STRINGSTRING
HSP90B1 HSP90B1 CYP1C1 CYP1C1 ATF1 ATF1 CACNA1S CACNA1S HCN3 HCN3 NDUFS4 NDUFS4 P2RX2 P2RX2 AQP8 AQP8 LOC112530475 LOC112530475 DMTN DMTN AKAP7 AKAP7 RAPGEF3 RAPGEF3 ABCC9 ABCC9 RAPGEF1 RAPGEF1 P2RY6 P2RY6 RAP1B RAP1B PCK2 PCK2 KCNQ1 KCNQ1 HCN2 HCN2 RAP1A RAP1A AANAT AANAT DGKQ DGKQ XRN1 XRN1 INPP5K INPP5K P2RX7 P2RX7 P2RX4 P2RX4 P2RX5 P2RX5 AQP1 AQP1 TRPM2 TRPM2 EEF2K EEF2K PCK1 PCK1 PIK3CG PIK3CG CREB1 CREB1 AKAP6 AKAP6 P2RY1 P2RY1 AREG AREG WT1 WT1 EZR EZR F1NA95_CHICK F1NA95_CHICK HCN1 HCN1 CRHBP CRHBP NT5E NT5E SLC26A3 SLC26A3 KCNJ11 KCNJ11 P2RX1 P2RX1 CASQ2 CASQ2 IGFBP5 IGFBP5 TMEM38B TMEM38B P2RX6 P2RX6 SLC26A6 SLC26A6 PANX1 PANX1 CIB2 CIB2 SLC6A1 SLC6A1 KDM1A KDM1A CYP1B1 CYP1B1 PKD2 PKD2 BCKDHB BCKDHB RYR2 RYR2 CFTR CFTR RYR3 RYR3 RAPGEF2 RAPGEF2 DUOX2 DUOX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HSP90B1Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). Has ATPase activity (By similarity). (795 aa)
CYP1C1Uncharacterized protein; Belongs to the cytochrome P450 family. (516 aa)
ATF1Activating transcription factor 1. (289 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha-1S; Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. (1887 aa)
HCN3Cyclic nucleotide-binding domain-containing protein. (821 aa)
NDUFS4NADH:ubiquinone oxidoreductase subunit S4. (294 aa)
P2RX2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (507 aa)
AQP8Aquaporin 8; Belongs to the MIP/aquaporin (TC 1.A.8) family. (253 aa)
LOC112530475B30.2/SPRY domain-containing protein. (311 aa)
DMTNAbLIM_anchor domain-containing protein. (687 aa)
AKAP7A-kinase anchoring protein 7. (468 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (1050 aa)
ABCC9ATP binding cassette subfamily C member 9. (1558 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1225 aa)
P2RY6P2Y purinoceptor 3; Receptor for extracellular ADP > UTP > ATP = UDP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (328 aa)
RAP1BRas-related protein Rap-1b. (268 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Facilitates the recycling of lactate carbon in the liver. (414 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (863 aa)
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (906 aa)
RAP1ARas-related protein Rap-1b; Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
AANATSerotonin N-acetyltransferase; Catalyzes the N-acetylation of serotonin into N- acetylserotonin; Belongs to the acetyltransferase family. AANAT subfamily. (205 aa)
DGKQDiacylglycerol kinase. (904 aa)
XRN15'-3' exoribonuclease 1. (1770 aa)
INPP5KIPPc domain-containing protein. (465 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (574 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (385 aa)
P2RX5P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (402 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (270 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1508 aa)
EEF2KEukaryotic elongation factor 2 kinase. (742 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate; Belongs to the phosphoenolpyruvate carboxykinase [...] (622 aa)
PIK3CGUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1106 aa)
CREB1cAMP response element-binding protein. (327 aa)
AKAP6A-kinase anchoring protein 6. (2342 aa)
P2RY1P2Y purinoceptor 1; Receptor for extracellular adenine nucleotides such as ADP. In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (By similarity). (362 aa)
AREGAmphiregulin. (210 aa)
WT1Uncharacterized protein. (417 aa)
EZREzrin. (585 aa)
F1NA95_CHICKAKAP7_NLS domain-containing protein. (256 aa)
HCN1Hyperpolarization activated cyclic nucleotide gated potassium channel 1. (846 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (345 aa)
NT5E5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (561 aa)
SLC26A3Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (754 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (397 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (392 aa)
CASQ2Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. (406 aa)
IGFBP5Insulin like growth factor binding protein 5. (269 aa)
TMEM38BTransmembrane protein 38B. (287 aa)
P2RX6Purinergic receptor P2X 6. (268 aa)
SLC26A6STAS domain-containing protein. (752 aa)
PANX1Pannexin; Structural component of the gap junctions and the hemichannels. (433 aa)
CIB2Uncharacterized protein. (203 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (598 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (826 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (536 aa)
PKD2Uncharacterized protein. (881 aa)
BCKDHBTransket_pyr domain-containing protein. (390 aa)
RYR2Ryanodine receptor 2. (4957 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa)
RYR3Uncharacterized protein. (4862 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1652 aa)
DUOX2Dual oxidase 2. (1533 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: medium (58%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.