Your Input: | |
| | ARID4A | ARID domain-containing protein. (1252 aa) |
| | RBBP5 | WD_REPEATS_REGION domain-containing protein. (539 aa) |
| | VPS72 | Vacuolar protein sorting 72 homolog. (365 aa) |
| | TAF12 | TFIID_20kDa domain-containing protein. (161 aa) |
| | MIER2 | MIER family member 2. (601 aa) |
| | NCOA6 | Nuclear receptor coactivator 6. (2054 aa) |
| | MLLT1 | MLLT1 super elongation complex subunit. (554 aa) |
| | SIN3A | HDAC_interact domain-containing protein. (1274 aa) |
| | METTL23 | Methyltransferase like 23. (230 aa) |
| | JMJD6 | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5- hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5- hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by it [...] (414 aa) |
| | DYDC2 | Uncharacterized protein. (168 aa) |
| | CDC73 | Parafibromin; Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). (531 aa) |
| | SF3B3 | Splicing factor 3b subunit 3. (1217 aa) |
| | HDAC3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May play a role in the regulation of the circadian clock in a deacetylase activity-independent manner (By similarity). (428 aa) |
| | WDR5B | WD_REPEATS_REGION domain-containing protein. (334 aa) |
| | SIRT1 | Deacetylase sirtuin-type domain-containing protein. (881 aa) |
| | JMJD1C | JmjC domain-containing protein. (2529 aa) |
| | ASH2L | B30.2/SPRY domain-containing protein. (611 aa) |
| | KAT2A | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (804 aa) |
| | USP3 | Ubiquitin carboxyl-terminal hydrolase. (520 aa) |
| | RBBP4 | Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. (425 aa) |
| | TRRAP | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3836 aa) |
| | KAT6A | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2008 aa) |
| | SIN3B | SIN3 transcription regulator family member B. (1075 aa) |
| | KDM2B | Lysine demethylase 2B. (683 aa) |
| | BAP1 | Ubiquitin carboxyl-terminal hydrolase BAP1; Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity); Belongs to the peptidase C12 family. BAP1 subfamily. (751 aa) |
| | KIAA2013 | KIAA2013. (590 aa) |
| | HDAC8 | Hist_deacetyl domain-containing protein. (368 aa) |
| | KAT6B | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1842 aa) |
| | TRIM37 | Uncharacterized protein. (983 aa) |
| | HDAC11 | Hist_deacetyl domain-containing protein. (357 aa) |
| | TAF4 | TATA-box binding protein associated factor 4. (1101 aa) |
| | PRDM6 | PR/SET domain 6. (570 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (261 aa) |
| | MRGBP | MRG domain binding protein. (233 aa) |
| | CTR9 | CTR9 homolog, Paf1/RNA polymerase II complex component. (1153 aa) |
| | DR1 | Protein Dr1; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity). (176 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | KDM8 | Lysine demethylase 8. (401 aa) |
| | JADE2 | Jade family PHD finger 2. (922 aa) |
| | PCGF5 | RING-type domain-containing protein. (256 aa) |
| | SETD5 | SET domain-containing protein. (1478 aa) |
| | EPC1 | Enhancer of polycomb homolog. (814 aa) |
| | SUDS3 | Uncharacterized protein. (413 aa) |
| | INCENP | Inner centromere protein; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central [...] (877 aa) |
| | KDM3B | Lysine demethylase 3B. (1738 aa) |
| | ATXN7L1 | Ataxin 7 like 1. (834 aa) |
| | TAF5 | Uncharacterized protein. (785 aa) |
| | RTF1 | RTF1 homolog, Paf1/RNA polymerase II complex component. (693 aa) |
| | KAT14 | N-acetyltransferase domain-containing protein. (781 aa) |
| | ZZZ3 | Uncharacterized protein. (905 aa) |
| | ING3 | Inhibitor of growth protein 3; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage (By similarity); Belongs to the ING family. (417 aa) |
| | PNO1 | RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA. Belongs to the PNO1 family. (242 aa) |
| | ELMSAN1 | ELM2 and Myb/SANT domain containing 1. (1116 aa) |
| | HAT1 | Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (408 aa) |
| | SETD7 | Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa) |
| | TRERF1 | Transcriptional regulating factor 1. (1163 aa) |
| | MTA3 | Metastasis associated 1 family member 3. (693 aa) |
| | KAT7 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (699 aa) |
| | SUPT7L | SPT7 like, STAGA complex gamma subunit. (412 aa) |
| | KDM4A | Uncharacterized protein. (1058 aa) |
| | BRMS1L | Breast cancer metastasis-suppressor 1-like protein; Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity; Belongs to the BRMS1 family. (373 aa) |
| | MBIP | MAP3K12 binding inhibitory protein 1. (352 aa) |
| | DPY30 | Uncharacterized protein. (99 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (552 aa) |
| | HDAC9 | Histone deacetylase 9; Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting other histone deacetylases. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2- dependent transcription (By similarity). (761 aa) |
| | TAF5L | TATA-box binding protein associated factor 5 like. (589 aa) |
| | RCOR1 | REST corepressor 1. (449 aa) |
| | NR1H4 | Farnesoid X receptor. (473 aa) |
| | CCNA2 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. (395 aa) |
| | PRDM5 | PR/SET domain 5. (633 aa) |
| | EP300 | E1A binding protein p300. (2450 aa) |
| | DTX3L | Deltex E3 ubiquitin ligase 3L. (737 aa) |
| | EPC2 | Enhancer of polycomb homolog. (807 aa) |
| | KDM1B | Lysine demethylase 1B. (896 aa) |
| | KDM5A | Lysine demethylase 5A. (1692 aa) |
| | PRMT8 | Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa) |
| | KMT5B | Lysine methyltransferase 5B. (857 aa) |
| | CHD4 | Uncharacterized protein. (1145 aa) |
| | ING4 | Inhibitor of growth protein 4; Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (By similarity); Belongs to the ING family. (249 aa) |
| | KANSL3 | KAT8 regulatory NSL complex subunit 3. (1110 aa) |
| | ASH1L | ASH1 like histone lysine methyltransferase. (3026 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (560 aa) |
| | MLLT3 | MLLT3 super elongation complex subunit. (578 aa) |
| | BEND3 | BEN domain containing 3. (836 aa) |
| | UFL1 | E3 UFM1-protein ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins; Belongs to the UFL1 family. (789 aa) |
| | WHSC1-2 | Uncharacterized protein. (592 aa) |
| | N6AMT1 | MTS domain-containing protein. (218 aa) |
| | USP16 | Ubiquitin carboxyl-terminal hydrolase 16; Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. (818 aa) |
| | SETD4 | SET domain-containing protein. (439 aa) |
| | KDM6A | Uncharacterized protein. (1484 aa) |
| | RBBP7 | Histone-binding protein RBBP7; Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. (466 aa) |
| | JADE3 | Jade family PHD finger 3. (815 aa) |
| | TEX30 | Uncharacterized protein. (225 aa) |
| | BRCA2 | Tower domain-containing protein. (3397 aa) |
| | ATM | Non-specific serine/threonine protein kinase. (3050 aa) |
| | SUV39H2 | Histone-lysine N-methyltransferase SUV39H2; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric re [...] (407 aa) |
| | SIRT7 | Deacetylase sirtuin-type domain-containing protein. (399 aa) |
| | C5H14ORF169 | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys- 4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethyla [...] (601 aa) |
| | KDM4C | Lysine demethylase 4C. (1069 aa) |
| | AURKA | Aurora kinase A; Belongs to the protein kinase superfamily. (409 aa) |
| | ING5 | Inhibitor of growth protein. (241 aa) |
| | HDAC4 | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (1080 aa) |
| | WDR82 | WD repeat-containing protein 82; Component of a chromatin regulatory complex involved in regulating chromatin structure in the nucleus; Belongs to the WD repeat SWD2 family. (313 aa) |
| | BCOR | BCL6 corepressor. (1759 aa) |
| | KDM3A | Lysine-specific demethylase 3A; Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate (By similarity). (1325 aa) |
| | SGF29 | SAGA-associated factor 29; Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me. (293 aa) |
| | HOPX | Homeodomain-only protein; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. May act via an interaction with SRF, leading to modulate the expression of SRF- dependent cardiac-specific genes and cardiac development. May act as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assist in chaperone-mediated protein refolding. (73 aa) |
| | MYSM1 | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). (857 aa) |
| | SETD1A | Histone-lysine N-methyltransferase SETD1B; Histone methyltransferase that specifically methylates 'Lys- 4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. (2008 aa) |
| | MYOD1 | Myoblast determination protein 1 homolog; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). (299 aa) |
| | ACTL6A | Actin like 6A; Belongs to the actin family. (429 aa) |
| | POLE3 | CBFD_NFYB_HMF domain-containing protein. (143 aa) |
| | SETDB1 | SET domain bifurcated histone lysine methyltransferase 1. (1386 aa) |
| | YEATS4 | GAS41. (227 aa) |
| | EOMES | T-box_assoc domain-containing protein. (661 aa) |
| | MIER1 | Mesoderm induction early response protein 1; Transcriptional repressor regulating the expression of a number of genes. Probably functions through recruitment of histone deacetylases involved in chromatin silencing (By similarity). (530 aa) |
| | WDR61 | WD repeat-containing protein 61. (326 aa) |
| | UBE2B | Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7. (643 aa) |
| | MSL2 | MSL complex subunit 2. (579 aa) |
| | KDM2A | Lysine demethylase 2A. (1272 aa) |
| | WAC | WW domain containing adaptor with coiled-coil. (646 aa) |
| | SIRT2 | Deacetylase sirtuin-type domain-containing protein. (485 aa) |
| | ENSGALP00000045013 | Protein kinase domain-containing protein. (209 aa) |
| | KDM5B | Lysine-specific demethylase 5B; Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor. May repress the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. (1616 aa) |
| | ATXN7L3 | Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. (340 aa) |
| | NAA50 | N-acetyltransferase domain-containing protein. (154 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (529 aa) |
| | PRDM2 | PR/SET domain 2. (1678 aa) |
| | OGT | O-linked N-acetylglucosamine (GlcNAc) transferase. (1035 aa) |
| | PAF1 | PAF1 homolog, Paf1/RNA polymerase II complex component. (488 aa) |
| | MEAF6 | Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vi [...] (202 aa) |
| | MINA | Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (473 aa) |
| | DOT1L | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1863 aa) |
| | BRD1 | Uncharacterized protein. (1243 aa) |
| | MBTD1 | Mbt domain containing 1. (685 aa) |
| | ENSGALP00000048091 | Uncharacterized protein. (459 aa) |
| | GTF3C4 | General transcription factor IIIC subunit 4. (813 aa) |
| | PRDM14 | PR/SET domain 14. (514 aa) |
| | TBR1 | T-box brain transcription factor 1. (677 aa) |
| | NAA40 | N(alpha)-acetyltransferase 40, NatD catalytic subunit. (280 aa) |
| | KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (826 aa) |
| | KANSL1 | KAT8 regulatory NSL complex subunit 1. (1174 aa) |
| | SF3B5 | Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa) |
| | PHF20L1 | PHD finger protein 20-like protein 1. (1090 aa) |
| | MECOM | MDS1 and EVI1 complex locus. (1245 aa) |
| | ACTL6B | Actin like 6B; Belongs to the actin family. (426 aa) |
| | TAF6L | TATA-box binding protein associated factor 6 like. (604 aa) |
| | BAZ1B | Bromodomain adjacent to zinc finger domain 1B. (1613 aa) |
| | UBE2A | Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | SETD3 | Actin-histidine N-methyltransferase; Protein-histidine N-methyltransferase that specifically mediates methylation of actin at 'His-73'. Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family. (647 aa) |
| | GCC1 | GRIP domain-containing protein. (784 aa) |
| | INCENPL | Uncharacterized protein. (837 aa) |
| | VRK2 | VRK serine/threonine kinase 2. (540 aa) |
| | SUV39H1 | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (267 aa) |
| | GATAD2A | GATA-type domain-containing protein. (599 aa) |
| | BMI1 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. (326 aa) |
| | PDPN | Uncharacterized protein. (146 aa) |
| | LEO1 | Uncharacterized protein. (657 aa) |
| | RBM14 | RNA binding motif protein 14. (750 aa) |
| | SMARCAD1 | Uncharacterized protein. (808 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (490 aa) |
| | ENSGALP00000052647 | HECT domain-containing protein. (283 aa) |
| | DCAF1 | DDB1 and CUL4 associated factor 1. (1505 aa) |
| | VRK3 | Protein kinase domain-containing protein. (453 aa) |
| | KMT2A | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3879 aa) |
| | PRDM13 | PR/SET domain 13. (582 aa) |
| | KAT2B | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (808 aa) |
| | SETBP1 | SET binding protein 1. (1612 aa) |
| | KANSL2 | KAT8 regulatory NSL complex subunit 2. (501 aa) |
| | HDAC10 | Histone deacetylase 10. (295 aa) |
| | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (737 aa) |
| | SMYD2 | N-lysine methyltransferase SMYD2; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'; Belongs to the class V-like SAM-binding methyltransferase superfamily. (436 aa) |
| | CREBBP | CREB binding protein. (2522 aa) |
| | USP7 | Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins, such as p53/TP53. Deubiquitinates p53/TP53, and thereby modulates p53/TP53 stability, p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. May be involved in cell proliferation during early embryonic development (By similarity). (1102 aa) |
| | ARID4B | AT-rich interaction domain 4B. (1228 aa) |
| | ZNF335 | Uncharacterized protein. (1473 aa) |
| | TADA3 | Transcriptional adaptor 3. (498 aa) |
| | BRD8 | Bromo domain-containing protein. (969 aa) |
| | MSL3 | MSL complex subunit 3. (522 aa) |
| | VRK1 | Protein kinase domain-containing protein. (568 aa) |
| | LOC415780 | TAFH domain-containing protein. (1024 aa) |
| | EZH1 | Enhancer of zeste 1 polycomb repressive complex 2 subunit. (789 aa) |
| | PHF20 | PHD finger protein 20. (1028 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break b [...] (1041 aa) |
| | KMT2D | Lysine methyltransferase 2D. (5362 aa) |
| | KDM7A | Lysine demethylase 7A. (1014 aa) |
| | BRPF1 | Uncharacterized protein. (1218 aa) |
| | SMYD5 | SET and MYND domain-containing protein 5; Belongs to the class V-like SAM-binding methyltransferase superfamily. (420 aa) |
| | ELK4 | ETS transcription factor ELK4. (478 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (489 aa) |
| | CHD5 | Chromodomain helicase DNA binding protein 5. (1966 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase alpha-5; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and that contributes to gene activation by histone phosphorylation. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcrip [...] (803 aa) |
| | EED | Polycomb protein EED; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity). (446 aa) |
| | MTA1 | Uncharacterized protein. (698 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (820 aa) |
| | MCRS1 | Microspherule protein 1. (513 aa) |
| | ZMPSTE24 | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (465 aa) |
| | NFYC | Nuclear transcription factor Y subunit gamma. (447 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. (480 aa) |
| | GTF2B | General transcription factor IIB. (344 aa) |
| | ENSGALP00000060489 | Hist_deacetyl domain-containing protein. (316 aa) |
| | SMYD1 | Uncharacterized protein. (491 aa) |
| | NTMT1 | Uncharacterized protein. (223 aa) |
| | MORF4L2 | MRG domain-containing protein. (385 aa) |
| | SIRT6 | Deacetylase sirtuin-type domain-containing protein. (378 aa) |
| | TADA1 | Uncharacterized protein. (335 aa) |
| | ENY2 | Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex [...] (96 aa) |
| | RHOGL-2 | Transcription initiation factor TFIID subunit. (1860 aa) |
| | PCGF1 | Polycomb group ring finger 1. (318 aa) |
| | KDM4B | Lysine demethylase 4B. (1168 aa) |
| | ENSGALP00000065166 | Uncharacterized protein. (329 aa) |
| | LOC107051165 | Uncharacterized protein. (230 aa) |
| | RLF | Rearranged L-myc fusion. (1901 aa) |
| | PWP1 | WD_REPEATS_REGION domain-containing protein. (575 aa) |
| | HR | JmjC domain-containing protein. (653 aa) |
| | SETDB2 | SET domain bifurcated histone lysine methyltransferase 2. (795 aa) |
| | MSL1 | MSL complex subunit 1. (537 aa) |
| | PCGF3 | Polycomb group ring finger 3. (264 aa) |
| | MCM3AP | MCM3AP_GANP domain-containing protein. (457 aa) |
| | TAF6 | TATA-box binding protein associated factor 6. (721 aa) |
| | ENSGALP00000066321 | ING domain-containing protein. (80 aa) |
| | WHSC1 | Uncharacterized protein. (537 aa) |
| | REST | Uncharacterized protein. (339 aa) |
| | YEATS2 | YEATS domain containing 2. (1398 aa) |
| | MTA2 | Metastasis associated 1 family member 2. (765 aa) |
| | HDAC7 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1250 aa) |
| | ENSGALP00000068282 | CHDCT2 domain-containing protein. (236 aa) |
| | GATAD2B | GATA zinc finger domain containing 2B. (783 aa) |
| | ENSGALP00000068544 | Uncharacterized protein. (132 aa) |
| | NEK11 | Uncharacterized protein. (64 aa) |
| | CRTC2 | TORC_N domain-containing protein. (320 aa) |
| | ENSGALP00000068700 | Uncharacterized protein. (103 aa) |
| | SMYD3 | SET and MYND domain containing 3. (487 aa) |
| | SETD2 | SET domain containing 2, histone lysine methyltransferase. (2523 aa) |
| | CDK5 | Protein kinase domain-containing protein. (522 aa) |
| | PCGF2 | RING-type domain-containing protein. (674 aa) |
| | PRDM16 | PR/SET domain 16. (1266 aa) |
| | RNF2 | Ring finger protein 2. (336 aa) |
| | EHMT1 | Uncharacterized protein. (1325 aa) |
| | KMT2C | Lysine methyltransferase 2C. (4824 aa) |
| | TBL1XR1 | Uncharacterized protein. (513 aa) |
| | DMAP1 | DNA methyltransferase 1 associated protein 1. (488 aa) |
| | NFYA | Uncharacterized protein. (401 aa) |
| | UBR2 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1758 aa) |
| | BRPF3 | Bromodomain and PHD finger containing 3. (1215 aa) |
| | KMT5A | SET domain-containing protein. (359 aa) |
| | RCOR3 | REST corepressor 3; May act as a component of a corepressor complex that represses transcription; Belongs to the CoREST family. (542 aa) |
| | MECP2 | Methyl-CpG binding protein 2. (208 aa) |
| | PCGF6 | Polycomb group ring finger 6. (365 aa) |
| | PRMT7 | Protein arginine N-methyltransferase 7; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being [...] (689 aa) |
| | ATXN7 | SCA7 domain-containing protein. (864 aa) |
| | SUPT3H | Uncharacterized protein. (435 aa) |
| | ENSGALP00000071400 | Uncharacterized protein. (222 aa) |
| | KMT5C | Lysine methyltransferase 5C. (449 aa) |
| | ENSGALP00000071894 | ELM2 domain-containing protein. (180 aa) |
| | ENSGALP00000072076 | Uncharacterized protein. (113 aa) |
| | ENSGALP00000072433 | Hist_deacetyl domain-containing protein. (266 aa) |
| | SETMAR | Uncharacterized protein. (297 aa) |
| | TBL1X | Uncharacterized protein. (523 aa) |
| | PHF2 | PHD finger protein 2. (1132 aa) |
| | MBD3 | MBD domain-containing protein. (312 aa) |
| | CBX8 | Chromobox 8. (388 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (302 aa) |
| | NSD3 | Nuclear receptor binding SET domain protein 3. (1436 aa) |
| | PRDM1 | PR/SET domain 1. (789 aa) |
| | RNF20 | E3 ubiquitin-protein ligase BRE1A; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). (1028 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (605 aa) |
| | ENSGALP00000073862 | Uncharacterized protein. (351 aa) |
| | LEF1 | HMG box domain-containing protein. (412 aa) |
| | JAK2 | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...] (1165 aa) |
| | JADE1 | Jade family PHD finger 1. (887 aa) |
| | ENSGALP00000074180 | CHDCT2 domain-containing protein. (220 aa) |
| | USP49 | Ubiquitin carboxyl-terminal hydrolase. (715 aa) |
