STRINGSTRING
SMC5 SMC5 SMC6 SMC6 BRCA2 BRCA2 RAD50 RAD50 RAD51 RAD51 RAD51C RAD51C RAD51D RAD51D NSMCE2 NSMCE2 XRCC3 XRCC3 ENSGALP00000065689 ENSGALP00000065689 ENSGALP00000070978 ENSGALP00000070978 ENSGALP00000072941 ENSGALP00000072941 ERCC4 ERCC4 TPRKB TPRKB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMC5Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; [...] (1065 aa)
SMC6SMC_N domain-containing protein. (1096 aa)
BRCA2Tower domain-containing protein. (3397 aa)
RAD50Zinc-hook domain-containing protein. (1313 aa)
RAD51DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. (339 aa)
RAD51CRAD51 paralog C. (360 aa)
RAD51DRECA_2 domain-containing protein. (327 aa)
NSMCE2SP-RING-type domain-containing protein. (239 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (382 aa)
ENSGALP00000065689Uncharacterized protein. (143 aa)
ENSGALP00000070978XRCC1_N domain-containing protein. (182 aa)
ENSGALP00000072941Uncharacterized protein. (909 aa)
ERCC4ERCC4 domain-containing protein. (903 aa)
TPRKBTP53RK binding protein; Belongs to the CGI121/TPRKB family. (174 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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