STRINGSTRING
DDI2 DDI2 METAP1 METAP1 CASP6 CASP6 PRSS12 PRSS12 XPNPEP3 XPNPEP3 METAP2 METAP2 IHH IHH SPRTN SPRTN OMA1 OMA1 SPCS3 SPCS3 LGMN LGMN DHCR24 DHCR24 ENSGALP00000045724 ENSGALP00000045724 CPZ CPZ IFT172 IFT172 OGT OGT RIPK2 RIPK2 C6H10orf54 C6H10orf54 BACE2 BACE2 MEP1A MEP1A ECE2 ECE2 TLL2 TLL2 TYSND1 TYSND1 CTSH CTSH TMEM208 TMEM208 ECEL1 ECEL1 DHH DHH APOH APOH BAK1 BAK1 BACE1 BACE1 MYRF MYRF HM13 HM13 DYNC2H1 DYNC2H1 PSEN2 PSEN2 ZMPSTE24 ZMPSTE24 TLL1 TLL1 SPCS2 SPCS2 IL1R2 IL1R2 CASP10 CASP10 CASP18 CASP18 APH1A APH1A CYSP1L CYSP1L PCSK4 PCSK4 PCSK2 PCSK2 ENSGALP00000067599 ENSGALP00000067599 DISP1 DISP1 ENSGALP00000068523 ENSGALP00000068523 PSEN1 PSEN1 HJV HJV PCSK9 PCSK9 LONP2 LONP2 RIPK3 RIPK3 PHEX PHEX LRRC27 LRRC27 KEL KEL PCSK7 PCSK7 ENSGALP00000073802 ENSGALP00000073802 MME MME MYRFL MYRFL CPM CPM ATP23 ATP23 SCG5 SCG5 FGG FGG SDE2 SDE2 NCSTN NCSTN CASP7 CASP7 CASP8 CASP8 FURIN FURIN FADD FADD YME1L1 YME1L1 TMPRSS4 TMPRSS4 CPN1 CPN1 PITRM1 PITRM1 SPPL3 SPPL3 PISD PISD F9 F9 C1R C1R PCSK1 PCSK1 PCSK5 PCSK5 HGFAC HGFAC SHH SHH F3 F3 NTL NTL PLAU PLAU CPD CPD ADAM10 ADAM10 P2RX7 P2RX7 CYFIP2 CYFIP2 ADAM19 ADAM19 PLAT PLAT MBTPS1 MBTPS1 APH1B APH1B STOML2 STOML2 PMPCA PMPCA CLN5 CLN5 SPCS1 SPCS1 MIPEP MIPEP CASP2 CASP2 ADAM17 ADAM17 IMMP1L IMMP1L FXN FXN APAF1 APAF1 IMMP2L IMMP2L ACE ACE PARL PARL CPE CPE SPG7 SPG7 GLG1 GLG1 ECE1 ECE1 CASP9 CASP9 MMEL1 MMEL1 CORIN CORIN AFG3L2 AFG3L2 CTSV CTSV ASPH-2 ASPH-2 PCSK6 PCSK6 ASPH ASPH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDI2Uncharacterized protein. (1017 aa)
METAP1Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (385 aa)
CASP6Uncharacterized protein; Belongs to the peptidase C14A family. (317 aa)
PRSS12Serine protease 12; Belongs to the peptidase S1 family. (823 aa)
XPNPEP3X-prolyl aminopeptidase 3. (502 aa)
METAP2Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily. (479 aa)
IHHIndian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. (408 aa)
SPRTNSprT-like N-terminal domain. (541 aa)
OMA1OMA1 zinc metallopeptidase. (564 aa)
SPCS3Signal peptidase complex subunit 3; Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (180 aa)
LGMNLegumain. (431 aa)
DHCR24FAD-binding PCMH-type domain-containing protein. (516 aa)
ENSGALP00000045724Uncharacterized protein. (235 aa)
CPZCarboxypeptidase Z; Cleaves substrates with C-terminal arginine residues. Modulates the Wnt signaling pathway, probably by cleaving some undefined protein. Regulates the development of skeletal elements during development, probably by activating WNT4. Belongs to the peptidase M14 family. (647 aa)
IFT172Intraflagellar transport 172. (1749 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1035 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (574 aa)
C6H10orf54Ig-like domain-containing protein. (310 aa)
BACE2Beta-secretase 2; Belongs to the peptidase A1 family. (633 aa)
MEP1AMeprin A subunit. (711 aa)
ECE2Uncharacterized protein. (814 aa)
TLL2Metalloendopeptidase. (978 aa)
TYSND1Trypsin domain containing 1. (493 aa)
CTSHUncharacterized protein; Belongs to the peptidase C1 family. (403 aa)
TMEM208Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy; Belongs to the TMEM208 family. (179 aa)
ECEL1Endothelin converting enzyme like 1. (763 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
APOHUncharacterized protein. (374 aa)
BAK1Uncharacterized protein. (216 aa)
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (497 aa)
MYRFMyelin regulatory factor. (985 aa)
HM13Histocompatibility minor 13. (701 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4301 aa)
PSEN2Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] (455 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (465 aa)
TLL1Tolloid-like protein 1; Protease which processes procollagen C-propeptides, such as chordin, probiglycan and prolysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis (By similarity). (1040 aa)
SPCS2Signal peptidase complex subunit 2. (110 aa)
IL1R2Interleukin 1 receptor type 2. (412 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (455 aa)
CASP18Initiator caspase; Belongs to the peptidase C14A family. (464 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (311 aa)
CYSP1LUncharacterized protein. (228 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4. (791 aa)
PCSK2Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. (644 aa)
ENSGALP00000067599Inhibitor_I29 domain-containing protein. (491 aa)
DISP1Dispatched RND transporter family member 1. (1640 aa)
ENSGALP00000068523Uncharacterized protein. (132 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa)
HJVHemojuvelin BMP co-receptor. (514 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (643 aa)
LONP2Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import; Belongs to the peptidase S16 family. ECO:0000256|PROSITE-. (856 aa)
RIPK3Uncharacterized protein. (424 aa)
PHEXUncharacterized protein. (747 aa)
LRRC27Death domain-containing protein. (291 aa)
KELUncharacterized protein. (720 aa)
PCSK7P/Homo B domain-containing protein. (799 aa)
ENSGALP00000073802Uncharacterized protein. (524 aa)
MMENeprilysin. (750 aa)
MYRFLMRF_C2 domain-containing protein. (221 aa)
CPMPeptidase_M14 domain-containing protein. (443 aa)
ATP23Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (242 aa)
SCG5Uncharacterized protein. (208 aa)
FGGFibrinogen C-terminal domain-containing protein. (438 aa)
SDE2SDE2 telomere maintenance homolog. (305 aa)
NCSTNNcstrn_small domain-containing protein. (717 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (309 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
FURINTrans Golgi network protease furin; Belongs to the peptidase S8 family. (789 aa)
FADDFas associated via death domain. (195 aa)
YME1L1AAA domain-containing protein. (722 aa)
TMPRSS4Uncharacterized protein; Belongs to the peptidase S1 family. (405 aa)
CPN1Uncharacterized protein. (453 aa)
PITRM1Pitrilysin metallopeptidase 1. (1033 aa)
SPPL3Signal peptide peptidase like 3. (384 aa)
PISDPhosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. (409 aa)
F9Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. (471 aa)
C1RComplement C1r; Belongs to the peptidase S1 family. (712 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (748 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1864 aa)
HGFACHGF activator. (511 aa)
SHHSonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa)
F3Coagulation factor III, tissue factor. (283 aa)
NTLUncharacterized protein; Belongs to the peptidase S1 family. (808 aa)
PLAUUrokinase-type plasminogen activator chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. (434 aa)
CPDCarboxypeptidase D. (1360 aa)
ADAM10Uncharacterized protein. (749 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (574 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
ADAM19ADAM19. (900 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (567 aa)
MBTPS1Membrane bound transcription factor peptidase, site 1. (1060 aa)
APH1BUncharacterized protein. (256 aa)
STOML2Stomatin like 2. (382 aa)
PMPCAUncharacterized protein; Belongs to the peptidase M16 family. (519 aa)
CLN5Uncharacterized protein. (339 aa)
SPCS1Uncharacterized protein. (166 aa)
MIPEPMitochondrial intermediate peptidase. (795 aa)
CASP2Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. (441 aa)
ADAM17Tumor necrosis factor alpha converting enzyme. (829 aa)
IMMP1LMitochondrial inner membrane protease subunit. (166 aa)
FXNFrataxin. (167 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
IMMP2LPeptidase_S24 domain-containing protein. (175 aa)
ACEAngiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. (1281 aa)
PARLRhomboid domain-containing protein. (355 aa)
CPECarboxypeptidase E. (469 aa)
SPG7AAA domain-containing protein. (768 aa)
GLG1Golgi apparatus protein 1; Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils) (By similarity). Binds fibroblast growth factor (FGF). May be involved in intracellular FGF trafficking and the regulation of cellular responses to FGFS. (1194 aa)
ECE1Endothelin converting enzyme-1. (752 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (418 aa)
MMEL1Membrane metalloendopeptidase like 1. (773 aa)
CORINCorin, serine peptidase. (1130 aa)
AFG3L2AFG3 like matrix AAA peptidase subunit 2. (806 aa)
CTSVCathepsin L1 heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. (353 aa)
ASPH-2Asp-B-Hydro_N domain-containing protein. (350 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (1024 aa)
ASPHAspartate beta-hydroxylase. (295 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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