(10 nodes) DNA N-glycosylase activity network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	NTHL1	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (281 aa)
	NEIL3	Nei like DNA glycosylase 3. (585 aa)
	NEIL2	FPG_CAT domain-containing protein. (328 aa)
	MBD4	Uncharacterized protein. (438 aa)
	UNG	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (299 aa)
	MPG	N-methylpurine DNA glycosylase. (273 aa)
	TDG	UDG domain-containing protein. (546 aa)
	MUTYH	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (511 aa)
	SMUG1	Single-strand-selective monofunctional uracil-DNA glycosylase 1. (332 aa)
	NEIL1	FPG_CAT domain-containing protein. (382 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MBD4	MUTYH	ENSGALP00000032601	ENSGALP00000059297	Uncharacterized protein.	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	0.574
MBD4	NEIL1	ENSGALP00000032601	ENSGALP00000002406	Uncharacterized protein.	FPG_CAT domain-containing protein.	0.574
MBD4	NEIL3	ENSGALP00000032601	ENSGALP00000017422	Uncharacterized protein.	Nei like DNA glycosylase 3.	0.435
MBD4	SMUG1	ENSGALP00000032601	ENSGALP00000071202	Uncharacterized protein.	Single-strand-selective monofunctional uracil-DNA glycosylase 1.	0.885
MBD4	TDG	ENSGALP00000032601	ENSGALP00000045187	Uncharacterized protein.	UDG domain-containing protein.	0.886
MPG	MUTYH	ENSGALP00000042308	ENSGALP00000059297	N-methylpurine DNA glycosylase.	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	0.642
MPG	NEIL2	ENSGALP00000042308	ENSGALP00000026842	N-methylpurine DNA glycosylase.	FPG_CAT domain-containing protein.	0.434
MPG	NEIL3	ENSGALP00000042308	ENSGALP00000017422	N-methylpurine DNA glycosylase.	Nei like DNA glycosylase 3.	0.509
MPG	NTHL1	ENSGALP00000042308	ENSGALP00000008999	N-methylpurine DNA glycosylase.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	0.652
MPG	SMUG1	ENSGALP00000042308	ENSGALP00000071202	N-methylpurine DNA glycosylase.	Single-strand-selective monofunctional uracil-DNA glycosylase 1.	0.459
MPG	TDG	ENSGALP00000042308	ENSGALP00000045187	N-methylpurine DNA glycosylase.	UDG domain-containing protein.	0.570
MPG	UNG	ENSGALP00000042308	ENSGALP00000033675	N-methylpurine DNA glycosylase.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.798
MUTYH	MBD4	ENSGALP00000059297	ENSGALP00000032601	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	Uncharacterized protein.	0.574
MUTYH	MPG	ENSGALP00000059297	ENSGALP00000042308	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	N-methylpurine DNA glycosylase.	0.642
MUTYH	NEIL1	ENSGALP00000059297	ENSGALP00000002406	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	FPG_CAT domain-containing protein.	0.714
MUTYH	NEIL2	ENSGALP00000059297	ENSGALP00000026842	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	FPG_CAT domain-containing protein.	0.712
MUTYH	NEIL3	ENSGALP00000059297	ENSGALP00000017422	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	Nei like DNA glycosylase 3.	0.912
MUTYH	NTHL1	ENSGALP00000059297	ENSGALP00000008999	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	0.911
MUTYH	SMUG1	ENSGALP00000059297	ENSGALP00000071202	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	Single-strand-selective monofunctional uracil-DNA glycosylase 1.	0.730
MUTYH	TDG	ENSGALP00000059297	ENSGALP00000045187	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	UDG domain-containing protein.	0.791