STRINGSTRING
MAPRE1 MAPRE1 TERF2 TERF2 TBCD TBCD PTTG2 PTTG2 CAMSAP1 CAMSAP1 BBS4 BBS4 SPDL1 SPDL1 TEN1 TEN1 TMOD1 TMOD1 CAMSAP2 CAMSAP2 DEF6 DEF6 INPP5K INPP5K ERCC4 ERCC4 PRELID1 PRELID1 EXOSC10 EXOSC10 SMG6 SMG6 KAT2A KAT2A MPHOSPH9 MPHOSPH9 CAPZB CAPZB MAD1L1 MAD1L1 CGNL1 CGNL1 KNTC1 KNTC1 TMOD3 TMOD3 TRIM37 TRIM37 VILL VILL KIF24 KIF24 MCM2 MCM2 PLK1 PLK1 KLHL22 KLHL22 PAK2 PAK2 C14H16orf45 C14H16orf45 CCP110 CCP110 NUBP1 NUBP1 ZWILCH ZWILCH TMEFF2 TMEFF2 ATRX ATRX ATXN7L1 ATXN7L1 BUB1 BUB1 PSMD10 PSMD10 CIB4 CIB4 SLC25A5 SLC25A5 WDR63 WDR63 LMOD2 LMOD2 PIK3CA PIK3CA MKKS MKKS PIF1 PIF1 TTBK2 TTBK2 SCFD1 SCFD1 MDM1 MDM1 PLEKHH2 PLEKHH2 KANK1 KANK1 BNIP3 BNIP3 FEZ2 FEZ2 SLC25A4 SLC25A4 SCIN SCIN OMA1 OMA1 MNAT1 MNAT1 IGF1 IGF1 TUBB2B TUBB2B RDX RDX CAPZA3 CAPZA3 FBXO5 FBXO5 PSMG2 PSMG2 NAT10 NAT10 TNKS2 TNKS2 ARHGAP28 ARHGAP28 TMEM39A TMEM39A CEP97 CEP97 ADD1 ADD1 TTK TTK GCLC GCLC ATM ATM LMOD3 LMOD3 PFN4 PFN4 MYOC MYOC SSH2 SSH2 SLC25A6 SLC25A6 FXN FXN RAD50 RAD50 FRMD7 FRMD7 HSPB1 HSPB1 SMCR8 SMCR8 PARL PARL KANK3 KANK3 TMSB4X TMSB4X LMOD1 LMOD1 TIGAR TIGAR ANKRD27 ANKRD27 RHPN1 RHPN1 MAP4 MAP4 TWF1 TWF1 TMEM67 TMEM67 RHPN2 RHPN2 CHTOP CHTOP SLIT2 SLIT2 TMSB15B TMSB15B FLCN FLCN TNKS TNKS PINK1 PINK1 PICK1 PICK1 MID1IP1 MID1IP1 SLX4 SLX4 DCP2 DCP2 ARFGEF1 ARFGEF1 CLASP1 CLASP1 CAPG CAPG CTC1 CTC1 TOP2A TOP2A BAZ1B BAZ1B LOC101749287 LOC101749287 HGF HGF ENSGALP00000050074 ENSGALP00000050074 FLII FLII CCNF CCNF ARHGEF18 ARHGEF18 APC APC HIP1R HIP1R ADD2 ADD2 SEC22B SEC22B TBC1D30 TBC1D30 GHITM GHITM TCHP TCHP TENT4B TENT4B CDK5RAP2 CDK5RAP2 TACC2 TACC2 RBM14 RBM14 TWF2 TWF2 LRRK2 LRRK2 NME6 NME6 ENSGALP00000052647 ENSGALP00000052647 SPTBN1 SPTBN1 ACAA2 ACAA2 MUL1 MUL1 PINX1 PINX1 KAT2B KAT2B ZW10 ZW10 OPA1 OPA1 TPR TPR ZNF207 ZNF207 GSN GSN MET MET BAK1 BAK1 BUB1B BUB1B ODF2L ODF2L STMN2 STMN2 RAD1 RAD1 GMFB GMFB LOC421441 LOC421441 CAPZA2 CAPZA2 CAPZA1 CAPZA1 FBXO43 FBXO43 TMOD2 TMOD2 TESK1 TESK1 WAPL WAPL VIL1 VIL1 MAD2L1 MAD2L1 STMN1 STMN1 ENSGALP00000061073 ENSGALP00000061073 TBC1D7 TBC1D7 BUB3 BUB3 CCDC84 CCDC84 FEZ1 FEZ1 TSPO2 TSPO2 TMEM14A TMEM14A STYXL1 STYXL1 TRIP13 TRIP13 TMEM39B TMEM39B ENSGALP00000065294 ENSGALP00000065294 FAM49B FAM49B LOC107051165 LOC107051165 DMTN DMTN SPTBN4L SPTBN4L SPTAN1 SPTAN1 ENSGALP00000067038 ENSGALP00000067038 C20orf27 C20orf27 ENSGALP00000067477 ENSGALP00000067477 ENSGALP00000067665 ENSGALP00000067665 INPP5J-2 INPP5J-2 SLC35F6 SLC35F6 RNF41 RNF41 CLASP2 CLASP2 ENSGALP00000068509 ENSGALP00000068509 TSPO TSPO ENSGALP00000068677 ENSGALP00000068677 TOM1L1 TOM1L1 ENSGALP00000069115 ENSGALP00000069115 SPTBN5 SPTBN5 SVIL SVIL TRARG1 TRARG1 SPTBN2 SPTBN2 PHLDB2 PHLDB2 ADD3 ADD3 ENSGALP00000070586 ENSGALP00000070586 FKBP4 FKBP4 XIRP2 XIRP2 ENSGALP00000070978 ENSGALP00000070978 ENSGALP00000071025 ENSGALP00000071025 ATXN7 ATXN7 ENSGALP00000071309 ENSGALP00000071309 KANK4 KANK4 TMSB4Y TMSB4Y TMOD4 TMOD4 RPS6KA2 RPS6KA2 PRKN PRKN ARHGAP6 ARHGAP6 MAP2 MAP2 SETMAR SETMAR WASF2 WASF2 VAT1 VAT1 ENSGALP00000073167 ENSGALP00000073167 TTBK2-2 TTBK2-2 HDGFL3 HDGFL3 LIMA1 LIMA1 CDK10 CDK10 ENSGALP00000074109 ENSGALP00000074109
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPRE1Microtubule-associated protein RP/EB family member 1; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Belongs to the MAPRE family. (263 aa)
TERF2Telomeric repeat-binding factor 2; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'- TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA r [...] (718 aa)
TBCDTubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP- bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes ep [...] (1203 aa)
PTTG2Uncharacterized protein. (193 aa)
CAMSAP1Calmodulin regulated spectrin associated protein 1. (1623 aa)
BBS4TPR_REGION domain-containing protein. (532 aa)
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex; Belongs to the Spindly family. (608 aa)
TEN1Uncharacterized protein. (126 aa)
TMOD1Uncharacterized protein. (359 aa)
CAMSAP2Calmodulin regulated spectrin associated protein family member 2. (1490 aa)
DEF6DEF6 guanine nucleotide exchange factor. (625 aa)
INPP5KIPPc domain-containing protein. (465 aa)
ERCC4ERCC4 domain-containing protein. (903 aa)
PRELID1PRELI domain-containing protein 1, mitochondrial; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. The TRIAP1:PRELID1 complex probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (By similarity). May be involved in hematopoiesis during avian development. (215 aa)
EXOSC10HRDC domain-containing protein. (910 aa)
SMG6SMG6 nonsense mediated mRNA decay factor. (1452 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (804 aa)
MPHOSPH9Uncharacterized protein. (698 aa)
CAPZBF-actin-capping protein subunit beta isoforms 1 and 2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the regulation of cell morphology and cytoskeletal organization. (277 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (717 aa)
CGNL1Cingulin like 1. (1294 aa)
KNTC1Rod_C domain-containing protein. (398 aa)
TMOD3Uncharacterized protein. (352 aa)
TRIM37Uncharacterized protein. (983 aa)
VILLVillin like. (860 aa)
KIF24Kinesin family member 24; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1427 aa)
MCM2DNA helicase; Belongs to the MCM family. (929 aa)
PLK1Serine/threonine-protein kinase PLK. (595 aa)
KLHL22BTB domain-containing protein. (638 aa)
PAK2Non-specific serine/threonine protein kinase. (521 aa)
C14H16orf45BMERB domain-containing protein. (204 aa)
CCP110Centriolar coiled-coil protein 110. (1008 aa)
NUBP1Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (323 aa)
ZWILCHZwilch kinetochore protein. (536 aa)
TMEFF2Transmembrane protein with EGF like and two follistatin like domains 2. (375 aa)
ATRXATRX chromatin remodeler. (2420 aa)
ATXN7L1Ataxin 7 like 1. (834 aa)
BUB1Uncharacterized protein. (1087 aa)
PSMD10ANK_REP_REGION domain-containing protein. (226 aa)
CIB4Uncharacterized protein. (190 aa)
SLC25A5Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (389 aa)
WDR63WD repeat domain 63. (860 aa)
LMOD2Leiomodin-2; Mediates nucleation of actin filaments and thereby promotes actin polymerization (By similarity). Plays a role in the regulation of actin filament length. Required for normal sarcomere organization in the heart, and for normal heart function (By similarity); Belongs to the tropomodulin family. (552 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MKKSUncharacterized protein. (570 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (617 aa)
TTBK2Tau tubulin kinase 2. (435 aa)
SCFD1Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (632 aa)
MDM1Nuclear protein MDM1; Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules. Belongs to the MDM1 family. (738 aa)
PLEKHH2Pleckstrin homology, MyTH4 and FERM domain containing H2. (1500 aa)
KANK1ANK_REP_REGION domain-containing protein. (1344 aa)
BNIP3BCL2 interacting protein 3. (155 aa)
FEZ2Fasciculation and elongation protein zeta 2. (369 aa)
SLC25A4Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
SCINAdseverin; Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Severing activity is inhibited by phosphatidylinositol 4,5-bis- phosphate (PIP2) (By similarity). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity). Plays a role in osteoclastogenesis (OCG) and actin cytoskel [...] (730 aa)
OMA1OMA1 zinc metallopeptidase. (564 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex fo [...] (153 aa)
TUBB2BTubulin beta-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (445 aa)
RDXRadixin; Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. (583 aa)
CAPZA3F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (290 aa)
FBXO5F-box protein 5. (406 aa)
PSMG2Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (273 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1012 aa)
TNKS2Poly [ADP-ribose] polymerase. (1166 aa)
ARHGAP28Rho GTPase activating protein 28. (490 aa)
TMEM39ATransmembrane protein 39A. (551 aa)
CEP97Uncharacterized protein. (622 aa)
ADD1Aldolase_II domain-containing protein. (736 aa)
TTKTTK protein kinase. (880 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (636 aa)
ATMNon-specific serine/threonine protein kinase. (3050 aa)
LMOD3Leiomodin 3. (524 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
MYOCMyocilin. (467 aa)
SSH2Slingshot protein phosphatase 2. (1395 aa)
SLC25A6Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
FXNFrataxin. (167 aa)
RAD50Zinc-hook domain-containing protein. (1313 aa)
FRMD7FERM domain containing 7. (686 aa)
HSPB1Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization; Belongs to the small heat shock protein (HSP20) family. (194 aa)
SMCR8SMCR8-C9orf72 complex subunit. (935 aa)
PARLRhomboid domain-containing protein. (355 aa)
KANK3KN motif and ankyrin repeat domains 3. (1168 aa)
TMSB4XThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
LMOD1Leiomodin 1. (624 aa)
TIGARTIGAR. (280 aa)
ANKRD27Uncharacterized protein. (1087 aa)
RHPN1Rhophilin Rho GTPase binding protein 1. (676 aa)
MAP4Microtubule-associated protein. (1119 aa)
TWF1Uncharacterized protein. (491 aa)
TMEM67Transmembrane protein 67. (976 aa)
RHPN2Uncharacterized protein. (532 aa)
CHTOPMothers against decapentaplegic homolog. (445 aa)
SLIT2Uncharacterized protein. (1533 aa)
TMSB15BThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
TNKSPoly [ADP-ribose] polymerase. (1269 aa)
PINK1PTEN induced kinase 1. (364 aa)
PICK1Protein interacting with PRKCA 1. (408 aa)
MID1IP1THRSP-like protein. (159 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1740 aa)
DCP2Decapping mRNA 2. (416 aa)
ARFGEF1ADP ribosylation factor guanine nucleotide exchange factor 1. (1846 aa)
CLASP1Cytoplasmic linker associated protein 1. (1499 aa)
CAPGCapping actin protein, gelsolin like. (327 aa)
CTC1Uncharacterized protein. (1282 aa)
TOP2ADNA topoisomerase 2-alpha; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in the regulation of circadian rhythm. (1553 aa)
BAZ1BBromodomain adjacent to zinc finger domain 1B. (1613 aa)
LOC101749287BMERB domain-containing protein. (192 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (726 aa)
ENSGALP00000050074Uncharacterized protein. (685 aa)
FLIIUncharacterized protein. (1228 aa)
CCNFCyclin F; Belongs to the cyclin family. (750 aa)
ARHGEF18Uncharacterized protein. (1567 aa)
APCAPC regulator of WNT signaling pathway. (2853 aa)
HIP1RUncharacterized protein. (977 aa)
ADD2Adducin 2. (775 aa)
SEC22BVesicle-trafficking protein SEC22b; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. (215 aa)
TBC1D30TBC1 domain family member 30. (858 aa)
GHITMUncharacterized protein; Belongs to the BI1 family. (346 aa)
TCHPUncharacterized protein. (373 aa)
TENT4BTerminal nucleotidyltransferase 4B. (684 aa)
CDK5RAP2Uncharacterized protein. (751 aa)
TACC2TACC_C domain-containing protein. (575 aa)
RBM14RNA binding motif protein 14. (750 aa)
TWF2Twinfilin-2; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin (By similarity). (385 aa)
LRRK2Uncharacterized protein. (2557 aa)
NME6Nucleoside diphosphate kinase. (186 aa)
ENSGALP00000052647HECT domain-containing protein. (283 aa)
SPTBN1Spectrin beta chain; Belongs to the spectrin family. (2362 aa)
ACAA2Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (423 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (252 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (356 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (808 aa)
ZW10Uncharacterized protein. (781 aa)
OPA1Dynamin-like 120 kDa protein, mitochondrial; Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Belongs to the TRAFAC class dynamin-like GT [...] (1014 aa)
TPRTranslocated promoter region, nuclear basket protein. (2472 aa)
ZNF207Zinc finger protein 207. (479 aa)
GSNGelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). (833 aa)
METUncharacterized protein. (1382 aa)
BAK1Uncharacterized protein. (216 aa)
BUB1BBUB1 N-terminal domain-containing protein. (1086 aa)
ODF2LOuter dense fiber of sperm tails 2 like. (692 aa)
STMN2Stathmin-2; Is a key regulator of neurite extension through regulation of microtubule instabilily. (179 aa)
RAD1RAD1 checkpoint DNA exonuclease. (281 aa)
GMFBGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (141 aa)
LOC421441PH domain-containing protein. (1734 aa)
CAPZA2F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. CapZ may mediate the attachment of the barbed ends of actin filaments to the Z-line. (286 aa)
CAPZA1F-actin-capping protein subunit alpha-1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. (286 aa)
FBXO43F-box protein 43. (478 aa)
TMOD2Tropomodulin 2. (351 aa)
TESK1Testis associated actin remodelling kinase 1. (736 aa)
WAPLWAPL domain-containing protein. (1239 aa)
VIL1Villin-1; Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the inte [...] (826 aa)
MAD2L1HORMA domain-containing protein. (206 aa)
STMN1Stathmin; Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules (By similarity). (172 aa)
ENSGALP00000061073PH_9 domain-containing protein. (674 aa)
TBC1D7TBC1 domain family member 7. (293 aa)
BUB3WD_REPEATS_REGION domain-containing protein. (392 aa)
CCDC84Coiled-coil domain containing 84. (306 aa)
FEZ1Fasciculation and elongation protein zeta 1. (393 aa)
TSPO2Translocator protein 2. (190 aa)
TMEM14ATransmembrane protein 14A. (97 aa)
STYXL1Tyrosine-protein phosphatase domain-containing protein. (325 aa)
TRIP13Pachytene checkpoint protein 2 homolog; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways (By similarity). (432 aa)
TMEM39BUncharacterized protein. (489 aa)
ENSGALP00000065294Uncharacterized protein. (1324 aa)
FAM49BFamily with sequence similarity 49 member B. (324 aa)
LOC107051165Uncharacterized protein. (230 aa)
DMTNAbLIM_anchor domain-containing protein. (687 aa)
SPTBN4LCalponin-homology (CH) domain-containing protein. (862 aa)
SPTAN1Spectrin alpha chain, non-erythrocytic 1; Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization. (2497 aa)
ENSGALP00000067038Uncharacterized protein. (384 aa)
C20orf27Calponin-homology (CH) domain-containing protein. (740 aa)
ENSGALP00000067477Uncharacterized protein. (178 aa)
ENSGALP00000067665Uncharacterized protein. (423 aa)
INPP5J-2SKICH domain-containing protein. (338 aa)
SLC35F6Uncharacterized protein. (72 aa)
RNF41Ring finger protein 41. (317 aa)
CLASP2Uncharacterized protein. (1506 aa)
ENSGALP00000068509CKK domain-containing protein. (392 aa)
TSPOUncharacterized protein. (516 aa)
ENSGALP00000068677Uncharacterized protein. (166 aa)
TOM1L1Target of myb1 like 1 membrane trafficking protein. (682 aa)
ENSGALP00000069115Calponin-homology (CH) domain-containing protein. (192 aa)
SPTBN5Uncharacterized protein. (3926 aa)
SVILSupervillin. (2303 aa)
TRARG1Trafficking regulator of GLUT4 (SLC2A4) 1. (176 aa)
SPTBN2Uncharacterized protein. (708 aa)
PHLDB2Pleckstrin homology like domain family B member 2. (1349 aa)
ADD3Aldolase_II domain-containing protein. (742 aa)
ENSGALP00000070586Uncharacterized protein. (1264 aa)
FKBP4Peptidylprolyl isomerase. (464 aa)
XIRP2LIM zinc-binding domain-containing protein. (123 aa)
ENSGALP00000070978XRCC1_N domain-containing protein. (182 aa)
ENSGALP00000071025Uncharacterized protein. (177 aa)
ATXN7SCA7 domain-containing protein. (864 aa)
ENSGALP00000071309Calponin-homology (CH) domain-containing protein. (153 aa)
KANK4KN motif and ankyrin repeat domains 4. (1010 aa)
TMSB4YThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
TMOD4Uncharacterized protein. (570 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (488 aa)
ARHGAP6Rho GTPase activating protein 6. (704 aa)
MAP2Microtubule-associated protein. (1955 aa)
SETMARUncharacterized protein. (297 aa)
WASF2WASP family member 2. (528 aa)
VAT1Vesicle amine transport 1. (401 aa)
ENSGALP00000073167Cnn_1N domain-containing protein. (48 aa)
TTBK2-2Uncharacterized protein. (577 aa)
HDGFL3HDGF like 3. (185 aa)
LIMA1LIM domain and actin binding 1. (764 aa)
CDK10Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (430 aa)
ENSGALP00000074109Hr1 domain-containing protein. (124 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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