(24 nodes) Regulation of muscle cell apoptotic process network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL12A	Interleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (203 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
	FNDC1	Fibronectin type III domain containing 1. (1489 aa)
	E2F3	E2F transcription factor 3. (341 aa)
	ATF4	ATF4. (354 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (872 aa)
	TIGAR	TIGAR. (280 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (426 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (681 aa)
	DIPK2A	Divergent protein kinase domain 2A. (479 aa)
	KIFAP3	Kinesin associated protein 3. (793 aa)
	MYOCD	Phosphatase and actin regulator. (908 aa)
	ENSGALP00000070665	Nuclear factor, erythroid 2. (326 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (288 aa)
	NKX2-5	Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Binds to the core DNA motif of promoter. Belongs to the NK-2 homeobox family. (294 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (881 aa)
	NFE2L2	BZIP domain-containing protein. (593 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (315 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1580 aa)
	GRIA4	Uncharacterized protein. (943 aa)
	SLC7A5	Large neutral amino acids transporter small subunit 1. (526 aa)
	APOH	Uncharacterized protein. (374 aa)
	BAG3	BCL2 associated athanogene 3. (560 aa)
	MFN2	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (762 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBRA1	ATG5	ENSGALP00000037597	ENSGALP00000050539	Autophagy and beclin 1 regulator 1.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.791
ATF4	NFE2L2	ENSGALP00000037099	ENSGALP00000074218	ATF4.	BZIP domain-containing protein.	0.550
ATG5	AMBRA1	ENSGALP00000050539	ENSGALP00000037597	Autophagy protein 5; Involved in autophagic vesicle formation.	Autophagy and beclin 1 regulator 1.	0.791
ATG5	MFN2	ENSGALP00000050539	ENSGALP00000007187	Autophagy protein 5; Involved in autophagic vesicle formation.	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.782
ATG5	SIRT1	ENSGALP00000050539	ENSGALP00000004350	Autophagy protein 5; Involved in autophagic vesicle formation.	Deacetylase sirtuin-type domain-containing protein.	0.807
E2F3	SIRT1	ENSGALP00000036527	ENSGALP00000004350	E2F transcription factor 3.	Deacetylase sirtuin-type domain-containing protein.	0.424
IL12A	IL12B	ENSGALP00000015585	ENSGALP00000002143	Interleukin-12 subunit alpha; Belongs to the IL-6 superfamily.	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.	0.900
IL12B	IL12A	ENSGALP00000002143	ENSGALP00000015585	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.	Interleukin-12 subunit alpha; Belongs to the IL-6 superfamily.	0.900
MFN2	ATG5	ENSGALP00000007187	ENSGALP00000050539	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.782
MFN2	SIRT1	ENSGALP00000007187	ENSGALP00000004350	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Deacetylase sirtuin-type domain-containing protein.	0.539
MYOCD	NKX2-5	ENSGALP00000069052	ENSGALP00000004542	Phosphatase and actin regulator.	Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Binds to the core DNA motif of promoter. Belongs to the NK-2 homeobox family.	0.805
NFE2L2	ATF4	ENSGALP00000074218	ENSGALP00000037099	BZIP domain-containing protein.	ATF4.	0.550
NFE2L2	SIRT1	ENSGALP00000074218	ENSGALP00000004350	BZIP domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.653
NKX2-5	MYOCD	ENSGALP00000004542	ENSGALP00000069052	Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Binds to the core DNA motif of promoter. Belongs to the NK-2 homeobox family.	Phosphatase and actin regulator.	0.805
SIRT1	ATG5	ENSGALP00000004350	ENSGALP00000050539	Deacetylase sirtuin-type domain-containing protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.807
SIRT1	E2F3	ENSGALP00000004350	ENSGALP00000036527	Deacetylase sirtuin-type domain-containing protein.	E2F transcription factor 3.	0.424
SIRT1	MFN2	ENSGALP00000004350	ENSGALP00000007187	Deacetylase sirtuin-type domain-containing protein.	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.539
SIRT1	NFE2L2	ENSGALP00000004350	ENSGALP00000074218	Deacetylase sirtuin-type domain-containing protein.	BZIP domain-containing protein.	0.653
SIRT1	SOD2	ENSGALP00000004350	ENSGALP00000019039	Deacetylase sirtuin-type domain-containing protein.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.699
SOD2	SIRT1	ENSGALP00000019039	ENSGALP00000004350	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	Deacetylase sirtuin-type domain-containing protein.	0.699