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| | HIBADH | 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (335 aa) |
| | DALRD3 | DALR anticodon binding domain containing 3. (640 aa) |
| | SLC1A3 | Amino acid transporter. (543 aa) |
| | NOS3 | Nitric oxide synthase; Produces nitric oxide (NO). (1402 aa) |
| | ACOT4-2 | Uncharacterized protein. (459 aa) |
| | ENSGALP00000073444 | Uncharacterized protein. (67 aa) |
| | CARS | Cysteine--tRNA ligase, cytoplasmic. (830 aa) |
| | ENSGALP00000072814 | AIRS_C domain-containing protein. (316 aa) |
| | CBSL | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (577 aa) |
| | SIRT4 | Sirtuin 4. (332 aa) |
| | HAL | Histidine ammonia-lyase; Belongs to the PAL/histidase family. (660 aa) |
| | SLC25A44 | Solute carrier family 25 member 44; Belongs to the mitochondrial carrier (TC 2.A.29) family. (313 aa) |
| | SEPHS2L | Uncharacterized protein. (392 aa) |
| | MECP2 | Methyl-CpG binding protein 2. (208 aa) |
| | AGXT2 | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (471 aa) |
| | PM20D1 | N-fatty-acyl-amino acid synthase/hydrolase PM20D1; Bidirectional N-fatty-acyl amino acid synthase/hydrolase that regulates the production of N-fatty-acyl amino acids. These metabolites are endogenous chemical uncouplers of mitochondrial respiration. In an UCP1-independent manner, maybe through interaction with mitochondrial transporters, they promote proton leakage into the mitochondrial matrix. Thereby, this secreted protein may indirectly regulate the bodily dissipation of chemical energy as heat through thermogenic respiration; Belongs to the peptidase M20A family. (567 aa) |
| | ILVBL | IlvB acetolactate synthase like; Belongs to the TPP enzyme family. (809 aa) |
| | LRRC47 | Leucine rich repeat containing 47. (566 aa) |
| | ENSGALP00000070065 | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (154 aa) |
| | SDSL | Uncharacterized protein. (514 aa) |
| | AADACL3B | Uncharacterized protein. (410 aa) |
| | CARS2 | Cysteinyl-tRNA synthetase 2, mitochondrial. (503 aa) |
| | ACCS | Aminotran_1_2 domain-containing protein. (876 aa) |
| | LOC107049913 | Uncharacterized protein. (290 aa) |
| | ENSGALP00000068833 | SHMT domain-containing protein. (497 aa) |
| | ENSGALP00000068655 | Glutamine amidotransferase type-1 domain-containing protein. (100 aa) |
| | ACMSD | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (396 aa) |
| | ASRGL1 | Asparaginase and isoaspartyl peptidase 1. (316 aa) |
| | ABAT | 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa) |
| | GCDH | Glutaryl-CoA dehydrogenase. (476 aa) |
| | ASNSD1 | Asparagine synthetase domain-containing protein 1. (636 aa) |
| | GLUL | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. When expressed in liver, it may be involved in detoxifying intramitochondrially generated ammonia. Also acts as glutamate decarboxylase by catalyzing the production of 4- aminobutanoate (gamma-aminobutyric acid, GABA) in a pyridoxal phosphate-independent manner. (413 aa) |
| | NOX4 | FAD-binding FR-type domain-containing protein. (639 aa) |
| | IL4I1 | Amine oxidase. (523 aa) |
| | BCAT1 | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (397 aa) |
| | RIMKLB | Ribosomal modification protein rimK like family member B. (386 aa) |
| | DGLUCY | D-glutamate cyclase. (617 aa) |
| | DPYD | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1025 aa) |
| | EPRS | Uncharacterized protein. (1689 aa) |
| | GSL | Glutamine synthetase. (434 aa) |
| | QARS | Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (879 aa) |
| | GARS | Uncharacterized protein. (859 aa) |
| | TPH1 | Tryptophan 5-hydroxylase 1; Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. (475 aa) |
| | ACY1 | M20_dimer domain-containing protein. (413 aa) |
| | MPST | Uncharacterized protein. (297 aa) |
| | ASPG | Asparaginase. (602 aa) |
| | IARS2 | Isoleucine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (1053 aa) |
| | CTPS1 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (668 aa) |
| | PLOD2 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (756 aa) |
| | GOT2 | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. May facilitate cellular uptake of long-chain free fatty acids (By similarity); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (427 aa) |
| | AADACL4B | Uncharacterized protein. (404 aa) |
| | SARS | AA_TRNA_LIGASE_II domain-containing protein. (753 aa) |
| | THNSL2 | Threonine synthase like 2. (494 aa) |
| | ASL2 | Argininosuccinate lyase; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. (572 aa) |
| | AADACL3A | Abhydrolase_3 domain-containing protein. (369 aa) |
| | DAO | D-amino acid oxidase. (348 aa) |
| | NOS2 | Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. NO may serve as both a paracrine and autocrine signal for modulating osteoclast bone resorption. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2 (By similarity); Belongs to the NOS family. (1136 aa) |
| | NOS1 | Nitric oxide synthase; Produces nitric oxide (NO). (1435 aa) |
| | ALDH4A1 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (551 aa) |
| | DBT | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (493 aa) |
| | QDPR | Uncharacterized protein. (238 aa) |
| | TARS2 | AA_TRNA_LIGASE_II domain-containing protein. (695 aa) |
| | SARDH | Sarcosine dehydrogenase. (463 aa) |
| | KYAT3 | Kynurenine aminotransferase 3. (482 aa) |
| | ACOT4 | BAAT_C domain-containing protein. (222 aa) |
| | DLST | Lipoyl-binding domain-containing protein. (474 aa) |
| | FARSA | Phenylalanine--tRNA ligase alpha subunit. (569 aa) |
| | AASS | Aminoadipate-semialdehyde synthase. (928 aa) |
| | GAD2 | Glutamate decarboxylase 2. (807 aa) |
| | MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (693 aa) |
| | ADHFE1 | Fe-ADH domain-containing protein. (465 aa) |
| | GLS2 | ANK_REP_REGION domain-containing protein. (667 aa) |
| | ENOPH1 | Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (437 aa) |
| | GPT2 | Glutamic--pyruvic transaminase 2. (544 aa) |
| | MRI1 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (347 aa) |
| | APIP | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis. (242 aa) |
| | ALDH18A1 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (802 aa) |
| | GAD1 | Glutamate decarboxylase 67. (590 aa) |
| | OAT | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa) |
| | AARS2 | AA_TRNA_LIGASE_II_ALA domain-containing protein; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. (958 aa) |
| | RARS | Arginine--tRNA ligase, cytoplasmic; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. (661 aa) |
| | ENSGALP00000053038 | Uncharacterized protein. (252 aa) |
| | FARS2 | Phenylalanyl-tRNA synthetase 2, mitochondrial. (449 aa) |
| | AZIN1 | Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (450 aa) |
| | ENSGALP00000052573 | tRNA-synt_1 domain-containing protein. (277 aa) |
| | HSD17B10 | Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (418 aa) |
| | GFPT2 | Glutamine-fructose-6-phosphate transaminase 2. (682 aa) |
| | HIBCH | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family. (385 aa) |
| | GFPT1 | Uncharacterized protein. (699 aa) |
| | GGT5 | Gamma-glutamyltransferase 5. (556 aa) |
| | ALDH5A1 | Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (548 aa) |
| | NARS2 | Asparaginyl-tRNA synthetase 2, mitochondrial. (478 aa) |
| | TH | Tyrosine hydroxylase. (491 aa) |
| | HARS | Uncharacterized protein. (501 aa) |
| | NARS | AA_TRNA_LIGASE_II domain-containing protein. (559 aa) |
| | BAAT | Bile acid-CoA:amino acid N-acyltransferase. (409 aa) |
| | AGMAT | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. (340 aa) |
| | PRODH2 | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (161 aa) |
| | MARS | Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (900 aa) |
| | GNMT | Methyltransf_25 domain-containing protein. (172 aa) |
| | BCKDHB | Transket_pyr domain-containing protein. (390 aa) |
| | GCSH | Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Belongs to the GcvH family. (164 aa) |
| | NIT2 | Nitrilase family member 2. (251 aa) |
| | ACADSB | Uncharacterized protein. (433 aa) |
| | IVD | Uncharacterized protein. (422 aa) |
| | FPGS | Folylpolyglutamate synthase. (660 aa) |
| | SHMT1 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (476 aa) |
| | HARS2 | AA_TRNA_LIGASE_II domain-containing protein. (514 aa) |
| | IARS1 | Isoleucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1281 aa) |
| | TDO2 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (478 aa) |
| | PYCR1 | Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (372 aa) |
| | PYCR3 | Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (271 aa) |
| | BCKDHA | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (448 aa) |
| | ACCSL | Aminotran_1_2 domain-containing protein. (377 aa) |
| | LARS2 | Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (911 aa) |
| | SARS2 | AA_TRNA_LIGASE_II domain-containing protein. (496 aa) |
| | PSPH | Uncharacterized protein. (226 aa) |
| | SCLY | Aminotran_5 domain-containing protein. (423 aa) |
| | GLUD2 | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). (553 aa) |
| | ADI1 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family. (180 aa) |
| | PIPOX | Pipecolic acid and sarcosine oxidase. (504 aa) |
| | LOC101747660 | Beta_elim_lyase domain-containing protein. (429 aa) |
| | AASDHPPT | ACPS domain-containing protein. (296 aa) |
| | DHFR | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA. (190 aa) |
| | IDO2 | Uncharacterized protein. (383 aa) |
| | ICMT | Protein-S-isoprenylcysteine O-methyltransferase. (297 aa) |
| | ASL1 | Delta-1 crystallin; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. (501 aa) |
| | ASS1 | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues; Belongs to the argininosuccinate synthase family. (416 aa) |
| | HDC | Uncharacterized protein. (664 aa) |
| | TPH2 | Neuronal tryptophan hydroxylase. (489 aa) |
| | HPDL | 4-hydroxyphenylpyruvate dioxygenase like. (387 aa) |
| | GLDC | Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH); Belongs to the GcvP family. (1004 aa) |
| | ATF4 | ATF4. (354 aa) |
| | TMED8 | GOLD domain-containing protein. (320 aa) |
| | DCT | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. (521 aa) |
| | HMGCL | Hydroxymethylglutaryl-CoA lyase, mitochondrial; Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. (348 aa) |
| | AGXT | Alanine--glyoxylate and serine--pyruvate aminotransferase. (473 aa) |
| | ACAT1 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (421 aa) |
| | MMUT | Methylmalonyl-CoA mutase. (748 aa) |
| | TDH | Epimerase domain-containing protein. (373 aa) |
| | CTPS2 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). (586 aa) |
| | ODC1 | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. (464 aa) |
| | GCLC | Glutamate-cysteine ligase catalytic subunit. (636 aa) |
| | HMGCLL1 | 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (338 aa) |
| | OTC | Ornithine carbamoyltransferase, mitochondrial. (354 aa) |
| | LOC418544 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (532 aa) |
| | RARS2 | DALR_1 domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (579 aa) |
| | QRSL1 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the amidase family. GatA subfamily. (524 aa) |
| | PSAT1 | Phosphoserine aminotransferase. (370 aa) |
| | ALDH1A1 | Retinal dehydrogenase 1; Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (By similarity). (509 aa) |
| | DDO | D-aspartate oxidase. (342 aa) |
| | HGD | Homogentisate 1,2-dioxygenase. (439 aa) |
| | WARS2 | Tryptophanyl tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (342 aa) |
| | ALDH8A1 | Aldehyde dehydrogenase 8 family member A1; Belongs to the aldehyde dehydrogenase family. (487 aa) |
| | AASDH | Aminoadipate-semialdehyde dehydrogenase. (1128 aa) |
| | PPAT | Amidophosphoribosyltransferase. (510 aa) |
| | DDC | Dopa decarboxylase. (485 aa) |
| | YARS2 | Tyrosine--tRNA ligase. (484 aa) |
| | PAH | Phenylalanine hydroxylase. (446 aa) |
| | THL | BH4_AAA_HYDROXYL_2 domain-containing protein. (443 aa) |
| | TST | Thiosulfate sulfurtransferase; Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA (By similarity). Formation of iron- sulfur complexes and cyanide detoxification. (294 aa) |
| | KYNU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (530 aa) |
| | IYD | Iodotyrosine deiodinase. (277 aa) |
| | DARS | AA_TRNA_LIGASE_II domain-containing protein. (503 aa) |
| | GCAT | Glycine C-acetyltransferase. (419 aa) |
| | AMDHD1 | Amidohydrolase domain containing 1. (435 aa) |
| | CTH | Cystathionine gamma-lyase. (399 aa) |
| | MCCC2L | Uncharacterized protein. (606 aa) |
| | WARS1 | Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (473 aa) |
| | MTR | Uncharacterized protein. (1362 aa) |
| | PARS2 | AA_TRNA_LIGASE_II domain-containing protein. (602 aa) |
| | GSTZ1 | Uncharacterized protein; Belongs to the GST superfamily. (266 aa) |
| | GMPS | Uncharacterized protein. (759 aa) |
| | ALDH6A1 | Aldehyde dehydrogenase 6 family member A1. (506 aa) |
| | GATB | Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily. (544 aa) |
| | HAAO | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (286 aa) |
| | ASNS | Asparagine synthetase [glutamine-hydrolyzing]. (561 aa) |
| | AADAT | Aminoadipate aminotransferase. (428 aa) |
| | ARG2 | Arginase. (356 aa) |
| | HAO1 | FMN hydroxy acid dehydrogenase domain-containing protein. (369 aa) |
| | DDAH1 | Uncharacterized protein. (322 aa) |
| | MTAP | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (280 aa) |
| | PRODH | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (602 aa) |
| | THNSL1 | Threonine synthase like 1. (734 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate; Belongs to the phosphoenolpyruvate carboxykinase [...] (622 aa) |
| | KMO | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (486 aa) |
| | LARS1 | Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1177 aa) |
| | GOT1 | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (412 aa) |
| | GATC | Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatC family. (140 aa) |
| | TTC36 | TPR_REGION domain-containing protein. (188 aa) |
| | UPB1 | Beta-ureidopropionase 1. (383 aa) |
| | FAH | Fumarylacetoacetase. (419 aa) |
| | THAP4 | THAP domain containing 4. (650 aa) |
| | FTCD | Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity); In the N-terminal section; belongs to the formiminotransferase family. (541 aa) |
| | EARS2 | Probable glutamate--tRNA ligase, mitochondrial; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (502 aa) |
| | FARSB | B5 domain-containing protein. (589 aa) |
| | MTHFR | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (651 aa) |
| | CCBL1 | Aminotran_1_2 domain-containing protein. (426 aa) |
| | BHMT2 | Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. (405 aa) |
| | HPD | 4-hydroxyphenylpyruvate dioxygenase. (393 aa) |
| | BLMH | Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity; Belongs to the peptidase C1 family. (455 aa) |
| | AADACL3C | Uncharacterized protein. (411 aa) |
| | MARS2 | Methionyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (572 aa) |
| | TARSL2 | AA_TRNA_LIGASE_II domain-containing protein. (784 aa) |
| | DARS2 | Aspartyl-tRNA synthetase 2, mitochondrial. (646 aa) |
| | AZIN2 | Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (520 aa) |
| | YARS | Tyrosine--tRNA ligase, cytoplasmic; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). (536 aa) |
| | TARS | AA_TRNA_LIGASE_II domain-containing protein. (791 aa) |
| | SRR | Serine racemase. (235 aa) |
| | CPS1 | Uncharacterized protein. (1446 aa) |
| | ETFA | ETF domain-containing protein. (346 aa) |
| | AARSD1 | AA_TRNA_LIGASE_II_ALA domain-containing protein. (409 aa) |
| | SRRL | ACT domain-containing protein. (536 aa) |
| | MCCC2 | Methylcrotonoyl-CoA carboxylase 2. (560 aa) |
| | CDO1 | Cysteine dioxygenase. (204 aa) |
| | AARS | AA_TRNA_LIGASE_II_ALA domain-containing protein; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. (968 aa) |
| | ACAD8 | Uncharacterized protein. (472 aa) |
| | KARS | Lysine--tRNA ligase. (590 aa) |
| | TAT | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (455 aa) |
| | AFMID | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (293 aa) |
