STRINGSTRING
AMBRA1 AMBRA1 ENSGALP00000073564 ENSGALP00000073564 VAT1 VAT1 PRKN PRKN DNM1L DNM1L BCL2L11 BCL2L11 CFAP70 CFAP70 MGARP MGARP PGAM5 PGAM5 MMP9 MMP9 TSPO TSPO RNF41 RNF41 SLC35F6 SLC35F6 MYO19 MYO19 FBXW9 FBXW9 TMEM135 TMEM135 GSK3B GSK3B LOC107051165 LOC107051165 FAM49B FAM49B MFF MFF TMEM14A TMEM14A TSPO2 TSPO2 MLLT11 MLLT11 TNFSF10 TNFSF10 BAK1 BAK1 LOC107049174 LOC107049174 MARCH5 MARCH5 PPARGC1A PPARGC1A OPA1 OPA1 MUL1 MUL1 ACAA2 ACAA2 ATP13A2 ATP13A2 STAT2 STAT2 ENSGALP00000052647 ENSGALP00000052647 HTRA2 HTRA2 RALBP1 RALBP1 GHITM GHITM HIP1R HIP1R FBXW7 FBXW7 HGF HGF PMAIP1 PMAIP1 BID BID PINK1 PINK1 DDHD2 DDHD2 FLCN FLCN VPS13D VPS13D VDAC1 VDAC1 GOLPH3 GOLPH3 TIGAR TIGAR BMF BMF PARL PARL FXN FXN SPIRE1L SPIRE1L SLC25A6 SLC25A6 SIRT7 SIRT7 LOC419074 LOC419074 GCLC GCLC HTT HTT FAM162A FAM162A KDR KDR SPIRE1 SPIRE1 SSBP1 SSBP1 IGF1 IGF1 FBXO7 FBXO7 DDHD1 DDHD1 PLA2G6 PLA2G6 MIEF1 MIEF1 EP300 EP300 OMA1 OMA1 SLC25A4 SLC25A4 BNIP3 BNIP3 ZDHHC6 ZDHHC6 SLC25A5 SLC25A5 PSMD10 PSMD10 PISD PISD MIEF2 MIEF2 PDCD5 PDCD5 VPS35 VPS35 GPER1 GPER1 RHOT1 RHOT1 PRELID1 PRELID1 RHOT2 RHOT2 STOML2 STOML2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AMBRA1Autophagy and beclin 1 regulator 1. (872 aa)
ENSGALP00000073564Uncharacterized protein. (243 aa)
VAT1Vesicle amine transport 1. (401 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (488 aa)
DNM1LUncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa)
BCL2L11BCL2 like 11. (179 aa)
CFAP70Cilia and flagella associated protein 70. (1296 aa)
MGARPMitochondria localized glutamic acid rich protein. (244 aa)
PGAM5PGAM family member 5, mitochondrial serine/threonine protein phosphatase. (352 aa)
MMP9Uncharacterized protein. (713 aa)
TSPOUncharacterized protein. (516 aa)
RNF41Ring finger protein 41. (317 aa)
SLC35F6Uncharacterized protein. (72 aa)
MYO19Myosin XIX; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (962 aa)
FBXW9F-box domain-containing protein. (337 aa)
TMEM135Transmembrane protein 135. (653 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
LOC107051165Uncharacterized protein. (230 aa)
FAM49BFamily with sequence similarity 49 member B. (324 aa)
MFFMitochondrial fission factor. (252 aa)
TMEM14ATransmembrane protein 14A. (97 aa)
TSPO2Translocator protein 2. (190 aa)
MLLT11MLLT11 transcription factor 7 cofactor. (83 aa)
TNFSF10TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (292 aa)
BAK1Uncharacterized protein. (216 aa)
LOC107049174Uncharacterized protein. (293 aa)
MARCH5E3 ubiquitin-protein ligase MARCHF5; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. (280 aa)
PPARGC1ARRM domain-containing protein. (795 aa)
OPA1Dynamin-like 120 kDa protein, mitochondrial; Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Belongs to the TRAFAC class dynamin-like GT [...] (1014 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (252 aa)
ACAA2Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (423 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1180 aa)
STAT2Signal transducer and activator of transcription. (961 aa)
ENSGALP00000052647HECT domain-containing protein. (283 aa)
HTRA2HtrA serine peptidase 2. (200 aa)
RALBP1Rho-GAP domain-containing protein. (654 aa)
GHITMUncharacterized protein; Belongs to the BI1 family. (346 aa)
HIP1RUncharacterized protein. (977 aa)
FBXW7Uncharacterized protein. (586 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (726 aa)
PMAIP1Uncharacterized protein. (54 aa)
BIDBH3-interacting domain death agonist; Induces caspases and apoptosis. Counters the protective effect of Bcl-2 (By similarity). (300 aa)
PINK1PTEN induced kinase 1. (364 aa)
DDHD2DDHD domain containing 2. (690 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4371 aa)
VDAC1Uncharacterized protein. (307 aa)
GOLPH3Uncharacterized protein. (294 aa)
TIGARTIGAR. (280 aa)
BMFUncharacterized protein. (200 aa)
PARLRhomboid domain-containing protein. (355 aa)
FXNFrataxin. (167 aa)
SPIRE1LKIND domain-containing protein. (634 aa)
SLC25A6Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
SIRT7Deacetylase sirtuin-type domain-containing protein. (399 aa)
LOC419074Uncharacterized protein. (765 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (636 aa)
HTTHuntingtin. (3095 aa)
FAM162AFamily with sequence similarity 162 member A. (151 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1348 aa)
SPIRE1Spire type actin nucleation factor 1. (841 aa)
SSBP1Uncharacterized protein. (149 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex fo [...] (153 aa)
FBXO7F-box domain-containing protein. (526 aa)
DDHD1DDHD domain containing 1. (807 aa)
PLA2G6Uncharacterized protein. (796 aa)
MIEF1Mitochondrial elongation factor 1. (464 aa)
EP300E1A binding protein p300. (2450 aa)
OMA1OMA1 zinc metallopeptidase. (564 aa)
SLC25A4Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
BNIP3BCL2 interacting protein 3. (155 aa)
ZDHHC6Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (353 aa)
SLC25A5Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (389 aa)
PSMD10ANK_REP_REGION domain-containing protein. (226 aa)
PISDPhosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. (409 aa)
MIEF2Mitochondrial elongation factor 2. (459 aa)
PDCD5Uncharacterized protein. (126 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (799 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
RHOT1Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). (618 aa)
PRELID1PRELI domain-containing protein 1, mitochondrial; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. The TRIAP1:PRELID1 complex probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (By similarity). May be involved in hematopoiesis during avian development. (215 aa)
RHOT2Mitochondrial Rho GTPase 2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). (618 aa)
STOML2Stomatin like 2. (382 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.