STRINGSTRING
VEGFA VEGFA ACVRL1 ACVRL1 PROK1 PROK1 PGF PGF APLN APLN VASH2 VASH2 RPTOR RPTOR GPR25 GPR25 NRARP NRARP CAV2 CAV2 SIRT6 SIRT6 BMPR2 BMPR2 AGTR1 AGTR1 VEGFD VEGFD TGFBR1 TGFBR1 ITGA4 ITGA4 CCR5 CCR5 NR4A1 NR4A1 SP1 SP1 IGF2 IGF2 SCG2 SCG2 NRAS NRAS FGF7 FGF7 LRG1 LRG1 APELA APELA ADAM17 ADAM17 APLNR APLNR KDR KDR VIP VIP BMP6 BMP6 PDGFB PDGFB VEGFC VEGFC HMGB2 HMGB2 PROK2 PROK2 HTR2B HTR2B JCAD JCAD FLT4 FLT4 AGGF1 AGGF1 MYDGF MYDGF SIRT1 SIRT1 PIK3CD PIK3CD IL10 IL10 ITGB3 ITGB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). (674 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (796 aa)
PROK1Prokineticin 1. (99 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (247 aa)
APLNApelin. (78 aa)
VASH2Vasohibin 2. (356 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1374 aa)
GPR25Apelin receptor 2; Belongs to the G-protein coupled receptor 1 family. (365 aa)
NRARPNOTCH regulated ankyrin repeat protein. (124 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (161 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (378 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1031 aa)
AGTR1Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. (359 aa)
VEGFDPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (378 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1021 aa)
CCR5Chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (355 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (743 aa)
SP1Transcription factor. (760 aa)
IGF2Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling. (187 aa)
SCG2Secretogranin II. (629 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
LRG1LRRCT domain-containing protein. (361 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
ADAM17Tumor necrosis factor alpha converting enzyme. (829 aa)
APLNRApelin receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1348 aa)
VIPIntestinal peptide PHI-27-like; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder; Belongs to the glucagon family. (200 aa)
BMP6Bone morphogenetic protein 6. (434 aa)
PDGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (251 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (586 aa)
HMGB2High mobility group protein B2; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner (By similarity). Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Involved in inflammatory response to antige [...] (207 aa)
PROK2Prokineticin 2. (109 aa)
HTR2BSerotonin receptor subtype 2b. (462 aa)
JCADJunctional cadherin 5 associated. (1325 aa)
FLT4Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1378 aa)
AGGF1Uncharacterized protein. (701 aa)
MYDGFUncharacterized protein. (167 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (881 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (781 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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