STRINGSTRING
PIK3C3 PIK3C3 TBC1D10A TBC1D10A RBSN RBSN PIKFYVE PIKFYVE VPS54 VPS54 TMEM87A TMEM87A VTI1B VTI1B HEATR5B HEATR5B HOOK1 HOOK1 TBC1D5 TBC1D5 WDR91 WDR91 PHETA2 PHETA2 ATG14 ATG14 FAM21C FAM21C RHOBTB3 RHOBTB3 RIC1 RIC1 TBC1D23 TBC1D23 SNX3 SNX3 HOOK3 HOOK3 DOP1A DOP1A RAB9A RAB9A GCC2 GCC2 CLN5 CLN5 RAB6A RAB6A SNX5 SNX5 RAB7B RAB7B VAMP3 VAMP3 TRAPPC10 TRAPPC10 VPS29 VPS29 VPS51 VPS51 PLEKHJ1 PLEKHJ1 AP1AR AP1AR ANKRD27 ANKRD27 SNX16 SNX16 VPS53 VPS53 RNF126 RNF126 CLTCL1 CLTCL1 CORO7 CORO7 PHETA1 PHETA1 SYT4 SYT4 PIK3R4 PIK3R4 STX8 STX8 YKT6 YKT6 SNX32 SNX32 LAMP1 LAMP1 AKTIP AKTIP WDR81 WDR81 GOLT1B GOLT1B WIPI1 WIPI1 STX16 STX16 SYT7 SYT7 PIP4K2B PIP4K2B KLHL20 KLHL20 SNX2 SNX2 VTI1A VTI1A VPS26A VPS26A ARL1 ARL1 RGP1 RGP1 RAB7A RAB7A SNX1 SNX1 ACTR2 ACTR2 TGOLN2 TGOLN2 DOP1B DOP1B WASH1 WASH1 SORT1 SORT1 EMP2 EMP2 HEATR5A HEATR5A RAB41 RAB41 SLC66A2 SLC66A2 CCDC91 CCDC91 GOLT1A GOLT1A SNX12 SNX12 KIF16B KIF16B LOC112530905 LOC112530905 VPS50 VPS50 ARFRP1 ARFRP1 PIP4K2A PIP4K2A STX5 STX5 TANC2 TANC2 RAB29 RAB29 SNF8 SNF8 ANKFY1 ANKFY1 RAB14 RAB14 VPS26B VPS26B UBE2O UBE2O RILP RILP BECN1 BECN1 STX10 STX10 SYS1 SYS1 BET1L BET1L SNX8 SNX8 VPS35 VPS35 RAB9B RAB9B CLTC CLTC GBF1 GBF1 VPS29L VPS29L TPCN2 TPCN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (944 aa)
TBC1D10ARab-GAP TBC domain-containing protein. (477 aa)
RBSNRabenosyn, RAB effector. (787 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2118 aa)
VPS54VPS54 subunit of GARP complex. (974 aa)
TMEM87ATransmembrane protein 87A. (528 aa)
VTI1BVesicle transport through interaction with t-SNAREs 1B. (232 aa)
HEATR5BHEAT repeat containing 5B. (2073 aa)
HOOK1Protein Hook homolog 1; May function to promote vesicle trafficking and/or fusion. (718 aa)
TBC1D5TBC1 domain family member 5. (834 aa)
WDR91WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport; Belongs to the WD repeat WDR91 family. (751 aa)
PHETA2PH domain containing endocytic trafficking adaptor 2. (252 aa)
ATG14Autophagy related 14. (492 aa)
FAM21CCAP-ZIP_m domain-containing protein. (1325 aa)
RHOBTB3Rho related BTB domain containing 3. (618 aa)
RIC1RIC1 homolog, RAB6A GEF complex partner 1. (1419 aa)
TBC1D23TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (By similarity). Plays a role in brain development (By similarity). May act as a general inhibitor of innate immunity signaling (By similarity). (679 aa)
SNX3PX domain-containing protein. (162 aa)
HOOK3Hook microtubule tethering protein 3. (713 aa)
DOP1ADOP1 leucine zipper like protein A. (2492 aa)
RAB9AUncharacterized protein. (201 aa)
GCC2GRIP and coiled-coil domain containing 2. (1693 aa)
CLN5Uncharacterized protein. (339 aa)
RAB6ARas-related protein Rab-6A; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Involved in COPI-independent retrograde transport from the Golgi to the ER. Belongs to the small GTPase superfamily. Rab family. (208 aa)
SNX5Sorting nexin; Involved in several stages of intracellular trafficking. (397 aa)
RAB7BRAB7B, member RAS oncogene family. (207 aa)
VAMP3V-SNARE coiled-coil homology domain-containing protein. (104 aa)
TRAPPC10Foie-gras_1 domain-containing protein. (1267 aa)
VPS29Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity). Acts also as component of the retriever complex. The retriever complex is an heterotrimeric complex related to retromer cargo-selective com [...] (185 aa)
VPS51Vacuolar protein sorting-associated protein 51 homolog; Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling. (787 aa)
PLEKHJ1Pleckstrin homology domain-containing family J member 1. (149 aa)
AP1ARAdaptor related protein complex 1 associated regulatory protein. (301 aa)
ANKRD27Uncharacterized protein. (1087 aa)
SNX16PX domain-containing protein. (347 aa)
VPS53Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). Acts as component of the EARP complex that is involved in endocytic recycling. (831 aa)
RNF126RING-type domain-containing protein. (385 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1679 aa)
CORO7Coronin; Belongs to the WD repeat coronin family. (1189 aa)
PHETA1PH domain containing endocytic trafficking adaptor 1. (238 aa)
SYT4Synaptotagmin 4. (425 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1426 aa)
STX8t-SNARE coiled-coil homology domain-containing protein. (273 aa)
YKT6Uncharacterized protein; Belongs to the synaptobrevin family. (198 aa)
SNX32Sorting nexin; Involved in several stages of intracellular trafficking. (406 aa)
LAMP1Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; Belongs to the LAMP family. (406 aa)
AKTIPAKT-interacting protein; May function to promote vesicle trafficking and/or fusion. May also regulate apoptosis (By similarity); Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily. (351 aa)
WDR81WD repeat domain 81. (1946 aa)
GOLT1BGolgi transport 1B. (138 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (508 aa)
STX16t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (326 aa)
SYT7Synaptotagmin 7. (403 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (422 aa)
KLHL20Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. It also specifically mediates 'Lys-33'-linked ubiquitination (By similarity). (613 aa)
SNX2PX domain-containing protein. (605 aa)
VTI1At-SNARE coiled-coil homology domain-containing protein. (224 aa)
VPS26AVPS26, retromer complex component A. (326 aa)
ARL1Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (231 aa)
RGP1Uncharacterized protein. (470 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
SNX1Sorting nexin 1. (514 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and r [...] (400 aa)
TGOLN2Uncharacterized protein. (445 aa)
DOP1BDOP1 leucine zipper like protein B. (2282 aa)
WASH1WASH complex subunit 1; Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and is required for its membrane targeting; Belongs to the WASH1 family. (485 aa)
SORT1Sortilin. (954 aa)
EMP2Epithelial membrane protein 2. (167 aa)
HEATR5AHEAT repeat containing 5A. (2031 aa)
RAB41Uncharacterized protein. (211 aa)
SLC66A2Solute carrier family 66 member 2. (271 aa)
CCDC91Coiled-coil domain containing 91. (444 aa)
GOLT1AGolgi transport 1A. (138 aa)
SNX12PX domain-containing protein. (211 aa)
KIF16BKinesin family member 16B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2059 aa)
LOC112530905Rab-GAP TBC domain-containing protein. (1368 aa)
VPS50Syndetin; Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. (997 aa)
ARFRP1ADP ribosylation factor related protein 1. (256 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha; Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity). (405 aa)
STX5Syntaxin 5; Belongs to the syntaxin family. (344 aa)
TANC2Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2. (2067 aa)
RAB29RAB29, member RAS oncogene family. (205 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
ANKFY1Ankyrin repeat and FYVE domain containing 1. (1076 aa)
RAB14Ras-related protein Rab-14; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development (By similarity); Belongs to the small GTPase superfamily. Rab family. (215 aa)
VPS26BVPS26, retromer complex component B. (336 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1374 aa)
RILPRab interacting lysosomal protein. (400 aa)
BECN1Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. (447 aa)
STX10Syntaxin-6; Involved in intracellular vesicle trafficking; Belongs to the syntaxin family. (254 aa)
SYS1Protein SYS1 homolog; Involved in protein trafficking. Belongs to the SYS1 family. (156 aa)
BET1Lt-SNARE coiled-coil homology domain-containing protein. (111 aa)
SNX8Sorting nexin 8. (448 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (799 aa)
RAB9BRAB9B, member RAS oncogene family. (261 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
GBF1Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1863 aa)
VPS29LVacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (232 aa)
TPCN2Uncharacterized protein. (753 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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