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| | GPLD1 | Glycosylphosphatidylinositol specific phospholipase D1. (856 aa) |
| | ANKRD11 | Ankyrin repeat domain 11. (2707 aa) |
| | GP1BB | Glycoprotein Ib platelet subunit beta. (202 aa) |
| | PTPN6 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (639 aa) |
| | HOXB4 | Homeobox protein Hox-B4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Deformed subfamily. (245 aa) |
| | HOXC11 | Homeobox C11. (193 aa) |
| | LOC100857622 | EXPERA domain-containing protein. (218 aa) |
| | OSTN | Uncharacterized protein. (148 aa) |
| | RAB23 | Uncharacterized protein. (237 aa) |
| | HOXA11 | Homeobox protein Hox-A11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (297 aa) |
| | NOG2 | Noggin; Belongs to the noggin family. (207 aa) |
| | CTNNB1 | Uncharacterized protein. (781 aa) |
| | TBX3 | T-box transcription factor TBX3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. (732 aa) |
| | NFIB | Nuclear factor 1 B-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (560 aa) |
| | EXFABP | Extracellular fatty acid-binding protein; Siderocalin-like lipocalin tightly binding a variety of bacterial ferric siderophores, also binds long-chain unsaturated fatty acids such as linoleic acid, oleic acid, arachidonic acid and, with a lower affinity, long chain saturated fatty acids such as steraic acid. May act as an antibacterial factor, through dual ligand specificity, both as a siderophore-sequestrating molecule and a lysophosphatidic acid (LPA) sensor; Belongs to the calycin superfamily. Lipocalin family. (178 aa) |
| | IMPAD1 | Inositol monophosphatase domain containing 1. (356 aa) |
| | HAND1 | Heart- and neural crest derivatives-expressed protein 1; Transcription factor (By similarity). Plays an essential role in cardiac morphogenesis. (202 aa) |
| | SH3PXD2B | SH3 and PX domains 2B. (876 aa) |
| | ENSGALP00000044025 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (617 aa) |
| | FGR | Proto-oncogene tyrosine-protein kinase Yrk; May participate in signaling pathways; Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. (536 aa) |
| | GLG1 | Golgi apparatus protein 1; Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils) (By similarity). Binds fibroblast growth factor (FGF). May be involved in intracellular FGF trafficking and the regulation of cellular responses to FGFS. (1194 aa) |
| | FAM20C | FAM20C golgi associated secretory pathway kinase. (556 aa) |
| | SOX5 | Transcription factor LSox5-II. (772 aa) |
| | MYF5 | Myogenic factor 5; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (258 aa) |
| | SIX2 | Sine oculis-related homeobox 2 homolog. (287 aa) |
| | DMRT2 | Doublesex and mab-3 related transcription factor 2. (597 aa) |
| | CSRNP1 | Cysteine and serine rich nuclear protein 1. (469 aa) |
| | OGN | Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. (294 aa) |
| | HOXA6 | Homeobox protein Hox-A6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (231 aa) |
| | HOXA1 | Homeobox A1. (320 aa) |
| | HOXA3 | Homeobox protein Hox-A3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (413 aa) |
| | ALX3 | ALX homeobox 3. (311 aa) |
| | TMEM38B | Transmembrane protein 38B. (287 aa) |
| | TNFSF11 | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (400 aa) |
| | WNT9B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (388 aa) |
| | RFLNA | Refilin A. (212 aa) |
| | AMER1 | APC membrane recruitment protein 1. (1163 aa) |
| | TGM2 | Protein-glutamine gamma-glutamyltransferase 2; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. (697 aa) |
| | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. (519 aa) |
| | HOXD3 | Homeobox D3. (413 aa) |
| | HOXD4 | Homeobox protein Hox-D4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'; Belongs to the Antp homeobox family. Deformed subfamily. (237 aa) |
| | HOXD10 | Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (339 aa) |
| | SOX9 | Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa) |
| | SEMA4D | Semaphorin-4D; Cell surface receptor for PLXNB1 that plays an important role in cell-cell signaling (By similarity). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (By similarity). (855 aa) |
| | BMPR1B | Bone morphogenetic protein receptor type-1B; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptiona (By similarity). Positively regulates chondrocyte differentiation. (502 aa) |
| | MATN3 | Matrilin-3; Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks. (452 aa) |
| | MUSTN1 | Musculoskeletal embryonic nuclear protein 1; May be involved in the development and regeneration of the musculoskeletal system; Belongs to the MUSTANG family. (78 aa) |
| | HAPLN3 | Hyaluronan and proteoglycan link protein 3. (359 aa) |
| | MYOC | Myocilin. (467 aa) |
| | FGF8 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa) |
| | PHOSPHO2 | Phosphatase, orphan 2. (244 aa) |
| | LEPR | Uncharacterized protein. (1148 aa) |
| | WNT11B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (386 aa) |
| | TGFB2 | Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (412 aa) |
| | CHAD | Uncharacterized protein. (361 aa) |
| | WDR48 | WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. (678 aa) |
| | HOXD9 | Homeobox protein Hox-D9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (302 aa) |
| | HOXA4 | Homeobox protein Hox-A4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'. (457 aa) |
| | SIX4 | SIX homeobox 4. (776 aa) |
| | FGF6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa) |
| | MMP13 | ZnMc domain-containing protein. (530 aa) |
| | LECT1 | Leukocyte cell-derived chemotaxin 1; Bifunctional growth regulator. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization (By similarity); Belongs to the chondromodulin-1 family. (347 aa) |
| | SHOX | Shox. (291 aa) |
| | IL17F | Uncharacterized protein. (169 aa) |
| | ARSE | Sulfatase domain-containing protein. (597 aa) |
| | ARSD | Sulfatase domain-containing protein. (596 aa) |
| | IFT172 | Intraflagellar transport 172. (1749 aa) |
| | BMP5 | BMP5. (453 aa) |
| | CYP26B1 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa) |
| | DDRGK1 | DDRGK domain containing 1. (221 aa) |
| | EIF2AK3 | Eukaryotic translation initiation factor 2 alpha kinase 3. (1085 aa) |
| | RIPPLY2 | Ripply transcriptional repressor 2. (131 aa) |
| | WHSC1-2 | Uncharacterized protein. (592 aa) |
| | VCAN | Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. (3559 aa) |
| | ZFAND5 | Uncharacterized protein. (334 aa) |
| | CDH2 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity). (912 aa) |
| | EVC | Uncharacterized protein. (984 aa) |
| | CYTL1 | Cytokine like 1. (132 aa) |
| | MSX1 | Homeobox protein GHOX-7; Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death. (288 aa) |
| | HEXB | Beta-hexosaminidase. (558 aa) |
| | TRIM45 | Tripartite motif containing 45. (358 aa) |
| | ASH1L | ASH1 like histone lysine methyltransferase. (3026 aa) |
| | E1C1Y1_CHICK | Uncharacterized protein. (351 aa) |
| | PEX7 | WD_REPEATS_REGION domain-containing protein. (360 aa) |
| | CDH7 | Cadherin-7; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. (785 aa) |
| | HAPLN2 | Hyaluronan and proteoglycan link protein 2. (374 aa) |
| | JAG2 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1300 aa) |
| | CREB3L2 | cAMP responsive element binding protein 3 like 2. (520 aa) |
| | BMP6 | Bone morphogenetic protein 6. (434 aa) |
| | EDN1 | Endothelin 1. (194 aa) |
| | BMP4 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. (404 aa) |
| | EP300 | E1A binding protein p300. (2450 aa) |
| | MGP | Matrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation; Belongs to the osteocalcin/matrix Gla protein family. (103 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (671 aa) |
| | IHH | Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. (408 aa) |
| | EPYC | Epiphycan; May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. (316 aa) |
| | PKDCCB | PIP49_C domain-containing protein. (378 aa) |
| | ITGB6 | Integrin beta; Belongs to the integrin beta chain family. (789 aa) |
| | HOXA9 | Homeobox protein Hox-A9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (260 aa) |
| | HOXA10 | Homeobox domain-containing protein. (364 aa) |
| | SNX10 | PX domain-containing protein. (201 aa) |
| | USP1 | Ubiquitin carboxyl-terminal hydrolase. (794 aa) |
| | TRIP11 | Thyroid hormone receptor interactor 11. (1980 aa) |
| | EDNRA | Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa) |
| | HMGA2 | High mobility group protein I-C. (109 aa) |
| | RAB33B | Ras-related protein Rab-33B; Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking (By similarity). It is involved in autophagy, acting as a modulator of autophagosome formation (By similarity); Belongs to the small GTPase superfamily. Rab family. (228 aa) |
| | IFT80 | Intraflagellar transport 80. (790 aa) |
| | IFT140 | WD_REPEATS_REGION domain-containing protein. (1453 aa) |
| | DLX5 | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. (286 aa) |
| | MKKS | Uncharacterized protein. (570 aa) |
| | ATP6AP1 | Uncharacterized protein. (455 aa) |
| | CTAGE1 | Otoraplin; Belongs to the MIA/OTOR family. (132 aa) |
| | ABI1 | Uncharacterized protein. (507 aa) |
| | CYR61 | CCN family member 1; Probable secreted regulatory protein. (375 aa) |
| | DDR1 | Uncharacterized protein. (873 aa) |
| | LHX5 | LIM homeobox protein 5. (402 aa) |
| | ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif 7. (1815 aa) |
| | SNAI1 | Snail like protein. (256 aa) |
| | BMP7 | Bone morphogenetic protein 7. (465 aa) |
| | FGF4 | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb development during embryogenesis (By similarity). (194 aa) |
| | WFIKKN2 | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (570 aa) |
| | LRRK1 | Leucine rich repeat kinase 1. (1998 aa) |
| | AKAP13 | Uncharacterized protein. (1341 aa) |
| | ACAN | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2089 aa) |
| | WDR60 | WD repeat domain 60. (1027 aa) |
| | RYK | Receptor like tyrosine kinase. (481 aa) |
| | SHH | Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa) |
| | SOX6 | HMG box domain-containing protein. (817 aa) |
| | PAFAH1B1 | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration. (410 aa) |
| | PKD1 | Polycystin 1, transient receptor potential channel interacting. (4382 aa) |
| | CER1 | Cerberus; Cytokine that acts as a regulator of the activity of Nodal/BMP pathways during the establishment of bilateral asymmetry in the head and trunk of the embryo; Belongs to the DAN family. (272 aa) |
| | FREM1 | FRAS1 related extracellular matrix 1. (2184 aa) |
| | LHX1 | LIM/homeobox protein Lhx1; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2. (406 aa) |
| | WNT9A | Protein Wnt-9a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a role in embryonic chondrocyte maturation and in embryonic bone mineralization (By similarity). (503 aa) |
| | WWOX | WW domain-containing oxidoreductase; Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development. Inhibits Wnt signaling (By similarity). Belongs to the short-chain dehydrogenases/reductases (SDR) family. (414 aa) |
| | WNT7A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | GP9 | Glycoprotein IX platelet. (208 aa) |
| | FBN1 | Fibrillin 1. (2861 aa) |
| | RFLNB | Refilin B. (208 aa) |
| | TMEM119 | Transmembrane protein 119. (245 aa) |
| | P3H1 | Prolyl 3-hydroxylase 1; Has prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly-sequences in collagens, especially types IV and V. May be involved in the secretoty pathway of cells. Has growth suppressive activity in fibroblasts (By similarity); Belongs to the leprecan family. (725 aa) |
| | NLE1 | Notchless homolog 1. (482 aa) |
| | SH2B3 | SH2B adaptor protein 3. (539 aa) |
| | SULF2 | Extracellular sulfatase. (873 aa) |
| | NPPC-2 | C-type natriuretic peptide; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity). (130 aa) |
| | SLC2A10 | Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (595 aa) |
| | IFITM5 | Uncharacterized protein. (131 aa) |
| | DLX1 | Homeodomain transcription factor DLX1. (255 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (574 aa) |
| | SRC | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (539 aa) |
| | LOC427439 | Nipped-B protein. (2783 aa) |
| | MMP2 | 72 kDa type IV collagenase; Belongs to the peptidase M10A family. (663 aa) |
| | PRRX1 | Paired mesoderm homeobox protein 1; May participate in maintenance of mesenchymal cell lineages derived from both mesoderm and the neural crest and in patterning of the limbs and the face. (245 aa) |
| | NOG | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling. Controls somitogenesis by sequestering the BMP-4 activity which in turn differentiates distinct subtypes of the mesoderm along the mediolateral axis. (387 aa) |
| | HOMER3 | Sema domain-containing protein; Belongs to the semaphorin family. (763 aa) |
| | NOTUM | Notum, palmitoleoyl-protein carboxylesterase. (496 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa) |
| | SNX19 | Sorting nexin 19. (981 aa) |
| | SPNS2 | Sphingolipid transporter 2. (510 aa) |
| | HOXB9 | Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (273 aa) |
| | WNT11 | Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters. (354 aa) |
| | TSKU | Tsukushin; Dorsalizing factor involved in the induction of Hensen node. Functions as an inhibitor of bone morphogenetic proteins (BMP) during gastrulation. (369 aa) |
| | WFIKKN1 | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (539 aa) |
| | SIX1 | Sine oculis-related homeobox 1 homolog. (282 aa) |
| | SP3 | Transcription factor Sp3; Transcriptional factor that can act as an activator or repressor depending on post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription (By similarity). Required for activation of SPARC transcription; Belongs to the Sp1 C2H2-type zinc-finger protein family. (771 aa) |
| | SP5 | Uncharacterized protein. (369 aa) |
| | EXTL1 | Uncharacterized protein; Belongs to the glycosyltransferase 47 family. (734 aa) |
| | TBC1D31 | TBC1 domain family member 31. (1081 aa) |
| | PITX2 | Pituitary homeobox 2; May play an important role in development and maintenance of anterior structures. May play a role in determining left-right asymmetry and in vasculogenesis during avian embryogenesis. (333 aa) |
| | CCN3 | CCN family member 3; Immediate-early protein likely to play a role in cell growth regulation. Its overexpression is associated with tumorigenesis and expression of a N-terminal-truncated version of CCN3 gene in chicken embryonic fibroblasts (CEF) is sufficient to induce the transformation of CEF in vitro. (351 aa) |
| | PKDCC | Protein kinase domain containing, cytoplasmic. (496 aa) |
| | HOXC6 | Homeobox C6. (271 aa) |
| | CHD9 | Chromodomain helicase DNA binding protein 9. (2820 aa) |
| | HOXC4 | Homeobox C4. (379 aa) |
| | KIAA1217 | KIAA1217. (1953 aa) |
| | CDH15 | Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. (792 aa) |
| | OSR2 | Uncharacterized protein. (412 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (385 aa) |
| | ENSGALP00000048186 | Uncharacterized protein. (528 aa) |
| | EXT2 | Uncharacterized protein; Belongs to the glycosyltransferase 47 family. (717 aa) |
| | FOXN3 | Forkhead box N3. (532 aa) |
| | ZBTB32 | Uncharacterized protein. (665 aa) |
| | HOXB5 | Homeobox protein Hox-B5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (264 aa) |
| | ANXA2P2 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. (339 aa) |
| | CTC1 | Uncharacterized protein. (1282 aa) |
| | BNC2 | Basonuclin 2. (1059 aa) |
| | PTN | Pleiotrophin; Secreted growth factor that mediates its signal through cell- surface proteoglycan and non-proteoglycan receptors (By similarity). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (By similarity). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration (By similarity); Belongs to the pleiotrophin family. (165 aa) |
| | CHRD | Uncharacterized protein. (1208 aa) |
| | HOXB3 | Homeobox protein Hox-B3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (399 aa) |
| | SMAD1 | Mothers against decapentaplegic homolog. (465 aa) |
| | MEF2D | MADS-box domain-containing protein. (570 aa) |
| | DDR2 | Discoidin domain receptor tyrosine kinase 2. (901 aa) |
| | HOXC8 | Homeobox protein Hox-C8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (242 aa) |
| | C9H2ORF82 | Uncharacterized protein. (121 aa) |
| | NOV | CTCK domain-containing protein. (360 aa) |
| | RUNX2 | Runt-related transcription factor. (472 aa) |
| | WNT5B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (436 aa) |
| | HHIP | Hedgehog interacting protein. (697 aa) |
| | HOXB7 | Homeobox B7. (217 aa) |
| | FLI1 | Uncharacterized protein. (432 aa) |
| | TTC9 | Tetratricopeptide repeat domain 9. (208 aa) |
| | KIT | Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via [...] (960 aa) |
| | SDC3 | Syndecan-3; Cell surface proteoglycan that may bear both heparan sulfate and chondroitin sulfate. The multiple functional domains provide potential sites for mediating the adhesive cell-matrix interactions and cytoskeletal reorganization involved in limb chondrogenesis. Interaction with other matrix ligands as well as phosphorylation and shedding of the ectodomain might be involved in cell shape changes that occur during chondrogenesis. Furthermore, shedding of the ectodomain might break the adhesive interactions that promoted condensation, thus facilitating the deposition of cartilage [...] (405 aa) |
| | PHOSPHO1 | Phosphoethanolamine/phosphocholine phosphatase; Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization. Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. (268 aa) |
| | MIGA2 | Mitoguardin 2. (591 aa) |
| | BARX2 | Homeodomain transcription factor BARX2B. (267 aa) |
| | LOC427025 | Nipped-B protein. (2769 aa) |
| | DLX2 | Distal-less homeobox 2. (253 aa) |
| | HSPB11 | F5/8 type C domain-containing protein. (141 aa) |
| | MDFI | MyoD family inhibitor. (161 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | COL2A1 | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. (1420 aa) |
| | HOXD13 | Homeobox protein Hox-D13; Sequence-specific transcription factor that binds gene promoters and activates their transcription (By similarity). Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (303 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa) |
| | CHST11 | Carbohydrate sulfotransferase. (342 aa) |
| | SRF | Serum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. (492 aa) |
| | HOXC10 | Homeobox domain-containing protein. (354 aa) |
| | UNCX | Homeobox domain-containing protein. (199 aa) |
| | FGF18 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | SULF1 | Sulfatase 1. (862 aa) |
| | HOXC9 | Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (262 aa) |
| | PTPRC | Uncharacterized protein. (1237 aa) |
| | BGLAP | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (97 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (360 aa) |
| | DEAF1 | DEAF1. (546 aa) |
| | CHD7 | Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity). (3009 aa) |
| | SNAI2 | Uncharacterized protein. (258 aa) |
| | TRPS1 | Transcriptional repressor GATA binding 1. (1061 aa) |
| | SHOX2 | Short stature homeobox 2. (316 aa) |
| | BBS2 | Bardet-Biedl syndrome 2 protein homolog. (721 aa) |
| | EPHA2 | EPH receptor A2. (1288 aa) |
| | ANXA6 | Annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores (By similarity). (782 aa) |
| | TBX2 | T-box transcription factor 2. (693 aa) |
| | COL1A1 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1453 aa) |
| | NPR3 | Natriuretic peptide receptor 3. (521 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1031 aa) |
| | TAPT1 | Transmembrane anterior posterior transformation protein 1 homolog; Plays a role in primary cilia formation. May act as a downstream effector of HOXC8 during development. May be involved in cartilage and bone development. May play a role in the differentiation of cranial neural crest cells; Belongs to the TAPT1 family. (657 aa) |
| | HOXB6 | Homeobox protein Hox-B6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (222 aa) |
| | ITGB8 | Integrin beta; Belongs to the integrin beta chain family. (787 aa) |
| | WDR19 | WD_REPEATS_REGION domain-containing protein. (470 aa) |
| | HOXC5 | Homeobox domain-containing protein. (222 aa) |
| | GSC | Homeobox protein goosecoid; Involved in the development of the organizer region in the gastrula (Hensen node in chicken). (346 aa) |
| | WISP1 | Uncharacterized protein. (359 aa) |
| | DHRS3 | Uncharacterized protein. (302 aa) |
| | BCAN | Brevican. (968 aa) |
| | HEXA | Beta-hexosaminidase. (631 aa) |
| | RPL13 | 60S ribosomal protein L13; Belongs to the eukaryotic ribosomal protein eL13 family. (211 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | MCPH1 | Uncharacterized protein. (589 aa) |
| | HOXD12 | Homeobox protein Hox-D12; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (266 aa) |
| | ZNF385A | Zinc finger protein 385A. (319 aa) |
| | MKS1 | MKS transition zone complex subunit 1. (562 aa) |
| | HOXA5 | Homeobox protein Hox-A5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By similarity); Belongs to the Antp homeobox family. (318 aa) |
| | VPS33B | Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (667 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound he [...] (1106 aa) |
| | NKX3-2 | Homeobox domain-containing protein. (275 aa) |
| | NPPC | C-type natriuretic peptide. (121 aa) |
| | HOXD8 | Homeobox protein Hox-D8. (268 aa) |
| | FAM20CL | Fam20C domain-containing protein. (139 aa) |
| | EXT1 | Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (484 aa) |
| | RUNX1 | Runt-related transcription factor. (472 aa) |
| | ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif 12. (1580 aa) |
| | ATG9A | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (919 aa) |
| | SLC10A7 | Sodium/bile acid cotransporter 7; Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization. Also involved in the regulation of cellular calcium homeostasis. Does not show transport activity towards bile acids or steroid sulfates. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (355 aa) |
| | WHSC1 | Uncharacterized protein. (537 aa) |
| | SLC38A10 | Solute carrier family 38 member 10. (1251 aa) |
| | MBTPS2 | Membrane bound transcription factor peptidase, site 2. (494 aa) |
| | LOC426626 | Uncharacterized protein. (228 aa) |
| | HYAL3 | Hyaluronidase. (584 aa) |
| | ZFPM1 | Zinc finger protein, FOG family member 1. (1079 aa) |
| | RANBP3L | RAN binding protein 3 like. (534 aa) |
| | ENSGALP00000068281 | ANK_REP_REGION domain-containing protein. (213 aa) |
| | LRRC17 | p37NB protein. (437 aa) |
| | MMP9 | Uncharacterized protein. (713 aa) |
| | ARID5A | AT-rich interaction domain 5A. (618 aa) |
| | SETD2 | SET domain containing 2, histone lysine methyltransferase. (2523 aa) |
| | NCAN | Uncharacterized protein. (1325 aa) |
| | LOC101750889 | LRRCT domain-containing protein. (714 aa) |
| | ATG9B | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (771 aa) |
| | INPPL1 | Inositol polyphosphate phosphatase like 1. (1175 aa) |
| | BMP2 | Bone morphogenetic protein 2; Negatively regulates the structure and function of the limb apical ectodermal ridge. (392 aa) |
| | PSEN1 | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa) |
| | ENSGALP00000069955 | Uncharacterized protein. (496 aa) |
| | NAB2 | NGFI-A binding protein 2. (672 aa) |
| | ENSGALP00000070762 | Homeobox domain-containing protein. (160 aa) |
| | SGPL1 | Uncharacterized protein. (574 aa) |
| | RB1 | Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa) |
| | PHEX | Uncharacterized protein. (747 aa) |
| | LOC107050371 | Uncharacterized protein. (1015 aa) |
| | RDH10 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (446 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa) |
| | OSR1 | Uncharacterized protein. (260 aa) |
| | RUNX3 | RUNX family transcription factor 3. (607 aa) |
| | TMEM107 | Uncharacterized protein. (159 aa) |
| | HAPLN1 | Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix; Belongs to the HAPLN family. (355 aa) |
| | WASF2 | WASP family member 2. (528 aa) |
| | ENSGALP00000072609 | Uncharacterized protein. (215 aa) |
