(12 nodes) Glutamine family amino acid biosynthetic process network (Gallus gallus)

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	TMED8	GOLD domain-containing protein. (320 aa)
	OTC	Ornithine carbamoyltransferase, mitochondrial. (354 aa)
	ASS1	Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues; Belongs to the argininosuccinate synthase family. (416 aa)
	ASL1	Delta-1 crystallin; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. (501 aa)
	PYCR3	Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (271 aa)
	PYCR1	Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (372 aa)
	OAT	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
	ALDH18A1	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (802 aa)
	GLS2	ANK_REP_REGION domain-containing protein. (667 aa)
	ASL2	Argininosuccinate lyase; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. (572 aa)
	GSL	Glutamine synthetase. (434 aa)
	GLUL	Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. When expressed in liver, it may be involved in detoxifying intramitochondrially generated ammonia. Also acts as glutamate decarboxylase by catalyzing the production of 4- aminobutanoate (gamma-aminobutyric acid, GABA) in a pyridoxal phosphate-independent manner. (413 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH18A1	ASL1	ENSGALP00000053552	ENSGALP00000039143	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Delta-1 crystallin; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.	0.773
ALDH18A1	ASL2	ENSGALP00000053552	ENSGALP00000058708	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Argininosuccinate lyase; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.	0.804
ALDH18A1	ASS1	ENSGALP00000053552	ENSGALP00000038774	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues; Belongs to the argininosuccinate synthase family.	0.807
ALDH18A1	GLS2	ENSGALP00000053552	ENSGALP00000054545	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	ANK_REP_REGION domain-containing protein.	0.995
ALDH18A1	GLUL	ENSGALP00000053552	ENSGALP00000067937	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. When expressed in liver, it may be involved in detoxifying intramitochondrially generated ammonia. Also acts as glutamate decarboxylase by catalyzing the production of 4- aminobutanoate (gamma-aminobutyric acid, GABA) in a pyridoxal phosphate-independent manner.	0.930
ALDH18A1	GSL	ENSGALP00000053552	ENSGALP00000064271	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Glutamine synthetase.	0.930
ALDH18A1	OAT	ENSGALP00000053552	ENSGALP00000053373	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.999
ALDH18A1	OTC	ENSGALP00000053552	ENSGALP00000026160	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Ornithine carbamoyltransferase, mitochondrial.	0.630
ALDH18A1	PYCR1	ENSGALP00000053552	ENSGALP00000045219	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family.	0.946
ALDH18A1	PYCR3	ENSGALP00000053552	ENSGALP00000044266	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family.	0.891
ALDH18A1	TMED8	ENSGALP00000053552	ENSGALP00000036883	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	GOLD domain-containing protein.	0.870
ASL1	ALDH18A1	ENSGALP00000039143	ENSGALP00000053552	Delta-1 crystallin; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	0.773
ASL1	ASS1	ENSGALP00000039143	ENSGALP00000038774	Delta-1 crystallin; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.	Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues; Belongs to the argininosuccinate synthase family.	0.994
ASL1	GLS2	ENSGALP00000039143	ENSGALP00000054545	Delta-1 crystallin; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.	ANK_REP_REGION domain-containing protein.	0.496
ASL1	OAT	ENSGALP00000039143	ENSGALP00000053373	Delta-1 crystallin; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.987
ASL1	OTC	ENSGALP00000039143	ENSGALP00000026160	Delta-1 crystallin; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.	Ornithine carbamoyltransferase, mitochondrial.	0.811
ASL2	ALDH18A1	ENSGALP00000058708	ENSGALP00000053552	Argininosuccinate lyase; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	0.804
ASL2	ASS1	ENSGALP00000058708	ENSGALP00000038774	Argininosuccinate lyase; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.	Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues; Belongs to the argininosuccinate synthase family.	0.999
ASL2	GLS2	ENSGALP00000058708	ENSGALP00000054545	Argininosuccinate lyase; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.	ANK_REP_REGION domain-containing protein.	0.496
ASL2	OAT	ENSGALP00000058708	ENSGALP00000053373	Argininosuccinate lyase; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.986