STRINGSTRING
VRK1 VRK1 DYRK3 DYRK3 HIPK1 HIPK1 MTOR MTOR CSNK2A1 CSNK2A1 PDPK1 PDPK1 CDC42BPB CDC42BPB TGFBR2 TGFBR2 HIPK3 HIPK3 AMHR2 AMHR2 KIAA1549 KIAA1549 BCL2 BCL2 TTK TTK DYRK1A DYRK1A ACVR1 ACVR1 TNKS TNKS ACVR1B ACVR1B ULK1 ULK1 LRRK2 LRRK2 DCAF1 DCAF1 ROCK1 ROCK1 TGFBR1 TGFBR1 ROCK2 ROCK2 STK39 STK39 GSK3B GSK3B CSNK2A2 CSNK2A2 TTBK1 TTBK1 DYRK2 DYRK2 LOC107050958 LOC107050958 CDK5 CDK5 NLK NLK ENSGALP00000069922 ENSGALP00000069922 OXSR1 OXSR1 CDK10 CDK10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VRK1Protein kinase domain-containing protein. (568 aa)
DYRK3Dual specificity tyrosine phosphorylation regulated kinase 3. (575 aa)
HIPK1Homeodomain interacting protein kinase 1. (1237 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
CSNK2A1Casein kinase II subunit alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. May play an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 (By similarity). (391 aa)
PDPK1Protein kinase domain-containing protein. (556 aa)
CDC42BPBCDC42 binding protein kinase beta; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1714 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (671 aa)
HIPK3Protein kinase domain-containing protein. (1193 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (678 aa)
KIAA1549KIAA1549. (1898 aa)
BCL2Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
TTKTTK protein kinase. (880 aa)
DYRK1AProtein kinase domain-containing protein. (756 aa)
ACVR1Activin receptor type-1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin (By similarity). (524 aa)
TNKSPoly [ADP-ribose] polymerase. (1269 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (519 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1081 aa)
LRRK2Uncharacterized protein. (2557 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1505 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1483 aa)
STK39Serine/threonine kinase 39. (615 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
CSNK2A2Casein kinase II subunit alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily. (372 aa)
TTBK1Protein kinase domain-containing protein. (1419 aa)
DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2; Serine/threonine-protein kinase involved in the control of mitotic transition and the regulation of cellular growth and/or development. (662 aa)
LOC107050958Protein kinase domain-containing protein. (237 aa)
CDK5Protein kinase domain-containing protein. (522 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
ENSGALP00000069922Protein kinase domain-containing protein. (380 aa)
OXSR1Oxidative stress responsive kinase 1. (533 aa)
CDK10Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (430 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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