(36 nodes) Inclusion body network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RANGAP1	RanGAP1_C domain-containing protein. (579 aa)
	ENSGALP00000072532	Uncharacterized protein. (463 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (488 aa)
	SLF1	SMC5-SMC6 complex localization factor 1. (981 aa)
	PSEN1	Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa)
	PRDM16	PR/SET domain 16. (1266 aa)
	ATXN1	Ataxin 1. (798 aa)
	ATXN3L	Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (By similarity). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By [...] (375 aa)
	WDFY3	WD repeat and FYVE domain containing 3. (3531 aa)
	ENSGALP00000059185	Uncharacterized protein. (1062 aa)
	NUP153	Nucleoporin 153. (1455 aa)
	BAG5	BAG family molecular chaperone regulator 5; May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. (450 aa)
	NBN	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recr [...] (753 aa)
	KLHL14	Kelch-like protein 14. (622 aa)
	HOXC9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (262 aa)
	TPR	Translocated promoter region, nuclear basket protein. (2472 aa)
	SQSTM1	Sequestosome 1. (453 aa)
	LRRK2	Uncharacterized protein. (2557 aa)
	ARIH1	RBR-type E3 ubiquitin transferase. (552 aa)
	AGL	Amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase. (1530 aa)
	NUP98	Nucleoporin 98. (1772 aa)
	FGR	Proto-oncogene tyrosine-protein kinase Yrk; May participate in signaling pathways; Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. (536 aa)
	SNCB	Beta-synuclein; Belongs to the synuclein family. (272 aa)
	HSPB7	Heat shock protein family B (small) member 7; Belongs to the small heat shock protein (HSP20) family. (150 aa)
	HOXD3	Homeobox D3. (413 aa)
	ATF4	ATF4. (354 aa)
	HTT	Huntingtin. (3095 aa)
	FBXO7	F-box domain-containing protein. (526 aa)
	URB2	URB2 ribosome biogenesis homolog. (1543 aa)
	SFMBT2	Scm like with four mbt domains 2. (844 aa)
	XRN2	5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II (By similarity). Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. (949 aa)
	RAD18	Uncharacterized protein. (672 aa)
	EDEM1	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (616 aa)
	RNF32	Ring finger protein 32. (350 aa)
	TRIM37	Uncharacterized protein. (983 aa)
	HERPUD1	Homocysteine inducible ER protein with ubiquitin like domain 1. (401 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARIH1	PRKN	ENSGALP00000052127	ENSGALP00000071728	RBR-type E3 ubiquitin transferase.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.500
ATF4	EDEM1	ENSGALP00000037099	ENSGALP00000013528	ATF4.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.439
ATF4	HERPUD1	ENSGALP00000037099	ENSGALP00000001850	ATF4.	Homocysteine inducible ER protein with ubiquitin like domain 1.	0.616
ATXN1	ATXN3L	ENSGALP00000068564	ENSGALP00000068123	Ataxin 1.	Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (By similarity). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By [...]	0.803
ATXN1	HTT	ENSGALP00000068564	ENSGALP00000025163	Ataxin 1.	Huntingtin.	0.800
ATXN3L	ATXN1	ENSGALP00000068123	ENSGALP00000068564	Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (By similarity). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By [...]	Ataxin 1.	0.803
ATXN3L	HTT	ENSGALP00000068123	ENSGALP00000025163	Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (By similarity). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By [...]	Huntingtin.	0.895
ATXN3L	PRKN	ENSGALP00000068123	ENSGALP00000071728	Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (By similarity). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By [...]	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.980
BAG5	PRKN	ENSGALP00000057492	ENSGALP00000071728	BAG family molecular chaperone regulator 5; May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.428
BAG5	SQSTM1	ENSGALP00000057492	ENSGALP00000053754	BAG family molecular chaperone regulator 5; May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.	Sequestosome 1.	0.453
EDEM1	ATF4	ENSGALP00000013528	ENSGALP00000037099	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	ATF4.	0.439
EDEM1	HERPUD1	ENSGALP00000013528	ENSGALP00000001850	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Homocysteine inducible ER protein with ubiquitin like domain 1.	0.487
ENSGALP00000059185	NUP153	ENSGALP00000059185	ENSGALP00000057748	Uncharacterized protein.	Nucleoporin 153.	0.649
ENSGALP00000059185	NUP98	ENSGALP00000059185	ENSGALP00000050065	Uncharacterized protein.	Nucleoporin 98.	0.883
ENSGALP00000059185	RANGAP1	ENSGALP00000059185	ENSGALP00000019492	Uncharacterized protein.	RanGAP1_C domain-containing protein.	0.917
ENSGALP00000059185	TPR	ENSGALP00000059185	ENSGALP00000054116	Uncharacterized protein.	Translocated promoter region, nuclear basket protein.	0.523
ENSGALP00000072532	NUP153	ENSGALP00000072532	ENSGALP00000057748	Uncharacterized protein.	Nucleoporin 153.	0.649
ENSGALP00000072532	NUP98	ENSGALP00000072532	ENSGALP00000050065	Uncharacterized protein.	Nucleoporin 98.	0.883
ENSGALP00000072532	RANGAP1	ENSGALP00000072532	ENSGALP00000019492	Uncharacterized protein.	RanGAP1_C domain-containing protein.	0.917
ENSGALP00000072532	TPR	ENSGALP00000072532	ENSGALP00000054116	Uncharacterized protein.	Translocated promoter region, nuclear basket protein.	0.523