STRINGSTRING
RB1CC1 RB1CC1 FOXO3 FOXO3 TRIM14 TRIM14 UFL1 UFL1 HTT HTT SNX30 SNX30 EPM2A EPM2A SVIP SVIP AMBRA1 AMBRA1 SMCR8 SMCR8 RNF152 RNF152 ATF6 ATF6 VPS13D VPS13D TMEM59 TMEM59 WAC WAC FYCO1 FYCO1 TFEB TFEB RIPK2 RIPK2 FLCN FLCN ZC3H12A ZC3H12A PINK1 PINK1 SESN1 SESN1 LRSAM1 LRSAM1 TMEM173 TMEM173 SNX7 SNX7 ULK1 ULK1 LRRK2 LRRK2 ROCK1 ROCK1 SESN2 SESN2 TRIM8 TRIM8 WIPI1 WIPI1 NPRL3 NPRL3 TP53INP1 TP53INP1 NOD1 NOD1 FOXO1 FOXO1 LOC107051192 LOC107051192 DCN DCN ATG101 ATG101 SCOC SCOC GSK3B GSK3B TSC1 TSC1 LARP1 LARP1 WDR24 WDR24 BCL2L11 BCL2L11 RIPK3 RIPK3 PRKN PRKN GPSM1 GPSM1 TPCN3 TPCN3 TP53INP2 TP53INP2 SESN3 SESN3 SPTLC1 SPTLC1 CALCOCO2 CALCOCO2 C9orf72 C9orf72 NPRL2 NPRL2 SIRT1 SIRT1 BECN1 BECN1 E1C066_CHICK E1C066_CHICK SH3BP4 SH3BP4 PLEKHF1 PLEKHF1 ULK2 ULK2 TSC2 TSC2 SESN2-2 SESN2-2 DEPDC5 DEPDC5 HSPB8 HSPB8 TPCN1 TPCN1 BAG3 BAG3 RAB3GAP2 RAB3GAP2 IFNG IFNG BNIP3 BNIP3 PRKAA2 PRKAA2 SNX4 SNX4 RAB3GAP1 RAB3GAP1 FBXO7 FBXO7 KDR KDR PRKAA1 PRKAA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RB1CC1RB1 inducible coiled-coil 1. (1598 aa)
FOXO3Forkhead box O3. (660 aa)
TRIM14Uncharacterized protein. (433 aa)
UFL1E3 UFM1-protein ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins; Belongs to the UFL1 family. (789 aa)
HTTHuntingtin. (3095 aa)
SNX30Sorting nexin family member 30. (438 aa)
EPM2ALaforin. (319 aa)
SVIPUncharacterized protein. (80 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (872 aa)
SMCR8SMCR8-C9orf72 complex subunit. (935 aa)
RNF152E3 ubiquitin-protein ligase RNF152; E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation; Belongs to the RNF152 family. (203 aa)
ATF6Activating transcription factor 6. (671 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4371 aa)
TMEM59Uncharacterized protein. (325 aa)
WACWW domain containing adaptor with coiled-coil. (646 aa)
FYCO1Uncharacterized protein. (1540 aa)
TFEBBHLH domain-containing protein. (493 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (574 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (681 aa)
PINK1PTEN induced kinase 1. (364 aa)
SESN1Sestrin 1. (564 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (728 aa)
TMEM173Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (By similarity). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (By similarity). Acts by binding cyclic dinucleotides: recognizes and binds cyclic di- GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus [...] (379 aa)
SNX7Sorting nexin 7. (445 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1081 aa)
LRRK2Uncharacterized protein. (2557 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
SESN2Uncharacterized protein. (474 aa)
TRIM8RING-type domain-containing protein. (551 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (508 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (582 aa)
TP53INP1Uncharacterized protein. (237 aa)
NOD1Uncharacterized protein. (951 aa)
FOXO1Fork-head domain-containing protein. (727 aa)
LOC107051192RanBP2-type domain-containing protein. (1255 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (357 aa)
ATG101Autophagy related 101. (236 aa)
SCOCUncharacterized protein. (120 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
TSC1Uncharacterized protein. (275 aa)
LARP1La ribonucleoprotein domain family member 1. (1046 aa)
WDR24GATOR complex protein WDR24; As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. (789 aa)
BCL2L11BCL2 like 11. (179 aa)
RIPK3Uncharacterized protein. (424 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (488 aa)
GPSM1G protein signaling modulator 1. (666 aa)
TPCN3Uncharacterized protein. (783 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (213 aa)
SESN3Sestrin 3. (492 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (476 aa)
CALCOCO2SKICH domain-containing protein. (357 aa)
C9orf72C9orf72-SMCR8 complex subunit. (336 aa)
NPRL2Uncharacterized protein. (378 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (881 aa)
BECN1Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. (447 aa)
E1C066_CHICKUncharacterized protein. (258 aa)
SH3BP4SH3 domain binding protein 4. (964 aa)
PLEKHF1Pleckstrin homology and FYVE domain containing 1. (273 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1001 aa)
TSC2TSC complex subunit 2. (1872 aa)
SESN2-2Uncharacterized protein. (450 aa)
DEPDC5DEP domain-containing protein. (1592 aa)
HSPB8Heat shock protein family B (small) member 8; Belongs to the small heat shock protein (HSP20) family. (197 aa)
TPCN1Two pore segment channel 1. (817 aa)
BAG3BCL2 associated athanogene 3. (560 aa)
RAB3GAP2Uncharacterized protein. (1382 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (164 aa)
BNIP3BCL2 interacting protein 3. (155 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
SNX4Sorting nexin 4. (435 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (1014 aa)
FBXO7F-box domain-containing protein. (526 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1348 aa)
PRKAA1Non-specific serine/threonine protein kinase. (560 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.