STRINGSTRING
SOX9 SOX9 PLP1 PLP1 SOX13 SOX13 GFAP GFAP CRB1 CRB1 GPR157 GPR157 TSPAN2 TSPAN2 DNER DNER EIF2B1 EIF2B1 VTN VTN ABL1 ABL1 DLX1 DLX1 ASPA ASPA C1QA C1QA SOX8 SOX8 WASF3L WASF3L B4GALT5 B4GALT5 RELN RELN PPP3R1 PPP3R1 NCSTN NCSTN VAX1 VAX1 DUSP10 DUSP10 MPP5 MPP5 EIF2B3 EIF2B3 LYN LYN EIF2B2 EIF2B2 CDKN2C CDKN2C PLPP3 PLPP3 ROR1 ROR1 NKX6-2 NKX6-2 METTL14 METTL14 SOX10 SOX10 CDH2 CDH2 B4GALT6 B4GALT6 ROR2 ROR2 SH3TC1 SH3TC1 ARHGEF10 ARHGEF10 NRROS NRROS MYOC MYOC APP APP PHOX2B PHOX2B TTC21B TTC21B EOMES EOMES METRNL METRNL CNTF CNTF NFIB NFIB SIRT2 SIRT2 CTNNB1 CTNNB1 OLIG2 OLIG2 LAMB2 LAMB2 TPPP TPPP PICK1 PICK1 CDH15 CDH15 MMP24 MMP24 ILK ILK EIF2B4 EIF2B4 SMO SMO PRDM8 PRDM8 PARD3 PARD3 DAG1 DAG1 DLX2 DLX2 EIF2B5 EIF2B5 ABL2 ABL2 TENM4 TENM4 CNP CNP NKX2-2 NKX2-2 PTPRZ1 PTPRZ1 NKX6-1 NKX6-1 METTL3 METTL3 HDAC1 HDAC1 ENSGALP00000060823 ENSGALP00000060823 ADAM22 ADAM22 ENSGALP00000065224 ENSGALP00000065224 FGF5 FGF5 GCM1 GCM1 METRN METRN DLL1 DLL1 ZNF488 ZNF488 FA2H FA2H CDK5 CDK5 GPR17 GPR17 PSEN1 PSEN1 NAB2 NAB2 LOC101750972 LOC101750972 WASF3 WASF3 LEF1 LEF1 SHH SHH
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SOX9Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
PLP1Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin; Belongs to the myelin proteolipid protein family. (277 aa)
SOX13SRY-box transcription factor 13. (666 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (422 aa)
CRB1Crumbs cell polarity complex component 1. (807 aa)
GPR157G protein-coupled receptor 157. (318 aa)
TSPAN2Tetraspanin. (222 aa)
DNERDelta/notch like EGF repeat containing. (718 aa)
EIF2B1Eukaryotic translation initiation factor 2B subunit alpha; Belongs to the eIF-2B alpha/beta/delta subunits family. (302 aa)
VTNSMB domain-containing protein. (453 aa)
ABL1Tyrosine-protein kinase. (1111 aa)
DLX1Homeodomain transcription factor DLX1. (255 aa)
ASPAAspartoacylase. (361 aa)
C1QAComplement C1q A chain. (243 aa)
SOX8Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. (470 aa)
WASF3LWH2 domain-containing protein. (507 aa)
B4GALT5Beta-1,4-galactosyltransferase 5. (590 aa)
RELNReelin; Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity); Belongs to the reel [...] (3462 aa)
PPP3R1Protein phospatase 3 regulatory subunit B alpha isoform type 1. (170 aa)
NCSTNNcstrn_small domain-containing protein. (717 aa)
VAX1Ventral anterior homeobox 1; Transcription factor that plays a role in establishing dorsal-ventral polarity in the neural retina. (325 aa)
DUSP10Uncharacterized protein. (478 aa)
MPP5Uncharacterized protein; Belongs to the MAGUK family. (675 aa)
EIF2B3NTP_transferase domain-containing protein. (479 aa)
LYNTyrosine-protein kinase. (491 aa)
EIF2B2Uncharacterized protein; Belongs to the eIF-2B alpha/beta/delta subunits family. (553 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (167 aa)
PLPP3acidPPc domain-containing protein. (313 aa)
ROR1Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (896 aa)
NKX6-2Homeobox domain-containing protein. (364 aa)
METTL14N6-adenosine-methyltransferase non-catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. (459 aa)
SOX10Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. (461 aa)
CDH2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity). (912 aa)
B4GALT6Uncharacterized protein. (382 aa)
ROR2Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (934 aa)
SH3TC1SH3 domain and tetratricopeptide repeats 1. (1341 aa)
ARHGEF10Rho guanine nucleotide exchange factor 10. (1352 aa)
NRROSNegative regulator of reactive oxygen species. (701 aa)
MYOCMyocilin. (467 aa)
APPBPTI/Kunitz inhibitor domain-containing protein. (751 aa)
PHOX2BPaired like homeobox 2B. (292 aa)
TTC21BTetratricopeptide repeat domain 21B. (1411 aa)
EOMEST-box_assoc domain-containing protein. (661 aa)
METRNLMeteorin like, glial cell differentiation regulator. (292 aa)
CNTFCiliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. (195 aa)
NFIBNuclear factor 1 B-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (560 aa)
SIRT2Deacetylase sirtuin-type domain-containing protein. (485 aa)
CTNNB1Uncharacterized protein. (781 aa)
OLIG2Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord. (298 aa)
LAMB2Uncharacterized protein. (1802 aa)
TPPPTubulin polymerization promoting protein. (219 aa)
PICK1Protein interacting with PRKCA 1. (408 aa)
CDH15Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. (792 aa)
MMP24Matrix metallopeptidase 24. (596 aa)
ILKIntegrin-linked kinase. (452 aa)
EIF2B4Eukaryotic translation initiation factor 2B subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (330 aa)
SMOSmoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa)
PRDM8PR/SET domain 8. (336 aa)
PARD3Uncharacterized protein. (1352 aa)
DAG1Peptidase S72 domain-containing protein. (896 aa)
DLX2Distal-less homeobox 2. (253 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (711 aa)
ABL2Tyrosine-protein kinase. (1159 aa)
TENM4Uncharacterized protein. (2766 aa)
CNPUncharacterized protein. (534 aa)
NKX2-2Homeobox domain-containing protein. (272 aa)
PTPRZ1Protein-tyrosine-phosphatase. (2343 aa)
NKX6-1NK6 homeobox 1. (272 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (548 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. (480 aa)
ENSGALP00000060823Ig-like domain-containing protein. (511 aa)
ADAM22ADAM metallopeptidase domain 22. (967 aa)
ENSGALP00000065224Uncharacterized protein. (381 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (292 aa)
GCM1GCM domain-containing protein. (373 aa)
METRNMeteorin, glial cell differentiation regulator. (294 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (893 aa)
ZNF488Zinc finger protein 488. (535 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (373 aa)
CDK5Protein kinase domain-containing protein. (522 aa)
GPR17G_PROTEIN_RECEP_F1_2 domain-containing protein. (104 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa)
NAB2NGFI-A binding protein 2. (672 aa)
LOC101750972Peptidase S72 domain-containing protein. (1177 aa)
WASF3WASP family member 3. (502 aa)
LEF1HMG box domain-containing protein. (412 aa)
SHHSonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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