STRINGSTRING
RAB1B RAB1B STX17 STX17 STX5 STX5 PDCD10 PDCD10 VPS13B VPS13B ARHGAP21 ARHGAP21 ATP8B4 ATP8B4 COG6 COG6 DYM DYM ENSGALP00000071604 ENSGALP00000071604 RAB2A RAB2A DNAJC28 DNAJC28 ATP8B3 ATP8B3 TMED2 TMED2 ENSGALP00000068902 ENSGALP00000068902 LOC423110 LOC423110 ENSGALP00000068544 ENSGALP00000068544 CLASP2 CLASP2 ENSGALP00000068288 ENSGALP00000068288 CIT CIT RAB15 RAB15 ENSGALP00000066493 ENSGALP00000066493 ENSGALP00000066467 ENSGALP00000066467 LOC107051165 LOC107051165 RAB30 RAB30 CSNK1A1 CSNK1A1 ATP8B1 ATP8B1 LMAN2L LMAN2L YWHAZ YWHAZ ARL1 ARL1 VTI1A VTI1A ENSGALP00000058230 ENSGALP00000058230 BAG5 BAG5 TJAP1 TJAP1 LMAN2 LMAN2 TTC38 TTC38 DYNC2H1 DYNC2H1 TANGO2 TANGO2 VRK1 VRK1 ENSGALP00000055781 ENSGALP00000055781 USO1 USO1 STX16 STX16 LOC107049174 LOC107049174 FHDC1 FHDC1 PI4K2B PI4K2B ZW10 ZW10 GOLPH3L GOLPH3L COG1 COG1 VCPIP1 VCPIP1 ENSGALP00000052647 ENSGALP00000052647 VAMP4 VAMP4 LRRK2 LRRK2 SEC22B SEC22B SMIM7 SMIM7 TRAPPC8 TRAPPC8 ATP8B2 ATP8B2 UBXN2A UBXN2A USP6NL USP6NL BHLHA15 BHLHA15 CORO7 CORO7 CLASP1 CLASP1 SEC16B SEC16B ARFGEF1 ARFGEF1 COG5 COG5 TTC38L TTC38L UBXN2B UBXN2B COG8 COG8 BCAS3 BCAS3 LMAN1L LMAN1L GOLPH3 GOLPH3 TICAM1 TICAM1 RAB8A RAB8A SURF4 SURF4 TMED7 TMED7 BET1 BET1 VPS51 VPS51 LYSMD2 LYSMD2 COG3 COG3 GCC2 GCC2 TRAPPC12 TRAPPC12 TMED11 TMED11 HTT HTT HACE1 HACE1 BLZF1 BLZF1 LYSMD3 LYSMD3 YIPF7 YIPF7 OPTN OPTN COG2 COG2 GOLGA5 GOLGA5 TRIP11 TRIP11 YIPF4 YIPF4 GORASP2 GORASP2 VTI1B VTI1B TMED3 TMED3 FBXW8 FBXW8 YIPF5 YIPF5 LYSMD4 LYSMD4 FAM174B FAM174B TBC1D20 TBC1D20 NSFL1C NSFL1C COG7 COG7 PI4K2A PI4K2A GORASP1 GORASP1 TMED5 TMED5 GBF1 GBF1 VMP1 VMP1 GOLGA2 GOLGA2 STX10 STX10 PLEKHM2 PLEKHM2 COG4 COG4 SEC16A SEC16A RAB29 RAB29 TMED6 TMED6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAB1BUncharacterized protein. (228 aa)
STX17t-SNARE coiled-coil homology domain-containing protein. (302 aa)
STX5Syntaxin 5; Belongs to the syntaxin family. (344 aa)
PDCD10Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development. Belongs to the PDCD10 family. (212 aa)
VPS13BUncharacterized protein. (511 aa)
ARHGAP21Uncharacterized protein. (1998 aa)
ATP8B4Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1191 aa)
COG6Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. (643 aa)
DYMDymeclin; Necessary for correct organization of Golgi apparatus. (724 aa)
ENSGALP00000071604Uncharacterized protein. (406 aa)
RAB2ARas-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex; Belongs to the small GTPase superfamily. Rab family. (212 aa)
DNAJC28DnaJ heat shock protein family (Hsp40) member C28. (373 aa)
ATP8B3Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1352 aa)
TMED2GOLD domain-containing protein. (208 aa)
ENSGALP00000068902Chorein_N domain-containing protein. (141 aa)
LOC423110Rab-GAP TBC domain-containing protein. (564 aa)
ENSGALP00000068544Uncharacterized protein. (132 aa)
CLASP2Uncharacterized protein. (1506 aa)
ENSGALP00000068288Uncharacterized protein. (65 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2068 aa)
RAB15RAB15, member RAS oncogene family. (211 aa)
ENSGALP00000066493FH2 domain-containing protein. (168 aa)
ENSGALP00000066467Uncharacterized protein. (248 aa)
LOC107051165Uncharacterized protein. (230 aa)
RAB30RAB30, member RAS oncogene family. (203 aa)
CSNK1A1Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly. (370 aa)
ATP8B1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1249 aa)
LMAN2LLectin, mannose binding 2 like. (345 aa)
YWHAZ14-3-3 protein zeta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). (251 aa)
ARL1Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (231 aa)
VTI1At-SNARE coiled-coil homology domain-containing protein. (224 aa)
ENSGALP00000058230Uncharacterized protein. (317 aa)
BAG5BAG family molecular chaperone regulator 5; May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. (450 aa)
TJAP1Uncharacterized protein. (640 aa)
LMAN2Lectin, mannose binding 2. (337 aa)
TTC38Uncharacterized protein. (466 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4301 aa)
TANGO2Uncharacterized protein. (284 aa)
VRK1Protein kinase domain-containing protein. (568 aa)
ENSGALP00000055781Cullin_Nedd8 domain-containing protein. (146 aa)
USO1Uncharacterized protein. (963 aa)
STX16t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (326 aa)
LOC107049174Uncharacterized protein. (293 aa)
FHDC1FH2 domain-containing protein. (741 aa)
PI4K2BPhosphatidylinositol 4-kinase type 2-beta; Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5- bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity). (479 aa)
ZW10Uncharacterized protein. (781 aa)
GOLPH3LGolgi phosphoprotein 3 like. (279 aa)
COG1Uncharacterized protein. (957 aa)
VCPIP1OTU domain-containing protein. (1216 aa)
ENSGALP00000052647HECT domain-containing protein. (283 aa)
VAMP4Vesicle associated membrane protein 4. (141 aa)
LRRK2Uncharacterized protein. (2557 aa)
SEC22BVesicle-trafficking protein SEC22b; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. (215 aa)
SMIM7Uncharacterized protein. (113 aa)
TRAPPC8Trafficking protein particle complex 8. (1472 aa)
ATP8B2Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1282 aa)
UBXN2AUncharacterized protein. (290 aa)
USP6NLRab-GAP TBC domain-containing protein. (841 aa)
BHLHA15Basic helix-loop-helix family member a15. (166 aa)
CORO7Coronin; Belongs to the WD repeat coronin family. (1189 aa)
CLASP1Cytoplasmic linker associated protein 1. (1499 aa)
SEC16BProtein transport protein Sec16B; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes. (1084 aa)
ARFGEF1ADP ribosylation factor guanine nucleotide exchange factor 1. (1846 aa)
COG5Uncharacterized protein. (941 aa)
TTC38LUncharacterized protein. (279 aa)
UBXN2BUBX domain-containing protein 2B; Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. Regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. (402 aa)
COG8Conserved oligomeric Golgi complex subunit 8; Belongs to the COG8 family. (599 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (946 aa)
LMAN1LL-type lectin-like domain-containing protein. (598 aa)
GOLPH3Uncharacterized protein. (294 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (735 aa)
RAB8ARas-related protein Rab-8A; May be involved in vesicular trafficking and neurotransmitter release; Belongs to the small GTPase superfamily. Rab family. (207 aa)
SURF4Surfeit locus protein 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. (269 aa)
TMED7GOLD domain-containing protein; Belongs to the EMP24/GP25L family. (330 aa)
BET1t-SNARE coiled-coil homology domain-containing protein. (115 aa)
VPS51Vacuolar protein sorting-associated protein 51 homolog; Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling. (787 aa)
LYSMD2LysM domain-containing protein. (195 aa)
COG3Component of oligomeric golgi complex 3. (825 aa)
GCC2GRIP and coiled-coil domain containing 2. (1693 aa)
TRAPPC12Trafficking protein particle complex 12. (790 aa)
TMED11GOLD domain-containing protein. (217 aa)
HTTHuntingtin. (3095 aa)
HACE1E3 ubiquitin-protein ligase HACE1; E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. (942 aa)
BLZF1Basic leucine zipper nuclear factor 1. (397 aa)
LYSMD3LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. (375 aa)
YIPF7Uncharacterized protein. (258 aa)
OPTNOptineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. (557 aa)
COG2Component of oligomeric golgi complex 2. (739 aa)
GOLGA5Golgin A5. (735 aa)
TRIP11Thyroid hormone receptor interactor 11. (1980 aa)
YIPF4Protein YIPF4; Involved in the maintenance of the Golgi structure. Belongs to the YIP1 family. (249 aa)
GORASP2GRASP55_65 domain-containing protein. (441 aa)
VTI1BVesicle transport through interaction with t-SNAREs 1B. (232 aa)
TMED3GOLD domain-containing protein. (212 aa)
FBXW8F-box and WD repeat domain containing 8. (582 aa)
YIPF5Protein YIPF. (254 aa)
LYSMD4LysM domain containing 4. (305 aa)
FAM174BFamily with sequence similarity 174 member B. (152 aa)
TBC1D20TBC1 domain family member 20. (394 aa)
NSFL1CNSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. (379 aa)
COG7Uncharacterized protein. (769 aa)
PI4K2API3K/PI4K domain-containing protein. (466 aa)
GORASP1GRASP55_65 domain-containing protein. (426 aa)
TMED5GOLD domain-containing protein. (226 aa)
GBF1Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1863 aa)
VMP1Vacuole membrane protein 1. (406 aa)
GOLGA2Uncharacterized protein. (1253 aa)
STX10Syntaxin-6; Involved in intracellular vesicle trafficking; Belongs to the syntaxin family. (254 aa)
PLEKHM2Pleckstrin homology and RUN domain containing M2. (1040 aa)
COG4Cog4 domain-containing protein. (771 aa)
SEC16AProtein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (2201 aa)
RAB29RAB29, member RAS oncogene family. (205 aa)
TMED6GOLD domain-containing protein. (252 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (16%) [HD]