STRINGSTRING
TSG101 TSG101 ERC2 ERC2 SYT9 SYT9 NTL NTL DOC2B DOC2B RPH3A RPH3A ARFGEF2 ARFGEF2 SYT12 SYT12 RIMS4 RIMS4 P2RX7 P2RX7 RAB8B RAB8B UNC13D UNC13D UNC13B UNC13B SYNGR3 SYNGR3 PSEN1 PSEN1 SNAP47 SNAP47 SYCN SYCN TRARG1 TRARG1 CDK5 CDK5 ENSGALP00000068651 ENSGALP00000068651 SYTL1 SYTL1 STXBP5 STXBP5 LOC112530958 LOC112530958 ENSGALP00000074167 ENSGALP00000074167 RAB11B RAB11B SNX19 SNX19 EXOC3L1 EXOC3L1 SDF4 SDF4 SYT6 SYT6 STX17 STX17 TXLNA TXLNA RIMS3 RIMS3 STX19 STX19 SYTL3 SYTL3 RAB15 RAB15 LGI3 LGI3 WASH1 WASH1 ENSGALP00000066829 ENSGALP00000066829 RAB27A RAB27A ENSGALP00000066581 ENSGALP00000066581 STXBP6 STXBP6 STX3 STX3 DMTN DMTN EXOC6B EXOC6B PLEK PLEK UNC13C-2 UNC13C-2 RIMS2 RIMS2 CPLANE2 CPLANE2 STXBP3 STXBP3 ENSGALP00000065007 ENSGALP00000065007 GRP GRP CADPS2 CADPS2 RAB3IL1 RAB3IL1 RAB11FIP1 RAB11FIP1 RAB44 RAB44 EXOC4 EXOC4 SYT10 SYT10 CLNK CLNK C16orf89 C16orf89 SRCIN1 SRCIN1 RAB11FIP5 RAB11FIP5 ENSGALP00000073215 ENSGALP00000073215 ERC1 ERC1 SYTL4 SYTL4 RPH3AL RPH3AL VPS11 VPS11 SYT14 SYT14 RAB10L RAB10L TPH1 TPH1 EXOC3L EXOC3L SCAMP1 SCAMP1 TMEM79 TMEM79 RASGRP1 RASGRP1 SYT11 SYT11 SYT15 SYT15 LOC422353 LOC422353 SYT7 SYT7 SYT17 SYT17 SEC11C SEC11C EXOC7 EXOC7 NT5DC3 NT5DC3 RAB2B RAB2B RAPGEF4 RAPGEF4 MYH9 MYH9 NT5DC2 NT5DC2 PTGDS PTGDS STXBP1 STXBP1 YKT6 YKT6 CPLX4 CPLX4 KIT KIT RABEPK RABEPK SYT4 SYT4 CFTR CFTR SEC11A SEC11A STXBP5L STXBP5L RAB3A RAB3A EXOC6 EXOC6 PTGDR PTGDR TMEM167B TMEM167B SNAP29 SNAP29 RAB25 RAB25 SYTL2 SYTL2 ITSN1 ITSN1 SYT2 SYT2 LYN LYN LAT2 LAT2 EXOC1 EXOC1 EXOC8 EXOC8 RIMS1-2 RIMS1-2 RAB26 RAB26 SCFD2 SCFD2 CADPS CADPS UNC13C UNC13C RAB12 RAB12 STX2 STX2 STX1A STX1A UNC13A UNC13A TC2N TC2N RAB3IP RAB3IP COPS5 COPS5 SYNJ1 SYNJ1 SYNGR2 SYNGR2 CPLX2 CPLX2 EXOC1L EXOC1L SYT1 SYT1 RAB8A RAB8A CPLX3 CPLX3 SNAPIN SNAPIN LIN7C LIN7C LOC422308 LOC422308 SCRN1 SCRN1 RAB10 RAB10 VAMP3 VAMP3 KCNB1 KCNB1 RAB31 RAB31 VAMP7 VAMP7 ADORA2B ADORA2B BLK BLK LRRC1 LRRC1 SYTL5 SYTL5 RIMS1 RIMS1 CPLX1 CPLX1 SYK SYK CRHBP CRHBP RAB3C RAB3C LLGL1 LLGL1 EXOC3 EXOC3 EXOC2 EXOC2 WASHC3 WASHC3 EXOC5 EXOC5 PRSS12 PRSS12 SYT16 SYT16 STX11 STX11 TNFAIP2 TNFAIP2 EXOC3L4 EXOC3L4 LIN7A LIN7A RAB3B RAB3B RAB11FIP2 RAB11FIP2 SNAP23 SNAP23 STEAP2 STEAP2 SNAP25 SNAP25 VPS18 VPS18 LLGL2 LLGL2 SYT13 SYT13 RAB11A RAB11A SYT8 SYT8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TSG101Uncharacterized protein. (390 aa)
ERC2ELKS/RAB6-interacting/CAST family member 2. (979 aa)
SYT9Synaptotagmin 9. (528 aa)
NTLUncharacterized protein; Belongs to the peptidase S1 family. (808 aa)
DOC2BDouble C2-like domain-containing protein. (398 aa)
RPH3AC2 domain-containing protein. (115 aa)
ARFGEF2ADP ribosylation factor guanine nucleotide exchange factor 2. (1792 aa)
SYT12C2 domain-containing protein. (417 aa)
RIMS4Regulating synaptic membrane exocytosis 4. (446 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (574 aa)
RAB8BRAB8B, member RAS oncogene family. (201 aa)
UNC13DUnc-13 homolog D. (708 aa)
UNC13BUnc-13 homolog B. (1574 aa)
SYNGR3MARVEL domain-containing protein. (295 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa)
SNAP47Synaptosome associated protein 47. (461 aa)
SYCNSyncollin. (131 aa)
TRARG1Trafficking regulator of GLUT4 (SLC2A4) 1. (176 aa)
CDK5Protein kinase domain-containing protein. (522 aa)
ENSGALP00000068651Uncharacterized protein. (150 aa)
SYTL1Uncharacterized protein. (806 aa)
STXBP5Syntaxin binding protein 5. (1152 aa)
LOC112530958Uncharacterized protein. (149 aa)
ENSGALP00000074167Uncharacterized protein. (178 aa)
RAB11BUncharacterized protein. (218 aa)
SNX19Sorting nexin 19. (981 aa)
EXOC3L1Exocyst complex component 3 like 1. (753 aa)
SDF445 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family. (356 aa)
SYT6Synaptotagmin 6. (414 aa)
STX17t-SNARE coiled-coil homology domain-containing protein. (302 aa)
TXLNATaxilin alpha. (546 aa)
RIMS3Regulating synaptic membrane exocytosis 3. (377 aa)
STX19Syntaxin 19; Belongs to the syntaxin family. (291 aa)
SYTL3Synaptotagmin like 3. (620 aa)
RAB15RAB15, member RAS oncogene family. (211 aa)
LGI3Leucine rich repeat LGI family member 3. (511 aa)
WASH1WASH complex subunit 1; Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and is required for its membrane targeting; Belongs to the WASH1 family. (485 aa)
ENSGALP00000066829Uncharacterized protein. (105 aa)
RAB27ARab27a. (221 aa)
ENSGALP00000066581Uncharacterized protein. (532 aa)
STXBP6V-SNARE coiled-coil homology domain-containing protein. (210 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (462 aa)
DMTNAbLIM_anchor domain-containing protein. (687 aa)
EXOC6BExocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (810 aa)
PLEKUncharacterized protein. (353 aa)
UNC13C-2Uncharacterized protein. (411 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1495 aa)
CPLANE2Ciliogenesis and planar polarity effector 2. (225 aa)
STXBP3Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (601 aa)
ENSGALP00000065007Uncharacterized protein. (162 aa)
GRPGastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (Probable). Stimulates pancreatic protein and fluid secretion, and increases acid secretion from the avian proventriculus. Belongs to the bombesin/neuromedin-B/ranatensin family. (164 aa)
CADPS2Calcium dependent secretion activator 2. (1298 aa)
RAB3IL1Sec2p domain-containing protein. (376 aa)
RAB11FIP1RAB11 family interacting protein 1. (1259 aa)
RAB44Uncharacterized protein. (1276 aa)
EXOC4Sec8_exocyst domain-containing protein. (1018 aa)
SYT10Synaptotagmin 10. (525 aa)
CLNKSH2 domain-containing protein. (175 aa)
C16orf89Chromosome 16 open reading frame 89. (330 aa)
SRCIN1SRC kinase signaling inhibitor 1. (1571 aa)
RAB11FIP5Uncharacterized protein. (1661 aa)
ENSGALP00000073215C2 domain-containing protein. (91 aa)
ERC1ELKS/RAB6-interacting/CAST family member 1. (1121 aa)
SYTL4Synaptotagmin like 4. (690 aa)
RPH3ALUncharacterized protein. (295 aa)
VPS11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (957 aa)
SYT14Synaptotagmin 14. (828 aa)
RAB10LUncharacterized protein. (208 aa)
TPH1Tryptophan 5-hydroxylase 1; Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. (475 aa)
EXOC3LUncharacterized protein. (651 aa)
SCAMP1Secretory carrier-associated membrane protein. (481 aa)
TMEM79Transmembrane protein 79. (435 aa)
RASGRP1RAS guanyl releasing protein 1. (480 aa)
SYT11Synaptotagmin 11. (432 aa)
SYT15Uncharacterized protein. (416 aa)
LOC422353Uncharacterized protein. (968 aa)
SYT7Synaptotagmin 7. (403 aa)
SYT17Synaptotagmin 17. (474 aa)
SEC11CSignal peptidase complex catalytic subunit SEC11. (177 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (787 aa)
NT5DC35'-nucleotidase domain containing 3. (546 aa)
RAB2BUncharacterized protein. (428 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1026 aa)
MYH9Myosin-9; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. (1960 aa)
NT5DC25'-nucleotidase domain containing 2. (572 aa)
PTGDSLipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (185 aa)
STXBP1Syntaxin-binding protein 1; May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxins, components of the synaptic vesicle fusion machinery. May play a role in determining the specificity of intracellular fusion reactions (By similarity). Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
YKT6Uncharacterized protein; Belongs to the synaptobrevin family. (198 aa)
CPLX4Complexin 4. (130 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via [...] (960 aa)
RABEPKRab9 effector protein with kelch motifs; Rab9 effector required for endosome to trans-Golgi network (TGN) transport. (371 aa)
SYT4Synaptotagmin 4. (425 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa)
SEC11ASignal peptidase complex catalytic subunit SEC11. (179 aa)
STXBP5LSyntaxin binding protein 5 like. (1184 aa)
RAB3ARAB3A, member RAS oncogene family. (220 aa)
EXOC6Exocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (808 aa)
PTGDRProstaglandin D2 receptor. (362 aa)
TMEM167BUncharacterized protein. (170 aa)
SNAP29t-SNARE coiled-coil homology domain-containing protein. (248 aa)
RAB25RAB25, member RAS oncogene family. (209 aa)
SYTL2Synaptotagmin like 2. (863 aa)
ITSN1Intersectin 1. (1696 aa)
SYT2Synaptotagmin 2. (490 aa)
LYNTyrosine-protein kinase. (491 aa)
LAT2Linker for activation of T-cells family member 2; Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells. May also be involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization through the recruitment of GRB2. (198 aa)
EXOC1Exocyst complex component 1. (920 aa)
EXOC8Exocyst complex component 8; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (744 aa)
RIMS1-2PDZ domain-containing protein. (506 aa)
RAB26RAB26, member RAS oncogene family. (190 aa)
SCFD2Sec1 family domain containing 2; Belongs to the STXBP/unc-18/SEC1 family. (652 aa)
CADPSUncharacterized protein. (1322 aa)
UNC13CUncharacterized protein. (1097 aa)
RAB12RAB12, member RAS oncogene family. (290 aa)
STX2t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (288 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (407 aa)
UNC13AUncharacterized protein. (1738 aa)
TC2NTandem C2 domains, nuclear. (373 aa)
RAB3IPUncharacterized protein. (467 aa)
COPS5MPN domain-containing protein. (337 aa)
SYNJ1Synaptojanin 1. (1536 aa)
SYNGR2Synaptogyrin. (225 aa)
CPLX2Uncharacterized protein. (134 aa)
EXOC1LExocyst complex component 1 like. (170 aa)
SYT1Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. May play a role in dendrite formation by melanocytes; Belongs to the synaptotagmin family. (430 aa)
RAB8ARas-related protein Rab-8A; May be involved in vesicular trafficking and neurotransmitter release; Belongs to the small GTPase superfamily. Rab family. (207 aa)
CPLX3Uncharacterized protein. (157 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (126 aa)
LIN7CProtein lin-7 homolog C; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains (By similarity); Belongs to the lin-7 family. (197 aa)
LOC422308Sec3-PIP2_bind domain-containing protein. (860 aa)
SCRN1Secernin 1. (414 aa)
RAB10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Plays also a specific role in asymmetric protein transport to the plasma mem [...] (200 aa)
VAMP3V-SNARE coiled-coil homology domain-containing protein. (104 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (863 aa)
RAB31RAB31, member RAS oncogene family. (195 aa)
VAMP7Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for focal exocytosis of late endocytic vesicles during phagosome formation (By similarity); Belongs to the synaptobrevin family. (220 aa)
ADORA2BAdenosine receptor A2b; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (340 aa)
BLKTyrosine-protein kinase. (526 aa)
LRRC1Leucine rich repeat containing 1. (797 aa)
SYTL5Synaptotagmin like 5. (764 aa)
RIMS1C2 domain-containing protein. (261 aa)
CPLX1Complexin 1. (134 aa)
SYKTyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can a [...] (636 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (345 aa)
RAB3CRAB3C, member RAS oncogene family. (227 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1234 aa)
EXOC3Uncharacterized protein. (745 aa)
EXOC2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (925 aa)
WASHC3WASH complex subunit 3. (201 aa)
EXOC5Uncharacterized protein. (867 aa)
PRSS12Serine protease 12; Belongs to the peptidase S1 family. (823 aa)
SYT16Synaptotagmin 16. (582 aa)
STX11Syntaxin 11. (288 aa)
TNFAIP2TNF alpha induced protein 2. (688 aa)
EXOC3L4Exocyst complex component 3 like 4. (706 aa)
LIN7ALin-7 homolog A, crumbs cell polarity complex component. (306 aa)
RAB3BRAB3B, member RAS oncogene family. (226 aa)
RAB11FIP2RAB11 family interacting protein 2. (510 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (209 aa)
STEAP2STEAP2 metalloreductase. (489 aa)
SNAP25Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion (By similarity). Belongs to the SNAP-25 family. (206 aa)
VPS18Pep3_Vps18 domain-containing protein. (974 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1026 aa)
SYT13C2 domain-containing protein. (430 aa)
RAB11ARas-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling (By similarity). (216 aa)
SYT8Synaptotagmin 8. (396 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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