(85 nodes) Factors involved in megakaryocyte development and platelet production network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	DOCK5	Dedicator of cytokinesis 5; Belongs to the DOCK family. (1877 aa)
	DOCK2	Dedicator of cytokinesis 2; Belongs to the DOCK family. (1835 aa)
	JMJD1C	JmjC domain-containing protein. (2529 aa)
	CAPZB	F-actin-capping protein subunit beta isoforms 1 and 2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the regulation of cell morphology and cytoskeletal organization. (277 aa)
	MFN2	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (762 aa)
	SH2B3	SH2B adaptor protein 3. (539 aa)
	AKAP10	A-kinase anchoring protein 10. (617 aa)
	AKAP1	A-kinase anchoring protein 1. (883 aa)
	DOCK11	Dedicator of cytokinesis 11; Belongs to the DOCK family. (2068 aa)
	LOC425049	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
	KIF3B	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (739 aa)
	KIF3A	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (706 aa)
	PRKAR2A	Protein kinase cAMP-dependent type II regulatory subunit alpha. (400 aa)
	RAC1	GTPase cRac1A. (192 aa)
	TUBB1	Tubulin beta-6 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (446 aa)
	PRKAR2B	Protein kinase cAMP-dependent type II regulatory subunit beta. (415 aa)
	RBSN	Rabenosyn, RAB effector. (787 aa)
	EHD3	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa)
	KIF6	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (737 aa)
	KIF2C	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (733 aa)
	DOCK8	Dedicator of cytokinesis 8; Belongs to the DOCK family. (2036 aa)
	KIF28P	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (997 aa)
	KIF26B	Kinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2119 aa)
	KIF25	Kinesin family member 25; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (496 aa)
	RCOR1	REST corepressor 1. (449 aa)
	KIF26A	Kinesin family member 26A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1893 aa)
	KIF18A	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (969 aa)
	TUBB2B	Tubulin beta-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (445 aa)
	CENPE	Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2228 aa)
	PHF21A	PHD-type domain-containing protein. (679 aa)
	GATA2	GATA-binding factor 2; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (466 aa)
	GATA6	Transcription factor GATA-6; Transcriptional activator. (387 aa)
	H3F3C	Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
	PRKAR1A	cAMP-dependent protein kinase type I-alpha regulatory subunit. (382 aa)
	TUBAL3	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (459 aa)
	KIF3C	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (749 aa)
	HMG20B	High mobility group 20B. (319 aa)
	PRKACB	Uncharacterized protein; Belongs to the protein kinase superfamily. (398 aa)
	HIST1H3H	Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
	KIF11	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1065 aa)
	TUBA1A	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
	LIMD2	LIM zinc-binding domain-containing protein. (147 aa)
	DOCK1	Dedicator of cytokinesis 1; Belongs to the DOCK family. (1866 aa)
	KIF21A	Kinesin family member 21A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1721 aa)
	LOC100857858	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
	CBX5	Chromobox 5. (189 aa)
	TUBA1B	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (466 aa)
	KIF15	Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1402 aa)
	KIF13B	Kinesin family member 13B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1737 aa)
	TUBA8A	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (447 aa)
	RAD51C	RAD51 paralog C. (360 aa)
	KDM1A	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (826 aa)
	KIF21B	Kinesin family member 21B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1629 aa)
	PRKAR1B	Protein kinase cAMP-dependent type I regulatory subunit beta. (422 aa)
	KIF23	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (972 aa)
	DOCK3	Dedicator of cytokinesis 3; Belongs to the DOCK family. (2047 aa)
	AK3	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (234 aa)
	KIF18B	Kinesin-like protein KIF18B; May play an important role in microtubule plus-end depolymerizing activity in mitotic cells; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (797 aa)
	RACGAP1	Rac GTPase activating protein 1. (638 aa)
	TUBB6	Tubulin beta-5 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
	CARMIL1	Uncharacterized protein. (1429 aa)
	ZFPM2	Zinc finger protein, FOG family member 2. (1151 aa)
	CAPZA2	F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. CapZ may mediate the attachment of the barbed ends of actin filaments to the Z-line. (286 aa)
	CAPZA1	F-actin-capping protein subunit alpha-1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. (286 aa)
	MFN1	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (740 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. (480 aa)
	KIFAP3	Kinesin associated protein 3. (793 aa)
	CDC42	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] (194 aa)
	KIF1A	Kinesin family member 1A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1803 aa)
	ENSGALP00000066559	LIM zinc-binding domain-containing protein. (1012 aa)
	DOCK4	Dedicator of cytokinesis 4; Belongs to the DOCK family. (2023 aa)
	KIF27	Kinesin family member 27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1399 aa)
	ZFPM1	Zinc finger protein, FOG family member 1. (1079 aa)
	DOCK7	Dedicator of cytokinesis 7; Belongs to the DOCK family. (2172 aa)
	DOCK9	Dedicator of cytokinesis 9; Belongs to the DOCK family. (2105 aa)
	GATA3	GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa)
	LOC112530163	SH2 domain-containing protein. (839 aa)
	RAD51B	RAD51 paralog B. (415 aa)
	DOCK10	Dedicator of cytokinesis 10; Belongs to the DOCK family. (2212 aa)
	XIRP2	LIM zinc-binding domain-containing protein. (123 aa)
	KIF16B	Kinesin family member 16B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2059 aa)
	ITPK1	Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. May also act as an isomerase that interconverts the inositol tetrakisphos [...] (455 aa)
	KIF9	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (812 aa)
	KIF1B	Kinesin family member 1B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1816 aa)
	EHD2	EH domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP1	AKAP10	ENSGALP00000008930	ENSGALP00000007445	A-kinase anchoring protein 1.	A-kinase anchoring protein 10.	0.452
AKAP1	PRKACB	ENSGALP00000008930	ENSGALP00000041979	A-kinase anchoring protein 1.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.862
AKAP1	PRKAR1A	ENSGALP00000008930	ENSGALP00000033915	A-kinase anchoring protein 1.	cAMP-dependent protein kinase type I-alpha regulatory subunit.	0.670
AKAP1	PRKAR1B	ENSGALP00000008930	ENSGALP00000050473	A-kinase anchoring protein 1.	Protein kinase cAMP-dependent type I regulatory subunit beta.	0.667
AKAP1	PRKAR2A	ENSGALP00000008930	ENSGALP00000011344	A-kinase anchoring protein 1.	Protein kinase cAMP-dependent type II regulatory subunit alpha.	0.669
AKAP1	PRKAR2B	ENSGALP00000008930	ENSGALP00000013072	A-kinase anchoring protein 1.	Protein kinase cAMP-dependent type II regulatory subunit beta.	0.667
AKAP10	AKAP1	ENSGALP00000007445	ENSGALP00000008930	A-kinase anchoring protein 10.	A-kinase anchoring protein 1.	0.452
AKAP10	PRKACB	ENSGALP00000007445	ENSGALP00000041979	A-kinase anchoring protein 10.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.661
AKAP10	PRKAR1A	ENSGALP00000007445	ENSGALP00000033915	A-kinase anchoring protein 10.	cAMP-dependent protein kinase type I-alpha regulatory subunit.	0.769
AKAP10	PRKAR1B	ENSGALP00000007445	ENSGALP00000050473	A-kinase anchoring protein 10.	Protein kinase cAMP-dependent type I regulatory subunit beta.	0.769
AKAP10	PRKAR2A	ENSGALP00000007445	ENSGALP00000011344	A-kinase anchoring protein 10.	Protein kinase cAMP-dependent type II regulatory subunit alpha.	0.769
AKAP10	PRKAR2B	ENSGALP00000007445	ENSGALP00000013072	A-kinase anchoring protein 10.	Protein kinase cAMP-dependent type II regulatory subunit beta.	0.769
CAPZA1	CAPZA2	ENSGALP00000056898	ENSGALP00000056878	F-actin-capping protein subunit alpha-1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.	F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. CapZ may mediate the attachment of the barbed ends of actin filaments to the Z-line.	0.968
CAPZA1	CAPZB	ENSGALP00000056898	ENSGALP00000006415	F-actin-capping protein subunit alpha-1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.	F-actin-capping protein subunit beta isoforms 1 and 2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the regulation of cell morphology and cytoskeletal organization.	0.999
CAPZA1	CARMIL1	ENSGALP00000056898	ENSGALP00000056037	F-actin-capping protein subunit alpha-1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.	Uncharacterized protein.	0.959
CAPZA2	CAPZA1	ENSGALP00000056878	ENSGALP00000056898	F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. CapZ may mediate the attachment of the barbed ends of actin filaments to the Z-line.	F-actin-capping protein subunit alpha-1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.	0.968
CAPZA2	CAPZB	ENSGALP00000056878	ENSGALP00000006415	F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. CapZ may mediate the attachment of the barbed ends of actin filaments to the Z-line.	F-actin-capping protein subunit beta isoforms 1 and 2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the regulation of cell morphology and cytoskeletal organization.	0.984
CAPZA2	CARMIL1	ENSGALP00000056878	ENSGALP00000056037	F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. CapZ may mediate the attachment of the barbed ends of actin filaments to the Z-line.	Uncharacterized protein.	0.623
CAPZB	CAPZA1	ENSGALP00000006415	ENSGALP00000056898	F-actin-capping protein subunit beta isoforms 1 and 2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the regulation of cell morphology and cytoskeletal organization.	F-actin-capping protein subunit alpha-1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.	0.999
CAPZB	CAPZA2	ENSGALP00000006415	ENSGALP00000056878	F-actin-capping protein subunit beta isoforms 1 and 2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the regulation of cell morphology and cytoskeletal organization.	F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. CapZ may mediate the attachment of the barbed ends of actin filaments to the Z-line.	0.984