(12 nodes) Negative regulation of lipid storage network (Gallus gallus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (781 aa)
	TTC39B	Tetratricopeptide repeat domain 39B. (554 aa)
	TTC39A	Tetratricopeptide repeat domain 39A. (576 aa)
	PTPN2	Uncharacterized protein. (597 aa)
	PNPLA2	PNPLA2/ATGL. (483 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (890 aa)
	PPARA	Uncharacterized protein. (468 aa)
	ABHD4	AB hydrolase-1 domain-containing protein. (385 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (498 aa)
	PNPLA3	Patatin like phospholipase domain containing 3. (543 aa)
	PPARD	Uncharacterized protein. (545 aa)
	NR1H3	Uncharacterized protein. (519 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD4	PNPLA2	ENSGALP00000053319	ENSGALP00000023449	AB hydrolase-1 domain-containing protein.	PNPLA2/ATGL.	0.946
ABHD4	PNPLA3	ENSGALP00000053319	ENSGALP00000069032	AB hydrolase-1 domain-containing protein.	Patatin like phospholipase domain containing 3.	0.776
ABHD4	PPARA	ENSGALP00000053319	ENSGALP00000053048	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.432
ABHD4	PPARG	ENSGALP00000053319	ENSGALP00000067699	AB hydrolase-1 domain-containing protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.458
NR1H3	PPARA	ENSGALP00000073715	ENSGALP00000053048	Uncharacterized protein.	Uncharacterized protein.	0.551
NR1H3	PPARG	ENSGALP00000073715	ENSGALP00000067699	Uncharacterized protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.529
PNPLA2	ABHD4	ENSGALP00000023449	ENSGALP00000053319	PNPLA2/ATGL.	AB hydrolase-1 domain-containing protein.	0.946
PNPLA2	PNPLA3	ENSGALP00000023449	ENSGALP00000069032	PNPLA2/ATGL.	Patatin like phospholipase domain containing 3.	0.908
PNPLA2	PPARA	ENSGALP00000023449	ENSGALP00000053048	PNPLA2/ATGL.	Uncharacterized protein.	0.639
PNPLA2	PPARD	ENSGALP00000023449	ENSGALP00000072840	PNPLA2/ATGL.	Uncharacterized protein.	0.451
PNPLA2	PPARG	ENSGALP00000023449	ENSGALP00000067699	PNPLA2/ATGL.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.729
PNPLA2	TTC39B	ENSGALP00000023449	ENSGALP00000008685	PNPLA2/ATGL.	Tetratricopeptide repeat domain 39B.	0.567
PNPLA3	ABHD4	ENSGALP00000069032	ENSGALP00000053319	Patatin like phospholipase domain containing 3.	AB hydrolase-1 domain-containing protein.	0.776
PNPLA3	PNPLA2	ENSGALP00000069032	ENSGALP00000023449	Patatin like phospholipase domain containing 3.	PNPLA2/ATGL.	0.908
PNPLA3	PPARA	ENSGALP00000069032	ENSGALP00000053048	Patatin like phospholipase domain containing 3.	Uncharacterized protein.	0.512
PNPLA3	PPARG	ENSGALP00000069032	ENSGALP00000067699	Patatin like phospholipase domain containing 3.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.490
PPARA	ABHD4	ENSGALP00000053048	ENSGALP00000053319	Uncharacterized protein.	AB hydrolase-1 domain-containing protein.	0.432
PPARA	NR1H3	ENSGALP00000053048	ENSGALP00000073715	Uncharacterized protein.	Uncharacterized protein.	0.551
PPARA	PNPLA2	ENSGALP00000053048	ENSGALP00000023449	Uncharacterized protein.	PNPLA2/ATGL.	0.639
PPARA	PNPLA3	ENSGALP00000053048	ENSGALP00000069032	Uncharacterized protein.	Patatin like phospholipase domain containing 3.	0.512