STRINGSTRING
TIGAR TIGAR HRAS HRAS MYC MYC LOC112530162 LOC112530162 WRN WRN XRCC5 XRCC5 MAP3K20 MAP3K20 TLK2 TLK2 PMLL PMLL POLB POLB ZMPSTE24 ZMPSTE24 HSF1 HSF1 PTPRC PTPRC ATR ATR FANCD2 FANCD2 ERCC6 ERCC6 EGR1 EGR1 CRYAB CRYAB BCL2 BCL2 PRKAA1 PRKAA1 BRCA2 BRCA2 ATM ATM XRCC2 XRCC2 BAK1 BAK1 BCL2L1 BCL2L1 YAP1 YAP1 XRCC6 XRCC6 CHEK2 CHEK2 KDM1A KDM1A DCUN1D3 DCUN1D3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TIGARTIGAR. (280 aa)
HRASGTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (429 aa)
LOC112530162Uncharacterized protein. (159 aa)
WRNUncharacterized protein. (1622 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (711 aa)
MAP3K20Uncharacterized protein. (791 aa)
TLK2Tousled like kinase 2. (809 aa)
PMLLUncharacterized protein. (464 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (181 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (465 aa)
HSF1Heat shock factor protein 1; Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription [...] (343 aa)
PTPRCUncharacterized protein. (1237 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2660 aa)
FANCD2Uncharacterized protein. (1510 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1495 aa)
EGR1Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (510 aa)
CRYABAlpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. (174 aa)
BCL2Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
PRKAA1Non-specific serine/threonine protein kinase. (560 aa)
BRCA2Tower domain-containing protein. (3397 aa)
ATMNon-specific serine/threonine protein kinase. (3050 aa)
XRCC2X-ray repair cross complementing 2. (279 aa)
BAK1Uncharacterized protein. (216 aa)
BCL2L1Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity). (229 aa)
YAP1Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation (By similarity); Belongs to the YAP1 family. (500 aa)
XRCC6X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic s [...] (647 aa)
CHEK2Uncharacterized protein. (524 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (826 aa)
DCUN1D3Defective in cullin neddylation 1 domain containing 3. (303 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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