(20 nodes) Blood vessel remodeling network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa)
	LOC107050371	Uncharacterized protein. (1015 aa)
	ENSGALP00000069955	Uncharacterized protein. (496 aa)
	ACVRL1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (796 aa)
	SEMA3C	Semaphorin-3C; Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin; Belongs to the semaphorin family. (751 aa)
	ENSGALP00000065224	Uncharacterized protein. (381 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1031 aa)
	EPAS1	Endothelial PAS domain protein 1. (867 aa)
	CHD7	Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity). (3009 aa)
	BAK1	Uncharacterized protein. (216 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (288 aa)
	RSPO3	Uncharacterized protein. (275 aa)
	ENSGALP00000048186	Uncharacterized protein. (528 aa)
	DBH	Dopamine beta-hydroxylase. (584 aa)
	CHD9	Chromodomain helicase DNA binding protein 9. (2820 aa)
	HOXA3	Homeobox protein Hox-A3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (413 aa)
	FGF8	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1216 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (709 aa)
	CRB1	Crumbs cell polarity complex component 1. (807 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	BMPR2	ENSGALP00000068483	ENSGALP00000058326	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.966
BMPR2	ACVRL1	ENSGALP00000058326	ENSGALP00000068483	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.966
CHD7	FGF8	ENSGALP00000056921	ENSGALP00000032574	Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity).	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family.	0.532
DLL4	JAG1	ENSGALP00000013851	ENSGALP00000014662	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.729
ENSGALP00000048186	ENSGALP00000069955	ENSGALP00000048186	ENSGALP00000069955	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSGALP00000048186	LOC107050371	ENSGALP00000048186	ENSGALP00000071652	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSGALP00000069955	ENSGALP00000048186	ENSGALP00000069955	ENSGALP00000048186	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSGALP00000069955	LOC107050371	ENSGALP00000069955	ENSGALP00000071652	Uncharacterized protein.	Uncharacterized protein.	0.900
FGF8	CHD7	ENSGALP00000032574	ENSGALP00000056921	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family.	Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity).	0.532
FGF8	HOXA3	ENSGALP00000032574	ENSGALP00000041461	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family.	Homeobox protein Hox-A3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family.	0.485
FGF8	JAG1	ENSGALP00000032574	ENSGALP00000014662	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.600
HOXA3	FGF8	ENSGALP00000041461	ENSGALP00000032574	Homeobox protein Hox-A3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family.	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family.	0.485
JAG1	DLL4	ENSGALP00000014662	ENSGALP00000013851	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.729
JAG1	FGF8	ENSGALP00000014662	ENSGALP00000032574	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family.	0.600
LOC107050371	ENSGALP00000048186	ENSGALP00000071652	ENSGALP00000048186	Uncharacterized protein.	Uncharacterized protein.	0.899
LOC107050371	ENSGALP00000069955	ENSGALP00000071652	ENSGALP00000069955	Uncharacterized protein.	Uncharacterized protein.	0.900