(41 nodes) Regulation of centrosome duplication network (Gallus gallus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (881 aa)
	KAT2A	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (804 aa)
	TRIM37	Uncharacterized protein. (983 aa)
	NUBP1	Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (323 aa)
	MDM1	Nuclear protein MDM1; Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules. Belongs to the MDM1 family. (738 aa)
	PLK4	POLO box domain-containing protein. (566 aa)
	CHMP5	Uncharacterized protein. (219 aa)
	CEP76	Centrosomal protein 76. (641 aa)
	NAT10	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1012 aa)
	GEN1	GEN1 Holliday junction 5' flap endonuclease. (941 aa)
	TMEM67	Transmembrane protein 67. (976 aa)
	FBXW5	Uncharacterized protein. (588 aa)
	XPO1	Importin N-terminal domain-containing protein. (1071 aa)
	CEP295	ALMS_motif domain-containing protein. (1947 aa)
	ENSGALP00000050074	Uncharacterized protein. (685 aa)
	ENSGALP00000050097	Protein kinase domain-containing protein. (109 aa)
	CCNF	Cyclin F; Belongs to the cyclin family. (750 aa)
	CDK5RAP2	Uncharacterized protein. (751 aa)
	RBM14	RNA binding motif protein 14. (750 aa)
	PDCD6IP	BRO1 domain-containing protein. (887 aa)
	KAT2B	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (808 aa)
	CHORDC1	Cysteine and histidine-rich domain-containing protein 1; Regulates centrosome duplication. (331 aa)
	NPM1	Nucleophosmin; Acts as a chaperonin for the core histones H3, H2B and H4. Associated with nucleolar ribonucleoprotein structures and bind single- stranded nucleic acids. It may function in the assembly and/or transport of ribosome. May stimulate endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA. May inhibit endonuclease activity on AP single-stranded RNA (By similarity). Belongs to the nucleoplasmin family. (404 aa)
	XRCC3	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (382 aa)
	ALMS1	ALMS_motif domain-containing protein. (2862 aa)
	CCDC84	Coiled-coil domain containing 84. (306 aa)
	SPICE1	Uncharacterized protein. (886 aa)
	C6H10ORF90	Centro_C10orf90 domain-containing protein. (603 aa)
	ROCK2	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1483 aa)
	ENSGALP00000066589	Uncharacterized protein. (349 aa)
	PKHD1	Uncharacterized protein. (551 aa)
	CEP120	Centrosomal protein 120. (1006 aa)
	ENSGALP00000069823	Uncharacterized protein. (167 aa)
	NPM2	Nucleophosmin/nucleoplasmin 2. (250 aa)
	ENSGALP00000071132	Uncharacterized protein. (386 aa)
	ENSGALP00000072166	IPT/TIG domain-containing protein. (239 aa)
	ENSGALP00000073167	Cnn_1N domain-containing protein. (48 aa)
	STIL	STIL centriolar assembly protein. (1330 aa)
	CEP131	Centrosomal protein 131. (1161 aa)
	ENSGALP00000074151	annotation not available (66 aa)
	ENSGALP00000074194	Uncharacterized protein. (401 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK5RAP2	ENSGALP00000050074	ENSGALP00000052204	ENSGALP00000050074	Uncharacterized protein.	Uncharacterized protein.	0.932
CEP120	CEP131	ENSGALP00000068100	ENSGALP00000073853	Centrosomal protein 120.	Centrosomal protein 131.	0.400
CEP120	CEP76	ENSGALP00000068100	ENSGALP00000022439	Centrosomal protein 120.	Centrosomal protein 76.	0.589
CEP120	PLK4	ENSGALP00000068100	ENSGALP00000016553	Centrosomal protein 120.	POLO box domain-containing protein.	0.754
CEP120	SPICE1	ENSGALP00000068100	ENSGALP00000063577	Centrosomal protein 120.	Uncharacterized protein.	0.929
CEP120	STIL	ENSGALP00000068100	ENSGALP00000073567	Centrosomal protein 120.	STIL centriolar assembly protein.	0.600
CEP131	CEP120	ENSGALP00000073853	ENSGALP00000068100	Centrosomal protein 131.	Centrosomal protein 120.	0.400
CEP131	PLK4	ENSGALP00000073853	ENSGALP00000016553	Centrosomal protein 131.	POLO box domain-containing protein.	0.692
CEP131	SPICE1	ENSGALP00000073853	ENSGALP00000063577	Centrosomal protein 131.	Uncharacterized protein.	0.429
CEP76	CEP120	ENSGALP00000022439	ENSGALP00000068100	Centrosomal protein 76.	Centrosomal protein 120.	0.589
CEP76	MDM1	ENSGALP00000022439	ENSGALP00000016111	Centrosomal protein 76.	Nuclear protein MDM1; Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules. Belongs to the MDM1 family.	0.426
CEP76	PLK4	ENSGALP00000022439	ENSGALP00000016553	Centrosomal protein 76.	POLO box domain-containing protein.	0.755
CEP76	RBM14	ENSGALP00000022439	ENSGALP00000052291	Centrosomal protein 76.	RNA binding motif protein 14.	0.483
CEP76	STIL	ENSGALP00000022439	ENSGALP00000073567	Centrosomal protein 76.	STIL centriolar assembly protein.	0.715
CEP76	TRIM37	ENSGALP00000022439	ENSGALP00000008139	Centrosomal protein 76.	Uncharacterized protein.	0.474
CHMP5	PDCD6IP	ENSGALP00000021459	ENSGALP00000053723	Uncharacterized protein.	BRO1 domain-containing protein.	0.607
ENSGALP00000050074	CDK5RAP2	ENSGALP00000050074	ENSGALP00000052204	Uncharacterized protein.	Uncharacterized protein.	0.932
ENSGALP00000050097	PLK4	ENSGALP00000050097	ENSGALP00000016553	Protein kinase domain-containing protein.	POLO box domain-containing protein.	0.900
ENSGALP00000050097	STIL	ENSGALP00000050097	ENSGALP00000073567	Protein kinase domain-containing protein.	STIL centriolar assembly protein.	0.814
ENSGALP00000066589	ENSGALP00000069823	ENSGALP00000066589	ENSGALP00000069823	Uncharacterized protein.	Uncharacterized protein.	0.808