(11 nodes) Cytolysis network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MMD2	Monocyte to macrophage differentiation associated 2. (288 aa)
	C8G	Complement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family. (201 aa)
	MMD	Uncharacterized protein. (303 aa)
	CATH1	Cathelicidin-1; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response. (148 aa)
	CAMP	Cathelicidin-2; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response. (154 aa)
	LYG2	Lysozyme g; Belongs to the glycosyl hydrolase 23 family. (211 aa)
	C7	Uncharacterized protein. (834 aa)
	C8B	MACPF domain-containing protein. (584 aa)
	C8A	Complement C8 alpha chain. (603 aa)
	LYZ	Lysozyme C; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus; Belongs to the glycosyl hydrolase 22 family. (147 aa)
	CATH3	Cathelicidin-3; May bind bacterial lipopolysaccharide (LPS). May have antimicrobial activity and play a role in the innate immune response (By similarity). (151 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C7	C8A	ENSGALP00000023901	ENSGALP00000017612	Uncharacterized protein.	Complement C8 alpha chain.	0.652
C7	C8B	ENSGALP00000023901	ENSGALP00000017617	Uncharacterized protein.	MACPF domain-containing protein.	0.715
C7	C8G	ENSGALP00000023901	ENSGALP00000051350	Uncharacterized protein.	Complement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family.	0.893
C8A	C7	ENSGALP00000017612	ENSGALP00000023901	Complement C8 alpha chain.	Uncharacterized protein.	0.652
C8A	C8B	ENSGALP00000017612	ENSGALP00000017617	Complement C8 alpha chain.	MACPF domain-containing protein.	0.912
C8A	C8G	ENSGALP00000017612	ENSGALP00000051350	Complement C8 alpha chain.	Complement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family.	0.816
C8B	C7	ENSGALP00000017617	ENSGALP00000023901	MACPF domain-containing protein.	Uncharacterized protein.	0.715
C8B	C8A	ENSGALP00000017617	ENSGALP00000017612	MACPF domain-containing protein.	Complement C8 alpha chain.	0.912
C8B	C8G	ENSGALP00000017617	ENSGALP00000051350	MACPF domain-containing protein.	Complement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family.	0.921
C8G	C7	ENSGALP00000051350	ENSGALP00000023901	Complement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family.	Uncharacterized protein.	0.893
C8G	C8A	ENSGALP00000051350	ENSGALP00000017612	Complement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family.	Complement C8 alpha chain.	0.816
C8G	C8B	ENSGALP00000051350	ENSGALP00000017617	Complement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family.	MACPF domain-containing protein.	0.921
CAMP	CATH1	ENSGALP00000030658	ENSGALP00000042184	Cathelicidin-2; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response.	Cathelicidin-1; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response.	0.988
CAMP	CATH3	ENSGALP00000030658	ENSGALP00000056590	Cathelicidin-2; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response.	Cathelicidin-3; May bind bacterial lipopolysaccharide (LPS). May have antimicrobial activity and play a role in the innate immune response (By similarity).	0.982
CAMP	LYG2	ENSGALP00000030658	ENSGALP00000027012	Cathelicidin-2; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response.	Lysozyme g; Belongs to the glycosyl hydrolase 23 family.	0.532
CAMP	LYZ	ENSGALP00000030658	ENSGALP00000016177	Cathelicidin-2; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response.	Lysozyme C; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus; Belongs to the glycosyl hydrolase 22 family.	0.561
CATH1	CAMP	ENSGALP00000042184	ENSGALP00000030658	Cathelicidin-1; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response.	Cathelicidin-2; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response.	0.988
CATH1	CATH3	ENSGALP00000042184	ENSGALP00000056590	Cathelicidin-1; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response.	Cathelicidin-3; May bind bacterial lipopolysaccharide (LPS). May have antimicrobial activity and play a role in the innate immune response (By similarity).	0.902
CATH1	LYZ	ENSGALP00000042184	ENSGALP00000016177	Cathelicidin-1; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response.	Lysozyme C; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus; Belongs to the glycosyl hydrolase 22 family.	0.571
CATH3	CAMP	ENSGALP00000056590	ENSGALP00000030658	Cathelicidin-3; May bind bacterial lipopolysaccharide (LPS). May have antimicrobial activity and play a role in the innate immune response (By similarity).	Cathelicidin-2; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response.	0.982