(121 nodes) Ras protein signal transduction network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EPS8L3	SH3 domain-containing protein. (572 aa)
	KIAA0355	KIAA0355. (1058 aa)
	RHOGL	Uncharacterized protein. (191 aa)
	KSR1	Protein kinase domain-containing protein. (112 aa)
	RAB35	Uncharacterized protein. (201 aa)
	BCL6	B-cell lymphoma 6 protein homolog; Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, repres [...] (708 aa)
	RASGRF1	Ras protein specific guanine nucleotide releasing factor 1. (1284 aa)
	ARHGDIA	Uncharacterized protein. (204 aa)
	RAB33B	Ras-related protein Rab-33B; Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking (By similarity). It is involved in autophagy, acting as a modulator of autophagosome formation (By similarity); Belongs to the small GTPase superfamily. Rab family. (228 aa)
	ARHGAP5	Rho GTPase activating protein 5. (1505 aa)
	RAB21	RAB21, member RAS oncogene family. (213 aa)
	RASGRP3	Uncharacterized protein. (691 aa)
	LOC429032	Rho-GAP domain-containing protein. (568 aa)
	PLEKHG7	Chromosome 12 open reading frame 74. (764 aa)
	CCNA2	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. (395 aa)
	SGSM3	Small G protein signaling modulator 3. (741 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1330 aa)
	WASF1	WASP family member 1. (562 aa)
	RASGRF2	Ras protein specific guanine nucleotide releasing factor 2. (1232 aa)
	RAB9A	Uncharacterized protein. (201 aa)
	CYFIP1	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
	RAP2A	RAP2A, member of RAS oncogene family. (183 aa)
	RAB39A	RAB39A, member RAS oncogene family. (216 aa)
	ARHGDIB	Uncharacterized protein. (200 aa)
	RIT1	Uncharacterized protein. (213 aa)
	JUN	Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. (310 aa)
	CDC42EP4	CDC42 effector protein 4. (302 aa)
	NTN1	Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors. (688 aa)
	RAP2C	Uncharacterized protein. (183 aa)
	CSDE1	Uncharacterized protein. (794 aa)
	SETDB1	SET domain bifurcated histone lysine methyltransferase 1. (1386 aa)
	RAB33A	RAB33A, member RAS oncogene family. (224 aa)
	NKIRAS2	NF-kappa-B inhibitor-interacting Ras-like protein 2; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. (191 aa)
	DOK3	Docking protein 3; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. Plays a role as negative regulator of the mobilization of calcium ions and of calcium signaling. (426 aa)
	RERG	RAS like estrogen regulated growth inhibitor. (199 aa)
	RHOU	Ras homolog family member U. (280 aa)
	RHOV	Ras homolog family member V. (231 aa)
	RHOG	Ras homolog family member G. (348 aa)
	NRAS	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
	SYNJ2BP-2	PDZ domain-containing protein. (146 aa)
	RIT2	Ras like without CAAX 2. (217 aa)
	USP28	Ubiquitin carboxyl-terminal hydrolase 28; Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome. Deubiquitinates ZNF304, hence may prevent ZNF304 degradation by the prote [...] (1086 aa)
	ENSGALP00000044404	Uncharacterized protein. (612 aa)
	ENSGALP00000044845	PTB domain-containing protein. (147 aa)
	RAP1A	Ras-related protein Rap-1b; Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
	GPSM2	G protein signaling modulator 2. (663 aa)
	RALGPS2	Ras-specific guanine nucleotide-releasing factor RalGPS1; Guanine nucleotide exchange factor. May be involved in cytoskeletal organization. (584 aa)
	TAX1BP3	Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. (124 aa)
	BRAP	Uncharacterized protein. (556 aa)
	MAPKAPK5	Protein kinase domain-containing protein. (465 aa)
	RAB9B	RAB9B, member RAS oncogene family. (261 aa)
	KRAS	Uncharacterized protein. (189 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. Mediates transcriptional repression by direct binding to HDAC2. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their [...] (1417 aa)
	RAPGEF6	Uncharacterized protein. (1585 aa)
	RACGAP1	Rac GTPase activating protein 1. (638 aa)
	RAP2B	RAP2B, member of RAS oncogene family. (118 aa)
	GNA13	G protein subunit alpha 13. (377 aa)
	PLCE1	Phosphoinositide phospholipase C. (2255 aa)
	FARP2	FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1049 aa)
	RAPGEF4	Rap guanine nucleotide exchange factor 4. (1026 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
	RAPGEFL1	Rap guanine nucleotide exchange factor like 1. (599 aa)
	C15orf62	Chromosome 15 open reading frame 62. (176 aa)
	USP8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (331 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1319 aa)
	PPP1R21	Protein phosphatase 1 regulatory subunit 21; Putative regulator of protein phosphatase 1 (PP1) activity. May play a role in the endosomal sorting process or in endosome maturation pathway. (814 aa)
	RAPGEF2	Rap guanine nucleotide exchange factor 2. (1652 aa)
	ITGA3	Uncharacterized protein; Belongs to the integrin alpha chain family. (1108 aa)
	TMEM19	Transmembrane protein 19. (336 aa)
	ADGRG1	Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (695 aa)
	PHACTR4	Phosphatase and actin regulator 4; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the RHO/ROCK pathway (By similarity). (199 aa)
	ARHGAP35	Rho GTPase activating protein 35. (1613 aa)
	CDC42EP1	CDC42 effector protein 1. (388 aa)
	RAPGEF5	Rap guanine nucleotide exchange factor 5. (683 aa)
	MYO9B	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2214 aa)
	KPNB1	Karyopherin subunit beta 1. (876 aa)
	RALA	RAS like proto-oncogene A. (206 aa)
	NGFR	Tumor necrosis factor receptor superfamily member 16; Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (By similarity). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (By similarity). Necessary for the circadian oscillatio [...] (416 aa)
	RAB12	RAB12, member RAS oncogene family. (290 aa)
	AGTR1	Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. (359 aa)
	KSR2	Kinase suppressor of ras 2. (970 aa)
	SHTN1	Shootin 1. (649 aa)
	RFXANK	ANK_REP_REGION domain-containing protein. (283 aa)
	RAB39B	RAB39B, member RAS oncogene family. (213 aa)
	DOK1	Docking protein 1. (570 aa)
	EPS8L2	Uncharacterized protein. (199 aa)
	RASGRP1	RAS guanyl releasing protein 1. (480 aa)
	TNFRSF14	Death domain-containing protein. (314 aa)
	EPS8	Epidermal growth factor receptor pathway substrate 8. (828 aa)
	RAB30	RAB30, member RAS oncogene family. (203 aa)
	ROCK2	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1483 aa)
	CDC42	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] (194 aa)
	CNKSR1	Connector enhancer of kinase suppressor of Ras 1. (811 aa)
	DBNL	ADF-H domain-containing protein. (124 aa)
	ENSGALP00000066581	Uncharacterized protein. (532 aa)
	ARHGDIG	Uncharacterized protein. (623 aa)
	DOK2	Docking protein 2. (641 aa)
	RASGEF1A	RasGEF domain family member 1A. (491 aa)
	NKIRAS1	NFKB inhibitor interacting Ras like 1. (230 aa)
	USP8-2	Rhodanese domain-containing protein. (602 aa)
	GNA12	G protein subunit alpha 12. (287 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3. (1050 aa)
	RIPOR1	RHO family interacting cell polarization regulator 1. (1279 aa)
	CTNNAL1	Catenin alpha like 1. (787 aa)
	LOC107056280	Uncharacterized protein. (466 aa)
	RASGEF1B	RasGEF domain family member 1B. (515 aa)
	RALGPS1	Ras-specific guanine nucleotide-releasing factor RalGPS1. (621 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1225 aa)
	ENSGALP00000069991	Uncharacterized protein. (109 aa)
	RALB	RAS like proto-oncogene B. (259 aa)
	RAP1B	Ras-related protein Rap-1b. (268 aa)
	MRAS	R-Ras3. (208 aa)
	RRAS	Uncharacterized protein. (234 aa)
	NISCH	Nischarin. (1415 aa)
	RB1	Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa)
	CDC42EP3	CDC42 effector protein 3. (253 aa)
	WASF2	WASP family member 2. (528 aa)
	RAB4A	RAB4A, member RAS oncogene family. (255 aa)
	RASSF1	Ras association domain family member 1. (456 aa)
	HRAS	GTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
	RHOH	Ras homolog family member H. (191 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRG1	ENSGALP00000069991	ENSGALP00000049008	ENSGALP00000069991	Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.583
ADGRG1	GNA12	ENSGALP00000049008	ENSGALP00000068420	Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family.	G protein subunit alpha 12.	0.583
ADGRG1	GNA13	ENSGALP00000049008	ENSGALP00000055111	Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family.	G protein subunit alpha 13.	0.758
AGTR1	GNA12	ENSGALP00000057556	ENSGALP00000068420	Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.	G protein subunit alpha 12.	0.919
AGTR1	GNA13	ENSGALP00000057556	ENSGALP00000055111	Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.	G protein subunit alpha 13.	0.915
ARHGAP35	ARHGAP5	ENSGALP00000048386	ENSGALP00000016217	Rho GTPase activating protein 35.	Rho GTPase activating protein 5.	0.901
ARHGAP35	CDC42	ENSGALP00000048386	ENSGALP00000065867	Rho GTPase activating protein 35.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...]	0.598
ARHGAP35	HRAS	ENSGALP00000048386	ENSGALP00000073065	Rho GTPase activating protein 35.	GTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.551
ARHGAP35	KRAS	ENSGALP00000048386	ENSGALP00000056138	Rho GTPase activating protein 35.	Uncharacterized protein.	0.551
ARHGAP35	NRAS	ENSGALP00000048386	ENSGALP00000043468	Rho GTPase activating protein 35.	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.551
ARHGAP35	RHOG	ENSGALP00000048386	ENSGALP00000043362	Rho GTPase activating protein 35.	Ras homolog family member G.	0.504
ARHGAP5	ARHGAP35	ENSGALP00000016217	ENSGALP00000048386	Rho GTPase activating protein 5.	Rho GTPase activating protein 35.	0.901
ARHGAP5	CDC42	ENSGALP00000016217	ENSGALP00000065867	Rho GTPase activating protein 5.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...]	0.593
ARHGAP5	RASGEF1B	ENSGALP00000016217	ENSGALP00000069449	Rho GTPase activating protein 5.	RasGEF domain family member 1B.	0.477
ARHGAP5	RHOG	ENSGALP00000016217	ENSGALP00000043362	Rho GTPase activating protein 5.	Ras homolog family member G.	0.494
ARHGAP5	RHOH	ENSGALP00000016217	ENSGALP00000073598	Rho GTPase activating protein 5.	Ras homolog family member H.	0.523
ARHGDIA	ARHGDIB	ENSGALP00000013738	ENSGALP00000029993	Uncharacterized protein.	Uncharacterized protein.	0.425
ARHGDIA	ARHGDIG	ENSGALP00000013738	ENSGALP00000066806	Uncharacterized protein.	Uncharacterized protein.	0.466
ARHGDIA	CDC42	ENSGALP00000013738	ENSGALP00000065867	Uncharacterized protein.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...]	0.873
ARHGDIA	NGFR	ENSGALP00000013738	ENSGALP00000046489	Uncharacterized protein.	Tumor necrosis factor receptor superfamily member 16; Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (By similarity). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (By similarity). Necessary for the circadian oscillatio [...]	0.501