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PRPF39 PRPF39 SNRPE SNRPE RNF113B RNF113B SF3A2 SF3A2 SYF2 SYF2 SF3A3 SF3A3 CWC25 CWC25 BCAS2 BCAS2 SNIP1 SNIP1 LUC7L LUC7L SMU1 SMU1 SF3B3 SF3B3 SNRPC SNRPC PRPF8 PRPF8 LSM4 LSM4 RBM22 RBM22 BUD31 BUD31 ISY1 ISY1 TFIP11 TFIP11 PRPF6 PRPF6 U2AF2 U2AF2 HTATSF1 HTATSF1 SNRPD3 SNRPD3 SNRPA1 SNRPA1 SF3A1 SF3A1 SF3B1 SF3B1 CRNKL1 CRNKL1 PRPF4 PRPF4 CWC22 CWC22 LSM8 LSM8 AQR AQR SNW1 SNW1 PRPF38A PRPF38A SNU13 SNU13 PHF5A PHF5A PRPF40A PRPF40A SF3B4 SF3B4 DHX15 DHX15 CDC40 CDC40 SF3B6 SF3B6 WBP4 WBP4 EIF4A3 EIF4A3 NWD1 NWD1 MFAP1 MFAP1 LUC7L2 LUC7L2 YJU2 YJU2 BUD13 BUD13 SNRPN SNRPN DHX8 DHX8 LUC7L3 LUC7L3 SF3B5 SF3B5 LSM3 LSM3 PPIE PPIE SNRPD1 SNRPD1 CASC3 CASC3 RBM8A RBM8A SNRPD2 SNRPD2 PRPF18 PRPF18 SNRNP200 SNRNP200 ZMAT2 ZMAT2 LSM5 LSM5 PRPF19 PRPF19 PLRG1 PLRG1 CWC15 CWC15 SNRPF SNRPF LSM6 LSM6 CWC27 CWC27 EFTUD2 EFTUD2 TXNL4A TXNL4A CCDC12 CCDC12 CCDC130 CCDC130 SNRPGP15 SNRPGP15 PPIL1 PPIL1 LOC112530170 LOC112530170 ENSGALP00000070086 ENSGALP00000070086
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRPF39Pre-mRNA processing factor 39. (680 aa)
SNRPESmall nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (92 aa)
RNF113BZinc finger protein 183. (328 aa)
SF3A2Splicing factor 3a subunit 2. (315 aa)
SYF2Uncharacterized protein. (252 aa)
SF3A3Splicing factor 3a subunit 3. (501 aa)
CWC25CWC25 spliceosome associated protein homolog. (416 aa)
BCAS2Uncharacterized protein. (225 aa)
SNIP1Smad nuclear interacting protein 1. (364 aa)
LUC7LLUC7 like. (332 aa)
SMU1WD40 repeat-containing protein SMU1; Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity). Belongs to the WD repeat SMU1 family. (513 aa)
SF3B3Splicing factor 3b subunit 3. (1217 aa)
SNRPCU1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (160 aa)
PRPF8Pre-mRNA processing factor 8. (2335 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (138 aa)
RBM22Pre-mRNA-splicing factor RBM22; Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Belongs to the SLT11 family. (420 aa)
BUD31BUD31 homolog. (144 aa)
ISY1Uncharacterized protein. (280 aa)
TFIP11Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. (827 aa)
PRPF6Pre-mRNA processing factor 6. (941 aa)
U2AF2U2 small nuclear RNA auxiliary factor 2. (699 aa)
HTATSF1HIV-1 Tat specific factor 1. (450 aa)
SNRPD3Small nuclear ribonucleoprotein Sm D3. (126 aa)
SNRPA1LRRcap domain-containing protein. (255 aa)
SF3A1Uncharacterized protein. (790 aa)
SF3B1Splicing factor 3b subunit 1. (1301 aa)
CRNKL1Crooked neck pre-mRNA splicing factor 1. (686 aa)
PRPF4Pre-mRNA processing factor 4. (537 aa)
CWC22Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. (926 aa)
LSM8U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (96 aa)
AQRAquarius intron-binding spliceosomal factor. (1513 aa)
SNW1SNW domain containing 1. (538 aa)
PRPF38APRP38_assoc domain-containing protein. (312 aa)
SNU13Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (128 aa)
PHF5AUncharacterized protein. (110 aa)
PRPF40APre-mRNA processing factor 40 homolog A. (853 aa)
SF3B4Splicing factor 3b subunit 4. (418 aa)
DHX15Uncharacterized protein. (762 aa)
CDC40WD_REPEATS_REGION domain-containing protein. (580 aa)
SF3B6Splicing factor 3b subunit 6. (91 aa)
WBP4WW domain-binding protein 4; Involved in pre-mRNA splicing as a component of the spliceosome. May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex. (398 aa)
EIF4A3Eukaryotic initiation factor 4A-III; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the [...] (412 aa)
NWD1WD_REPEATS_REGION domain-containing protein. (425 aa)
MFAP1Microfibrillar-associated protein 1; Involved in pre-mRNA splicing as a component of the spliceosome; Belongs to the MFAP1 family. (439 aa)
LUC7L2Uncharacterized protein. (398 aa)
YJU2YJU2 splicing factor homolog. (421 aa)
BUD13BUD13 homolog. (770 aa)
SNRPNSmall nuclear ribonucleoprotein-associated protein B; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (By similarity). Is also a component of the minor U12 spliceosome (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity). (240 aa)
DHX8DEAH-box helicase 8. (1163 aa)
LUC7L3Uncharacterized protein. (469 aa)
SF3B5Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa)
LSM3Uncharacterized protein. (102 aa)
PPIEPeptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (321 aa)
SNRPD1Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family. (119 aa)
CASC3CASC3 exon junction complex subunit. (657 aa)
RBM8ARNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (163 aa)
SNRPD2Small nuclear ribonucleoprotein Sm D2. (146 aa)
PRPF18SFM domain-containing protein. (351 aa)
SNRNP200Helicase_PWI domain-containing protein. (614 aa)
ZMAT2U1-type domain-containing protein. (199 aa)
LSM5U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (91 aa)
PRPF19Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity; Belongs to the WD repeat PRP19 family. (504 aa)
PLRG1Pleiotropic regulator 1. (516 aa)
CWC15Uncharacterized protein. (230 aa)
SNRPFSm domain-containing protein. (86 aa)
LSM6Sm domain-containing protein. (80 aa)
CWC27CWC27 spliceosome associated cyclophilin. (477 aa)
EFTUD2116 kDa U5 small nuclear ribonucleoprotein component; Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (By similarity). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (By similarity). (1222 aa)
TXNL4AThioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (142 aa)
CCDC12Uncharacterized protein. (207 aa)
CCDC130Coiled-coil domain containing 130. (337 aa)
SNRPGP15Small nuclear ribonucleoprotein G. (76 aa)
PPIL1Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (298 aa)
LOC112530170SEC63 domain-containing protein. (235 aa)
ENSGALP00000070086Uncharacterized protein. (597 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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