(19 nodes) Regulation of tumor necrosis factor-mediated signaling pathway network (Gallus gallus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	PIAS4	Protein inhibitor of activated STAT 4. (493 aa)
	TNFRSF1A	Uncharacterized protein. (427 aa)
	UBE2K	Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
	ADIPOQ	C1q domain-containing protein. (244 aa)
	OTULIN	OTU deubiquitinase with linear linkage specificity. (319 aa)
	NKIRAS1	NFKB inhibitor interacting Ras like 1. (230 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (488 aa)
	PTPN2	Uncharacterized protein. (597 aa)
	ADAM17	Tumor necrosis factor alpha converting enzyme. (829 aa)
	RIPK1	Uncharacterized protein. (682 aa)
	NKIRAS2	NF-kappa-B inhibitor-interacting Ras-like protein 2; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. (191 aa)
	TRAIP	RING-type domain-containing protein. (516 aa)
	GAS6	Growth arrest specific 6. (667 aa)
	LOC420294	Uncharacterized protein; Belongs to the peptidase C19 family. (787 aa)
	NR1H4	Farnesoid X receptor. (473 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (941 aa)
	SPATA2	Uncharacterized protein. (523 aa)
	APOA1	Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. (264 aa)
	BIRC7	Baculoviral IAP repeat containing 7. (409 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	APOA1	ENSGALP00000008899	ENSGALP00000011510	C1q domain-containing protein.	Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family.	0.528
ADIPOQ	NR1H4	ENSGALP00000008899	ENSGALP00000018906	C1q domain-containing protein.	Farnesoid X receptor.	0.485
APOA1	ADIPOQ	ENSGALP00000011510	ENSGALP00000008899	Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family.	C1q domain-containing protein.	0.528
BIRC7	RIPK1	ENSGALP00000009239	ENSGALP00000036418	Baculoviral IAP repeat containing 7.	Uncharacterized protein.	0.485
BIRC7	TNFRSF1A	ENSGALP00000009239	ENSGALP00000049756	Baculoviral IAP repeat containing 7.	Uncharacterized protein.	0.641
CYLD	LOC420294	ENSGALP00000016104	ENSGALP00000058598	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	Uncharacterized protein; Belongs to the peptidase C19 family.	0.903
CYLD	OTULIN	ENSGALP00000016104	ENSGALP00000067404	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	OTU deubiquitinase with linear linkage specificity.	0.613
CYLD	RIPK1	ENSGALP00000016104	ENSGALP00000036418	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	Uncharacterized protein.	0.981
CYLD	SPATA2	ENSGALP00000016104	ENSGALP00000013007	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	Uncharacterized protein.	0.911
CYLD	TNFRSF1A	ENSGALP00000016104	ENSGALP00000049756	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	Uncharacterized protein.	0.880
LOC420294	CYLD	ENSGALP00000058598	ENSGALP00000016104	Uncharacterized protein; Belongs to the peptidase C19 family.	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	0.903
LOC420294	RIPK1	ENSGALP00000058598	ENSGALP00000036418	Uncharacterized protein; Belongs to the peptidase C19 family.	Uncharacterized protein.	0.967
LOC420294	SPATA2	ENSGALP00000058598	ENSGALP00000013007	Uncharacterized protein; Belongs to the peptidase C19 family.	Uncharacterized protein.	0.910
LOC420294	TNFRSF1A	ENSGALP00000058598	ENSGALP00000049756	Uncharacterized protein; Belongs to the peptidase C19 family.	Uncharacterized protein.	0.880
NR1H4	ADIPOQ	ENSGALP00000018906	ENSGALP00000008899	Farnesoid X receptor.	C1q domain-containing protein.	0.485
OTULIN	CYLD	ENSGALP00000067404	ENSGALP00000016104	OTU deubiquitinase with linear linkage specificity.	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	0.613
PRKN	UBE2K	ENSGALP00000071728	ENSGALP00000058907	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family.	0.475
RIPK1	BIRC7	ENSGALP00000036418	ENSGALP00000009239	Uncharacterized protein.	Baculoviral IAP repeat containing 7.	0.485
RIPK1	CYLD	ENSGALP00000036418	ENSGALP00000016104	Uncharacterized protein.	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	0.981
RIPK1	LOC420294	ENSGALP00000036418	ENSGALP00000058598	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C19 family.	0.967