STRINGSTRING
KLF10 KLF10 WNT11 WNT11 WNT3 WNT3 HOMER3 HOMER3 NOG NOG CBFB CBFB MMP2 MMP2 IFITM5 IFITM5 TMEM119 TMEM119 SOX8 SOX8 WWOX WWOX CER1 CER1 FBXL15 FBXL15 GDF10 GDF10 SNAI1 SNAI1 ADAMTS7 ADAMTS7 CREB3L1 CREB3L1 AHSG AHSG CYR61 CYR61 DLX5 DLX5 CALCR CALCR IFT80 IFT80 SPP1 SPP1 SNX10 SNX10 PKDCCB PKDCCB IHH IHH MGP MGP BMP4 BMP4 BMP6 BMP6 BCL2 BCL2 CLEC3A CLEC3A PEX7 PEX7 RIPPLY2 RIPPLY2 EIF2AK3 EIF2AK3 MMP13 MMP13 SIRT7 SIRT7 PHOSPHO2 PHOSPHO2 MYOC MYOC BMPR1B BMPR1B TGFB3 TGFB3 ATF4 ATF4 SEMA4D SEMA4D IBSP IBSP IGFBP5 IGFBP5 GLIS1 GLIS1 SOX9 SOX9 ALPL ALPL TNFSF11 TNFSF11 MN1 MN1 TMEM38B TMEM38B MYF5 MYF5 FGR FGR IMPAD1 IMPAD1 PTH PTH CTNNB1 CTNNB1 MEF2D MEF2D NOG2 NOG2 SP3 SP3 TBC1D31 TBC1D31 MSX2 MSX2 PKDCC PKDCC EXT2 EXT2 ZBTB32 ZBTB32 BMP8A BMP8A ANXA2P2 ANXA2P2 SMO SMO BMP3 BMP3 LGR4 LGR4 PTN PTN SMAD1 SMAD1 NOV NOV RUNX2 RUNX2 PHOSPHO1 PHOSPHO1 SOST SOST DHX36 DHX36 MAPK14 MAPK14 DMP1 DMP1 DHH DHH FGF18 FGF18 BGLAP BGLAP MAPK11 MAPK11 CLEC3B CLEC3B SNAI2 SNAI2 EPHA2 EPHA2 COL1A1 COL1A1 BMPR2 BMPR2 TAPT1 TAPT1 JUND JUND WISP1 WISP1 IGSF10 IGSF10 TNFRSF11A TNFRSF11A PDLIM7 PDLIM7 CSF1 CSF1 NPPC NPPC RUNX1 RUNX1 ADAMTS12 ADAMTS12 SORT1 SORT1 ANKH ANKH ADAR ADAR SUCO SUCO TRAF6 TRAF6 MMP9 MMP9 PTHLH PTHLH INPPL1 INPPL1 BMP2 BMP2 CTHRC1 CTHRC1 TNN TNN NAB2 NAB2 SLC26A2 SLC26A2 PHEX PHEX BMPR1A BMPR1A RUNX3 RUNX3 FSTL3 FSTL3 GPLD1 GPLD1 LOC100857622 LOC100857622 LEF1 LEF1 TP53INP2 TP53INP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLF10Kruppel like factor 10. (436 aa)
WNT11Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters. (354 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
HOMER3Sema domain-containing protein; Belongs to the semaphorin family. (763 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling. Controls somitogenesis by sequestering the BMP-4 activity which in turn differentiates distinct subtypes of the mesoderm along the mediolateral axis. (387 aa)
CBFBUncharacterized protein. (187 aa)
MMP272 kDa type IV collagenase; Belongs to the peptidase M10A family. (663 aa)
IFITM5Uncharacterized protein. (131 aa)
TMEM119Transmembrane protein 119. (245 aa)
SOX8Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. (470 aa)
WWOXWW domain-containing oxidoreductase; Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development. Inhibits Wnt signaling (By similarity). Belongs to the short-chain dehydrogenases/reductases (SDR) family. (414 aa)
CER1Cerberus; Cytokine that acts as a regulator of the activity of Nodal/BMP pathways during the establishment of bilateral asymmetry in the head and trunk of the embryo; Belongs to the DAN family. (272 aa)
FBXL15F-box and leucine rich repeat protein 15. (299 aa)
GDF10Growth differentiation factor 10. (283 aa)
SNAI1Snail like protein. (256 aa)
ADAMTS7ADAM metallopeptidase with thrombospondin type 1 motif 7. (1815 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (506 aa)
AHSGAlpha 2-HS glycoprotein. (344 aa)
CYR61CCN family member 1; Probable secreted regulatory protein. (375 aa)
DLX5Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. (286 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (469 aa)
IFT80Intraflagellar transport 80. (790 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (264 aa)
SNX10PX domain-containing protein. (201 aa)
PKDCCBPIP49_C domain-containing protein. (378 aa)
IHHIndian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. (408 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation; Belongs to the osteocalcin/matrix Gla protein family. (103 aa)
BMP4Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. (404 aa)
BMP6Bone morphogenetic protein 6. (434 aa)
BCL2Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
CLEC3AC-type lectin domain-containing protein. (193 aa)
PEX7WD_REPEATS_REGION domain-containing protein. (360 aa)
RIPPLY2Ripply transcriptional repressor 2. (131 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1085 aa)
MMP13ZnMc domain-containing protein. (530 aa)
SIRT7Deacetylase sirtuin-type domain-containing protein. (399 aa)
PHOSPHO2Phosphatase, orphan 2. (244 aa)
MYOCMyocilin. (467 aa)
BMPR1BBone morphogenetic protein receptor type-1B; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptiona (By similarity). Positively regulates chondrocyte differentiation. (502 aa)
TGFB3Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (535 aa)
ATF4ATF4. (354 aa)
SEMA4DSemaphorin-4D; Cell surface receptor for PLXNB1 that plays an important role in cell-cell signaling (By similarity). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (By similarity). (855 aa)
IBSPBone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment (By similarity). (200 aa)
IGFBP5Insulin like growth factor binding protein 5. (269 aa)
GLIS1GLIS family zinc finger 1. (851 aa)
SOX9Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
ALPLAlkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. (519 aa)
TNFSF11TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (400 aa)
MN1MN1 proto-oncogene, transcriptional regulator. (1210 aa)
TMEM38BTransmembrane protein 38B. (287 aa)
MYF5Myogenic factor 5; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (258 aa)
FGRProto-oncogene tyrosine-protein kinase Yrk; May participate in signaling pathways; Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. (536 aa)
IMPAD1Inositol monophosphatase domain containing 1. (356 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (119 aa)
CTNNB1Uncharacterized protein. (781 aa)
MEF2DMADS-box domain-containing protein. (570 aa)
NOG2Noggin; Belongs to the noggin family. (207 aa)
SP3Transcription factor Sp3; Transcriptional factor that can act as an activator or repressor depending on post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription (By similarity). Required for activation of SPARC transcription; Belongs to the Sp1 C2H2-type zinc-finger protein family. (771 aa)
TBC1D31TBC1 domain family member 31. (1081 aa)
MSX2Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Binds to DNA (By similarity). Morphogenetic role; Belongs to the Msh homeobox family. (259 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (496 aa)
EXT2Uncharacterized protein; Belongs to the glycosyltransferase 47 family. (717 aa)
ZBTB32Uncharacterized protein. (665 aa)
BMP8ATGF_BETA_2 domain-containing protein. (410 aa)
ANXA2P2Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. (339 aa)
SMOSmoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (462 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (952 aa)
PTNPleiotrophin; Secreted growth factor that mediates its signal through cell- surface proteoglycan and non-proteoglycan receptors (By similarity). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (By similarity). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration (By similarity); Belongs to the pleiotrophin family. (165 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
NOVCTCK domain-containing protein. (360 aa)
RUNX2Runt-related transcription factor. (472 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase; Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization. Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. (268 aa)
SOSTSclerostin. (213 aa)
DHX36DEAH-box helicase 36. (987 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
DMP1Uncharacterized protein. (429 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (97 aa)
MAPK11Mitogen-activated protein kinase. (360 aa)
CLEC3BTetranectin. (201 aa)
SNAI2Uncharacterized protein. (258 aa)
EPHA2EPH receptor A2. (1288 aa)
COL1A1Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1453 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1031 aa)
TAPT1Transmembrane anterior posterior transformation protein 1 homolog; Plays a role in primary cilia formation. May act as a downstream effector of HOXC8 during development. May be involved in cartilage and bone development. May play a role in the differentiation of cranial neural crest cells; Belongs to the TAPT1 family. (657 aa)
JUNDTranscription factor jun-D; Belongs to the bZIP family. Jun subfamily. (323 aa)
WISP1Uncharacterized protein. (359 aa)
IGSF10Uncharacterized protein. (1620 aa)
TNFRSF11ATNF receptor superfamily member 11a. (656 aa)
PDLIM7PDZ and LIM domain protein 7; May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. May be involved in bone formation (By similarity). (425 aa)
CSF1Uncharacterized protein. (493 aa)
NPPCC-type natriuretic peptide. (121 aa)
RUNX1Runt-related transcription factor. (472 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1580 aa)
SORT1Sortilin. (954 aa)
ANKHUncharacterized protein. (493 aa)
ADARRNA-specific Adenosine deaminase Transcript variant M. (1153 aa)
SUCOSUN domain containing ossification factor. (1251 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
MMP9Uncharacterized protein. (713 aa)
PTHLHParathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport; Belongs to the parathyroid hormone family. (214 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1175 aa)
BMP2Bone morphogenetic protein 2; Negatively regulates the structure and function of the limb apical ectodermal ridge. (392 aa)
CTHRC1Collagen triple helix repeat containing 1. (314 aa)
TNNTenascin N. (1125 aa)
NAB2NGFI-A binding protein 2. (672 aa)
SLC26A2Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (715 aa)
PHEXUncharacterized protein. (747 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
RUNX3RUNX family transcription factor 3. (607 aa)
FSTL3Follistatin like 3. (286 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (856 aa)
LOC100857622EXPERA domain-containing protein. (218 aa)
LEF1HMG box domain-containing protein. (412 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (213 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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