(24 nodes) Regulation of lipid storage network (Gallus gallus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

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protein homology

Your Input:
	NR1H3	Uncharacterized protein. (519 aa)
	FITM2	Fat storage inducing transmembrane protein 2. (396 aa)
	PPARD	Uncharacterized protein. (545 aa)
	PNPLA3	Patatin like phospholipase domain containing 3. (543 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (498 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (503 aa)
	PLIN2	Perilipin; Belongs to the perilipin family. (446 aa)
	SREBF2	Sterol regulatory element binding transcription factor 2. (1112 aa)
	ABHD4	AB hydrolase-1 domain-containing protein. (385 aa)
	PPARA	Uncharacterized protein. (468 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (890 aa)
	VSTM2B	V-set and transmembrane domain containing 2B. (279 aa)
	VSTM2A	V-set and transmembrane domain containing 2A. (236 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (681 aa)
	SREBF1	BHLH domain-containing protein. (1116 aa)
	PLA2G10	Phospholipase A(2). (155 aa)
	PLA2G10L	Phospholipase A(2). (158 aa)
	PNPLA2	PNPLA2/ATGL. (483 aa)
	PTPN2	Uncharacterized protein. (597 aa)
	SLC35F5	Solute carrier family 35 member F5. (505 aa)
	TTC39A	Tetratricopeptide repeat domain 39A. (576 aa)
	TTC39B	Tetratricopeptide repeat domain 39B. (554 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (881 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (781 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD4	PLIN2	ENSGALP00000053319	ENSGALP00000063487	AB hydrolase-1 domain-containing protein.	Perilipin; Belongs to the perilipin family.	0.793
ABHD4	PNPLA2	ENSGALP00000053319	ENSGALP00000023449	AB hydrolase-1 domain-containing protein.	PNPLA2/ATGL.	0.946
ABHD4	PNPLA3	ENSGALP00000053319	ENSGALP00000069032	AB hydrolase-1 domain-containing protein.	Patatin like phospholipase domain containing 3.	0.776
ABHD4	PPARA	ENSGALP00000053319	ENSGALP00000053048	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.432
ABHD4	PPARG	ENSGALP00000053319	ENSGALP00000067699	AB hydrolase-1 domain-containing protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.458
FITM2	PLIN2	ENSGALP00000072936	ENSGALP00000063487	Fat storage inducing transmembrane protein 2.	Perilipin; Belongs to the perilipin family.	0.517
FITM2	PNPLA3	ENSGALP00000072936	ENSGALP00000069032	Fat storage inducing transmembrane protein 2.	Patatin like phospholipase domain containing 3.	0.494
NR1H3	PPARA	ENSGALP00000073715	ENSGALP00000053048	Uncharacterized protein.	Uncharacterized protein.	0.551
NR1H3	PPARG	ENSGALP00000073715	ENSGALP00000067699	Uncharacterized protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.529
NR1H3	SIRT1	ENSGALP00000073715	ENSGALP00000004350	Uncharacterized protein.	Deacetylase sirtuin-type domain-containing protein.	0.481
NR1H3	SREBF1	ENSGALP00000073715	ENSGALP00000043197	Uncharacterized protein.	BHLH domain-containing protein.	0.746
NR1H3	SREBF2	ENSGALP00000073715	ENSGALP00000057563	Uncharacterized protein.	Sterol regulatory element binding transcription factor 2.	0.481
PLIN2	ABHD4	ENSGALP00000063487	ENSGALP00000053319	Perilipin; Belongs to the perilipin family.	AB hydrolase-1 domain-containing protein.	0.793
PLIN2	FITM2	ENSGALP00000063487	ENSGALP00000072936	Perilipin; Belongs to the perilipin family.	Fat storage inducing transmembrane protein 2.	0.517
PLIN2	PNPLA2	ENSGALP00000063487	ENSGALP00000023449	Perilipin; Belongs to the perilipin family.	PNPLA2/ATGL.	0.723
PLIN2	PNPLA3	ENSGALP00000063487	ENSGALP00000069032	Perilipin; Belongs to the perilipin family.	Patatin like phospholipase domain containing 3.	0.586
PLIN2	PPARA	ENSGALP00000063487	ENSGALP00000053048	Perilipin; Belongs to the perilipin family.	Uncharacterized protein.	0.538
PLIN2	PPARG	ENSGALP00000063487	ENSGALP00000067699	Perilipin; Belongs to the perilipin family.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.795
PLIN2	SREBF1	ENSGALP00000063487	ENSGALP00000043197	Perilipin; Belongs to the perilipin family.	BHLH domain-containing protein.	0.597
PLIN2	SREBF2	ENSGALP00000063487	ENSGALP00000057563	Perilipin; Belongs to the perilipin family.	Sterol regulatory element binding transcription factor 2.	0.499