(86 nodes) Protein phosphatase binding network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	STX17	t-SNARE coiled-coil homology domain-containing protein. (302 aa)
	STYXL1	Tyrosine-protein phosphatase domain-containing protein. (325 aa)
	SIRPA	Uncharacterized protein. (381 aa)
	KIFAP3	Kinesin associated protein 3. (793 aa)
	SH3RF2	SH3 domain containing ring finger 2. (644 aa)
	AP3B2	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1046 aa)
	LOC771545	Ig-like domain-containing protein. (262 aa)
	SMG5	PINc domain-containing protein. (1049 aa)
	SMTNL2	Smoothelin like 2. (468 aa)
	PHACTR3	Phosphatase and actin regulator. (585 aa)
	LGALS3	Galectin. (258 aa)
	PPP1R9B-2	Uncharacterized protein. (1349 aa)
	PPP1R3B	Protein phosphatase 1 regulatory subunit. (301 aa)
	HSP90B1	Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). Has ATPase activity (By similarity). (795 aa)
	MET	Uncharacterized protein. (1382 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1240 aa)
	SMG7	SMG7 nonsense mediated mRNA decay factor. (1141 aa)
	VRK3	Protein kinase domain-containing protein. (453 aa)
	SKAP2	Src kinase associated phosphoprotein 2. (391 aa)
	ENSA	Alpha-endosulfine; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). (117 aa)
	AKAP11	A-kinase anchoring protein 11. (1957 aa)
	PTPA	Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (321 aa)
	PPP1R9B	Protein phosphatase 1 regulatory subunit 9B. (790 aa)
	BOD1	Uncharacterized protein. (81 aa)
	FBXL2	F-box and leucine rich repeat protein 2. (436 aa)
	ANAPC4	Anaphase promoting complex subunit 4. (838 aa)
	AP3B1	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1113 aa)
	PHACTR4	Phosphatase and actin regulator 4; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the RHO/ROCK pathway (By similarity). (199 aa)
	CDH15	Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. (792 aa)
	PPP6R2	Protein phosphatase 6 regulatory subunit 2. (929 aa)
	CTNNB1	Uncharacterized protein. (781 aa)
	ANKLE2	Ankyrin repeat and LEM domain containing 2. (1212 aa)
	BOD1L1	Uncharacterized protein. (2328 aa)
	CTTNBP2NL	CTTNBP2 N-terminal like. (679 aa)
	TPPNR1L	Uncharacterized protein. (647 aa)
	ANAPC5	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (756 aa)
	ARPP19	cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity); Belongs to the endosulfine family. (112 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (872 aa)
	ROS1	Proto-oncogene tyrosine-protein kinase ROS; Orphan receptor tyrosine kinase (RTK) that may activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream si [...] (2311 aa)
	PPP1R3D	Protein phosphatase 1 regulatory subunit 3D. (312 aa)
	JUP	Plakoglobin. (747 aa)
	PPME1	Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. (388 aa)
	MTMR9	Myotubularin phosphatase domain-containing protein. (550 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1085 aa)
	GRIN3A	Glutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1126 aa)
	CDH2	Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity). (912 aa)
	BCL2	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
	AKAP5	Uncharacterized protein. (596 aa)
	NEK2	Protein kinase domain-containing protein. (444 aa)
	SHOC2	Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes (By similarity); Belongs to the SHOC2 family. (582 aa)
	MTMR3	Uncharacterized protein. (1257 aa)
	MASTL	Serine/threonine-protein kinase greatwall; Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser- 62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity hi [...] (889 aa)
	PPP1R3C	Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (314 aa)
	CSF1R	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (967 aa)
	FLT4	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1378 aa)
	SRC	Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (539 aa)
	ANAPC7	Anaphase promoting complex subunit 7. (565 aa)
	PPP1R16B	ANK_REP_REGION domain-containing protein. (571 aa)
	FBXL20	F-box and leucine rich repeat protein 20. (436 aa)
	CDC27	Uncharacterized protein. (833 aa)
	PPP1R3A	Protein phosphatase 1 regulatory subunit 3A. (1088 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1238 aa)
	ENSGALP00000066082	Uncharacterized protein. (99 aa)
	PPP1R9A	Protein phosphatase 1 regulatory subunit 9A. (1342 aa)
	STRN	Striatin. (802 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
	PPP6R3	Serine/threonine-protein phosphatase 6 regulatory subunit 3; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit (By similarity); Belongs to the SAPS family. (885 aa)
	GINS4	Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (307 aa)
	PHACTR1	Phosphatase and actin regulator 1; Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in formation of actin stress fibers. (647 aa)
	MAP2K7	Mitogen-activated protein kinase kinase 7. (1088 aa)
	GNA12	G protein subunit alpha 12. (287 aa)
	MTMR9LP	Myotubularin phosphatase domain-containing protein. (574 aa)
	ENSGALP00000069273	EST1_DNA_bind domain-containing protein. (492 aa)
	MTMR4	Myotubularin related protein 4. (1221 aa)
	ENSGALP00000069991	Uncharacterized protein. (109 aa)
	IGBP1	Uncharacterized protein. (338 aa)
	LOC107051250	WD_REPEATS_REGION domain-containing protein. (406 aa)
	PPP1R10	Protein phosphatase 1 regulatory subunit 10. (453 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (850 aa)
	KCNQ1	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (863 aa)
	STRN3	Striatin 3. (811 aa)
	SKAP1	Src kinase associated phosphoprotein 1. (355 aa)
	ENSGALP00000072498	Uncharacterized protein. (171 aa)
	FBXO41	F-box protein 41. (795 aa)
	ENSGALP00000073499	Uncharacterized protein. (85 aa)
	MVP	Major vault protein; Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport (By similarity). (918 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY8	GINS4	ENSGALP00000054389	ENSGALP00000067569	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.	0.499
AMBRA1	BCL2	ENSGALP00000037597	ENSGALP00000020984	Autophagy and beclin 1 regulator 1.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.753
AMBRA1	STX17	ENSGALP00000037597	ENSGALP00000074169	Autophagy and beclin 1 regulator 1.	t-SNARE coiled-coil homology domain-containing protein.	0.515
ANAPC4	ANAPC5	ENSGALP00000049992	ENSGALP00000038461	Anaphase promoting complex subunit 4.	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	0.999
ANAPC4	ANAPC7	ENSGALP00000049992	ENSGALP00000006056	Anaphase promoting complex subunit 4.	Anaphase promoting complex subunit 7.	0.998
ANAPC4	BOD1L1	ENSGALP00000049992	ENSGALP00000042774	Anaphase promoting complex subunit 4.	Uncharacterized protein.	0.843
ANAPC4	CDC27	ENSGALP00000049992	ENSGALP00000000830	Anaphase promoting complex subunit 4.	Uncharacterized protein.	0.999
ANAPC4	NEK2	ENSGALP00000049992	ENSGALP00000016000	Anaphase promoting complex subunit 4.	Protein kinase domain-containing protein.	0.992
ANAPC5	ANAPC4	ENSGALP00000038461	ENSGALP00000049992	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	Anaphase promoting complex subunit 4.	0.999
ANAPC5	ANAPC7	ENSGALP00000038461	ENSGALP00000006056	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	Anaphase promoting complex subunit 7.	0.998
ANAPC5	CDC27	ENSGALP00000038461	ENSGALP00000000830	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	Uncharacterized protein.	0.999
ANAPC5	NEK2	ENSGALP00000038461	ENSGALP00000016000	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	Protein kinase domain-containing protein.	0.818
ANAPC7	ANAPC4	ENSGALP00000006056	ENSGALP00000049992	Anaphase promoting complex subunit 7.	Anaphase promoting complex subunit 4.	0.998
ANAPC7	ANAPC5	ENSGALP00000006056	ENSGALP00000038461	Anaphase promoting complex subunit 7.	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	0.998
ANAPC7	CDC27	ENSGALP00000006056	ENSGALP00000000830	Anaphase promoting complex subunit 7.	Uncharacterized protein.	0.998
ANAPC7	NEK2	ENSGALP00000006056	ENSGALP00000016000	Anaphase promoting complex subunit 7.	Protein kinase domain-containing protein.	0.856
ARPP19	BOD1	ENSGALP00000038292	ENSGALP00000050880	cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity); Belongs to the endosulfine family.	Uncharacterized protein.	0.519
ARPP19	MASTL	ENSGALP00000038292	ENSGALP00000012119	cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity); Belongs to the endosulfine family.	Serine/threonine-protein kinase greatwall; Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser- 62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity hi [...]	0.944
BCL2	AMBRA1	ENSGALP00000020984	ENSGALP00000037597	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Autophagy and beclin 1 regulator 1.	0.753
BCL2	CDH2	ENSGALP00000020984	ENSGALP00000024371	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity).	0.470