STRINGSTRING
OXT OXT GH GH GNRH1 GNRH1 STC1 STC1 UTS2 UTS2 EDN2 EDN2 C1QTNF12 C1QTNF12 AGRP AGRP TSHB-2 TSHB-2 FNDC5 FNDC5 GHRH GHRH NPPC-2 NPPC-2 FBN1 FBN1 ADIPOQ ADIPOQ INS INS UTS2B UTS2B SST SST GHRL GHRL TRH TRH LOC417800 LOC417800 NPY NPY FAP FAP HCRT HCRT FSHB FSHB PRL PRL EDN1 EDN1 IGF1 IGF1 PMCH PMCH IAPP IAPP SPX SPX VIP VIP AVP AVP RLN3 RLN3 TTR TTR FNDC4 FNDC4 C1QTNF9B C1QTNF9B NMU NMU GCG GCG NPPA NPPA APELA APELA COPA COPA STC2 STC2 NTS NTS LOC396365 LOC396365 METRNL METRNL CNP1 CNP1 INHBB INHBB GAL GAL GPHB5 GPHB5 PPY PPY INHBA INHBA CCK CCK PTH PTH ENSGALP00000046712 ENSGALP00000046712 PIBPPDD4L PIBPPDD4L IGF2 IGF2 SEC11A SEC11A CRH CRH ECRG4 ECRG4 UCN3 UCN3 LOC100859819 LOC100859819 SEC11C SEC11C CARTPT CARTPT CALCA CALCA EDN3 EDN3 PRLH PRLH ADM ADM PYY PYY ADCYAP1 ADCYAP1 POMC POMC LOC112531842 LOC112531842 CHGB CHGB NPPC NPPC INHBE INHBE GIP GIP ENSGALP00000066347 ENSGALP00000066347 METRN METRN PTHLH PTHLH MLN MLN APLN APLN GRP GRP INHBC INHBC CGA CGA QRFP QRFP UCN UCN INHA INHA OSTN OSTN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OXTMesotocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (124 aa)
GHSomatotropin; Growth hormone plays an important role in growth control. (216 aa)
GNRH1GnRH-associated peptide 1; Stimulates the secretion of gonadotropins; Belongs to the GnRH family. (92 aa)
STC1Stanniocalcin 1. (247 aa)
UTS2Preprourotensin II. (124 aa)
EDN2Endothelin-2. (179 aa)
C1QTNF12C1q and TNF related 12. (320 aa)
AGRPAgouti-related protein. (233 aa)
TSHB-2Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. (134 aa)
FNDC5Fibronectin type III domain containing 5 variant. (220 aa)
GHRHGHRH/PACAP-like. (172 aa)
NPPC-2C-type natriuretic peptide; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity). (130 aa)
FBN1Fibrillin 1. (2861 aa)
ADIPOQC1q domain-containing protein. (244 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
UTS2BUncharacterized protein. (126 aa)
SSTSomatostatin-14; Somatostatin inhibits the release of somatotropin. (116 aa)
GHRLPreproghrelin. (116 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems; Belongs to the TRH family. (260 aa)
LOC417800Uncharacterized protein. (225 aa)
NPYC-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (97 aa)
FAPUncharacterized protein; Belongs to the peptidase S9B family. (759 aa)
HCRTUncharacterized protein. (148 aa)
FSHBFollicle stimulating hormone, beta polypeptide. (131 aa)
PRLProlactin. (229 aa)
EDN1Endothelin 1. (194 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex fo [...] (153 aa)
PMCHPMCH. (163 aa)
IAPPAmyloid protein. (135 aa)
SPXSpexin hormone. (116 aa)
VIPIntestinal peptide PHI-27-like; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder; Belongs to the glucagon family. (200 aa)
AVPVasotocin-neurophysin VT; Vasotocin is an antidiuretic hormone. (161 aa)
RLN3Relaxin-like peptide locus B. (192 aa)
TTRTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (168 aa)
FNDC4Fibronectin type-III domain-containing protein. (206 aa)
C1QTNF9BC1q domain-containing protein. (340 aa)
NMUNeuromedin-U-25; Stimulates uterine smooth muscle contraction and causes selective vasoconstriction; Belongs to the NmU family. (181 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. (206 aa)
NPPAAtrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity). (140 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
COPACoatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1224 aa)
STC2Stanniocalcin 2. (306 aa)
NTSNeurotensin. (164 aa)
LOC396365Gastrin/cholecystokinin-like peptide; Potent stimulus of gastric acid, but not of pancreatic secretion; Belongs to the gastrin/cholecystokinin family. (105 aa)
METRNLMeteorin like, glial cell differentiation regulator. (292 aa)
CNP1C-type natriuretic peptide 1. (123 aa)
INHBBInhibin beta B chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (392 aa)
GALGalanin variant 1. (141 aa)
GPHB5Glycoprotein hormone subunit beta 5. (129 aa)
PPYPancreatic hormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions; Belongs to the NPY family. (80 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Induces somatostatin in the ciliary ganglion neurons and may [...] (424 aa)
CCKCholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes. (130 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (119 aa)
ENSGALP00000046712Uncharacterized protein. (1194 aa)
PIBPPDD4LPhosphoinositide phospholipase C. (1139 aa)
IGF2Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling. (187 aa)
SEC11ASignal peptidase complex catalytic subunit SEC11. (179 aa)
CRHCorticotropin releasing hormone. (167 aa)
ECRG4ECRG4 augurin precursor. (112 aa)
UCN3Urocortin 3. (154 aa)
LOC100859819CARTL. (113 aa)
SEC11CSignal peptidase complex catalytic subunit SEC11. (177 aa)
CARTPTCART prepropeptide. (111 aa)
CALCACalcitonin; Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. (138 aa)
EDN3Endothelin 3. (151 aa)
PRLHUncharacterized protein. (87 aa)
ADMUncharacterized protein. (73 aa)
PYYPeptide YY-like; This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. Belongs to the NPY family. (90 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide 27; Primary role of GRF is to release GH from the pituitary; Belongs to the glucagon family. (172 aa)
POMCUncharacterized protein. (251 aa)
LOC112531842Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (147 aa)
CHGBChromogranin B. (673 aa)
NPPCC-type natriuretic peptide. (121 aa)
INHBETGF_BETA_2 domain-containing protein. (349 aa)
GIPGLUCAGON domain-containing protein. (139 aa)
ENSGALP00000066347COesterase domain-containing protein. (363 aa)
METRNMeteorin, glial cell differentiation regulator. (294 aa)
PTHLHParathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport; Belongs to the parathyroid hormone family. (214 aa)
MLNMotilin; Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle; Belongs to the motilin family. (115 aa)
APLNApelin. (78 aa)
GRPGastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (Probable). Stimulates pancreatic protein and fluid secretion, and increases acid secretion from the avian proventriculus. Belongs to the bombesin/neuromedin-B/ranatensin family. (164 aa)
INHBCInhibin subunit beta C. (351 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
QRFPUncharacterized protein. (122 aa)
UCNUrocortin. (100 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family. (360 aa)
OSTNUncharacterized protein. (148 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.