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| | CYP2C23a | Cytochrome P450 2H1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (491 aa) |
| | MSMO1 | Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family. (296 aa) |
| | HAAO | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (286 aa) |
| | ABCE1 | Uncharacterized protein. (599 aa) |
| | EGLN3 | Egl-9 family hypoxia inducible factor 3. (241 aa) |
| | CYP4B7 | Uncharacterized protein; Belongs to the cytochrome P450 family. (504 aa) |
| | CYP4A22 | Uncharacterized protein. (507 aa) |
| | ALKBH1 | Fe2OG dioxygenase domain-containing protein. (413 aa) |
| | CYP46A1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (499 aa) |
| | DPH3P1 | DPH-type MB domain-containing protein. (82 aa) |
| | CYP2J19 | Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa) |
| | PPEF2 | Serine/threonine-protein phosphatase with EF-hands. (738 aa) |
| | CYP27C1 | Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (416 aa) |
| | GBE | Eye-globin; Belongs to the globin family. (151 aa) |
| | CYP2D6 | Cytochrome P450 CYP2D49; Belongs to the cytochrome P450 family. (502 aa) |
| | ACO2 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (785 aa) |
| | THL | BH4_AAA_HYDROXYL_2 domain-containing protein. (443 aa) |
| | PAH | Phenylalanine hydroxylase. (446 aa) |
| | CYP4V2 | Uncharacterized protein; Belongs to the cytochrome P450 family. (530 aa) |
| | P3H3 | Prolyl 3-hydroxylase 3. (716 aa) |
| | FBXL5 | F-box and leucine rich repeat protein 5. (837 aa) |
| | CYP26B1 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa) |
| | PPEF1 | Serine/threonine-protein phosphatase. (632 aa) |
| | CYP2AC1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa) |
| | DOHH | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF- 5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. (299 aa) |
| | ISCA2 | Iron-sulfur cluster assembly 2. (186 aa) |
| | C5H14ORF169 | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys- 4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethyla [...] (601 aa) |
| | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. (527 aa) |
| | MELTF | Ovotransferrin; Belongs to the transferrin family. (738 aa) |
| | AGMO | Alkylglycerol monooxygenase; Belongs to the sterol desaturase family. (510 aa) |
| | FXN | Frataxin. (167 aa) |
| | TPH2 | Neuronal tryptophan hydroxylase. (489 aa) |
| | CYGB | Cytoglobin; Belongs to the globin family. (179 aa) |
| | CYP1A1 | Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa) |
| | CYP11A1 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (508 aa) |
| | ALKBH2 | Fe2OG dioxygenase domain-containing protein. (245 aa) |
| | SCD | FA_desaturase domain-containing protein; Belongs to the fatty acid desaturase type 1 family. (582 aa) |
| | HBA1 | Hemoglobin subunit alpha-A; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (142 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (536 aa) |
| | P4HA1 | Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. (536 aa) |
| | ALKBH3 | Uncharacterized protein. (389 aa) |
| | P3H2 | Prolyl 3-hydroxylase 2; Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens (By similarity). Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that lack 4-hydroxyproline in the third position (By similarity). (694 aa) |
| | CRTAP | Cartilage-associated protein; Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues; Belongs to the leprecan family. (393 aa) |
| | MINA | Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (473 aa) |
| | CYP7B1 | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (487 aa) |
| | CYP26A1 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] (492 aa) |
| | CYP21A1 | Steroid 21-hydroxylase; Belongs to the cytochrome P450 family. (478 aa) |
| | P4HA3 | Prolyl 4-hydroxylase subunit alpha 3. (402 aa) |
| | ADI1 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family. (180 aa) |
| | SAAL1 | Uncharacterized protein. (463 aa) |
| | CYP1C1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (516 aa) |
| | LOC101749846 | Uncharacterized protein; Belongs to the cytochrome P450 family. (668 aa) |
| | LOC416959 | Ovotransferrin; Belongs to the transferrin family. (738 aa) |
| | P4HA2 | Prolyl 4-hydroxylase subunit alpha-2; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. (536 aa) |
| | TF | Ovotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. There are two forms of hen transferrin, ovotransferrin, found in the ovoducts and, serum transferrin, secreted by the liver. Serum transferrin may also have a role in stimulating cell proliferation and is regulated by iron levels. Ovotransferrin has a bacteriostatic function and, is not controlled by iron levels. (756 aa) |
| | CH25H | Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (274 aa) |
| | CYP20A1 | Cytochrome P450 family 20 subfamily A member 1. (463 aa) |
| | KDM7A | Lysine demethylase 7A. (1014 aa) |
| | ACP5 | Tartrate-resistant acid phosphatase type 5. (321 aa) |
| | FTO | FTO_NTD domain-containing protein. (565 aa) |
| | CYP26C1 | Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (510 aa) |
| | CYP2J21 | Uncharacterized protein; Belongs to the cytochrome P450 family. (558 aa) |
| | DNAJC24 | Uncharacterized protein. (343 aa) |
| | CYP2W1 | Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (505 aa) |
| | CYP2J22 | Uncharacterized protein; Belongs to the cytochrome P450 family. (491 aa) |
| | BBOX1 | Gamma-butyrobetaine hydroxylase 1. (431 aa) |
| | PLOD2 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (756 aa) |
| | ALOX15B | Uncharacterized protein. (667 aa) |
| | CYP2AC7 | Uncharacterized protein; Belongs to the cytochrome P450 family. (501 aa) |
| | CYP2J23 | Uncharacterized protein; Belongs to the cytochrome P450 family. (491 aa) |
| | MIOX | Myo-inositol oxygenase. (284 aa) |
| | TPH1 | Tryptophan 5-hydroxylase 1; Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. (475 aa) |
| | CYP2AC2 | Uncharacterized protein; Belongs to the cytochrome P450 family. (496 aa) |
| | CYP2AB3 | Uncharacterized protein; Belongs to the cytochrome P450 family. (488 aa) |
| | SCD5 | Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (294 aa) |
| | CYP51A1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (496 aa) |
| | CYP39A1 | Cytochrome P450 family 39 subfamily A member 1; Belongs to the cytochrome P450 family. (466 aa) |
| | LOC112530469 | Uncharacterized protein. (846 aa) |
| | CYP19A1 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (502 aa) |
| | ISCU | Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (158 aa) |
| | ENSGALP00000068450 | Uncharacterized protein. (96 aa) |
| | FA2H | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (373 aa) |
| | OGFOD3 | 2-oxoglutarate and iron dependent oxygenase domain containing 3. (323 aa) |
| | TBXAS1 | Thromboxane A synthase 1; Belongs to the cytochrome P450 family. (535 aa) |
| | EGLN1 | Uncharacterized protein. (443 aa) |
| | SC5D | Sterol-C5-desaturase; Belongs to the sterol desaturase family. (442 aa) |
| | TSSC1 | WD_REPEATS_REGION domain-containing protein. (395 aa) |
| | LYRM4 | Uncharacterized protein; Belongs to the complex I LYR family. (89 aa) |
| | NFU1 | Nfu_N domain-containing protein. (252 aa) |
| | TMLHE | Trimethyllysine dioxygenase, mitochondrial; Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML). (418 aa) |
| | PHF2 | PHD finger protein 2. (1132 aa) |
| | FAXDC2 | Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (335 aa) |
| | ALKBH8 | AlkB homolog 8, tRNA methyltransferase. (723 aa) |
| | P3H4 | Prolyl 3-hydroxylase family member 4 (non-enzymatic). (434 aa) |
| | FTL | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (278 aa) |
| | CYP2U1 | Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family. (524 aa) |
| | XDH | Xanthine dehydrogenase/oxidase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. (1358 aa) |
| | CYP2R1 | Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family. (646 aa) |
| | ALOX5 | Arachidonate 5-lipoxygenase. (751 aa) |
| | CYP2C23b | Cytochrome P450 2H2; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (491 aa) |
| | HIF1AN | Hypoxia inducible factor 1 subunit alpha inhibitor. (345 aa) |
| | CYP2C18 | Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa) |
| | CCNDBP1 | Cyclin D1 binding protein 1. (335 aa) |
| | P3H1 | Prolyl 3-hydroxylase 1; Has prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly-sequences in collagens, especially types IV and V. May be involved in the secretoty pathway of cells. Has growth suppressive activity in fibroblasts (By similarity); Belongs to the leprecan family. (725 aa) |
| | PLOD1 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. (730 aa) |
| | CYP3A5 | Uncharacterized protein. (508 aa) |
| | CYP3A4 | Uncharacterized protein; Belongs to the cytochrome P450 family. (540 aa) |
| | CYP2W1-2 | Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa) |
| | OGFOD2 | 2-oxoglutarate and iron dependent oxygenase domain containing 2. (347 aa) |
| | PIGS | Phosphatidylinositol glycan anchor biosynthesis class S. (552 aa) |
| | OGFOD1 | 2-oxoglutarate and iron dependent oxygenase domain containing 1. (537 aa) |
| | CDO1 | Cysteine dioxygenase. (204 aa) |
| | TTI2 | TELO2 interacting protein 2. (471 aa) |
| | CYP1A2 | Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa) |
| | CYP7A1 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (513 aa) |
| | RP11-400G3.5 | Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa) |
| | HBAD | Hemoglobin subunit alpha-D; Involved in oxygen transport from the lung to the various peripheral tissues. (141 aa) |
| | TH | Tyrosine hydroxylase. (491 aa) |
| | CYP2AB2 | Uncharacterized protein; Belongs to the cytochrome P450 family. (488 aa) |
| | TYW5 | tRNA wybutosine-synthesizing protein 5; tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a- amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes (By similarity). (318 aa) |
| | CYP2AB5 | Uncharacterized protein. (831 aa) |
| | HBZ | Hemoglobin subunit pi; The pi' chain is the counterpart of the alpha chain in the major early embryonic hemoglobin P; Belongs to the globin family. (142 aa) |
| | FTH1 | Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). (180 aa) |
| | P4HTM | Prolyl 4-hydroxylase, transmembrane. (496 aa) |
| | AOX1 | Uncharacterized protein. (1328 aa) |
| | AOX2 | Uncharacterized protein. (1337 aa) |
| | CYP2AB1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (489 aa) |
