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| | CYFIP1 | Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa) |
| | DCUN1D5 | DCN1-like protein. (236 aa) |
| | GAS1 | Growth arrest specific 1. (159 aa) |
| | DPYSL2 | Dihydropyrimidinase-related protein 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. (676 aa) |
| | ADAM17 | Tumor necrosis factor alpha converting enzyme. (829 aa) |
| | EPM2A | Laforin. (319 aa) |
| | TGFB2 | Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (412 aa) |
| | WNT11B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (386 aa) |
| | ING5 | Inhibitor of growth protein. (241 aa) |
| | ISLR | Immunoglobulin superfamily containing leucine rich repeat. (422 aa) |
| | CLSTN1 | Uncharacterized protein. (971 aa) |
| | ROS1 | Proto-oncogene tyrosine-protein kinase ROS; Orphan receptor tyrosine kinase (RTK) that may activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream si [...] (2311 aa) |
| | EXOSC9 | Polymyositis/scleroderma autoantigen 1. (440 aa) |
| | SEMA4D | Semaphorin-4D; Cell surface receptor for PLXNB1 that plays an important role in cell-cell signaling (By similarity). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (By similarity). (855 aa) |
| | JUN | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. (310 aa) |
| | IGFBP5 | Insulin like growth factor binding protein 5. (269 aa) |
| | FXN | Frataxin. (167 aa) |
| | NTN1 | Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors. (688 aa) |
| | EIF4G2 | Eukaryotic translation initiation factor 4 gamma 2; Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases (By similarity). (902 aa) |
| | GDF9 | Growth differentiation factor 9. (454 aa) |
| | SUPV3L1 | ATP-dependent RNA helicase SUPV3L1, mitochondrial; Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation o [...] (794 aa) |
| | SEMA4G | Semaphorin 4G; Belongs to the semaphorin family. (841 aa) |
| | SERTAD2 | SERTA domain-containing protein. (316 aa) |
| | RERG | RAS like estrogen regulated growth inhibitor. (199 aa) |
| | SEMA3A | Semaphorin-3A; Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to neuropilin; Belongs to the semaphorin family. (815 aa) |
| | USP47 | Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). (1376 aa) |
| | ZFYVE27 | Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. (413 aa) |
| | ISLR2 | Ig-like domain-containing protein. (699 aa) |
| | NANOS1 | Nanos C2HC-type zinc finger 1; Belongs to the nanos family. (254 aa) |
| | IGFBP7 | Insulin like growth factor binding protein 7. (327 aa) |
| | RNF157 | Ring finger protein 157. (750 aa) |
| | INHBA | Inhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Induces somatostatin in the ciliary ganglion neurons and may [...] (424 aa) |
| | DCUN1D3 | Defective in cullin neddylation 1 domain containing 3. (303 aa) |
| | CHTOP | Mothers against decapentaplegic homolog. (445 aa) |
| | SEMA3F | Sema domain-containing protein; Belongs to the semaphorin family. (838 aa) |
| | SLIT2 | Uncharacterized protein. (1533 aa) |
| | ST7 | Suppressor of tumorigenicity 7 protein homolog. (554 aa) |
| | PTCH2 | Patched 2. (1266 aa) |
| | NDUFA13 | NADH:ubiquinone oxidoreductase subunit A13. (144 aa) |
| | SPHK1 | Sphingosine kinase 1. (649 aa) |
| | CCN3 | CCN family member 3; Immediate-early protein likely to play a role in cell growth regulation. Its overexpression is associated with tumorigenesis and expression of a N-terminal-truncated version of CCN3 gene in chicken embryonic fibroblasts (CEF) is sufficient to induce the transformation of CEF in vitro. (351 aa) |
| | FLCN | UDENN FLCN/SMCR8-type domain-containing protein. (579 aa) |
| | SYT2 | Synaptotagmin 2. (490 aa) |
| | ADNP2 | ADNP homeobox 2. (1055 aa) |
| | DISC1 | DISC1 scaffold protein. (856 aa) |
| | ACVR1B | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (519 aa) |
| | SYT4 | Synaptotagmin 4. (425 aa) |
| | MUC6 | Mucin-6; Ovomucin, the glycoprotein responsible for the gel properties of egg white, is composed for 2 subunits, alpha-ovomucin/MUC5B and beta-ovomucin/MUC6. (1173 aa) |
| | SEMA3E | Semaphorin-3E; Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Induces the collapse and paralysis of neuronal growth cones. Plays an important role in ensuring the specificity of synapse formation (By similarity); Belongs to the se [...] (779 aa) |
| | TCHP | Uncharacterized protein. (373 aa) |
| | PTPRD | Protein tyrosine phosphatase receptor type D. (1963 aa) |
| | ULK1 | Unc-51 like autophagy activating kinase 1. (1081 aa) |
| | NME6 | Nucleoside diphosphate kinase. (186 aa) |
| | SESN2 | Uncharacterized protein. (474 aa) |
| | MUL1 | Mitochondrial E3 ubiquitin protein ligase 1. (252 aa) |
| | BCL11A | Uncharacterized protein. (796 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa) |
| | PRDM11 | PR/SET domain 11. (1184 aa) |
| | SMAD7 | Mothers against decapentaplegic homolog. (388 aa) |
| | SRF | Serum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. (492 aa) |
| | SEMA5B | Semaphorin 5B. (1150 aa) |
| | STK11 | Serine/threonine-protein kinase STK11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity (By similarity). (426 aa) |
| | SEMA3B | Semaphorin 3B. (608 aa) |
| | SYT17 | Synaptotagmin 17. (474 aa) |
| | PTPRS | Receptor-type tyrosine-protein phosphatase S; Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (By similarity). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for norm [...] (1924 aa) |
| | MTPN | Myotrophin; Regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex (By similarity); Belongs to the myotrophin family. (118 aa) |
| | SMAD7B | Mothers against decapentaplegic homolog. (388 aa) |
| | DDX49 | Uncharacterized protein; Belongs to the DEAD box helicase family. (479 aa) |
| | DERL2 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa) |
| | DBN1 | Drebrin; Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (By similarity). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in synaptic plasticity (By similarity). (652 aa) |
| | SHTN1 | Shootin 1. (649 aa) |
| | LAMTOR2 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (312 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1031 aa) |
| | ZNF639 | Uncharacterized protein. (481 aa) |
| | DERL3 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (279 aa) |
| | IST1 | IST1 factor associated with ESCRT-III. (366 aa) |
| | SEMA6C | Semaphorin 6C; Belongs to the semaphorin family. (837 aa) |
| | ENSGALP00000060823 | Ig-like domain-containing protein. (511 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (884 aa) |
| | PLAA | Phospholipase A2 activating protein. (794 aa) |
| | EXTL3 | Exostosin like glycosyltransferase 3; Belongs to the glycosyltransferase 47 family. (919 aa) |
| | PMLL | Uncharacterized protein. (464 aa) |
| | EXOSC2 | S1 domain-containing protein. (294 aa) |
| | C6H10ORF90 | Centro_C10orf90 domain-containing protein. (603 aa) |
| | OLFM2 | Olfactomedin 2. (437 aa) |
| | SMARCA4 | Uncharacterized protein. (1178 aa) |
| | CAPRIN2 | Caprin family member 2. (1267 aa) |
| | LOC112530215 | Sema domain-containing protein; Belongs to the semaphorin family. (606 aa) |
| | ENSGALP00000065860 | LRRCT domain-containing protein. (525 aa) |
| | CDC42 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] (194 aa) |
| | SEMA6D | Semaphorin 6D; Belongs to the semaphorin family. (1088 aa) |
| | SEMA3C | Semaphorin-3C; Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin; Belongs to the semaphorin family. (751 aa) |
| | DBNL | ADF-H domain-containing protein. (124 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa) |
| | SEMA4C | Semaphorin 4C; Belongs to the semaphorin family. (1080 aa) |
| | EPB41L3 | Erythrocyte membrane protein band 4.1 like 3. (1367 aa) |
| | LAMTOR1 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa) |
| | SEMA5A | Semaphorin 5A. (1076 aa) |
| | SEMA6B | Sema domain-containing protein; Belongs to the semaphorin family. (870 aa) |
| | LGI1 | LRRCT domain-containing protein. (543 aa) |
| | SOCS2 | Uncharacterized protein. (227 aa) |
| | CDKL5 | Cyclin dependent kinase like 5. (1024 aa) |
| | DIP2B | Disco interacting protein 2 homolog B. (1572 aa) |
| | DCSTAMP | Dendrocyte expressed seven transmembrane protein. (472 aa) |
| | ACVRL1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (796 aa) |
| | CDK5 | Protein kinase domain-containing protein. (522 aa) |
| | NTRK2 | BDNF/NT-3 growth factors receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, [...] (842 aa) |
| | PTHLH | Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport; Belongs to the parathyroid hormone family. (214 aa) |
| | DCBLD2 | Uncharacterized protein. (722 aa) |
| | MYOCD | Phosphatase and actin regulator. (908 aa) |
| | LOC107056280 | Uncharacterized protein. (466 aa) |
| | SLIT3 | Uncharacterized protein. (1641 aa) |
| | CTDP1 | CTD phosphatase subunit 1. (1047 aa) |
| | CTTN | Src substrate protein p85; Contributes to the organization of the actin cytoskeleton and cell shape (By similarity). Plays a role in the formation of lamellipodia and in cell migration (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones, and may play a role in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cel [...] (516 aa) |
| | IGFBP4 | IGFBP N-terminal domain-containing protein. (284 aa) |
| | RB1 | Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa) |
| | SLC9A1 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (850 aa) |
| | UCN | Urocortin. (100 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (488 aa) |
| | RPTOR | Regulatory associated protein of MTOR complex 1. (1374 aa) |
| | BDNF | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (254 aa) |
| | MAP2 | Microtubule-associated protein. (1955 aa) |
| | DAB2 | DAB adaptor protein 2. (715 aa) |
| | MAPT | Microtubule-associated protein. (788 aa) |
| | INO80 | Uncharacterized protein. (1565 aa) |
| | HDGFRP2 | PWWP domain-containing protein. (641 aa) |
| | SPART | Spartin. (631 aa) |
| | NGF | Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. (284 aa) |
| | OSTN | Uncharacterized protein. (148 aa) |
| | ITSN2 | Intersectin 2. (1771 aa) |
| | JADE1 | Jade family PHD finger 1. (887 aa) |
| | CRLF3 | Fibronectin type-III domain-containing protein. (439 aa) |
| | MTOR | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa) |
| | OCM | Parvalbumin, thymic CPV3; Binds two calcium ions. (109 aa) |
| | FN1 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity). (2526 aa) |
| | MFSD2A | Major facilitator superfamily domain containing 2A. (528 aa) |
| | PPT1 | Uncharacterized protein. (300 aa) |
| | SH3BP4 | SH3 domain binding protein 4. (964 aa) |
| | ADAM10 | Uncharacterized protein. (749 aa) |
| | BRAT1 | BRCA1 associated ATM activator 1. (842 aa) |
| | BAP1 | Ubiquitin carboxyl-terminal hydrolase BAP1; Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity); Belongs to the peptidase C12 family. BAP1 subfamily. (751 aa) |
| | SEMA3G | Semaphorin 3G; Belongs to the semaphorin family. (761 aa) |
| | URI1 | URI1 prefoldin like chaperone. (506 aa) |
| | TRPV2 | Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (785 aa) |
| | MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also play a role in signal transduction in response to DNA damage. May regulate the activation of the [...] (211 aa) |
| | SMURF1 | E3 ubiquitin-protein ligase. (744 aa) |
| | ULK2 | Unc-51 like autophagy activating kinase 2. (1001 aa) |
| | VGLL4 | Uncharacterized protein. (294 aa) |
| | SERPINE2 | SERPIN domain-containing protein; Belongs to the serpin family. (442 aa) |
| | OLFM3 | Olfactomedin 3. (458 aa) |
| | WFDC1 | WAP four-disulfide core domain protein 1; Has growth inhibitory activity. (222 aa) |
| | IP6K2 | Kinase; Belongs to the inositol phosphokinase (IPK) family. (424 aa) |
| | SEMA3DL | Ig-like domain-containing protein. (165 aa) |
| | FAM122A | Protein FAM122A; Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity. Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA). (284 aa) |
| | FHL1 | Four and a half LIM domains 1. (297 aa) |
| | MUL1L | RING-type domain-containing protein. (418 aa) |
| | TSG101 | Uncharacterized protein. (390 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (193 aa) |
| | KLHL22 | BTB domain-containing protein. (638 aa) |
| | RYK | Receptor like tyrosine kinase. (481 aa) |
| | KIAA1024 | DD1 protein. (916 aa) |
| | SEMA3D | Semaphorin-3D; Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin; Belongs to the semaphorin family. (761 aa) |
| | NUBP1 | Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (323 aa) |
| | BCL6 | B-cell lymphoma 6 protein homolog; Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, repres [...] (708 aa) |
| | CDA | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (191 aa) |
| | RTN4R | Reticulon 4 receptor. (483 aa) |
| | KAZALD1 | Kazal type serine peptidase inhibitor domain 1. (296 aa) |
| | MAP2K5 | Uncharacterized protein. (582 aa) |
| | ADNP | Activity dependent neuroprotector homeobox. (1210 aa) |
| | NDUFS3 | Complex1_30kDa domain-containing protein; Belongs to the complex I 30 kDa subunit family. (257 aa) |
| | PSMD10 | ANK_REP_REGION domain-containing protein. (226 aa) |
| | SEMA4B | Semaphorin 4B; Belongs to the semaphorin family. (861 aa) |
| | CIB4 | Uncharacterized protein. (190 aa) |
| | F2 | Uncharacterized protein; Belongs to the peptidase S1 family. (644 aa) |
| | HRG | Uncharacterized protein. (1078 aa) |
| | COMMD5 | COMM domain-containing protein. (226 aa) |
| | IFRD1 | Uncharacterized protein. (434 aa) |
| | AKAP6 | A-kinase anchoring protein 6. (2342 aa) |
| | SMARCA2 | Uncharacterized protein. (1594 aa) |
| | CDKN2C | Cyclin dependent kinase inhibitor 2C. (167 aa) |
| | CDKN2AIP | CDKN2A interacting protein. (662 aa) |
| | IHH | Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. (408 aa) |
| | FGFR1OP | FGFR1 oncogene partner. (369 aa) |
| | RUFY3 | RUN and FYVE domain containing 3. (667 aa) |
| | KIF26A | Kinesin family member 26A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1893 aa) |
| | WT1 | Uncharacterized protein. (417 aa) |
| | CGRRF1 | Cell growth regulator with ring finger domain 1. (342 aa) |
| | NOL12 | Uncharacterized protein. (214 aa) |
| | EDN1 | Endothelin 1. (194 aa) |
| | BCL2 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa) |
| | CLSTN3 | Calsyntenin 3. (1024 aa) |
| | MSX1 | Homeobox protein GHOX-7; Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death. (288 aa) |
| | TOMM70 | Translocase of outer mitochondrial membrane 70. (583 aa) |
| | N6AMT1 | MTS domain-containing protein. (218 aa) |
| | OGFRL1 | Opioid growth factor receptor like 1. (652 aa) |
| | DSCAM | Down syndrome cell adhesion molecule homolog; Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self- avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (By similarity). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor [...] (2034 aa) |
| | RBBP7 | Histone-binding protein RBBP7; Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. (466 aa) |
| | GOLGA4 | Golgin A4. (2285 aa) |
| | BMP10 | TGF_BETA_2 domain-containing protein. (425 aa) |
| | PI16 | SCP domain-containing protein; Belongs to the CRISP family. (784 aa) |
| | WNT11 | Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters. (354 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | SEMA7A | Sema domain-containing protein; Belongs to the semaphorin family. (636 aa) |
| | ST7L | Suppressor of tumorigenicity 7 protein-like. (623 aa) |
| | KIF14 | Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1616 aa) |
| | SEMA6A | Semaphorin-6A isoform4; Belongs to the semaphorin family. (1044 aa) |
| | OLFM1 | Noelin; Contributes to the regulation of axonal growth (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube. (485 aa) |
| | CREB3 | cAMP responsive element binding protein 3. (390 aa) |
| | SIRT1 | Deacetylase sirtuin-type domain-containing protein. (881 aa) |
| | FRZB | Secreted frizzled-related protein 3; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. (315 aa) |
| | RND2 | Uncharacterized protein. (227 aa) |
| | HOMER3 | Sema domain-containing protein; Belongs to the semaphorin family. (763 aa) |
