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KLHL20 KLHL20 TGFBI TGFBI TJAP1 TJAP1 BACE1 BACE1 GGA1 GGA1 STX16 STX16 LOC107049174 LOC107049174 WIPI1 WIPI1 ATP2C1 ATP2C1 PI4K2B PI4K2B GOLPH3L GOLPH3L YIPF1 YIPF1 ENSGALP00000052965 ENSGALP00000052965 VAMP4 VAMP4 LRRK2 LRRK2 ARFIP1 ARFIP1 STX8 STX8 MARCHF4 MARCHF4 YIPF6 YIPF6 CLVS1 CLVS1 ATP8B2 ATP8B2 PHETA1 PHETA1 ATP9B ATP9B IGF2R IGF2R CORO7 CORO7 MMP24 MMP24 ARFGEF1 ARFGEF1 BACE2 BACE2 CHST7 CHST7 AP4B1 AP4B1 GOLGA4 GOLGA4 TRAPPC9 TRAPPC9 CHST2 CHST2 IMPAD1 IMPAD1 FAM91A1 FAM91A1 WDR11 WDR11 ARFIP2 ARFIP2 RAB38 RAB38 CHAC1 CHAC1 GOLPH3 GOLPH3 PLEKHJ1 PLEKHJ1 CHST3 CHST3 OCRL OCRL PIFO PIFO SLC24A5 SLC24A5 RAB10 RAB10 RAB7B RAB7B RAB31 RAB31 MLANA MLANA ATP7B ATP7B GCC2 GCC2 DOP1A DOP1A TBC1D23 TBC1D23 PAM PAM CLVS2 CLVS2 PCSK1 PCSK1 LLGL1 LLGL1 YIPF7 YIPF7 SNX9 SNX9 RELCH RELCH RAB32 RAB32 CBY1 CBY1 PHETA2 PHETA2 CLBA1 CLBA1 WLS WLS PLEKHA8 PLEKHA8 PLPP3 PLPP3 CNST CNST DPY30 DPY30 CFAP97 CFAP97 YIPF4 YIPF4 BIRC6 BIRC6 LGR5 LGR5 TRAPPC6A TRAPPC6A FUT4 FUT4 SNAP25 SNAP25 CCDC186 CCDC186 VPS54 VPS54 ARL5B ARL5B CHST1 CHST1 FURIN FURIN GGA3 GGA3 ATP9A ATP9A ATP7A ATP7A YIPF5 YIPF5 SMPD4 SMPD4 PI4K2A PI4K2A GGA2 GGA2 GBF1 GBF1 GH GH PIH1D3 PIH1D3 ARFGEF2 ARFGEF2 GPER1 GPER1 SYS1 SYS1 STX10 STX10 AZIN2 AZIN2 C17orf75 C17orf75 C11H16orf70 C11H16orf70 INPP5K INPP5K SCAMP2 SCAMP2 RAB14 RAB14 CHST6 CHST6 CHST4 CHST4 AFTPH AFTPH LOC107050235 LOC107050235 ENSGALP00000073042 ENSGALP00000073042 MARCH1 MARCH1 PCSK7 PCSK7 ENSGALP00000072815 ENSGALP00000072815 VPS13B VPS13B ATP8B4 ATP8B4 SCAMP5 SCAMP5 ENSGALP00000071604 ENSGALP00000071604 ARFRP1 ARFRP1 GSAP GSAP TSSC1 TSSC1 ATP8B3 ATP8B3 SCAMP3 SCAMP3 ATXN2 ATXN2 CALN1 CALN1 ATG9B ATG9B HMP19 HMP19 RBFOX1 RBFOX1 ENSGALP00000068902 ENSGALP00000068902 ATP11A ATP11A CLASP2 CLASP2 CCDC91 CCDC91 SLC66A2 SLC66A2 RAB29 RAB29 RNF215 RNF215 ARL5A ARL5A PCSK4 PCSK4 SLC10A7 SLC10A7 ENSGALP00000066467 ENSGALP00000066467 DOP1B DOP1B ATP11C ATP11C POSTN POSTN TGOLN2 TGOLN2 ATG9A ATG9A RAB30 RAB30 SCAMP4 SCAMP4 ATP8B1 ATP8B1 TMEM165 TMEM165 FUT9 FUT9 SCAMP1 SCAMP1 TEPSIN TEPSIN TMEM79 TMEM79 SYT11 SYT11 M6PR M6PR ARL1 ARL1 TMEM230 TMEM230 CABP7 CABP7 ENSGALP00000058230 ENSGALP00000058230
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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KLHL20Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. It also specifically mediates 'Lys-33'-linked ubiquitination (By similarity). (613 aa)
TGFBIUncharacterized protein. (680 aa)
TJAP1Uncharacterized protein. (640 aa)
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (497 aa)
GGA1Golgi associated, gamma adaptin ear containing, ARF binding protein 1. (665 aa)
STX16t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (326 aa)
LOC107049174Uncharacterized protein. (293 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (508 aa)
ATP2C1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (965 aa)
PI4K2BPhosphatidylinositol 4-kinase type 2-beta; Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5- bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity). (479 aa)
GOLPH3LGolgi phosphoprotein 3 like. (279 aa)
YIPF1Protein YIPF. (306 aa)
ENSGALP00000052965Adaptin_N domain-containing protein. (250 aa)
VAMP4Vesicle associated membrane protein 4. (141 aa)
LRRK2Uncharacterized protein. (2557 aa)
ARFIP1AH domain-containing protein. (420 aa)
STX8t-SNARE coiled-coil homology domain-containing protein. (273 aa)
MARCHF4Membrane associated ring-CH-type finger 4. (390 aa)
YIPF6Protein YIPF. (231 aa)
CLVS1Clavesin 1. (332 aa)
ATP8B2Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1282 aa)
PHETA1PH domain containing endocytic trafficking adaptor 1. (238 aa)
ATP9BPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1139 aa)
IGF2RFibronectin type-II domain-containing protein. (2561 aa)
CORO7Coronin; Belongs to the WD repeat coronin family. (1189 aa)
MMP24Matrix metallopeptidase 24. (596 aa)
ARFGEF1ADP ribosylation factor guanine nucleotide exchange factor 1. (1846 aa)
BACE2Beta-secretase 2; Belongs to the peptidase A1 family. (633 aa)
CHST7Sulfotransferase; Belongs to the sulfotransferase 1 family. (464 aa)
AP4B1AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (534 aa)
GOLGA4Golgin A4. (2285 aa)
TRAPPC9Trafficking protein particle complex 9. (996 aa)
CHST2Sulfotransferase; Belongs to the sulfotransferase 1 family. (427 aa)
IMPAD1Inositol monophosphatase domain containing 1. (356 aa)
FAM91A1Family with sequence similarity 91 member A1. (843 aa)
WDR11WD repeat domain 11. (1222 aa)
ARFIP2ADP ribosylation factor interacting protein 2. (394 aa)
RAB38RAB38, member RAS oncogene family. (212 aa)
CHAC1Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (254 aa)
GOLPH3Uncharacterized protein. (294 aa)
PLEKHJ1Pleckstrin homology domain-containing family J member 1. (149 aa)
CHST3Carbohydrate sulfotransferase 3; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices (By similarity). (458 aa)
OCRLRho-GAP domain-containing protein. (1013 aa)
PIFOPrimary cilia formation. (198 aa)
SLC24A5Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (423 aa)
RAB10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Plays also a specific role in asymmetric protein transport to the plasma mem [...] (200 aa)
RAB7BRAB7B, member RAS oncogene family. (207 aa)
RAB31RAB31, member RAS oncogene family. (195 aa)
MLANAMelan-A. (113 aa)
ATP7BATPase copper transporting beta. (1530 aa)
GCC2GRIP and coiled-coil domain containing 2. (1693 aa)
DOP1ADOP1 leucine zipper like protein A. (2492 aa)
TBC1D23TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (By similarity). Plays a role in brain development (By similarity). May act as a general inhibitor of innate immunity signaling (By similarity). (679 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (970 aa)
CLVS2Clavesin 2. (327 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (748 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1234 aa)
YIPF7Uncharacterized protein. (258 aa)
SNX9Sorting nexin. (600 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1363 aa)
RAB32Uncharacterized protein. (218 aa)
CBY1Uncharacterized protein. (126 aa)
PHETA2PH domain containing endocytic trafficking adaptor 2. (252 aa)
CLBA1Clathrin binding box of aftiphilin containing 1. (336 aa)
WLSProtein wntless homolog; May play an essential role in Wnt signaling pathway. May be required for Wnt-dependent patterning processes (By similarity). Belongs to the wntless family. (541 aa)
PLEKHA8Pleckstrin homology domain containing A8. (522 aa)
PLPP3acidPPc domain-containing protein. (313 aa)
CNSTConsortin, connexin sorting protein. (509 aa)
DPY30Uncharacterized protein. (99 aa)
CFAP97Uncharacterized protein. (464 aa)
YIPF4Protein YIPF4; Involved in the maintenance of the Golgi structure. Belongs to the YIP1 family. (249 aa)
BIRC6Baculoviral IAP repeat containing 6. (4856 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (909 aa)
TRAPPC6AUncharacterized protein. (158 aa)
FUT4Glyco_tran_10_N domain-containing protein. (356 aa)
SNAP25Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion (By similarity). Belongs to the SNAP-25 family. (206 aa)
CCDC186Coiled-coil domain containing 186. (919 aa)
VPS54VPS54 subunit of GARP complex. (974 aa)
ARL5BUncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (179 aa)
CHST1Sulfotransferase; Belongs to the sulfotransferase 1 family. (418 aa)
FURINTrans Golgi network protease furin; Belongs to the peptidase S8 family. (789 aa)
GGA3Uncharacterized protein. (754 aa)
ATP9APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1047 aa)
ATP7AATPase copper transporting alpha. (1494 aa)
YIPF5Protein YIPF. (254 aa)
SMPD4Sphingomyelin phosphodiesterase 4. (827 aa)
PI4K2API3K/PI4K domain-containing protein. (466 aa)
GGA2Uncharacterized protein. (490 aa)
GBF1Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1863 aa)
GHSomatotropin; Growth hormone plays an important role in growth control. (216 aa)
PIH1D3PIH1 domain containing 3. (191 aa)
ARFGEF2ADP ribosylation factor guanine nucleotide exchange factor 2. (1792 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
SYS1Protein SYS1 homolog; Involved in protein trafficking. Belongs to the SYS1 family. (156 aa)
STX10Syntaxin-6; Involved in intracellular vesicle trafficking; Belongs to the syntaxin family. (254 aa)
AZIN2Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (520 aa)
C17orf75Chromosome 17 open reading frame 75. (287 aa)
C11H16orf70Uncharacterized protein. (423 aa)
INPP5KIPPc domain-containing protein. (465 aa)
SCAMP2Secretory carrier-associated membrane protein. (333 aa)
RAB14Ras-related protein Rab-14; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development (By similarity); Belongs to the small GTPase superfamily. Rab family. (215 aa)
CHST6Sulfotransferase; Belongs to the sulfotransferase 1 family. (393 aa)
CHST4Sulfotransferase; Belongs to the sulfotransferase 1 family. (379 aa)
AFTPHAftiphilin. (884 aa)
LOC107050235LsmAD domain-containing protein. (331 aa)
ENSGALP00000073042Rho-GAP domain-containing protein. (180 aa)
MARCH1RING-CH-type domain-containing protein. (559 aa)
PCSK7P/Homo B domain-containing protein. (799 aa)
ENSGALP00000072815VHS domain-containing protein. (90 aa)
VPS13BUncharacterized protein. (511 aa)
ATP8B4Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1191 aa)
SCAMP5Secretory carrier-associated membrane protein. (235 aa)
ENSGALP00000071604Uncharacterized protein. (406 aa)
ARFRP1ADP ribosylation factor related protein 1. (256 aa)
GSAPGamma-secretase activating protein. (908 aa)
TSSC1WD_REPEATS_REGION domain-containing protein. (395 aa)
ATP8B3Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1352 aa)
SCAMP3Uncharacterized protein. (459 aa)
ATXN2Ataxin 2. (1066 aa)
CALN1Calneuron 1. (256 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (771 aa)
HMP19Uncharacterized protein. (193 aa)
RBFOX1RNA binding protein fox-1 homolog 1; RNA-binding protein that regulates alternative splicing events. (418 aa)
ENSGALP00000068902Chorein_N domain-containing protein. (141 aa)
ATP11APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1174 aa)
CLASP2Uncharacterized protein. (1506 aa)
CCDC91Coiled-coil domain containing 91. (444 aa)
SLC66A2Solute carrier family 66 member 2. (271 aa)
RAB29RAB29, member RAS oncogene family. (205 aa)
RNF215Ring finger protein 215. (317 aa)
ARL5AADP ribosylation factor like GTPase 5A. (103 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4. (791 aa)
SLC10A7Sodium/bile acid cotransporter 7; Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization. Also involved in the regulation of cellular calcium homeostasis. Does not show transport activity towards bile acids or steroid sulfates. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (355 aa)
ENSGALP00000066467Uncharacterized protein. (248 aa)
DOP1BDOP1 leucine zipper like protein B. (2282 aa)
ATP11CPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1265 aa)
POSTNUncharacterized protein. (857 aa)
TGOLN2Uncharacterized protein. (445 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (919 aa)
RAB30RAB30, member RAS oncogene family. (203 aa)
SCAMP4Secretory carrier-associated membrane protein. (229 aa)
ATP8B1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1249 aa)
TMEM165GDT1 family protein. (322 aa)
FUT9CFUT9. (359 aa)
SCAMP1Secretory carrier-associated membrane protein. (481 aa)
TEPSINTEPSIN adaptor related protein complex 4 accessory protein. (568 aa)
TMEM79Transmembrane protein 79. (435 aa)
SYT11Synaptotagmin 11. (432 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (328 aa)
ARL1Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (231 aa)
TMEM230Transmembrane protein 230; Involved in trafficking and recycling of synaptic vesicles. Belongs to the TMEM134/TMEM230 family. (120 aa)
CABP7Calcium binding protein 7. (215 aa)
ENSGALP00000058230Uncharacterized protein. (317 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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