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| | RAD21L1 | RAD21 cohesin complex component like 1. (673 aa) |
| | POLL | DNA polymerase lambda. (844 aa) |
| | SAMHD1 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Functions during S phase at stalled DNA replication forks to promote the resection [...] (614 aa) |
| | CDC45 | Cell division cycle 45. (566 aa) |
| | RECQL5 | Uncharacterized protein. (1052 aa) |
| | BRCA1 | Uncharacterized protein. (1749 aa) |
| | ERCC4 | ERCC4 domain-containing protein. (903 aa) |
| | RPA1 | Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (614 aa) |
| | CDK1 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle (By similarity). It is required in higher cells for entry into S-phase and mitosis (By similarity). p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). May play a role in regulating the amplitude of the cyclic expression of circadian clock genes (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (303 aa) |
| | LOC427439 | Nipped-B protein. (2783 aa) |
| | MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also play a role in signal transduction in response to DNA damage. May regulate the activation of the [...] (211 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1020 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (929 aa) |
| | CDC7 | Cell division cycle 7. (564 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1341 aa) |
| | NSMCE1 | NSE1 homolog, SMC5-SMC6 complex component. (256 aa) |
| | TM4SF19 | Uncharacterized protein. (220 aa) |
| | RMI2 | RecQ-mediated genome instability protein 2; Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. (137 aa) |
| | EPC1 | Enhancer of polycomb homolog. (814 aa) |
| | BLM | Bloom syndrome protein homolog; ATP-dependent DNA helicase that unwinds single- and double- stranded DNA in a 3'-5' direction. Participates in DNA replication and repair (By similarity). Involved in 5'-end resection of DNA during double-strand break (DSB) repair (By similarity). Negatively regulates sister chromatid exchange (SCE) (By similarity). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (By similarity). Binds DNA. Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (By similarity). Belongs to the helicase family. R [...] (1380 aa) |
| | MCM8 | DNA helicase MCM8; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. (830 aa) |
| | EXD2 | 3'-5' exonuclease domain-containing protein. (621 aa) |
| | SHFM1 | Uncharacterized protein. (70 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | PSMD14 | MPN domain-containing protein. (310 aa) |
| | HELQ | Helicase, POLQ like. (1048 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (328 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | RMI1 | RecQ-mediated genome instability protein 1; Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A- mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity). (627 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (859 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (661 aa) |
| | MCM9 | DNA helicase MCM9; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. (1169 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (912 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3167 aa) |
| | SMC5 | Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; [...] (1065 aa) |
| | MMS22L | Protein MMS22-like; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. (1399 aa) |
| | SMC6 | SMC_N domain-containing protein. (1096 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (941 aa) |
| | FANCB | Uncharacterized protein. (965 aa) |
| | MCM3 | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (812 aa) |
| | BRCA2 | Tower domain-containing protein. (3397 aa) |
| | ATM | Non-specific serine/threonine protein kinase. (3050 aa) |
| | MRE11 | Double-strand break repair protein MRE11; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restr [...] (709 aa) |
| | RAD51AP1 | Uncharacterized protein. (255 aa) |
| | WDR48 | WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. (678 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (825 aa) |
| | MEIOB | Meiosis specific with OB-fold. (344 aa) |
| | RNF138 | Ring finger protein 138. (246 aa) |
| | RAD54L | DNA repair and recombination protein RAD54-like; Involved in DNA repair and mitotic recombination; Belongs to the SNF2/RAD54 helicase family. (804 aa) |
| | ZSWIM7 | SWIM-type domain-containing protein. (140 aa) |
| | LOC427025 | Nipped-B protein. (2769 aa) |
| | LOC101748706 | Uncharacterized protein. (2151 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (279 aa) |
| | NABP1 | Nucleic acid binding protein 1. (209 aa) |
| | ZFYVE26 | Zinc finger FYVE-type containing 26. (2561 aa) |
| | AP5Z1 | Adaptor related protein complex 5 subunit zeta 1. (814 aa) |
| | RAD51 | DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. (339 aa) |
| | MCMDC2 | Uncharacterized protein. (356 aa) |
| | MBTD1 | Mbt domain containing 1. (685 aa) |
| | RAD54B | DNA repair and recombination protein RAD54B; Involved in DNA repair and mitotic recombination; Belongs to the SNF2/RAD54 helicase family. (918 aa) |
| | NSMCE2 | SP-RING-type domain-containing protein. (239 aa) |
| | RAD21 | Uncharacterized protein. (633 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (284 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recr [...] (753 aa) |
| | NABP2 | Nucleic acid binding protein 2. (225 aa) |
| | PRKDC | DNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act a [...] (4132 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (382 aa) |
| | RAD52 | DNA repair protein RAD52 homolog; Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase (By similarity). (422 aa) |
| | RAD51AP2 | Uncharacterized protein. (1331 aa) |
| | INTS3 | Integrator complex subunit 3. (1116 aa) |
| | ENSGALP00000065485 | GIY-YIG domain-containing protein. (71 aa) |
| | NUCKS1 | Uncharacterized protein. (355 aa) |
| | ENSGALP00000066976 | Uncharacterized protein. (39 aa) |
| | INIP | SOSS complex subunit C; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) (By similarity). (155 aa) |
| | WRN | Uncharacterized protein. (1622 aa) |
| | RAD51B | RAD51 paralog B. (415 aa) |
| | RAD51C | RAD51 paralog C. (360 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1740 aa) |
| | RAD51D | RECA_2 domain-containing protein. (327 aa) |
| | AP5S1 | Adaptor related protein complex 5 subunit sigma 1. (184 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (752 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (937 aa) |
| | FANCM | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double- stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a mova [...] (2101 aa) |
| | ENSGALP00000070978 | XRCC1_N domain-containing protein. (182 aa) |
| | FBXO18 | F-box DNA helicase 1; 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (By similarity). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress: p [...] (1021 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1034 aa) |
| | INO80 | Uncharacterized protein. (1565 aa) |
| | SFR1 | Swi5-dependent recombination DNA repair protein 1 homolog; Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (By similarity). May act as a transcriptional modulator for ESR1 (By similarity). (222 aa) |
| | SWI5 | SWI5 homologous recombination repair protein. (117 aa) |
| | ANKLE1 | Ankyrin repeat and LEM domain containing 1. (609 aa) |
