STRINGSTRING
DLX2 DLX2 GFAP GFAP TP73 TP73 SKI SKI NOTCH1 NOTCH1 LINGO1 LINGO1 MTOR MTOR DLX1 DLX1 ASPA ASPA SERPINE2 SERPINE2 SOX8 SOX8 ABCC8 ABCC8 F2 F2 SPINT1 SPINT1 VEGFC VEGFC NKX6-2 NKX6-2 IL6ST IL6ST NF2 NF2 DAAM2 DAAM2 NTN1 NTN1 IL34 IL34 SYNJ1 SYNJ1 WNT2 WNT2 SIRT2 SIRT2 WNT2B WNT2B CTNNB1 CTNNB1 LYN LYN OLIG2 OLIG2 GSX2 GSX2 IL1B IL1B TENM4 TENM4 SLC7A5 SLC7A5 TGFB1 TGFB1 PTPRZ1 PTPRZ1 TNFRSF1B TNFRSF1B TMEM98 TMEM98 NKX6-1 NKX6-1 RNF10 RNF10 HDAC1 HDAC1 ENSGALP00000060823 ENSGALP00000060823 CLCF1 CLCF1 PLAG1 PLAG1 DAAM1 DAAM1 IL6 IL6 NR1D1 NR1D1 MECP2 MECP2 RB1 RB1 NF2L NF2L ZNF365 ZNF365
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLX2Distal-less homeobox 2. (253 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (422 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (660 aa)
SKISki oncogene; May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. May function in TGF-beta signaling (By similarity). (750 aa)
NOTCH1Uncharacterized protein. (2561 aa)
LINGO1Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity). (558 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
DLX1Homeodomain transcription factor DLX1. (255 aa)
ASPAAspartoacylase. (361 aa)
SERPINE2SERPIN domain-containing protein; Belongs to the serpin family. (442 aa)
SOX8Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. (470 aa)
ABCC8ATP binding cassette subfamily C member 8. (1595 aa)
F2Uncharacterized protein; Belongs to the peptidase S1 family. (644 aa)
SPINT1Uncharacterized protein. (509 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (586 aa)
NKX6-2Homeobox domain-containing protein. (364 aa)
IL6STGlycoprotein 130. (918 aa)
NF2FERM domain-containing protein. (595 aa)
DAAM2Disheveled-associated activator of morphogenesis 2; Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal [...] (1187 aa)
NTN1Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors. (688 aa)
IL34Interleukin 34. (178 aa)
SYNJ1Synaptojanin 1. (1536 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
SIRT2Deacetylase sirtuin-type domain-containing protein. (485 aa)
WNT2BProtein Wnt-2b; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Acts as an upstream regulator of FGF10 in the lateral plate mesoderm during limb initiation in the embryo. (385 aa)
CTNNB1Uncharacterized protein. (781 aa)
LYNTyrosine-protein kinase. (491 aa)
OLIG2Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord. (298 aa)
GSX2GS homeobox 2. (263 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
TENM4Uncharacterized protein. (2766 aa)
SLC7A5Large neutral amino acids transporter small subunit 1. (526 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (392 aa)
PTPRZ1Protein-tyrosine-phosphatase. (2343 aa)
TNFRSF1BUncharacterized protein. (462 aa)
TMEM98Transmembrane protein 98. (222 aa)
NKX6-1NK6 homeobox 1. (272 aa)
RNF10Ring finger protein 10. (803 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. (480 aa)
ENSGALP00000060823Ig-like domain-containing protein. (511 aa)
CLCF1Cardiotrophin like cytokine factor 1. (356 aa)
PLAG1Zinc finger protein PLAG1; Transcription factor and proto-oncogene whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation. (501 aa)
DAAM1Uncharacterized protein. (1100 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (678 aa)
MECP2Methyl-CpG binding protein 2. (208 aa)
RB1Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa)
NF2LFERM domain-containing protein. (648 aa)
ZNF365Uncharacterized protein. (403 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (18%) [HD]