STRINGSTRING
STX12 STX12 TPRG1L TPRG1L RAB40B RAB40B SLC18A1 SLC18A1 ROGDI ROGDI UNC13B UNC13B C11H16orf70 C11H16orf70 RAB8B RAB8B STX10 STX10 PPT1 PPT1 SYT12 SYT12 SYT9 SYT9 BTBD8 BTBD8 ABCC8 ABCC8 GRIN2A GRIN2A SYP SYP RAB35 RAB35 TRAPPC4 TRAPPC4 LOC772071 LOC772071 ATP6AP1 ATP6AP1 SNAP25 SNAP25 NCSTN NCSTN ATP6V0C ATP6V0C SLC18A2 SLC18A2 VTI1B VTI1B RAB3B RAB3B STON2 STON2 COPS4 COPS4 BIN1 BIN1 STX11 STX11 SYNGR1 SYNGR1 TMEM163 TMEM163 TRIM9 TRIM9 THL THL GABRA2 GABRA2 RAB3C RAB3C WFS1 WFS1 SV2C SV2C BSN BSN ATP6AP2 ATP6AP2 RAB10 RAB10 APP APP SNAPIN SNAPIN CPLX3 CPLX3 RAB8A RAB8A SYT1 SYT1 SYPL1 SYPL1 SYNGR2 SYNGR2 COPS5 COPS5 SYNDIG1 SYNDIG1 UNC13A UNC13A STX1A STX1A SVOP SVOP STX2 STX2 RAB12 RAB12 UNC13C UNC13C SLC40A1 SLC40A1 RAB26 RAB26 RAB40C RAB40C AMPH AMPH SEPT5 SEPT5 SYT2 SYT2 ATP6V0A1 ATP6V0A1 DISC1 DISC1 RAB3A RAB3A SNAP91 SNAP91 BORCS5 BORCS5 ATP6V1C1 ATP6V1C1 SLC4A8 SLC4A8 TH TH PICALM PICALM PTPRD PTPRD SEPT4 SEPT4 LRRK2 LRRK2 VAMP4 VAMP4 GRIA1 GRIA1 LAMP1 LAMP1 CLTB CLTB VAMP2 VAMP2 VPS45 VPS45 BCL2L1 BCL2L1 SYN3 SYN3 SLC32A1 SLC32A1 GAD2 GAD2 STX16 STX16 LOC100857259 LOC100857259 SYPL2 SYPL2 SLC17A6 SLC17A6 PTPRS PTPRS SLC17A8 SLC17A8 SYT7 SYT7 STX7 STX7 SV2B SV2B MCTP2 MCTP2 VTI1A VTI1A TMEM230 TMEM230 SEPT2L SEPT2L LAMP5 LAMP5 SYT11 SYT11 SCAMP1 SCAMP1 RAB10L RAB10L MFF MFF SLC30A3 SLC30A3 UNC13C-2 UNC13C-2 STX3 STX3 SEPTIN2 SEPTIN2 LGI3 LGI3 RAB15 RAB15 APBA1 APBA1 STX19 STX19 DTNBP1 DTNBP1 SYN2 SYN2 TRARG1 TRARG1 SNAP47 SNAP47 CLTA CLTA SYNGR3 SYNGR3 ENSGALP00000070006 ENSGALP00000070006 STON1 STON1 NTF3 NTF3 ENSGALP00000070662 ENSGALP00000070662 DNM1L DNM1L BDNF BDNF APBA2 APBA2 SV2A SV2A NGF NGF MCTP1 MCTP1 VAMP1 VAMP1 ENSGALP00000074167 ENSGALP00000074167
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STX12Syntaxin 12; Belongs to the syntaxin family. (272 aa)
TPRG1LTumor protein p63 regulated 1 like. (270 aa)
RAB40BSOCS box domain-containing protein. (278 aa)
SLC18A1Solute carrier family 18 member A1. (515 aa)
ROGDIRogdi atypical leucine zipper. (286 aa)
UNC13BUnc-13 homolog B. (1574 aa)
C11H16orf70Uncharacterized protein. (423 aa)
RAB8BRAB8B, member RAS oncogene family. (201 aa)
STX10Syntaxin-6; Involved in intracellular vesicle trafficking; Belongs to the syntaxin family. (254 aa)
PPT1Uncharacterized protein. (300 aa)
SYT12C2 domain-containing protein. (417 aa)
SYT9Synaptotagmin 9. (528 aa)
BTBD8BTB domain containing 8. (1780 aa)
ABCC8ATP binding cassette subfamily C member 8. (1595 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1458 aa)
SYPMARVEL domain-containing protein. (338 aa)
RAB35Uncharacterized protein. (201 aa)
TRAPPC4Uncharacterized protein. (293 aa)
LOC772071ENTH domain-containing protein. (624 aa)
ATP6AP1Uncharacterized protein. (455 aa)
SNAP25Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion (By similarity). Belongs to the SNAP-25 family. (206 aa)
NCSTNNcstrn_small domain-containing protein. (717 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (154 aa)
SLC18A2Solute carrier family 18 member A2. (633 aa)
VTI1BVesicle transport through interaction with t-SNAREs 1B. (232 aa)
RAB3BRAB3B, member RAS oncogene family. (226 aa)
STON2Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family. (887 aa)
COPS4PCI domain-containing protein. (411 aa)
BIN1Uncharacterized protein. (442 aa)
STX11Syntaxin 11. (288 aa)
SYNGR1Synaptogyrin. (233 aa)
TMEM163Transmembrane protein 163. (274 aa)
TRIM9Tripartite motif containing 9. (802 aa)
THLBH4_AAA_HYDROXYL_2 domain-containing protein. (443 aa)
GABRA2Gamma-aminobutyric acid type A receptor alpha2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (455 aa)
RAB3CRAB3C, member RAS oncogene family. (227 aa)
WFS1Wolframin ER transmembrane glycoprotein. (874 aa)
SV2CSynaptic vesicle glycoprotein 2C. (727 aa)
BSNBassoon presynaptic cytomatrix protein. (3627 aa)
ATP6AP2Uncharacterized protein. (354 aa)
RAB10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Plays also a specific role in asymmetric protein transport to the plasma mem [...] (200 aa)
APPBPTI/Kunitz inhibitor domain-containing protein. (751 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (126 aa)
CPLX3Uncharacterized protein. (157 aa)
RAB8ARas-related protein Rab-8A; May be involved in vesicular trafficking and neurotransmitter release; Belongs to the small GTPase superfamily. Rab family. (207 aa)
SYT1Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. May play a role in dendrite formation by melanocytes; Belongs to the synaptotagmin family. (430 aa)
SYPL1MARVEL domain-containing protein. (236 aa)
SYNGR2Synaptogyrin. (225 aa)
COPS5MPN domain-containing protein. (337 aa)
SYNDIG1Synapse differentiation inducing 1. (256 aa)
UNC13AUncharacterized protein. (1738 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (407 aa)
SVOPSV2 related protein. (548 aa)
STX2t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (288 aa)
RAB12RAB12, member RAS oncogene family. (290 aa)
UNC13CUncharacterized protein. (1097 aa)
SLC40A1Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (581 aa)
RAB26RAB26, member RAS oncogene family. (190 aa)
RAB40CSOCS box domain-containing protein. (281 aa)
AMPHAmphiphysin; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton. (682 aa)
SEPT5Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (485 aa)
SYT2Synaptotagmin 2. (490 aa)
ATP6V0A1V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). (863 aa)
DISC1DISC1 scaffold protein. (856 aa)
RAB3ARAB3A, member RAS oncogene family. (220 aa)
SNAP91ENTH domain-containing protein. (907 aa)
BORCS5BLOC-1-related complex subunit 5; As part of a BORC-like complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motor. Belongs to the BORCS5 family. (196 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
SLC4A8Anion exchange protein. (1068 aa)
THTyrosine hydroxylase. (491 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (609 aa)
PTPRDProtein tyrosine phosphatase receptor type D. (1963 aa)
SEPT4Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (476 aa)
LRRK2Uncharacterized protein. (2557 aa)
VAMP4Vesicle associated membrane protein 4. (141 aa)
GRIA1Uncharacterized protein. (902 aa)
LAMP1Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; Belongs to the LAMP family. (406 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (228 aa)
VAMP2V-SNARE coiled-coil homology domain-containing protein. (114 aa)
VPS45Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (397 aa)
BCL2L1Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity). (229 aa)
SYN3Synapsin III. (582 aa)
SLC32A1Solute carrier family 32 member 1. (521 aa)
GAD2Glutamate decarboxylase 2. (807 aa)
STX16t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (326 aa)
LOC100857259Aa_trans domain-containing protein. (486 aa)
SYPL2Synaptophysin like 2. (425 aa)
SLC17A6MFS domain-containing protein. (585 aa)
PTPRSReceptor-type tyrosine-protein phosphatase S; Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (By similarity). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for norm [...] (1924 aa)
SLC17A8MFS domain-containing protein. (587 aa)
SYT7Synaptotagmin 7. (403 aa)
STX7t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (258 aa)
SV2BSynaptic vesicle glycoprotein 2B. (705 aa)
MCTP2Multiple C2 and transmembrane domain containing 2. (895 aa)
VTI1At-SNARE coiled-coil homology domain-containing protein. (224 aa)
TMEM230Transmembrane protein 230; Involved in trafficking and recycling of synaptic vesicles. Belongs to the TMEM134/TMEM230 family. (120 aa)
SEPT2LSeptin-2; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongat [...] (349 aa)
LAMP5Lysosomal associated membrane protein family member 5. (344 aa)
SYT11Synaptotagmin 11. (432 aa)
SCAMP1Secretory carrier-associated membrane protein. (481 aa)
RAB10LUncharacterized protein. (208 aa)
MFFMitochondrial fission factor. (252 aa)
SLC30A3Solute carrier family 30 member 3. (439 aa)
UNC13C-2Uncharacterized protein. (411 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (462 aa)
SEPTIN2Septin 2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (362 aa)
LGI3Leucine rich repeat LGI family member 3. (511 aa)
RAB15RAB15, member RAS oncogene family. (211 aa)
APBA1Amyloid beta precursor protein binding family A member 1. (824 aa)
STX19Syntaxin 19; Belongs to the syntaxin family. (291 aa)
DTNBP1Dysbindin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neuri [...] (369 aa)
SYN2Synapsin_C domain-containing protein. (296 aa)
TRARG1Trafficking regulator of GLUT4 (SLC2A4) 1. (176 aa)
SNAP47Synaptosome associated protein 47. (461 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (245 aa)
SYNGR3MARVEL domain-containing protein. (295 aa)
ENSGALP00000070006Synaptophysin. (351 aa)
STON1Stonin-1; May be involved in the endocytic machinery. (823 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons. (270 aa)
ENSGALP00000070662Uncharacterized protein. (243 aa)
DNM1LUncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (254 aa)
APBA2Amyloid beta precursor protein binding family A member 2. (755 aa)
SV2ASynaptic vesicle glycoprotein 2A. (751 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. (284 aa)
MCTP1Multiple C2 and transmembrane domain containing 1. (954 aa)
VAMP1V-SNARE coiled-coil homology domain-containing protein. (119 aa)
ENSGALP00000074167Uncharacterized protein. (178 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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