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| | SNRPE | Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (92 aa) |
| | HNRNPM | Uncharacterized protein. (709 aa) |
| | RNF113B | Zinc finger protein 183. (328 aa) |
| | PPP1R8 | FHA domain-containing protein. (354 aa) |
| | SF3A2 | Splicing factor 3a subunit 2. (315 aa) |
| | SYF2 | Uncharacterized protein. (252 aa) |
| | SF3A3 | Splicing factor 3a subunit 3. (501 aa) |
| | CWC25 | CWC25 spliceosome associated protein homolog. (416 aa) |
| | PRKRIP1 | PRKR-interacting protein 1 homolog; Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA (By similarity). (189 aa) |
| | PRPF38B | Uncharacterized protein. (549 aa) |
| | BCAS2 | Uncharacterized protein. (225 aa) |
| | SNIP1 | Smad nuclear interacting protein 1. (364 aa) |
| | SMU1 | WD40 repeat-containing protein SMU1; Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity). Belongs to the WD repeat SMU1 family. (513 aa) |
| | SF3B3 | Splicing factor 3b subunit 3. (1217 aa) |
| | SNRPC | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (160 aa) |
| | PRPF8 | Pre-mRNA processing factor 8. (2335 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1117 aa) |
| | LSM4 | U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (138 aa) |
| | DDX5 | Uncharacterized protein; Belongs to the DEAD box helicase family. (603 aa) |
| | DHX35 | DEAH-box helicase 35. (712 aa) |
| | RBM44 | RRM domain-containing protein. (470 aa) |
| | C9orf78 | Chromosome 9 open reading frame 78. (289 aa) |
| | ZCCHC8 | Zinc finger CCHC domain-containing protein 8; Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short- lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. May be involved in pre- mRNA splicing; Belongs to the ZCCHC8 family. (708 aa) |
| | RBM22 | Pre-mRNA-splicing factor RBM22; Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Belongs to the SLT11 family. (420 aa) |
| | BUD31 | BUD31 homolog. (144 aa) |
| | RBM41 | RNA binding motif protein 41. (398 aa) |
| | GPATCH1 | G-patch domain containing 1. (901 aa) |
| | PPIH | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (177 aa) |
| | ISY1 | Uncharacterized protein. (280 aa) |
| | RNPC3 | RNA binding region (RNP1, RRM) containing 3. (550 aa) |
| | TFIP11 | Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. (827 aa) |
| | ESS2 | Ess-2 splicing factor homolog. (598 aa) |
| | PRPF6 | Pre-mRNA processing factor 6. (941 aa) |
| | RBM17 | RNA binding motif protein 17. (401 aa) |
| | HTATSF1 | HIV-1 Tat specific factor 1. (450 aa) |
| | TRA2B | Transformer-2 beta. (289 aa) |
| | SNRPD3 | Small nuclear ribonucleoprotein Sm D3. (126 aa) |
| | CTNNBL1 | Catenin beta like 1. (563 aa) |
| | SNRPA1 | LRRcap domain-containing protein. (255 aa) |
| | SF3A1 | Uncharacterized protein. (790 aa) |
| | SF3B1 | Splicing factor 3b subunit 1. (1301 aa) |
| | ZMAT5 | C3H1-type domain-containing protein. (170 aa) |
| | CRNKL1 | Crooked neck pre-mRNA splicing factor 1. (686 aa) |
| | SMNDC1 | Survival motor neuron domain containing 1. (238 aa) |
| | PRPF4 | Pre-mRNA processing factor 4. (537 aa) |
| | CWC22 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. (926 aa) |
| | LSM8 | U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (96 aa) |
| | ZCRB1 | Uncharacterized protein. (216 aa) |
| | AQR | Aquarius intron-binding spliceosomal factor. (1513 aa) |
| | GEMIN2 | Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family. (263 aa) |
| | PNN | Pinin, desmosome associated protein. (691 aa) |
| | ZC2HC1C | Zinc finger C2HC-type containing 1C. (510 aa) |
| | SNW1 | SNW domain containing 1. (538 aa) |
| | PRPF38A | PRP38_assoc domain-containing protein. (312 aa) |
| | TRA2A | RRM domain-containing protein. (277 aa) |
| | WBP11 | Uncharacterized protein. (648 aa) |
| | SNU13 | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (128 aa) |
| | PHF5A | Uncharacterized protein. (110 aa) |
| | PRPF40A | Pre-mRNA processing factor 40 homolog A. (853 aa) |
| | HNRNPK | Heterogeneous nuclear ribonucleoprotein K. (427 aa) |
| | PRPF4B | Pre-mRNA processing factor 4B. (1105 aa) |
| | ZNF830 | Zinc finger protein 830. (532 aa) |
| | SF3B4 | Splicing factor 3b subunit 4. (418 aa) |
| | FRG1BP | Uncharacterized protein. (256 aa) |
| | DHX15 | Uncharacterized protein. (762 aa) |
| | SKIV2L2 | Uncharacterized protein. (1197 aa) |
| | PPWD1 | Peptidylprolyl isomerase domain and WD repeat containing 1. (625 aa) |
| | CDC40 | WD_REPEATS_REGION domain-containing protein. (580 aa) |
| | TXNL4B | Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (149 aa) |
| | U2AF1 | U2snRNP auxiliary factor small subunit. (237 aa) |
| | SF3B6 | Splicing factor 3b subunit 6. (91 aa) |
| | ZRSR2 | Zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2. (333 aa) |
| | WBP4 | WW domain-binding protein 4; Involved in pre-mRNA splicing as a component of the spliceosome. May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex. (398 aa) |
| | CWF19L2 | CWF19 like cell cycle control factor 2. (852 aa) |
| | PDCD7 | Programmed cell death 7. (434 aa) |
| | DHX38 | Uncharacterized protein. (1230 aa) |
| | EIF4A3 | Eukaryotic initiation factor 4A-III; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the [...] (412 aa) |
| | PRPF3 | U4/U6 small nuclear ribonucleoprotein Prp3; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). (684 aa) |
| | AAR2 | Uncharacterized protein. (382 aa) |
| | NWD1 | WD_REPEATS_REGION domain-containing protein. (425 aa) |
| | CACTIN | Cactin, spliceosome C complex subunit. (731 aa) |
| | MFAP1 | Microfibrillar-associated protein 1; Involved in pre-mRNA splicing as a component of the spliceosome; Belongs to the MFAP1 family. (439 aa) |
| | SNRPB2 | Small nuclear ribonucleoprotein polypeptide B2. (226 aa) |
| | SNRNP25 | Small nuclear ribonucleoprotein U11/U12 subunit 25. (129 aa) |
| | WDR25 | WD repeat domain 25. (523 aa) |
| | LUC7L2 | Uncharacterized protein. (398 aa) |
| | YJU2 | YJU2 splicing factor homolog. (421 aa) |
| | SNRNP48 | Small nuclear ribonucleoprotein U11/U12 subunit 48. (306 aa) |
| | DHX32 | DEAH-box helicase 32 (putative). (363 aa) |
| | RBM3 | Cold-inducible RNA-binding protein. (190 aa) |
| | NCL | Nucleolin; Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. (691 aa) |
| | BUD13 | BUD13 homolog. (770 aa) |
| | DDX41 | Uncharacterized protein. (617 aa) |
| | SNRPN | Small nuclear ribonucleoprotein-associated protein B; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (By similarity). Is also a component of the minor U12 spliceosome (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity). (240 aa) |
| | DHX8 | DEAH-box helicase 8. (1163 aa) |
| | LUC7L3 | Uncharacterized protein. (469 aa) |
| | SF3B5 | Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa) |
| | HNRNPR | Uncharacterized protein. (661 aa) |
| | DQX1 | DEAQ-box RNA dependent ATPase 1. (743 aa) |
| | LSM3 | Uncharacterized protein. (102 aa) |
| | PPIE | Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (321 aa) |
| | DNAJC17 | J domain-containing protein. (311 aa) |
| | GPKOW | G-patch domain-containing protein. (244 aa) |
| | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (724 aa) |
| | SNRPD1 | Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family. (119 aa) |
| | CASC3 | CASC3 exon junction complex subunit. (657 aa) |
| | RBM8A | RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (163 aa) |
| | LGALS3 | Galectin. (258 aa) |
| | SRRM1 | Serine/arginine repetitive matrix protein 1; Involved in pre-mRNA splicing and processing events. Belongs to the splicing factor SR family. (924 aa) |
| | PRPF18 | SFM domain-containing protein. (351 aa) |
| | NCMAP | Non-compact myelin associated protein. (101 aa) |
| | DDX23 | DEAD-box helicase 23. (816 aa) |
| | SNRNP200 | Helicase_PWI domain-containing protein. (614 aa) |
| | SRSF2 | Serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. (221 aa) |
| | EIF4A2 | Eukaryotic initiation factor 4A-II; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). (390 aa) |
| | ZMAT2 | U1-type domain-containing protein. (199 aa) |
| | SLU7 | Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. (671 aa) |
| | LSM5 | U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (91 aa) |
| | PRPF19 | Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity; Belongs to the WD repeat PRP19 family. (504 aa) |
| | PLRG1 | Pleiotropic regulator 1. (516 aa) |
| | CWC15 | Uncharacterized protein. (230 aa) |
| | HNRNPKL | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. May play an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression (By similarity). (428 aa) |
| | SNRPF | Sm domain-containing protein. (86 aa) |
| | MAGOH | Protein mago nashi homolog; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby infl [...] (154 aa) |
| | RBMXL1 | RRM domain-containing protein. (385 aa) |
| | LSM6 | Sm domain-containing protein. (80 aa) |
| | CWC27 | CWC27 spliceosome associated cyclophilin. (477 aa) |
| | EFTUD2 | 116 kDa U5 small nuclear ribonucleoprotein component; Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (By similarity). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (By similarity). (1222 aa) |
| | TXNL4A | Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (142 aa) |
| | CDC5L | Cell division cycle 5 like. (1410 aa) |
| | CCDC12 | Uncharacterized protein. (207 aa) |
| | CCDC130 | Coiled-coil domain containing 130. (337 aa) |
| | ENSGALP00000066377 | Helicase C-terminal domain-containing protein. (528 aa) |
| | SNRPGP15 | Small nuclear ribonucleoprotein G. (76 aa) |
| | ENSGALP00000067656 | Uncharacterized protein. (174 aa) |
| | ADAR | RNA-specific Adenosine deaminase Transcript variant M. (1153 aa) |
| | PPIL1 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (298 aa) |
| | RBMX2 | RRM domain-containing protein. (253 aa) |
| | PPIL2 | Uncharacterized protein. (539 aa) |
| | LOC112530170 | SEC63 domain-containing protein. (235 aa) |
| | SNRNP35 | RRM domain-containing protein. (263 aa) |
| | ENSGALP00000070086 | Uncharacterized protein. (597 aa) |
| | PRPF39 | Pre-mRNA processing factor 39. (680 aa) |
| | SNRPD2 | Small nuclear ribonucleoprotein Sm D2. (146 aa) |
| | U2AF2 | U2 small nuclear RNA auxiliary factor 2. (699 aa) |
| | PPIL3 | Peptidyl-prolyl cis-trans isomerase-like 3; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily. (161 aa) |
| | ENSGALP00000070935 | Uncharacterized protein. (468 aa) |
| | SUGP1 | Uncharacterized protein. (698 aa) |
| | MYEF2 | Uncharacterized protein. (616 aa) |
| | SYNCRIP | Uncharacterized protein. (623 aa) |
| | PTBP2 | Polypyrimidine tract binding protein 2. (675 aa) |
| | LUC7L | LUC7 like. (332 aa) |
