PSMD11PCI domain-containing protein. (422 aa)
PSMD12PCI domain-containing protein. (456 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMD4VWFA domain-containing protein. (376 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
PSMD3PCI domain-containing protein. (602 aa)
RPS27AUbiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
LOC101747587Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...] (305 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. (376 aa)
PSMC2AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa)
PSMB6Proteasome subunit beta. (204 aa)
PSME3Proteasome activator complex subunit 3; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity). (421 aa)
PSMC6AAA domain-containing protein; Belongs to the AAA ATPase family. (431 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (400 aa)
PSMC5AAA domain-containing protein; Belongs to the AAA ATPase family. (427 aa)
NFE2L2BZIP domain-containing protein. (593 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.