STRINGSTRING
CAV1 CAV1 LCK LCK CASP9 CASP9 CARD9 CARD9 APH1B APH1B PCOLCE2 PCOLCE2 SIRT1 SIRT1 PRELID1 PRELID1 FASLG FASLG FN1 FN1 CYFIP2 CYFIP2 AIFM1 AIFM1 GPER1 GPER1 DIABLO DIABLO PDCD5 PDCD5 F3 F3 MUL1L MUL1L CTSD CTSD CLPX CLPX FADD FADD HSPD1 HSPD1 PSME4 PSME4 CFLAR CFLAR CAV3 CAV3 CASP8 CASP8 CYR61 CYR61 NCSTN NCSTN LGMN LGMN CYCS CYCS PSMD14 PSMD14 DAP DAP FBLN1 FBLN1 FAM162A FAM162A ACER2 ACER2 IFT57 IFT57 CASP8AP2 CASP8AP2 AKIRIN2 AKIRIN2 EIF2AK3 EIF2AK3 DDRGK1 DDRGK1 CTSC CTSC RPS3 RPS3 CASP2 CASP2 WDR48 WDR48 APAF1 APAF1 FAS FAS TNFSF15 TNFSF15 TFAP4 TFAP4 ADRM1 ADRM1 ASPH-2 ASPH-2 ASPH ASPH ST18 ST18 ENSGALP00000045724 ENSGALP00000045724 MALT1 MALT1 RIPK2 RIPK2 LYN LYN ENSGALP00000047627 ENSGALP00000047627 C6H10orf54 C6H10orf54 BID BID PMAIP1 PMAIP1 HIP1R HIP1R UACA UACA PRR7 PRR7 CTSH CTSH ARL6IP5 ARL6IP5 HTRA2 HTRA2 HIP1 HIP1 PCASP3 PCASP3 MUL1 MUL1 GRN GRN CLDN9 CLDN9 BAK1 BAK1 LAPTM5 LAPTM5 GRAMD4 GRAMD4 SOX7 SOX7 PCASP2 PCASP2 TNFSF10 TNFSF10 PSME3 PSME3 CASP10 CASP10 PMLL PMLL CASP18 CASP18 ROCK2 ROCK2 ACVR1C ACVR1C APH1A APH1A REST REST TTBK1 TTBK1 ENSGALP00000068079 ENSGALP00000068079 TANK TANK ENSGALP00000069448 ENSGALP00000069448 BCL2L11 BCL2L11 RIPK3 RIPK3 USP50 USP50 LRRC27 LRRC27 MYC MYC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CAV1Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). (178 aa)
LCKProto-oncogene tyrosine-protein kinase LCK; Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways (By similarity); Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. (508 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (418 aa)
CARD9Caspase recruitment domain family member 9. (574 aa)
APH1BUncharacterized protein. (256 aa)
PCOLCE2Procollagen C-endopeptidase enhancer 2. (408 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (881 aa)
PRELID1PRELI domain-containing protein 1, mitochondrial; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. The TRIAP1:PRELID1 complex probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (By similarity). May be involved in hematopoiesis during avian development. (215 aa)
FASLGTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (295 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity). (2526 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
AIFM1Uncharacterized protein. (689 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
DIABLOUncharacterized protein. (240 aa)
PDCD5Uncharacterized protein. (126 aa)
F3Coagulation factor III, tissue factor. (283 aa)
MUL1LRING-type domain-containing protein. (418 aa)
CTSDCathepsin D heavy chain; Acid protease active in intracellular protein breakdown. In chicken it is a key enzyme for yolk formation as it is capable of catalyzing intra oocytic break down of protein components of both vitellogenin and VLDL. (398 aa)
CLPXUncharacterized protein. (630 aa)
FADDFas associated via death domain. (195 aa)
HSPD160 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per rin [...] (573 aa)
PSME4Uncharacterized protein. (1821 aa)
CFLARUncharacterized protein; Belongs to the peptidase C14A family. (493 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
CYR61CCN family member 1; Probable secreted regulatory protein. (375 aa)
NCSTNNcstrn_small domain-containing protein. (717 aa)
LGMNLegumain. (431 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PSMD14MPN domain-containing protein. (310 aa)
DAPDeath associated protein 1. (104 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes; Belongs to the fibulin family. (704 aa)
FAM162AFamily with sequence similarity 162 member A. (151 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
IFT57Intraflagellar transport 57. (532 aa)
CASP8AP2Caspase 8 associated protein 2. (2028 aa)
AKIRIN2Akirin. (191 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1085 aa)
DDRGK1DDRGK domain containing 1. (221 aa)
CTSCPept_C1 domain-containing protein; Belongs to the peptidase C1 family. (532 aa)
RPS3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
CASP2Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. (441 aa)
WDR48WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. (678 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
FASUncharacterized protein. (339 aa)
TNFSF15TL1A. (239 aa)
TFAP4Transcription factor AP-4. (338 aa)
ADRM1Proteasomal ubiquitin receptor ADRM1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engag [...] (405 aa)
ASPH-2Asp-B-Hydro_N domain-containing protein. (350 aa)
ASPHAspartate beta-hydroxylase. (295 aa)
ST18ST18 C2H2C-type zinc finger transcription factor. (1144 aa)
ENSGALP00000045724Uncharacterized protein. (235 aa)
MALT1MALT1 paracaspase. (816 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (574 aa)
LYNTyrosine-protein kinase. (491 aa)
ENSGALP00000047627Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (101 aa)
C6H10orf54Ig-like domain-containing protein. (310 aa)
BIDBH3-interacting domain death agonist; Induces caspases and apoptosis. Counters the protective effect of Bcl-2 (By similarity). (300 aa)
PMAIP1Uncharacterized protein. (54 aa)
HIP1RUncharacterized protein. (977 aa)
UACAUveal autoantigen with coiled-coil domains and ankyrin repeats. (1402 aa)
PRR7Proline rich 7, synaptic. (231 aa)
CTSHUncharacterized protein; Belongs to the peptidase C1 family. (403 aa)
ARL6IP5PRA1 family protein 3; Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity- dependent manner. May be involved in membrane traffic. (187 aa)
HTRA2HtrA serine peptidase 2. (200 aa)
HIP1Huntingtin interacting protein 1. (1008 aa)
PCASP3Uncharacterized protein. (632 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (252 aa)
GRNUncharacterized protein. (287 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (214 aa)
BAK1Uncharacterized protein. (216 aa)
LAPTM5Lysosomal protein transmembrane 5. (256 aa)
GRAMD4GRAM domain containing 4. (568 aa)
SOX7Uncharacterized protein. (377 aa)
PCASP2Uncharacterized protein. (741 aa)
TNFSF10TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (292 aa)
PSME3Proteasome activator complex subunit 3; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity). (421 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (455 aa)
PMLLUncharacterized protein. (464 aa)
CASP18Initiator caspase; Belongs to the peptidase C14A family. (464 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1483 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (495 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (311 aa)
RESTUncharacterized protein. (339 aa)
TTBK1Protein kinase domain-containing protein. (1419 aa)
ENSGALP00000068079Ephrin RBD domain-containing protein; Belongs to the ephrin family. (286 aa)
TANKTBD domain-containing protein. (422 aa)
ENSGALP00000069448Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (409 aa)
BCL2L11BCL2 like 11. (179 aa)
RIPK3Uncharacterized protein. (424 aa)
USP50UCH domain-containing protein. (115 aa)
LRRC27Death domain-containing protein. (291 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (429 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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