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| | RAB29 | RAB29, member RAS oncogene family. (205 aa) |
| | STX12 | Syntaxin 12; Belongs to the syntaxin family. (272 aa) |
| | LDLRAP1 | Low density lipoprotein receptor adaptor protein 1. (144 aa) |
| | SH3GL1 | Endophilin-A2; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). Belongs to the endophilin family. (472 aa) |
| | UBXN6 | UBX domain protein 6. (438 aa) |
| | RABGAP1 | RAB GTPase activating protein 1. (1069 aa) |
| | SNX19 | Sorting nexin 19. (981 aa) |
| | ANKFY1 | Ankyrin repeat and FYVE domain containing 1. (1076 aa) |
| | RAB14 | Ras-related protein Rab-14; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development (By similarity); Belongs to the small GTPase superfamily. Rab family. (215 aa) |
| | SLC35D3 | Solute carrier family 35 member D3. (424 aa) |
| | VPS26B | VPS26, retromer complex component B. (336 aa) |
| | ATP6V0D1 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa) |
| | RND2 | Uncharacterized protein. (227 aa) |
| | DNER | Delta/notch like EGF repeat containing. (718 aa) |
| | RAB5C | Ras-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity). (216 aa) |
| | STX10 | Syntaxin-6; Involved in intracellular vesicle trafficking; Belongs to the syntaxin family. (254 aa) |
| | RAB17 | RAB17, member RAS oncogene family. (213 aa) |
| | GPER1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa) |
| | TMEM184A | Transmembrane protein 184A. (425 aa) |
| | SNX8 | Sorting nexin 8. (448 aa) |
| | VPS35 | Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (799 aa) |
| | PLEKHF1 | Pleckstrin homology and FYVE domain containing 1. (273 aa) |
| | EPHA8 | EPH receptor A8. (1002 aa) |
| | WDFY1 | Uncharacterized protein. (410 aa) |
| | EPHA4 | Ephrin type-A receptor 4; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. U [...] (986 aa) |
| | ACKR2 | Atypical chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (290 aa) |
| | APPL1 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (806 aa) |
| | SH3GL3 | Endophilin-A3; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). Implicated in endocytosis of yolk proteins during oogenesis. (353 aa) |
| | GGA2 | Uncharacterized protein. (490 aa) |
| | PI4K2A | PI3K/PI4K domain-containing protein. (466 aa) |
| | F1NCI0_CHICK | DUF4704 domain-containing protein. (1936 aa) |
| | TSG101 | Uncharacterized protein. (390 aa) |
| | TF | Ovotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. There are two forms of hen transferrin, ovotransferrin, found in the ovoducts and, serum transferrin, secreted by the liver. Serum transferrin may also have a role in stimulating cell proliferation and is regulated by iron levels. Ovotransferrin has a bacteriostatic function and, is not controlled by iron levels. (756 aa) |
| | TM9SF4 | Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (668 aa) |
| | EPHB1 | Ephrin type-B receptor 1; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a role in axon guidance during nervous system development. May also play an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines [...] (1003 aa) |
| | SNX21 | Sorting nexin family member 21. (183 aa) |
| | LOC416959 | Ovotransferrin; Belongs to the transferrin family. (738 aa) |
| | ST8SIA2 | Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (375 aa) |
| | TLR4 | Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa) |
| | ARRDC4 | Arrestin domain containing 4. (472 aa) |
| | HGS | Hepatocyte growth factor-regulated tyrosine kinase substrate. (759 aa) |
| | RAB22A | Uncharacterized protein. (194 aa) |
| | RUBCN | Rubicon autophagy regulator. (904 aa) |
| | CLN6 | Uncharacterized protein. (317 aa) |
| | GGA3 | Uncharacterized protein. (754 aa) |
| | PTPN1 | Tyrosine-protein phosphatase non-receptor type 1; May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity). (475 aa) |
| | HSPD1 | 60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per rin [...] (573 aa) |
| | NAPEPLD | Lactamase_B domain-containing protein. (463 aa) |
| | TPCN1 | Two pore segment channel 1. (817 aa) |
| | TRAK2 | Trafficking kinesin protein 2. (901 aa) |
| | ALS2 | Alsin Rho guanine nucleotide exchange factor ALS2. (1649 aa) |
| | VPS18 | Pep3_Vps18 domain-containing protein. (974 aa) |
| | PLA2G4B | Phospholipase A2. (815 aa) |
| | LAMP3 | Uncharacterized protein. (471 aa) |
| | PIKFYVE | Phosphoinositide kinase, FYVE-type zinc finger containing. (2118 aa) |
| | COMMD1 | Copper metabolism domain containing 1. (215 aa) |
| | ADRB1 | Adrenoceptor beta 1. (477 aa) |
| | EHD4 | EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (542 aa) |
| | STEAP2 | STEAP2 metalloreductase. (489 aa) |
| | EHD3 | Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa) |
| | NCSTN | Ncstrn_small domain-containing protein. (717 aa) |
| | INPP5F | Inositol polyphosphate-5-phosphatase F. (1126 aa) |
| | VTI1B | Vesicle transport through interaction with t-SNAREs 1B. (232 aa) |
| | CLCN3 | Chloride channel protein. (866 aa) |
| | RAB21 | RAB21, member RAS oncogene family. (213 aa) |
| | SLC1A1 | Amino acid transporter. (527 aa) |
| | VIPAS39 | VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog. (497 aa) |
| | RNF11 | RING-type domain-containing protein. (154 aa) |
| | ZFYVE9 | Zinc finger FYVE domain-containing protein. (1416 aa) |
| | SNX13 | Uncharacterized protein. (969 aa) |
| | GPNMB | Glycoprotein nmb. (559 aa) |
| | WLS | Protein wntless homolog; May play an essential role in Wnt signaling pathway. May be required for Wnt-dependent patterning processes (By similarity). Belongs to the wntless family. (541 aa) |
| | RAB5A | Uncharacterized protein. (215 aa) |
| | CMTM6 | CKLF like MARVEL transmembrane domain containing 6. (183 aa) |
| | UHRF1BP1L | UHRF1 binding protein 1 like. (1450 aa) |
| | PLD4 | Phospholipase D family member 4. (514 aa) |
| | WDR91 | WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport; Belongs to the WD repeat WDR91 family. (751 aa) |
| | PHETA2 | PH domain containing endocytic trafficking adaptor 2. (252 aa) |
| | SNX4 | Sorting nexin 4. (435 aa) |
| | DTX3L | Deltex E3 ubiquitin ligase 3L. (737 aa) |
| | CCDC93 | Coiled-coil domain-containing protein 93; May be involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery. Belongs to the CCDC93 family. (617 aa) |
| | TMEM163 | Transmembrane protein 163. (274 aa) |
| | RAB32 | Uncharacterized protein. (218 aa) |
| | CXCR4 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa) |
| | CYTIP | Cytohesin 1 interacting protein. (342 aa) |
| | TOM1 | Target of Myb protein 1; May be involved in intracellular trafficking. Probable association with membranes; Belongs to the TOM1 family. (515 aa) |
| | WASHC3 | WASH complex subunit 3. (201 aa) |
| | NTRK1 | High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors that regulate distinct overlapping signali [...] (790 aa) |
| | TLR3 | Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa) |
| | KDR | Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1348 aa) |
| | FAM21C | CAP-ZIP_m domain-containing protein. (1325 aa) |
| | PACSIN2 | Protein kinase C and casein kinase substrate in neurons protein 2; Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. (485 aa) |
| | LLGL1 | LLGL scribble cell polarity complex component 1. (1234 aa) |
| | TPD52L1 | Tumor protein D53 homolog. (210 aa) |
| | CLVS2 | Clavesin 2. (327 aa) |
| | NSG1 | Neuronal vesicle trafficking-associated protein 1; Plays a role in the recycling mechanism in neurons of multiple receptors and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Belongs to the NSG family. (185 aa) |
| | CD274 | Uncharacterized protein. (471 aa) |
| | SH3GL2 | Endophilin-A1; Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature (By similarity). (353 aa) |
| | SNX3 | PX domain-containing protein. (162 aa) |
| | EPHA3 | Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in ca [...] (983 aa) |
| | ZFYVE16 | Zinc finger FYVE domain-containing protein. (1366 aa) |
| | HTT | Huntingtin. (3095 aa) |
| | SNX30 | Sorting nexin family member 30. (438 aa) |
| | ZFYVE28 | Uncharacterized protein. (354 aa) |
| | TMEM30A | Cell cycle control protein 50A; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. [...] (372 aa) |
| | ARC | Activity-regulated cytoskeleton-associated protein; Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis- dependent forms [...] (404 aa) |
| | PTP4A1 | TYR_PHOSPHATASE_2 domain-containing protein. (173 aa) |
| | WDFY2 | Uncharacterized protein. (400 aa) |
| | MTMR2 | Myotubularin-related protein 2; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3- phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity). (571 aa) |
| | PLA2G4EL7 | PLA2c domain-containing protein. (580 aa) |
| | ANXA1 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (342 aa) |
| | HPS6 | HPS6 biogenesis of lysosomal organelles complex 2 subunit 3. (819 aa) |
| | MELTF | Ovotransferrin; Belongs to the transferrin family. (738 aa) |
| | RAB31 | RAB31, member RAS oncogene family. (195 aa) |
| | NF2 | FERM domain-containing protein. (595 aa) |
| | RABGAP1L | Rab GTPase-activating protein 1-like; GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables [...] (816 aa) |
| | VAMP3 | V-SNARE coiled-coil homology domain-containing protein. (104 aa) |
| | APP | BPTI/Kunitz inhibitor domain-containing protein. (751 aa) |
| | OVAL | Ovalbumin; Non-inhibitory serpin. Storage protein of egg white. (386 aa) |
| | PARM1 | Prostate androgen-regulated mucin-like protein 1. (284 aa) |
| | MON2 | Uncharacterized protein. (1719 aa) |
| | ATP11B | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1148 aa) |
| | HAP1 | Uncharacterized protein. (851 aa) |
| | OCRL | Rho-GAP domain-containing protein. (1013 aa) |
| | PLEKHJ1 | Pleckstrin homology domain-containing family J member 1. (149 aa) |
| | SLC30A10 | Solute carrier family 30 member 10. (232 aa) |
| | PLA2G4EL3 | PLA2c domain-containing protein. (313 aa) |
| | PLA2G4EL5 | Phospholipase A2. (867 aa) |
| | PLA2G4EL2 | Phospholipase A2. (812 aa) |
| | ZFYVE26 | Zinc finger FYVE-type containing 26. (2561 aa) |
| | MMGT1 | Membrane magnesium transporter 1. (133 aa) |
| | CXCR7 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (364 aa) |
| | ANKRD27 | Uncharacterized protein. (1087 aa) |
| | ARRDC3 | Arrestin domain containing 3. (420 aa) |
| | RAB38 | RAB38, member RAS oncogene family. (212 aa) |
| | APPL2 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (671 aa) |
| | STAM | Signal transducing adaptor molecule. (522 aa) |
| | SYNDIG1 | Synapse differentiation inducing 1. (256 aa) |
| | RNF157 | Ring finger protein 157. (750 aa) |
| | SNX17 | Sorting nexin 17. (470 aa) |
| | ABCB6 | ATP binding cassette subfamily B member 6 (Langereis blood group). (894 aa) |
| | SNX16 | PX domain-containing protein. (347 aa) |
| | DNAJC13 | DnaJ heat shock protein family (Hsp40) member C13. (2245 aa) |
| | RCC2 | Regulator of chromosome condensation 2. (529 aa) |
| | LAPTM4B | Lysosomal protein transmembrane 4 beta. (224 aa) |
| | SORL1 | Sortilin-related receptor; Sorting receptor that directs numerous proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting (By similarity). Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated (By similarity). Sorting receptor for the BDNF receptor NTRK2/TRKB that facilitates NTRK2 trafficking between synaptic [...] (2205 aa) |
| | PMEPA1 | Uncharacterized protein. (286 aa) |
| | MTMR1 | Myotubularin related protein 1. (685 aa) |
| | SNX20 | PX domain-containing protein. (328 aa) |
| | INPP4A | Inositol polyphosphate-4-phosphatase type I A. (983 aa) |
| | ADRB2 | Adrenoceptor beta 2. (402 aa) |
| | PLEKHF2 | Pleckstrin homology domain-containing family F member 2; May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis. (249 aa) |
| | IGF2R | Fibronectin type-II domain-containing protein. (2561 aa) |
| | SNX27 | Uncharacterized protein. (550 aa) |
| | LIPG | Lipase G, endothelial type. (483 aa) |
| | PDLIM4 | PDZ and LIM domain protein 4; Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton (By similarity). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transpo [...] (330 aa) |
| | DAGLA | Diacylglycerol lipase alpha. (1025 aa) |
| | SNX7 | Sorting nexin 7. (445 aa) |
| | PHETA1 | PH domain containing endocytic trafficking adaptor 1. (238 aa) |
| | CFTR | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa) |
| | CLVS1 | Clavesin 1. (332 aa) |
| | PPP1R21 | Protein phosphatase 1 regulatory subunit 21; Putative regulator of protein phosphatase 1 (PP1) activity. May play a role in the endosomal sorting process or in endosome maturation pathway. (814 aa) |
| | TBC1D16 | TBC1 domain family member 16. (728 aa) |
| | ENSGALP00000051391 | FYVE-type domain-containing protein. (201 aa) |
| | USP8 | Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (331 aa) |
| | STX8 | t-SNARE coiled-coil homology domain-containing protein. (273 aa) |
| | UVRAG | C2 domain-containing protein. (707 aa) |
| | ATP6V0D2 | V-type proton ATPase subunit d 2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity); Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa) |
| | EEA1 | Early endosome antigen 1. (1450 aa) |
| | WASHC5 | WASH complex subunit 5. (1159 aa) |
| | MLC1 | Modulator of VRAC current 1. (379 aa) |
| | GRIA1 | Uncharacterized protein. (902 aa) |
| | LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1580 aa) |
| | WDR81 | WD repeat domain 81. (1946 aa) |
| | RCSD1 | CAP-ZIP_m domain-containing protein. (371 aa) |
| | TMEM127 | Transmembrane protein 127. (252 aa) |
| | PI4K2B | Phosphatidylinositol 4-kinase type 2-beta; Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5- bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity). (479 aa) |
| | PTP4A3 | Protein tyrosine phosphatase 4A3. (173 aa) |
| | PRDX3 | Peroxiredoxin 3. (309 aa) |
| | ITCH | E3 ubiquitin-protein ligase. (878 aa) |
| | GGA1 | Golgi associated, gamma adaptin ear containing, ARF binding protein 1. (665 aa) |
| | STX7 | t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (258 aa) |
| | USP10 | Ubiquitin carboxyl-terminal hydrolase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels (By similarity). (785 aa) |
| | RAB5B | Ras-related protein Rab-5B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (215 aa) |
| | STAM2 | Signal transducing adapter molecule 2; Involved in intracellular signal transduction mediated by EGF. As a protein associated with focal adhesions and actin filaments, it may play a role in EGF receptor-stimulated cytoskeletal reorganization. The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). (576 aa) |
| | NIPA1 | NIPA magnesium transporter 1. (323 aa) |
| | PTP4A2 | Protein tyrosine phosphatase 4A2. (172 aa) |
| | DERL2 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa) |
| | SNX2 | PX domain-containing protein. (605 aa) |
| | VPS41 | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (854 aa) |
| | VPS16 | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (838 aa) |
| | RABEP1 | Uncharacterized protein. (782 aa) |
| | TMEM108 | Transmembrane protein 108. (476 aa) |
| | TMEM230 | Transmembrane protein 230; Involved in trafficking and recycling of synaptic vesicles. Belongs to the TMEM134/TMEM230 family. (120 aa) |
| | DERL3 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (279 aa) |
| | VPS33A | Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (601 aa) |
| | SDCCAG3 | Uncharacterized protein. (135 aa) |
| | VPS26A | VPS26, retromer complex component A. (326 aa) |
| | RET | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1105 aa) |
| | LAMP5 | Lysosomal associated membrane protein family member 5. (344 aa) |
| | PLA2G4EL6 | PLA2c domain-containing protein. (554 aa) |
| | TMEM165 | GDT1 family protein. (322 aa) |
| | NEU3 | Sialidase domain-containing protein. (636 aa) |
| | ANGPTL3 | Fibrinogen C-terminal domain-containing protein. (464 aa) |
| | VPS33B | Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (667 aa) |
| | SNX1 | Sorting nexin 1. (514 aa) |
| | RUSC1 | RUN and SH3 domain containing 1. (1092 aa) |
| | SORCS2 | Sortilin related VPS10 domain containing receptor 2. (1169 aa) |
| | DBNL | ADF-H domain-containing protein. (124 aa) |
| | NEU2 | Neuraminidase 2. (413 aa) |
| | INPP5B | Inositol polyphosphate-5-phosphatase B. (942 aa) |
| | NEURL1B | Neuralized E3 ubiquitin protein ligase 1B. (793 aa) |
| | ENSGALP00000066581 | Uncharacterized protein. (532 aa) |
| | LITAF | Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role in the nucleus in regulating the expression of numerous cytokines. (148 aa) |
| | WASH1 | WASH complex subunit 1; Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and is required for its membrane targeting; Belongs to the WASH1 family. (485 aa) |
| | C1orf210 | Chromosome 1 open reading frame 210. (119 aa) |
| | SORT1 | Sortilin. (954 aa) |
| | PLD3 | PLD phosphodiesterase domain-containing protein. (204 aa) |
| | ENSGALP00000067311 | BEACH domain-containing protein. (161 aa) |
| | RPS6KC1 | Ribosomal protein S6 kinase C1. (1078 aa) |
| | TGFBRAP1 | Transforming growth factor beta receptor associated protein 1. (863 aa) |
| | HYAL3 | Hyaluronidase. (584 aa) |
| | ATP13A3 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1283 aa) |
| | USP8-2 | Rhodanese domain-containing protein. (602 aa) |
| | ENSGALP00000068244 | PLD phosphodiesterase domain-containing protein. (380 aa) |
| | SIGLEC1 | Uncharacterized protein. (606 aa) |
| | MXD3 | FYVE domain-containing protein. (619 aa) |
| | MARCH8 | RING-CH-type domain-containing protein. (581 aa) |
| | HMP19 | Uncharacterized protein. (193 aa) |
| | LOC107056280 | Uncharacterized protein. (466 aa) |
| | SGK3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa) |
| | LOC101747255 | Uncharacterized protein. (368 aa) |
| | SNX12 | PX domain-containing protein. (211 aa) |
| | TRAK1 | Trafficking kinesin protein 1. (1048 aa) |
| | RAPGEF1 | Rap guanine nucleotide exchange factor 1. (1225 aa) |
| | GRIPAP1 | Uncharacterized protein. (764 aa) |
| | VPS11 | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (957 aa) |
| | STEAP4 | STEAP4 metalloreductase. (472 aa) |
| | KIF16B | Kinesin family member 16B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2059 aa) |
| | ACKR4 | Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (385 aa) |
| | PCSK9 | Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (643 aa) |
| | NISCH | Nischarin. (1415 aa) |
| | DERL1 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (299 aa) |
| | KCNQ1 | Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (863 aa) |
| | NF2L | FERM domain-containing protein. (648 aa) |
| | RIN3 | Ras and Rab interactor 3. (983 aa) |
| | PLPP2 | Phospholipid phosphatase 2. (542 aa) |
| | WASF2 | WASP family member 2. (528 aa) |
| | ENSGALP00000072815 | VHS domain-containing protein. (90 aa) |
| | TPCN3 | Uncharacterized protein. (783 aa) |
| | MARCH1 | RING-CH-type domain-containing protein. (559 aa) |
| | MGRN1 | Mahogunin ring finger 1. (586 aa) |
| | ENSGALP00000073042 | Rho-GAP domain-containing protein. (180 aa) |
| | MVB12B | Uncharacterized protein. (332 aa) |
| | EHD2 | EH domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa) |
| | VPS8 | VPS8 subunit of CORVET complex. (1494 aa) |
| | ENSGALP00000073670 | Uncharacterized protein. (184 aa) |
