STRINGSTRING
RAB29 RAB29 STX12 STX12 LDLRAP1 LDLRAP1 SH3GL1 SH3GL1 UBXN6 UBXN6 RABGAP1 RABGAP1 SNX19 SNX19 ANKFY1 ANKFY1 RAB14 RAB14 SLC35D3 SLC35D3 VPS26B VPS26B ATP6V0D1 ATP6V0D1 RND2 RND2 DNER DNER RAB5C RAB5C STX10 STX10 RAB17 RAB17 GPER1 GPER1 TMEM184A TMEM184A SNX8 SNX8 VPS35 VPS35 PLEKHF1 PLEKHF1 EPHA8 EPHA8 WDFY1 WDFY1 EPHA4 EPHA4 ACKR2 ACKR2 APPL1 APPL1 SH3GL3 SH3GL3 GGA2 GGA2 PI4K2A PI4K2A F1NCI0_CHICK F1NCI0_CHICK TSG101 TSG101 TF TF TM9SF4 TM9SF4 EPHB1 EPHB1 SNX21 SNX21 LOC416959 LOC416959 ST8SIA2 ST8SIA2 TLR4 TLR4 ARRDC4 ARRDC4 HGS HGS RAB22A RAB22A RUBCN RUBCN CLN6 CLN6 GGA3 GGA3 PTPN1 PTPN1 HSPD1 HSPD1 NAPEPLD NAPEPLD TPCN1 TPCN1 TRAK2 TRAK2 ALS2 ALS2 VPS18 VPS18 PLA2G4B PLA2G4B LAMP3 LAMP3 PIKFYVE PIKFYVE COMMD1 COMMD1 ADRB1 ADRB1 EHD4 EHD4 STEAP2 STEAP2 EHD3 EHD3 NCSTN NCSTN INPP5F INPP5F VTI1B VTI1B CLCN3 CLCN3 RAB21 RAB21 SLC1A1 SLC1A1 VIPAS39 VIPAS39 RNF11 RNF11 ZFYVE9 ZFYVE9 SNX13 SNX13 GPNMB GPNMB WLS WLS RAB5A RAB5A CMTM6 CMTM6 UHRF1BP1L UHRF1BP1L PLD4 PLD4 WDR91 WDR91 PHETA2 PHETA2 SNX4 SNX4 DTX3L DTX3L CCDC93 CCDC93 TMEM163 TMEM163 RAB32 RAB32 CXCR4 CXCR4 CYTIP CYTIP TOM1 TOM1 WASHC3 WASHC3 NTRK1 NTRK1 TLR3 TLR3 KDR KDR FAM21C FAM21C PACSIN2 PACSIN2 LLGL1 LLGL1 TPD52L1 TPD52L1 CLVS2 CLVS2 NSG1 NSG1 CD274 CD274 SH3GL2 SH3GL2 SNX3 SNX3 EPHA3 EPHA3 ZFYVE16 ZFYVE16 HTT HTT SNX30 SNX30 ZFYVE28 ZFYVE28 TMEM30A TMEM30A ARC ARC PTP4A1 PTP4A1 WDFY2 WDFY2 MTMR2 MTMR2 PLA2G4EL7 PLA2G4EL7 ANXA1 ANXA1 HPS6 HPS6 MELTF MELTF RAB31 RAB31 NF2 NF2 RABGAP1L RABGAP1L VAMP3 VAMP3 APP APP OVAL OVAL PARM1 PARM1 MON2 MON2 ATP11B ATP11B HAP1 HAP1 OCRL OCRL PLEKHJ1 PLEKHJ1 SLC30A10 SLC30A10 PLA2G4EL3 PLA2G4EL3 PLA2G4EL5 PLA2G4EL5 PLA2G4EL2 PLA2G4EL2 ZFYVE26 ZFYVE26 MMGT1 MMGT1 CXCR7 CXCR7 ANKRD27 ANKRD27 ARRDC3 ARRDC3 RAB38 RAB38 APPL2 APPL2 STAM STAM SYNDIG1 SYNDIG1 RNF157 RNF157 SNX17 SNX17 ABCB6 ABCB6 SNX16 SNX16 DNAJC13 DNAJC13 RCC2 RCC2 LAPTM4B LAPTM4B SORL1 SORL1 PMEPA1 PMEPA1 MTMR1 MTMR1 SNX20 SNX20 INPP4A INPP4A ADRB2 ADRB2 PLEKHF2 PLEKHF2 IGF2R IGF2R SNX27 SNX27 LIPG LIPG PDLIM4 PDLIM4 DAGLA DAGLA SNX7 SNX7 PHETA1 PHETA1 CFTR CFTR CLVS1 CLVS1 PPP1R21 PPP1R21 TBC1D16 TBC1D16 ENSGALP00000051391 ENSGALP00000051391 USP8 USP8 STX8 STX8 UVRAG UVRAG ATP6V0D2 ATP6V0D2 EEA1 EEA1 WASHC5 WASHC5 MLC1 MLC1 GRIA1 GRIA1 LRP6 LRP6 WDR81 WDR81 RCSD1 RCSD1 TMEM127 TMEM127 PI4K2B PI4K2B PTP4A3 PTP4A3 PRDX3 PRDX3 ITCH ITCH GGA1 GGA1 STX7 STX7 USP10 USP10 RAB5B RAB5B STAM2 STAM2 NIPA1 NIPA1 PTP4A2 PTP4A2 DERL2 DERL2 SNX2 SNX2 VPS41 VPS41 VPS16 VPS16 RABEP1 RABEP1 TMEM108 TMEM108 TMEM230 TMEM230 DERL3 DERL3 VPS33A VPS33A SDCCAG3 SDCCAG3 VPS26A VPS26A RET RET LAMP5 LAMP5 PLA2G4EL6 PLA2G4EL6 TMEM165 TMEM165 NEU3 NEU3 ANGPTL3 ANGPTL3 VPS33B VPS33B SNX1 SNX1 RUSC1 RUSC1 SORCS2 SORCS2 DBNL DBNL NEU2 NEU2 INPP5B INPP5B NEURL1B NEURL1B ENSGALP00000066581 ENSGALP00000066581 LITAF LITAF WASH1 WASH1 C1orf210 C1orf210 SORT1 SORT1 PLD3 PLD3 ENSGALP00000067311 ENSGALP00000067311 RPS6KC1 RPS6KC1 TGFBRAP1 TGFBRAP1 HYAL3 HYAL3 ATP13A3 ATP13A3 USP8-2 USP8-2 ENSGALP00000068244 ENSGALP00000068244 SIGLEC1 SIGLEC1 MXD3 MXD3 MARCH8 MARCH8 HMP19 HMP19 LOC107056280 LOC107056280 SGK3 SGK3 LOC101747255 LOC101747255 SNX12 SNX12 TRAK1 TRAK1 RAPGEF1 RAPGEF1 GRIPAP1 GRIPAP1 VPS11 VPS11 STEAP4 STEAP4 KIF16B KIF16B ACKR4 ACKR4 PCSK9 PCSK9 NISCH NISCH DERL1 DERL1 KCNQ1 KCNQ1 NF2L NF2L RIN3 RIN3 PLPP2 PLPP2 WASF2 WASF2 ENSGALP00000072815 ENSGALP00000072815 TPCN3 TPCN3 MARCH1 MARCH1 MGRN1 MGRN1 ENSGALP00000073042 ENSGALP00000073042 MVB12B MVB12B EHD2 EHD2 VPS8 VPS8 ENSGALP00000073670 ENSGALP00000073670
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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RAB29RAB29, member RAS oncogene family. (205 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (272 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (144 aa)
SH3GL1Endophilin-A2; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). Belongs to the endophilin family. (472 aa)
UBXN6UBX domain protein 6. (438 aa)
RABGAP1RAB GTPase activating protein 1. (1069 aa)
SNX19Sorting nexin 19. (981 aa)
ANKFY1Ankyrin repeat and FYVE domain containing 1. (1076 aa)
RAB14Ras-related protein Rab-14; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development (By similarity); Belongs to the small GTPase superfamily. Rab family. (215 aa)
SLC35D3Solute carrier family 35 member D3. (424 aa)
VPS26BVPS26, retromer complex component B. (336 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
RND2Uncharacterized protein. (227 aa)
DNERDelta/notch like EGF repeat containing. (718 aa)
RAB5CRas-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity). (216 aa)
STX10Syntaxin-6; Involved in intracellular vesicle trafficking; Belongs to the syntaxin family. (254 aa)
RAB17RAB17, member RAS oncogene family. (213 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
TMEM184ATransmembrane protein 184A. (425 aa)
SNX8Sorting nexin 8. (448 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (799 aa)
PLEKHF1Pleckstrin homology and FYVE domain containing 1. (273 aa)
EPHA8EPH receptor A8. (1002 aa)
WDFY1Uncharacterized protein. (410 aa)
EPHA4Ephrin type-A receptor 4; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. U [...] (986 aa)
ACKR2Atypical chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (290 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (806 aa)
SH3GL3Endophilin-A3; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). Implicated in endocytosis of yolk proteins during oogenesis. (353 aa)
GGA2Uncharacterized protein. (490 aa)
PI4K2API3K/PI4K domain-containing protein. (466 aa)
F1NCI0_CHICKDUF4704 domain-containing protein. (1936 aa)
TSG101Uncharacterized protein. (390 aa)
TFOvotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. There are two forms of hen transferrin, ovotransferrin, found in the ovoducts and, serum transferrin, secreted by the liver. Serum transferrin may also have a role in stimulating cell proliferation and is regulated by iron levels. Ovotransferrin has a bacteriostatic function and, is not controlled by iron levels. (756 aa)
TM9SF4Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (668 aa)
EPHB1Ephrin type-B receptor 1; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a role in axon guidance during nervous system development. May also play an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines [...] (1003 aa)
SNX21Sorting nexin family member 21. (183 aa)
LOC416959Ovotransferrin; Belongs to the transferrin family. (738 aa)
ST8SIA2Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (375 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
ARRDC4Arrestin domain containing 4. (472 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate. (759 aa)
RAB22AUncharacterized protein. (194 aa)
RUBCNRubicon autophagy regulator. (904 aa)
CLN6Uncharacterized protein. (317 aa)
GGA3Uncharacterized protein. (754 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type 1; May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity). (475 aa)
HSPD160 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per rin [...] (573 aa)
NAPEPLDLactamase_B domain-containing protein. (463 aa)
TPCN1Two pore segment channel 1. (817 aa)
TRAK2Trafficking kinesin protein 2. (901 aa)
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1649 aa)
VPS18Pep3_Vps18 domain-containing protein. (974 aa)
PLA2G4BPhospholipase A2. (815 aa)
LAMP3Uncharacterized protein. (471 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2118 aa)
COMMD1Copper metabolism domain containing 1. (215 aa)
ADRB1Adrenoceptor beta 1. (477 aa)
EHD4EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (542 aa)
STEAP2STEAP2 metalloreductase. (489 aa)
EHD3Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa)
NCSTNNcstrn_small domain-containing protein. (717 aa)
INPP5FInositol polyphosphate-5-phosphatase F. (1126 aa)
VTI1BVesicle transport through interaction with t-SNAREs 1B. (232 aa)
CLCN3Chloride channel protein. (866 aa)
RAB21RAB21, member RAS oncogene family. (213 aa)
SLC1A1Amino acid transporter. (527 aa)
VIPAS39VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog. (497 aa)
RNF11RING-type domain-containing protein. (154 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1416 aa)
SNX13Uncharacterized protein. (969 aa)
GPNMBGlycoprotein nmb. (559 aa)
WLSProtein wntless homolog; May play an essential role in Wnt signaling pathway. May be required for Wnt-dependent patterning processes (By similarity). Belongs to the wntless family. (541 aa)
RAB5AUncharacterized protein. (215 aa)
CMTM6CKLF like MARVEL transmembrane domain containing 6. (183 aa)
UHRF1BP1LUHRF1 binding protein 1 like. (1450 aa)
PLD4Phospholipase D family member 4. (514 aa)
WDR91WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport; Belongs to the WD repeat WDR91 family. (751 aa)
PHETA2PH domain containing endocytic trafficking adaptor 2. (252 aa)
SNX4Sorting nexin 4. (435 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (737 aa)
CCDC93Coiled-coil domain-containing protein 93; May be involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery. Belongs to the CCDC93 family. (617 aa)
TMEM163Transmembrane protein 163. (274 aa)
RAB32Uncharacterized protein. (218 aa)
CXCR4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
CYTIPCytohesin 1 interacting protein. (342 aa)
TOM1Target of Myb protein 1; May be involved in intracellular trafficking. Probable association with membranes; Belongs to the TOM1 family. (515 aa)
WASHC3WASH complex subunit 3. (201 aa)
NTRK1High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors that regulate distinct overlapping signali [...] (790 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1348 aa)
FAM21CCAP-ZIP_m domain-containing protein. (1325 aa)
PACSIN2Protein kinase C and casein kinase substrate in neurons protein 2; Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. (485 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1234 aa)
TPD52L1Tumor protein D53 homolog. (210 aa)
CLVS2Clavesin 2. (327 aa)
NSG1Neuronal vesicle trafficking-associated protein 1; Plays a role in the recycling mechanism in neurons of multiple receptors and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Belongs to the NSG family. (185 aa)
CD274Uncharacterized protein. (471 aa)
SH3GL2Endophilin-A1; Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature (By similarity). (353 aa)
SNX3PX domain-containing protein. (162 aa)
EPHA3Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in ca [...] (983 aa)
ZFYVE16Zinc finger FYVE domain-containing protein. (1366 aa)
HTTHuntingtin. (3095 aa)
SNX30Sorting nexin family member 30. (438 aa)
ZFYVE28Uncharacterized protein. (354 aa)
TMEM30ACell cycle control protein 50A; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. [...] (372 aa)
ARCActivity-regulated cytoskeleton-associated protein; Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis- dependent forms [...] (404 aa)
PTP4A1TYR_PHOSPHATASE_2 domain-containing protein. (173 aa)
WDFY2Uncharacterized protein. (400 aa)
MTMR2Myotubularin-related protein 2; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3- phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity). (571 aa)
PLA2G4EL7PLA2c domain-containing protein. (580 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (342 aa)
HPS6HPS6 biogenesis of lysosomal organelles complex 2 subunit 3. (819 aa)
MELTFOvotransferrin; Belongs to the transferrin family. (738 aa)
RAB31RAB31, member RAS oncogene family. (195 aa)
NF2FERM domain-containing protein. (595 aa)
RABGAP1LRab GTPase-activating protein 1-like; GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables [...] (816 aa)
VAMP3V-SNARE coiled-coil homology domain-containing protein. (104 aa)
APPBPTI/Kunitz inhibitor domain-containing protein. (751 aa)
OVALOvalbumin; Non-inhibitory serpin. Storage protein of egg white. (386 aa)
PARM1Prostate androgen-regulated mucin-like protein 1. (284 aa)
MON2Uncharacterized protein. (1719 aa)
ATP11BPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1148 aa)
HAP1Uncharacterized protein. (851 aa)
OCRLRho-GAP domain-containing protein. (1013 aa)
PLEKHJ1Pleckstrin homology domain-containing family J member 1. (149 aa)
SLC30A10Solute carrier family 30 member 10. (232 aa)
PLA2G4EL3PLA2c domain-containing protein. (313 aa)
PLA2G4EL5Phospholipase A2. (867 aa)
PLA2G4EL2Phospholipase A2. (812 aa)
ZFYVE26Zinc finger FYVE-type containing 26. (2561 aa)
MMGT1Membrane magnesium transporter 1. (133 aa)
CXCR7G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (364 aa)
ANKRD27Uncharacterized protein. (1087 aa)
ARRDC3Arrestin domain containing 3. (420 aa)
RAB38RAB38, member RAS oncogene family. (212 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (671 aa)
STAMSignal transducing adaptor molecule. (522 aa)
SYNDIG1Synapse differentiation inducing 1. (256 aa)
RNF157Ring finger protein 157. (750 aa)
SNX17Sorting nexin 17. (470 aa)
ABCB6ATP binding cassette subfamily B member 6 (Langereis blood group). (894 aa)
SNX16PX domain-containing protein. (347 aa)
DNAJC13DnaJ heat shock protein family (Hsp40) member C13. (2245 aa)
RCC2Regulator of chromosome condensation 2. (529 aa)
LAPTM4BLysosomal protein transmembrane 4 beta. (224 aa)
SORL1Sortilin-related receptor; Sorting receptor that directs numerous proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting (By similarity). Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated (By similarity). Sorting receptor for the BDNF receptor NTRK2/TRKB that facilitates NTRK2 trafficking between synaptic [...] (2205 aa)
PMEPA1Uncharacterized protein. (286 aa)
MTMR1Myotubularin related protein 1. (685 aa)
SNX20PX domain-containing protein. (328 aa)
INPP4AInositol polyphosphate-4-phosphatase type I A. (983 aa)
ADRB2Adrenoceptor beta 2. (402 aa)
PLEKHF2Pleckstrin homology domain-containing family F member 2; May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis. (249 aa)
IGF2RFibronectin type-II domain-containing protein. (2561 aa)
SNX27Uncharacterized protein. (550 aa)
LIPGLipase G, endothelial type. (483 aa)
PDLIM4PDZ and LIM domain protein 4; Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton (By similarity). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transpo [...] (330 aa)
DAGLADiacylglycerol lipase alpha. (1025 aa)
SNX7Sorting nexin 7. (445 aa)
PHETA1PH domain containing endocytic trafficking adaptor 1. (238 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa)
CLVS1Clavesin 1. (332 aa)
PPP1R21Protein phosphatase 1 regulatory subunit 21; Putative regulator of protein phosphatase 1 (PP1) activity. May play a role in the endosomal sorting process or in endosome maturation pathway. (814 aa)
TBC1D16TBC1 domain family member 16. (728 aa)
ENSGALP00000051391FYVE-type domain-containing protein. (201 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (331 aa)
STX8t-SNARE coiled-coil homology domain-containing protein. (273 aa)
UVRAGC2 domain-containing protein. (707 aa)
ATP6V0D2V-type proton ATPase subunit d 2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity); Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
EEA1Early endosome antigen 1. (1450 aa)
WASHC5WASH complex subunit 5. (1159 aa)
MLC1Modulator of VRAC current 1. (379 aa)
GRIA1Uncharacterized protein. (902 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1580 aa)
WDR81WD repeat domain 81. (1946 aa)
RCSD1CAP-ZIP_m domain-containing protein. (371 aa)
TMEM127Transmembrane protein 127. (252 aa)
PI4K2BPhosphatidylinositol 4-kinase type 2-beta; Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5- bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity). (479 aa)
PTP4A3Protein tyrosine phosphatase 4A3. (173 aa)
PRDX3Peroxiredoxin 3. (309 aa)
ITCHE3 ubiquitin-protein ligase. (878 aa)
GGA1Golgi associated, gamma adaptin ear containing, ARF binding protein 1. (665 aa)
STX7t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (258 aa)
USP10Ubiquitin carboxyl-terminal hydrolase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels (By similarity). (785 aa)
RAB5BRas-related protein Rab-5B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (215 aa)
STAM2Signal transducing adapter molecule 2; Involved in intracellular signal transduction mediated by EGF. As a protein associated with focal adhesions and actin filaments, it may play a role in EGF receptor-stimulated cytoskeletal reorganization. The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). (576 aa)
NIPA1NIPA magnesium transporter 1. (323 aa)
PTP4A2Protein tyrosine phosphatase 4A2. (172 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
SNX2PX domain-containing protein. (605 aa)
VPS41Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (854 aa)
VPS16Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (838 aa)
RABEP1Uncharacterized protein. (782 aa)
TMEM108Transmembrane protein 108. (476 aa)
TMEM230Transmembrane protein 230; Involved in trafficking and recycling of synaptic vesicles. Belongs to the TMEM134/TMEM230 family. (120 aa)
DERL3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (279 aa)
VPS33AUncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (601 aa)
SDCCAG3Uncharacterized protein. (135 aa)
VPS26AVPS26, retromer complex component A. (326 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1105 aa)
LAMP5Lysosomal associated membrane protein family member 5. (344 aa)
PLA2G4EL6PLA2c domain-containing protein. (554 aa)
TMEM165GDT1 family protein. (322 aa)
NEU3Sialidase domain-containing protein. (636 aa)
ANGPTL3Fibrinogen C-terminal domain-containing protein. (464 aa)
VPS33BUncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (667 aa)
SNX1Sorting nexin 1. (514 aa)
RUSC1RUN and SH3 domain containing 1. (1092 aa)
SORCS2Sortilin related VPS10 domain containing receptor 2. (1169 aa)
DBNLADF-H domain-containing protein. (124 aa)
NEU2Neuraminidase 2. (413 aa)
INPP5BInositol polyphosphate-5-phosphatase B. (942 aa)
NEURL1BNeuralized E3 ubiquitin protein ligase 1B. (793 aa)
ENSGALP00000066581Uncharacterized protein. (532 aa)
LITAFLipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role in the nucleus in regulating the expression of numerous cytokines. (148 aa)
WASH1WASH complex subunit 1; Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and is required for its membrane targeting; Belongs to the WASH1 family. (485 aa)
C1orf210Chromosome 1 open reading frame 210. (119 aa)
SORT1Sortilin. (954 aa)
PLD3PLD phosphodiesterase domain-containing protein. (204 aa)
ENSGALP00000067311BEACH domain-containing protein. (161 aa)
RPS6KC1Ribosomal protein S6 kinase C1. (1078 aa)
TGFBRAP1Transforming growth factor beta receptor associated protein 1. (863 aa)
HYAL3Hyaluronidase. (584 aa)
ATP13A3Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1283 aa)
USP8-2Rhodanese domain-containing protein. (602 aa)
ENSGALP00000068244PLD phosphodiesterase domain-containing protein. (380 aa)
SIGLEC1Uncharacterized protein. (606 aa)
MXD3FYVE domain-containing protein. (619 aa)
MARCH8RING-CH-type domain-containing protein. (581 aa)
HMP19Uncharacterized protein. (193 aa)
LOC107056280Uncharacterized protein. (466 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa)
LOC101747255Uncharacterized protein. (368 aa)
SNX12PX domain-containing protein. (211 aa)
TRAK1Trafficking kinesin protein 1. (1048 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1225 aa)
GRIPAP1Uncharacterized protein. (764 aa)
VPS11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (957 aa)
STEAP4STEAP4 metalloreductase. (472 aa)
KIF16BKinesin family member 16B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2059 aa)
ACKR4Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (385 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (643 aa)
NISCHNischarin. (1415 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (299 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (863 aa)
NF2LFERM domain-containing protein. (648 aa)
RIN3Ras and Rab interactor 3. (983 aa)
PLPP2Phospholipid phosphatase 2. (542 aa)
WASF2WASP family member 2. (528 aa)
ENSGALP00000072815VHS domain-containing protein. (90 aa)
TPCN3Uncharacterized protein. (783 aa)
MARCH1RING-CH-type domain-containing protein. (559 aa)
MGRN1Mahogunin ring finger 1. (586 aa)
ENSGALP00000073042Rho-GAP domain-containing protein. (180 aa)
MVB12BUncharacterized protein. (332 aa)
EHD2EH domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa)
VPS8VPS8 subunit of CORVET complex. (1494 aa)
ENSGALP00000073670Uncharacterized protein. (184 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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