Your Input: | |||||
| LOC776719 | Uncharacterized protein. (671 aa) | ||||
| CD44 | Link domain-containing protein. (696 aa) | ||||
| SLC19A1 | Uncharacterized protein. (496 aa) | ||||
| IL6R | Uncharacterized protein. (445 aa) | ||||
| SLC4A11 | Solute carrier family 4 member 11. (867 aa) | ||||
| SLC2A13 | Solute carrier family 2 member 13; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (620 aa) | ||||
| PSEN2 | Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] (455 aa) | ||||
| ENSGALP00000059634 | Uncharacterized protein. (221 aa) | ||||
| RAB18 | Ras-related protein Rab-18; Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration (By similarity). (206 aa) | ||||
| P2RX2 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (507 aa) | ||||
| VSIG10L | Ig-like domain-containing protein. (433 aa) | ||||
| STXBP3 | Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (601 aa) | ||||
| SHROOM1 | Uncharacterized protein. (1313 aa) | ||||
| CIB3 | Calcium and integrin binding family member 3. (185 aa) | ||||
| SLC26A4 | Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (816 aa) | ||||
| SCNN1D | Sodium channel epithelial 1 delta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (640 aa) | ||||
| ENSGALP00000065672 | Uncharacterized protein. (283 aa) | ||||
| MPDZ | Uncharacterized protein. (2106 aa) | ||||
| SLC6A6 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (708 aa) | ||||
| PARD3B | Par-3 family cell polarity regulator beta. (1201 aa) | ||||
| SLC9A3R1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. May enhance Wnt signaling (By similarity). (366 aa) | ||||
| MYO1A | Unconventional myosin-Ia; Could play an important role in morphogenesis and function of intestinal microvilli; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1257 aa) | ||||
| ENSGALP00000066589 | Uncharacterized protein. (349 aa) | ||||
| EMP2 | Epithelial membrane protein 2. (167 aa) | ||||
| DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (893 aa) | ||||
| C20orf27 | Calponin-homology (CH) domain-containing protein. (740 aa) | ||||
| SHROOM3 | Shroom family member 3. (1997 aa) | ||||
| PKHD1 | Uncharacterized protein. (551 aa) | ||||
| ENSGALP00000067896 | Uncharacterized protein. (105 aa) | ||||
| ENSGALP00000068033 | Uncharacterized protein. (527 aa) | ||||
| AKAP7 | A-kinase anchoring protein 7. (468 aa) | ||||
| LOC107049680 | ATP-synt_ab domain-containing protein. (721 aa) | ||||
| CD36 | Uncharacterized protein; Belongs to the CD36 family. (471 aa) | ||||
| CFAP126 | Cilia and flagella associated protein 126. (195 aa) | ||||
| HAX1 | HCLS1 associated protein X-1. (315 aa) | ||||
| PSEN1 | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa) | ||||
| ENSGALP00000069823 | Uncharacterized protein. (167 aa) | ||||
| ENSGALP00000070136 | Uncharacterized protein. (121 aa) | ||||
| ATP6V1A | V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity. Belongs to the ATPase alpha/beta chains family. (617 aa) | ||||
| ADCY10L11 | Uncharacterized protein. (298 aa) | ||||
| PROM1L | Uncharacterized protein. (788 aa) | ||||
| ENSGALP00000071132 | Uncharacterized protein. (386 aa) | ||||
| ITPK1 | Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. May also act as an isomerase that interconverts the inositol tetrakisphos [...] (455 aa) | ||||
| SLC9A1 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (850 aa) | ||||
| KCNQ1 | Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (863 aa) | ||||
| PODXL | Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro- adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubul [...] (589 aa) | ||||
| LOC112530976 | FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (77 aa) | ||||
| SLC23A2 | Sodium vitamin C co-transporter 2. (658 aa) | ||||
| FZD6 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (709 aa) | ||||
| TEK | TEK receptor tyrosine kinase. (1128 aa) | ||||
| ENSGALP00000072166 | IPT/TIG domain-containing protein. (239 aa) | ||||
| SORBS2 | Sorbin and SH3 domain containing 2. (1206 aa) | ||||
| SLC4A7 | Anion exchange protein. (1243 aa) | ||||
| UMODL1 | Uncharacterized protein. (780 aa) | ||||
| FAT1 | FAT atypical cadherin 1. (4645 aa) | ||||
| CLDN7 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (407 aa) | ||||
| GJA1 | Gap junction alpha-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles. Belongs to the connexin family. Alpha-type (group II) subfamily. (381 aa) | ||||
| ENSGALP00000074194 | Uncharacterized protein. (401 aa) | ||||
| DSTYK | Dual serine/threonine and tyrosine protein kinase; May act as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (930 aa) | ||||
| SLC39A14 | Solute carrier family 39 member 14. (508 aa) | ||||
| F1NA95_CHICK | AKAP7_NLS domain-containing protein. (256 aa) | ||||
| SLC12A1 | Solute carrier family 12 member 1. (1097 aa) | ||||
| AQP1 | Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (270 aa) | ||||
| SLC9A3R2 | Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (354 aa) | ||||
| STK26 | Protein kinase domain-containing protein. (416 aa) | ||||
| SCNN1B | Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (667 aa) | ||||
| SLC22A18 | Solute carrier family 22 member 18. (427 aa) | ||||
| ATP12A | Sodium/potassium-transporting ATPase subunit alpha. (1033 aa) | ||||
| RHCG | Ammonium transporter Rh type C; Functions as an ammonia transporter. (467 aa) | ||||
| C1QTNF5 | C1q and TNF related 5. (585 aa) | ||||
| E1C7P2_CHICK | Uncharacterized protein. (264 aa) | ||||
| ATP6V1G1 | V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa) | ||||
| ABCC2 | Uncharacterized protein. (1538 aa) | ||||
| MYO1B | Myosin IB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1112 aa) | ||||
| PARD6B | PAR6B. (370 aa) | ||||
| ADAM17 | Tumor necrosis factor alpha converting enzyme. (829 aa) | ||||
| SLC26A3 | Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (754 aa) | ||||
| SLC7A1 | AA_permease_C domain-containing protein. (624 aa) | ||||
| LMO7 | LIM domain 7. (1608 aa) | ||||
| ATP4B | Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (299 aa) | ||||
| GPR143 | Uncharacterized protein. (391 aa) | ||||
| LOC421965 | Uncharacterized protein. (556 aa) | ||||
| TMEM30A | Cell cycle control protein 50A; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. [...] (372 aa) | ||||
| CDH2 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity). (912 aa) | ||||
| UPK1B | Tetraspanin. (283 aa) | ||||
| F1NFV7_CHICK | Uncharacterized protein. (1145 aa) | ||||
| SLC1A1 | Amino acid transporter. (527 aa) | ||||
| AKR1A1 | Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids. Acts as an aldehyde-detoxification enzyme (By similarity). Displays no reductase activity towards retinoids (By similarity). (365 aa) | ||||
| SLC29A4 | Solute carrier family 29 member 4. (527 aa) | ||||
| KCNK1 | Potassium channel subfamily K member. (336 aa) | ||||
| AMN | Uncharacterized protein. (477 aa) | ||||
| SLC39A8 | Solute carrier family 39 member 8. (493 aa) | ||||
| CTSV | Cathepsin L1 heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. (353 aa) | ||||
| SLC6A18 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (619 aa) | ||||
| SLC6A19 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (636 aa) | ||||
| SLC5A12 | Solute carrier family 5 member 12; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (629 aa) | ||||
| PARD6G | Par-6 family cell polarity regulator gamma. (384 aa) | ||||
| EZR | Ezrin. (585 aa) | ||||
| UPK3A | Uroplakin 3A. (264 aa) | ||||
| SLC34A2 | Uncharacterized protein. (673 aa) | ||||
| PROM1 | Uncharacterized protein. (868 aa) | ||||
| CIB4 | Uncharacterized protein. (190 aa) | ||||
| CPO | Carboxypeptidase O. (379 aa) | ||||
| DDR1 | Uncharacterized protein. (873 aa) | ||||
| CUBN | Cubilin. (3634 aa) | ||||
| JAG1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1216 aa) | ||||
| MPP5 | Uncharacterized protein; Belongs to the MAGUK family. (675 aa) | ||||
| USH2A | Usherin. (5190 aa) | ||||
| KCNK2 | Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (411 aa) | ||||
| ABCG5 | ATP binding cassette subfamily G member 5. (630 aa) | ||||
| ABCG8 | ATP binding cassette subfamily G member 8. (645 aa) | ||||
| SLC3A1 | Solute carrier family 3 member 1. (678 aa) | ||||
| AQP5 | Aquaporin 5; Belongs to the MIP/aquaporin (TC 1.A.8) family. (265 aa) | ||||
| AQP2 | Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (275 aa) | ||||
| MIP | Lens fiber major intrinsic protein; Water channel. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Belongs to the MIP/aquaporin (TC 1.A.8) family. (262 aa) | ||||
| ENPEP | Aminopeptidase. (943 aa) | ||||
| KCNE4 | Potassium voltage-gated channel subfamily E regulatory subunit 4. (161 aa) | ||||
| CYBRD1 | Cytochrome b reductase 1. (289 aa) | ||||
| CFTR | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa) | ||||
| DDR2 | Discoidin domain receptor tyrosine kinase 2. (901 aa) | ||||
| RAB18L | Uncharacterized protein. (204 aa) | ||||
| SHANK2 | SH3 and multiple ankyrin repeat domains 2. (1462 aa) | ||||
| DRAM2 | DNA damage regulated autophagy modulator 2. (266 aa) | ||||
| ECRG4 | ECRG4 augurin precursor. (112 aa) | ||||
| HIP1R | Uncharacterized protein. (977 aa) | ||||
| RAPGEF2 | Rap guanine nucleotide exchange factor 2. (1652 aa) | ||||
| PARD3 | Uncharacterized protein. (1352 aa) | ||||
| SLC6A20 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (647 aa) | ||||
| ATP6V0D2 | V-type proton ATPase subunit d 2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity); Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa) | ||||
| SLC22A4 | MFS domain-containing protein. (553 aa) | ||||
| ZMYND10 | Zinc finger MYND-type containing 10. (405 aa) | ||||
| DPP4 | Uncharacterized protein; Belongs to the peptidase S9B family. (760 aa) | ||||
| TMEM114 | Transmembrane protein 114. (211 aa) | ||||
| DUOX2 | Dual oxidase 2. (1533 aa) | ||||
| SLC7A5 | Large neutral amino acids transporter small subunit 1. (526 aa) | ||||
| ENSGALP00000054145 | Uncharacterized protein. (217 aa) | ||||
| ABCG2 | ATP-binding cassette sub-family G member 2. (701 aa) | ||||
| ABCC5 | ATP binding cassette subfamily C member 5. (1449 aa) | ||||
| ADCY8 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1240 aa) | ||||
| SLC7A9 | Uncharacterized protein. (493 aa) | ||||
| KIAA1614 | DUF4685 domain-containing protein. (752 aa) | ||||
| MREG | Melanoregulin. (208 aa) | ||||
| OSMR | Uncharacterized protein. (622 aa) | ||||
| SLC46A1 | Uncharacterized protein. (473 aa) | ||||
| ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (781 aa) | ||||
| FN1 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity). (2526 aa) | ||||
| NOTCH1 | Uncharacterized protein. (2561 aa) | ||||
| PRKCZ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa) | ||||
| PARD6A | Par-6 family cell polarity regulator alpha. (357 aa) | ||||
| CD34 | CD34 molecule. (385 aa) | ||||
| SLC26A9 | Solute carrier family 26 member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (806 aa) | ||||
| ATP6V1B2 | V-type proton ATPase subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Belongs to the ATPase alpha/beta chains family. (503 aa) | ||||
| PROM2 | Prominin 2. (824 aa) | ||||
| SLC22A5 | MFS domain-containing protein. (557 aa) | ||||
| SLC23A1 | Solute carrier family 23 member 1. (557 aa) | ||||
| SHROOM2 | Shroom family member 2. (1755 aa) | ||||
| MAL2 | MARVEL domain-containing protein. (178 aa) | ||||
| RAPGEF6 | Uncharacterized protein. (1585 aa) | ||||
| OTOA | Uncharacterized protein. (524 aa) | ||||
| AJAP1 | Adherens junctions associated protein 1. (266 aa) | ||||
| SCNN1G | Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (650 aa) | ||||
| CLDND1 | Uncharacterized protein. (251 aa) | ||||
| SLC2A1 | Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. (490 aa) | ||||
| CDH15 | Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. (792 aa) | ||||
| SCNN1A | Amiloride-sensitive sodium channel subunit alpha; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. (612 aa) | ||||
| SHROOM4 | Shroom family member 4. (1224 aa) | ||||
| EXOC1 | Exocyst complex component 1. (920 aa) | ||||
| CTSK | Cathepsin K; Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity). (334 aa) | ||||
| PATJ | PATJ crumbs cell polarity complex component. (1891 aa) | ||||
| PLPP1 | Phospholipid phosphatase 1. (284 aa) | ||||
| MSN | Moesin. (580 aa) | ||||
| SLC4A10 | Anion exchange protein. (1116 aa) | ||||
| FAM65B | Rho family-interacting cell polarization regulator 2; Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Requ [...] (1067 aa) | ||||
| SLC34A1 | Solute carrier family 34 member 1. (675 aa) | ||||
| PDGFRB | Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1073 aa) | ||||
| FZD3 | Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (666 aa) | ||||
| CLDN1 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa) | ||||
| MARVELD2 | MARVEL domain containing 2. (506 aa) | ||||
| SLC26A6 | STAS domain-containing protein. (752 aa) | ||||
| PDZD3 | PDZ domain containing 3. (531 aa) | ||||
| LOC422308 | Sec3-PIP2_bind domain-containing protein. (860 aa) | ||||
| PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (599 aa) | ||||
| CRB2 | Uncharacterized protein. (1469 aa) | ||||
| F2RL2 | Coagulation factor II thrombin receptor like 2. (378 aa) | ||||
| SLC12A2 | Solute carrier family 12 member 2. (1150 aa) | ||||
| PTPRO | Uncharacterized protein. (1268 aa) | ||||
| ANXA1 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (342 aa) | ||||