STRINGSTRING
TLNRD1 TLNRD1 ITGB3 ITGB3 PIP5K1C PIP5K1C PIP5K1A PIP5K1A INPP5E INPP5E MTSS2 MTSS2 INPP5K INPP5K PACSIN1 PACSIN1 PLCG1 PLCG1 APPL1 APPL1 MKLN1 MKLN1 PTPRJ PTPRJ MTMR14 MTMR14 TLR4 TLR4 FAM107A FAM107A JCAD JCAD RAB22A RAB22A TESC TESC CIB4 CIB4 ALS2 ALS2 MTM1 MTM1 ARHGEF26 ARHGEF26 MYO10L MYO10L KIF18A KIF18A EZR EZR PACSIN2 PACSIN2 RASA1 RASA1 MYO6 MYO6 PDE9A PDE9A ITGB1BP1 ITGB1BP1 MTMR9 MTMR9 RPS3 RPS3 NF2 NF2 S100B S100B NME2 NME2 ARF6 ARF6 APPL2 APPL2 S100A6 S100A6 FGR FGR WIPF1 WIPF1 ENSGALP00000044845 ENSGALP00000044845 PSD2 PSD2 BAIAP2 BAIAP2 BCAR1 BCAR1 MYO9B MYO9B PLEKHO1 PLEKHO1 KNSTRN KNSTRN SH3YL1 SH3YL1 ACTN1 ACTN1 COBL COBL PLA2G4F PLA2G4F HIP1R HIP1R ARHGAP45 ARHGAP45 PLCG2 PLCG2 PSD3 PSD3 ROCK1 ROCK1 MYO1C MYO1C MYH9 MYH9 ITGB1 ITGB1 SPRY4 SPRY4 ARHGAP18 ARHGAP18 TLN1 TLN1 FRMD4B FRMD4B EPHA2 EPHA2 AIF1L AIF1L VIL1 VIL1 EPS8L2 EPS8L2 TIRAP TIRAP TLN2 TLN2 NME3 NME3 ENSGALP00000065128 ENSGALP00000065128 CIB3 CIB3 EPS8 EPS8 PLEK PLEK DBNL DBNL SLC9A3R1 SLC9A3R1 ENSGALP00000066560 ENSGALP00000066560 ENSGALP00000066996 ENSGALP00000066996 NME1 NME1 ENSGALP00000067194 ENSGALP00000067194 SPATA13 SPATA13 CLIP1 CLIP1 INPP5J-2 INPP5J-2 CLASP2 CLASP2 LOC101752211 LOC101752211 MTMR9LP MTMR9LP LOC107056280 LOC107056280 ASAP3 ASAP3 ACAP1 ACAP1 CTTN CTTN XIRP2 XIRP2 LOC776273 LOC776273 INPP5J INPP5J PODXL PODXL NF2L NF2L ENSGALP00000071809 ENSGALP00000071809 WASF2 WASF2 ACAP2 ACAP2 C2CD5 C2CD5 LIMA1 LIMA1 EPS8L3 EPS8L3 EPB41L5 EPB41L5 LOC112530485 LOC112530485 ITGB7 ITGB7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLNRD1Talin rod domain containing 1. (355 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (781 aa)
PIP5K1CPIPK domain-containing protein. (667 aa)
PIP5K1APIPK domain-containing protein. (586 aa)
INPP5EInositol polyphosphate-5-phosphatase E. (659 aa)
MTSS2MTSS I-BAR domain containing 2. (822 aa)
INPP5KIPPc domain-containing protein. (465 aa)
PACSIN1Protein kinase C and casein kinase substrate in neurons 1. (403 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1277 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (806 aa)
MKLN1Uncharacterized protein. (733 aa)
PTPRJReceptor-type tyrosine-protein phosphatase eta; Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of several substrates. Plays a role in cell adhesion, migration, proliferation and differentiation (By similarity). May influence the potential of nonsensory supporting cells to either proliferate or differentiate into hair cells; Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. (1455 aa)
MTMR14Uncharacterized protein. (631 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
FAM107AFamily with sequence similarity 107 member A. (175 aa)
JCADJunctional cadherin 5 associated. (1325 aa)
RAB22AUncharacterized protein. (194 aa)
TESCCalcineurin B homologous protein 3; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin (By similarity). (214 aa)
CIB4Uncharacterized protein. (190 aa)
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1649 aa)
MTM1Myotubularin 1. (603 aa)
ARHGEF26Rho guanine nucleotide exchange factor 26. (784 aa)
MYO10LUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2219 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (969 aa)
EZREzrin. (585 aa)
PACSIN2Protein kinase C and casein kinase substrate in neurons protein 2; Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. (485 aa)
RASA1Uncharacterized protein. (1120 aa)
MYO6Unconventional myosin-VI; Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-su [...] (1276 aa)
PDE9APhosphodiesterase. (518 aa)
ITGB1BP1PID domain-containing protein. (208 aa)
MTMR9Myotubularin phosphatase domain-containing protein. (550 aa)
RPS3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
NF2FERM domain-containing protein. (595 aa)
S100BEF-hand domain-containing protein; Belongs to the S-100 family. (92 aa)
NME2Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). (153 aa)
ARF6ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May contribute to the regulation of dendritic branching, filopodia extension and dendritic spine development (By similarity). (175 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (671 aa)
S100A6Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity). (92 aa)
FGRProto-oncogene tyrosine-protein kinase Yrk; May participate in signaling pathways; Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. (536 aa)
WIPF1WH2 domain-containing protein. (494 aa)
ENSGALP00000044845PTB domain-containing protein. (147 aa)
PSD2Pleckstrin and Sec7 domain containing 2. (827 aa)
BAIAP2BAI1 associated protein 2. (573 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (905 aa)
MYO9BUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2214 aa)
PLEKHO1Pleckstrin homology domain-containing family O member 1; Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). (423 aa)
KNSTRNUncharacterized protein. (268 aa)
SH3YL1SH3 and SYLF domain containing 1. (340 aa)
ACTN1Alpha-actinin-1; F-actin cross-linking protein is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. (915 aa)
COBLCordon-bleu WH2 repeat protein. (1412 aa)
PLA2G4FPhospholipase A2. (895 aa)
HIP1RUncharacterized protein. (977 aa)
ARHGAP45Uncharacterized protein. (1112 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PSD3PH domain-containing protein. (375 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
MYO1CUnconventional myosin-Ic; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1083 aa)
MYH9Myosin-9; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. (1960 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (822 aa)
SPRY4Sprouty RTK signaling antagonist 4. (430 aa)
ARHGAP18Rho GTPase activating protein 18. (652 aa)
TLN1Talin-1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. Talin is a high molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts. (2558 aa)
FRMD4BFERM domain containing 4B. (1032 aa)
EPHA2EPH receptor A2. (1288 aa)
AIF1LAllograft inflammatory factor 1-like protein. (145 aa)
VIL1Villin-1; Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the inte [...] (826 aa)
EPS8L2Uncharacterized protein. (199 aa)
TIRAPTIR domain-containing protein. (231 aa)
TLN2Talin 2. (2523 aa)
NME3Nucleoside diphosphate kinase. (206 aa)
ENSGALP00000065128SH2 domain-containing protein. (126 aa)
CIB3Calcium and integrin binding family member 3. (185 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (828 aa)
PLEKUncharacterized protein. (353 aa)
DBNLADF-H domain-containing protein. (124 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. May enhance Wnt signaling (By similarity). (366 aa)
ENSGALP00000066560Uncharacterized protein. (172 aa)
ENSGALP00000066996Uncharacterized protein. (110 aa)
NME1NDK domain-containing protein; Belongs to the NDK family. (208 aa)
ENSGALP00000067194SEC7 domain-containing protein. (171 aa)
SPATA13Uncharacterized protein. (1391 aa)
CLIP1CAP-Gly domain-containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. (1444 aa)
INPP5J-2SKICH domain-containing protein. (338 aa)
CLASP2Uncharacterized protein. (1506 aa)
LOC101752211Uncharacterized protein. (95 aa)
MTMR9LPMyotubularin phosphatase domain-containing protein. (574 aa)
LOC107056280Uncharacterized protein. (466 aa)
ASAP3ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. (1057 aa)
ACAP1ArfGAP with coiled-coil, ankyrin repeat and PH domains 1. (618 aa)
CTTNSrc substrate protein p85; Contributes to the organization of the actin cytoskeleton and cell shape (By similarity). Plays a role in the formation of lamellipodia and in cell migration (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones, and may play a role in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cel [...] (516 aa)
XIRP2LIM zinc-binding domain-containing protein. (123 aa)
LOC7762731-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1303 aa)
INPP5JIPPc domain-containing protein. (274 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro- adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubul [...] (589 aa)
NF2LFERM domain-containing protein. (648 aa)
ENSGALP00000071809SH2 domain-containing protein. (217 aa)
WASF2WASP family member 2. (528 aa)
ACAP2Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). (823 aa)
C2CD5C2 calcium dependent domain containing 5. (1219 aa)
LIMA1LIM domain and actin binding 1. (764 aa)
EPS8L3SH3 domain-containing protein. (572 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (766 aa)
LOC112530485Uncharacterized protein. (326 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (538 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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